ES2668675T3 - Cristal de coenzima Q10 reducida que tiene una excelente estabilidad - Google Patents
Cristal de coenzima Q10 reducida que tiene una excelente estabilidad Download PDFInfo
- Publication number
- ES2668675T3 ES2668675T3 ES12802693.7T ES12802693T ES2668675T3 ES 2668675 T3 ES2668675 T3 ES 2668675T3 ES 12802693 T ES12802693 T ES 12802693T ES 2668675 T3 ES2668675 T3 ES 2668675T3
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- Prior art keywords
- crystal
- reduced coenzyme
- coenzyme
- reduced
- food
- Prior art date
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Classifications
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- C07C46/00—Preparation of quinones
- C07C46/10—Separation; Purification; Stabilisation; Use of additives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23K20/10—Organic substances
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- A—HUMAN NECESSITIES
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- A23K20/10—Organic substances
- A23K20/111—Aromatic compounds
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
- A23L2/52—Adding ingredients
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
- A61K8/355—Quinones
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/34—Separation; Purification; Stabilisation; Use of additives
- C07C41/40—Separation; Purification; Stabilisation; Use of additives by change of physical state, e.g. by crystallisation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/34—Separation; Purification; Stabilisation; Use of additives
- C07C41/46—Use of additives, e.g. for stabilisation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/78—Separation; Purification; Stabilisation; Use of additives
- C07C45/81—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/527—Unsaturated compounds containing keto groups bound to rings other than six-membered aromatic rings
- C07C49/577—Unsaturated compounds containing keto groups bound to rings other than six-membered aromatic rings containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C50/00—Quinones
- C07C50/26—Quinones containing groups having oxygen atoms singly bound to carbon atoms
- C07C50/28—Quinones containing groups having oxygen atoms singly bound to carbon atoms with monocyclic quinoid structure
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nutrition Science (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Crystallography & Structural Chemistry (AREA)
- Emergency Medicine (AREA)
- Birds (AREA)
- Mycology (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011141028 | 2011-06-24 | ||
| JP2011141028 | 2011-06-24 | ||
| PCT/JP2012/065869 WO2012176842A1 (ja) | 2011-06-24 | 2012-06-21 | 安定性に優れた還元型補酵素ｑ１０結晶 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2668675T3 true ES2668675T3 (es) | 2018-05-21 |
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| Application Number | Title | Priority Date | Filing Date |
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| ES12802693.7T Active ES2668675T3 (es) | 2011-06-24 | 2012-06-21 | Cristal de coenzima Q10 reducida que tiene una excelente estabilidad |
Country Status (12)
| Country | Link |
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| US (2) | US9388109B2 (en:Method) |
| EP (1) | EP2725004B1 (en:Method) |
| JP (1) | JP5998135B2 (en:Method) |
| KR (1) | KR101991143B1 (en:Method) |
| CN (1) | CN103635452B (en:Method) |
| AU (1) | AU2012274434B2 (en:Method) |
| BR (1) | BR112013032641B1 (en:Method) |
| CA (1) | CA2837695C (en:Method) |
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| ES (1) | ES2668675T3 (en:Method) |
| TW (1) | TWI568718B (en:Method) |
| WO (1) | WO2012176842A1 (en:Method) |
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| TW201613561A (en) * | 2014-02-17 | 2016-04-16 | Kaneka Corp | Composition comprising reduced coenzyme q10 |
| US10561667B2 (en) | 2015-07-24 | 2020-02-18 | Shenzhen Zhenxing Medical Technology Co., Ltd. | Orbit azine-fumarate, hydrate, crystal form and preparation method therefor |
| EP3755683A1 (en) * | 2018-02-23 | 2020-12-30 | Center for Intelligent Research in Crystal Engineering, S.L. | Cocrystals of ubiquinol and compositions comprising them |
| US11453633B2 (en) | 2018-08-30 | 2022-09-27 | Kaneka Corporation | Production method for crystal of reduced coenzyme Q10 having excellent stability |
| JP7389044B2 (ja) * | 2018-09-28 | 2023-11-29 | 株式会社カネカ | 安定性に優れた還元型補酵素ｑ１０結晶の製造方法 |
| US11471426B2 (en) | 2019-10-16 | 2022-10-18 | American River Nutrition, Llc | Compositions comprising quinone and/or quinol and methods of preparations and use thereof |
| WO2021161807A1 (ja) | 2020-02-12 | 2021-08-19 | 株式会社カネカ | ＦｏｒｍＩＩ型の還元型補酵素Ｑ１０結晶の製造方法 |
| CN113024362B (zh) * | 2021-03-10 | 2022-02-15 | 中国科学院上海药物研究所 | 一种辅酶qh与烟酰胺的共晶及其制备方法和用途 |
| US20240166589A1 (en) * | 2021-03-26 | 2024-05-23 | Kaneka Corporation | Method for producing form-ii type reduced coenzyme q10 crystal or crystalline solid of same, and crystallizing apparatus |
| JP7695993B2 (ja) * | 2021-03-26 | 2025-06-19 | 株式会社カネカ | ＦｏｒｍＩＩ型の還元型補酵素Ｑ１０結晶又はその結晶性固体の製造方法 |
| US12617744B2 (en) | 2021-03-26 | 2026-05-05 | Kaneka Corporation | Production method for reduced coenzyme Q10 form-II type crystal or crystalline solid thereof |
| WO2023120558A1 (ja) | 2021-12-24 | 2023-06-29 | 株式会社カネカ | 還元型補酵素ｑ１０の保存方法 |
| EP4454643A4 (en) | 2021-12-24 | 2025-11-05 | Kaneka Corp | REDUCED Q10 COENZYME PRESERVATION PROCESS |
| US20250195434A1 (en) * | 2022-03-17 | 2025-06-19 | Kaneka Corporation | Method for preserving solid composition that contains form ii type crystals of reduced coenzyme q10, and packing that contains said solid composition |
| WO2023176878A1 (ja) * | 2022-03-17 | 2023-09-21 | 株式会社カネカ | 還元型補酵素Ｑ１０のＦｏｒｍＩＩ型結晶を含有する固体組成物の保存方法及び前記固体組成物を含有する梱包体 |
| WO2023176871A1 (ja) | 2022-03-17 | 2023-09-21 | 株式会社カネカ | 還元型補酵素Ｑ１０のＦｏｒｍＩＩ型結晶を含有する固体組成物 |
| JPWO2024204380A1 (en:Method) * | 2023-03-30 | 2024-10-03 | ||
| JPWO2024204381A1 (en:Method) | 2023-03-30 | 2024-10-03 | ||
| CN117736076B (zh) * | 2023-12-19 | 2025-07-01 | 新开利安生物科技(海南)有限公司 | 一种还原型辅酶q10晶体及其制备方法 |
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| JP3889481B2 (ja) | 1996-08-16 | 2007-03-07 | 株式会社カネカ | 医薬組成物 |
| JP4577674B2 (ja) | 2000-03-03 | 2010-11-10 | リコーエレメックス株式会社 | 商品企画開発システム、商品企画開発方法および商品企画開発プログラムを記録したコンピュータ読み取り可能な記録媒体 |
| JP4170657B2 (ja) | 2001-07-13 | 2008-10-22 | 株式会社カネカ | 還元型補酵素ｑ１０の結晶化法 |
| TWI310029B (en:Method) | 2001-07-13 | 2009-05-21 | Kaneka Corp | |
| TWI237018B (en) | 2001-07-13 | 2005-08-01 | Kaneka Corp | Method of producing reduced coenzyme Q10 crystals |
| EP1408024B1 (en) * | 2001-07-13 | 2010-10-20 | Kaneka Corporation | METHOD OF CRYSTALLIZING REDUCED COENZYME Q sb 10 /sb FROM AQUEOUS SOLUTION |
| TWI235146B (en) | 2001-07-16 | 2005-07-01 | Kaneka Corp | Method of stabilizing reduced coenzyme q10 and method of acidic crystallization |
| TWI329510B (en) | 2001-10-10 | 2010-09-01 | Kaneka Corp | Method of stabilizing reduced coenzyme q10 |
| WO2004063131A1 (en) * | 2003-01-10 | 2004-07-29 | Kaneka Corporation | Method of purifying reduced coenzyme q |
| US7358402B2 (en) * | 2003-09-10 | 2008-04-15 | Kaneka Corporation | Reduced coenzyme Q10 crystal with excellent stability and composition containing said reduced coenzyme Q10 crystal |
| KR20060130016A (ko) * | 2003-09-10 | 2006-12-18 | 가부시키가이샤 가네카 | 안정성이 우수한 환원형 보효소 ｑ10 결정 및 환원형보효소 ｑ10 결정을 함유하는 조성물 |
| US20090088574A1 (en) | 2005-12-21 | 2009-04-02 | Eisai R&D Management Co., Ltd. | Crystal of 1,2-dihydropyridine compound (type iv) |
| DE102009059343A1 (de) | 2009-12-31 | 2011-07-07 | Muhr und Bender KG, 57439 | Federelement als offenes Wellenband |
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Also Published As
| Publication number | Publication date |
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| BR112013032641A2 (pt) | 2017-01-24 |
| CA2837695C (en) | 2019-12-31 |
| EP2725004B1 (en) | 2018-02-28 |
| CA2837695A1 (en) | 2012-12-27 |
| US20140120073A1 (en) | 2014-05-01 |
| JP5998135B2 (ja) | 2016-09-28 |
| DK2725004T3 (en) | 2018-04-16 |
| JPWO2012176842A1 (ja) | 2015-02-23 |
| CN103635452B (zh) | 2017-03-15 |
| AU2012274434B2 (en) | 2016-06-09 |
| KR101991143B1 (ko) | 2019-06-19 |
| WO2012176842A1 (ja) | 2012-12-27 |
| TWI568718B (zh) | 2017-02-01 |
| TW201311635A (zh) | 2013-03-16 |
| US20160289152A1 (en) | 2016-10-06 |
| US9556098B2 (en) | 2017-01-31 |
| CN103635452A (zh) | 2014-03-12 |
| BR112013032641B1 (pt) | 2018-10-30 |
| KR20140061350A (ko) | 2014-05-21 |
| US9388109B2 (en) | 2016-07-12 |
| AU2012274434A1 (en) | 2014-01-09 |
| EP2725004A1 (en) | 2014-04-30 |
| EP2725004A4 (en) | 2014-12-03 |
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