JP5998135B2 - 安定性に優れた還元型補酵素ｑ１０結晶 - Google Patents

安定性に優れた還元型補酵素ｑ１０結晶 Download PDF

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JP5998135B2
JP5998135B2 JP2013521617A JP2013521617A JP5998135B2 JP 5998135 B2 JP5998135 B2 JP 5998135B2 JP 2013521617 A JP2013521617 A JP 2013521617A JP 2013521617 A JP2013521617 A JP 2013521617A JP 5998135 B2 JP5998135 B2 JP 5998135B2
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reduced coenzyme
crystal
coenzyme
reduced
crystalline solid
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JPWO2012176842A1 (ja
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河内　秀夫
秀夫 河内
志郎 北村
志郎 北村
上田　恭義
恭義 上田
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Kaneka Corp
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Kaneka Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/527—Unsaturated compounds containing keto groups bound to rings other than six-membered aromatic rings
    • C07C49/577—Unsaturated compounds containing keto groups bound to rings other than six-membered aromatic rings containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C46/00—Preparation of quinones
    • C07C46/10—Separation; Purification; Stabilisation; Use of additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/111—Aromatic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
    • A23L2/52—Adding ingredients
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/347—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35—Ketones, e.g. benzophenone
    • A61K8/355—Quinones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/34—Separation; Purification; Stabilisation; Use of additives
    • C07C41/40—Separation; Purification; Stabilisation; Use of additives by change of physical state, e.g. by crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/34—Separation; Purification; Stabilisation; Use of additives
    • C07C41/46—Use of additives, e.g. for stabilisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/78—Separation; Purification; Stabilisation; Use of additives
    • C07C45/81—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/26—Quinones containing groups having oxygen atoms singly bound to carbon atoms
    • C07C50/28—Quinones containing groups having oxygen atoms singly bound to carbon atoms with monocyclic quinoid structure
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nutrition Science (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Birds (AREA)
  • Mycology (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
JP2013521617A 2011-06-24 2012-06-21 安定性に優れた還元型補酵素ｑ１０結晶 Active JP5998135B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2011141028 2011-06-24
JP2011141028 2011-06-24
PCT/JP2012/065869 WO2012176842A1 (ja) 2011-06-24 2012-06-21 安定性に優れた還元型補酵素ｑ１０結晶

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JPWO2012176842A1 JPWO2012176842A1 (ja) 2015-02-23
JP5998135B2 true JP5998135B2 (ja) 2016-09-28

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JP2013521617A Active JP5998135B2 (ja) 2011-06-24 2012-06-21 安定性に優れた還元型補酵素ｑ１０結晶

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US (2) US9388109B2 (en:Method)
EP (1) EP2725004B1 (en:Method)
JP (1) JP5998135B2 (en:Method)
KR (1) KR101991143B1 (en:Method)
CN (1) CN103635452B (en:Method)
AU (1) AU2012274434B2 (en:Method)
BR (1) BR112013032641B1 (en:Method)
CA (1) CA2837695C (en:Method)
DK (1) DK2725004T3 (en:Method)
ES (1) ES2668675T3 (en:Method)
TW (1) TWI568718B (en:Method)
WO (1) WO2012176842A1 (en:Method)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015122531A1 (ja) * 2014-02-17 2015-08-20 株式会社カネカ 還元型補酵素ｑ１０を含有する組成物
EP3327007B1 (en) 2015-07-24 2020-06-03 Shenzhen Zhenxing Medical Technology Co., Ltd. Orbit azine-fumarate, hydrate, crystal form and preparation method therefor
JP7348663B2 (ja) * 2018-02-23 2023-09-21 センター フォー インテリジェント リサーチ イン クリスタル エンジニアリング，エセ．エレ． ユビキノールの共結晶及びそれらを含む組成物
EP3845515B1 (en) * 2018-08-30 2025-11-12 Kaneka Corporation Production method for crystal of reduced coenzyme q10 having excellent stability
CN113166017B (zh) * 2018-09-28 2024-03-29 株式会社钟化 稳定性优异的还原型辅酶q10结晶的制造方法
US11471426B2 (en) 2019-10-16 2022-10-18 American River Nutrition, Llc Compositions comprising quinone and/or quinol and methods of preparations and use thereof
CN115087631B (zh) * 2020-02-12 2024-05-14 株式会社钟化 FormII型的还原型辅酶Q10结晶的制造方法
CN113024362B (zh) 2021-03-10 2022-02-15 中国科学院上海药物研究所 一种辅酶qh与烟酰胺的共晶及其制备方法和用途
JP7739411B2 (ja) * 2021-03-26 2025-09-16 株式会社カネカ ＦｏｒｍＩＩ型の還元型補酵素Ｑ１０結晶又はその結晶性固体の製造方法及び晶析装置
WO2022202213A1 (ja) * 2021-03-26 2022-09-29 株式会社カネカ ＦｏｒｍＩＩ型の還元型補酵素Ｑ１０結晶又はその結晶性固体の製造方法
WO2022202214A1 (ja) * 2021-03-26 2022-09-29 株式会社カネカ ＦｏｒｍＩＩ型の還元型補酵素Ｑ１０結晶又はその結晶性固体の製造方法
US20250059124A1 (en) 2021-12-24 2025-02-20 Kaneka Corporation Method for storing reduced coenzyme q10
WO2023120555A1 (ja) 2021-12-24 2023-06-29 株式会社カネカ 還元型補酵素ｑ１０の保存方法
WO2023176878A1 (ja) * 2022-03-17 2023-09-21 株式会社カネカ 還元型補酵素Ｑ１０のＦｏｒｍＩＩ型結晶を含有する固体組成物の保存方法及び前記固体組成物を含有する梱包体
JPWO2023176871A1 (en:Method) 2022-03-17 2023-09-21
US20250195434A1 (en) 2022-03-17 2025-06-19 Kaneka Corporation Method for preserving solid composition that contains form ii type crystals of reduced coenzyme q10, and packing that contains said solid composition
AU2024242859A1 (en) 2023-03-30 2025-11-13 Kaneka Corporation Crystal and preparation of reduced coenzyme q10
JPWO2024204380A1 (en:Method) * 2023-03-30 2024-10-03
CN117736076B (zh) * 2023-12-19 2025-07-01 新开利安生物科技(海南)有限公司 一种还原型辅酶q10晶体及其制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3889481B2 (ja) 1996-08-16 2007-03-07 株式会社カネカ 医薬組成物
JP4577674B2 (ja) 2000-03-03 2010-11-10 リコーエレメックス株式会社 商品企画開発システム、商品企画開発方法および商品企画開発プログラムを記録したコンピュータ読み取り可能な記録媒体
TWI310029B (en:Method) * 2001-07-13 2009-05-21 Kaneka Corp
JP4170657B2 (ja) * 2001-07-13 2008-10-22 株式会社カネカ 還元型補酵素ｑ１０の結晶化法
TWI237018B (en) 2001-07-13 2005-08-01 Kaneka Corp Method of producing reduced coenzyme Q10 crystals
AU2002318846B2 (en) 2001-07-13 2008-06-12 Kaneka Corporation Method of crystallizing reduced coenzyme Q10 from aqueous solution
TWI235146B (en) 2001-07-16 2005-07-01 Kaneka Corp Method of stabilizing reduced coenzyme q10 and method of acidic crystallization
TWI329510B (en) 2001-10-10 2010-09-01 Kaneka Corp Method of stabilizing reduced coenzyme q10
JP4579835B2 (ja) 2003-01-10 2010-11-10 株式会社カネカ 還元型補酵素ｑ１０の精製方法
US7358402B2 (en) * 2003-09-10 2008-04-15 Kaneka Corporation Reduced coenzyme Q10 crystal with excellent stability and composition containing said reduced coenzyme Q10 crystal
AU2004278194B2 (en) * 2003-09-10 2009-12-03 Kaneka Corporation Reduced coenzyme Q10 crystal excelling in stability and composition containing reduced coenzyme Q10 crystal
US20090088574A1 (en) 2005-12-21 2009-04-02 Eisai R&D Management Co., Ltd. Crystal of 1,2-dihydropyridine compound (type iv)
DE102009059343A1 (de) 2009-12-31 2011-07-07 Muhr und Bender KG, 57439 Federelement als offenes Wellenband

Also Published As

Publication number Publication date
EP2725004A4 (en) 2014-12-03
KR101991143B1 (ko) 2019-06-19
TW201311635A (zh) 2013-03-16
BR112013032641B1 (pt) 2018-10-30
CA2837695C (en) 2019-12-31
CN103635452B (zh) 2017-03-15
TWI568718B (zh) 2017-02-01
ES2668675T3 (es) 2018-05-21
CN103635452A (zh) 2014-03-12
US9388109B2 (en) 2016-07-12
US9556098B2 (en) 2017-01-31
CA2837695A1 (en) 2012-12-27
EP2725004A1 (en) 2014-04-30
US20140120073A1 (en) 2014-05-01
US20160289152A1 (en) 2016-10-06
AU2012274434B2 (en) 2016-06-09
JPWO2012176842A1 (ja) 2015-02-23
BR112013032641A2 (pt) 2017-01-24
EP2725004B1 (en) 2018-02-28
KR20140061350A (ko) 2014-05-21
DK2725004T3 (en) 2018-04-16
AU2012274434A1 (en) 2014-01-09
WO2012176842A1 (ja) 2012-12-27

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