JP5873616B2 - 乾燥粉末、またはそれから得られた溶液もしくは懸濁液の形態にある吸入用医薬組成物およびその製造方法 - Google Patents
乾燥粉末、またはそれから得られた溶液もしくは懸濁液の形態にある吸入用医薬組成物およびその製造方法 Download PDFInfo
- Publication number
- JP5873616B2 JP5873616B2 JP2008536060A JP2008536060A JP5873616B2 JP 5873616 B2 JP5873616 B2 JP 5873616B2 JP 2008536060 A JP2008536060 A JP 2008536060A JP 2008536060 A JP2008536060 A JP 2008536060A JP 5873616 B2 JP5873616 B2 JP 5873616B2
- Authority
- JP
- Japan
- Prior art keywords
- inhalation
- composition
- powder
- particles
- surfactant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI2005A001999 | 2005-10-21 | ||
| ITMI20051999 ITMI20051999A1 (it) | 2005-10-21 | 2005-10-21 | Formulazioni inalatorie di farmaci in fora di polvere secca per somministrazione come tale o con nebulizzatore e dotate di elevata erogabilita' respirabilita' e stabilita' |
| PCT/EP2006/067619 WO2007045689A2 (en) | 2005-10-21 | 2006-10-20 | Inhalatory pharmaceutical compositions in form of dry powders, solutions or suspensions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009512663A JP2009512663A (ja) | 2009-03-26 |
| JP2009512663A5 JP2009512663A5 (enExample) | 2009-11-26 |
| JP5873616B2 true JP5873616B2 (ja) | 2016-03-01 |
Family
ID=37806135
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008536060A Active JP5873616B2 (ja) | 2005-10-21 | 2006-10-20 | 乾燥粉末、またはそれから得られた溶液もしくは懸濁液の形態にある吸入用医薬組成物およびその製造方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US9138407B2 (enExample) |
| EP (1) | EP1937229B1 (enExample) |
| JP (1) | JP5873616B2 (enExample) |
| CY (1) | CY1116503T1 (enExample) |
| DK (1) | DK1937229T3 (enExample) |
| ES (1) | ES2537777T3 (enExample) |
| HU (1) | HUE026045T2 (enExample) |
| IT (1) | ITMI20051999A1 (enExample) |
| PL (1) | PL1937229T3 (enExample) |
| PT (1) | PT1937229E (enExample) |
| RU (1) | RU2497507C2 (enExample) |
| SI (1) | SI1937229T1 (enExample) |
| WO (1) | WO2007045689A2 (enExample) |
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| ATE486064T1 (de) | 2004-08-20 | 2010-11-15 | Mannkind Corp | Katalyse der diketopiperazinsynthese |
| HUE025151T2 (en) | 2004-08-23 | 2016-01-28 | Mannkind Corp | Diceto-piperazine salts for drug delivery |
| MX373000B (es) | 2005-09-14 | 2020-05-21 | Mannkind Corp | Metodo para formulacion de farmaco basado en el aumento de la afinidad de agentes activos hacia las superficies de microparticulas cristalinas. |
| US8497258B2 (en) | 2005-11-12 | 2013-07-30 | The Regents Of The University Of California | Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract |
| US10478574B2 (en) | 2006-01-19 | 2019-11-19 | Optinose As | Nasal administration |
| CN104383546B (zh) | 2006-02-22 | 2021-03-02 | 曼金德公司 | 用于改善包含二酮哌嗪和活性剂的微粒的药物性质的方法 |
| US8614236B2 (en) * | 2006-12-12 | 2013-12-24 | University Of Washington | Methods of treating pulmonary disease using acetazolamide and structurally related derivatives |
| GB2448183A (en) | 2007-04-05 | 2008-10-08 | Optinose As | Nasal powder delivery device |
| US20090143343A1 (en) * | 2007-11-13 | 2009-06-04 | Meritage Pharma, Inc. | Compositions for the treatment of inflammation of the gastrointestinal tract |
| US20100216754A1 (en) * | 2007-11-13 | 2010-08-26 | Meritage Pharma, Inc. | Compositions for the treatment of inflammation of the gastrointestinal tract |
| DK3354276T3 (da) | 2007-11-13 | 2020-03-30 | Meritage Pharma Inc | Sammensætninger til behandlingen af gastrointestinal inflammation |
| EP2534957B1 (en) | 2007-12-14 | 2015-05-27 | AeroDesigns, Inc | Delivering aerosolizable products |
| WO2009139506A1 (ja) * | 2008-05-15 | 2009-11-19 | Aspion株式会社 | 異なる物性の薬物の一剤形化 |
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| EP2609954B1 (en) | 2008-06-20 | 2021-12-29 | MannKind Corporation | An interactive apparatus for real-time profiling of inhalation efforts |
| TWI494123B (zh) | 2008-08-11 | 2015-08-01 | Mannkind Corp | 超快起作用胰島素之用途 |
| US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
| US8538707B2 (en) | 2009-03-11 | 2013-09-17 | Mannkind Corporation | Apparatus, system and method for measuring resistance of an inhaler |
| ES3003038T3 (en) * | 2009-03-18 | 2025-03-10 | Incarda Therapeutics Inc | Unit doses, aerosols, kits, and methods for treating heart conditions by pulmonary administration |
| AU2010259943C1 (en) | 2009-06-12 | 2016-03-03 | Mannkind Corporation | Diketopiperazine microparticles with defined specific surface areas |
| JP5784622B2 (ja) | 2009-11-03 | 2015-09-24 | マンカインド コーポレ−ション | 吸入活動をシミュレートするための装置及び方法 |
| RU2445119C2 (ru) * | 2010-05-25 | 2012-03-20 | Сергей Викторович Чепур | Фармацевтическая композиция и способ ее ингаляционного введения |
| RU2531455C2 (ru) | 2010-06-21 | 2014-10-20 | Маннкайнд Корпорейшн | Системы и способы доставки сухих порошковых лекарств |
| EP4008326A1 (en) * | 2010-09-29 | 2022-06-08 | Pulmatrix Operating Company, Inc. | Monovalent metal cation dry powders for inhalation |
| GB2488992A (en) * | 2011-03-10 | 2012-09-19 | Advanced Ophthalmic Pharma Ltd | Medicament dispenser |
| MX353285B (es) | 2011-04-01 | 2018-01-05 | Mannkind Corp | Paquete de blister para cartuchos farmaceuticos. |
| CN103501791B (zh) * | 2011-05-03 | 2016-05-18 | 奇斯药制品公司 | 用于通过吸入给药的改良皮质类固醇悬浮制剂 |
| WO2012174472A1 (en) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | High capacity diketopiperazine microparticles |
| HK1201475A1 (en) | 2011-10-24 | 2015-09-04 | Mannkind Corporation | Methods and compositions for treating pain |
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| JP6197515B2 (ja) * | 2012-10-19 | 2017-09-20 | 大正製薬株式会社 | 医薬組成物 |
| WO2014066856A1 (en) | 2012-10-26 | 2014-05-01 | Mannkind Corporation | Inhalable influenza vaccine compositions and methods |
| US9757395B2 (en) | 2012-12-20 | 2017-09-12 | Otitopic Inc. | Dry powder inhaler and methods of use |
| US9757529B2 (en) | 2012-12-20 | 2017-09-12 | Otitopic Inc. | Dry powder inhaler and methods of use |
| KR20180092324A (ko) * | 2013-03-13 | 2018-08-20 | 포레스트 래보러토리즈 홀딩스 리미티드 | 미분화된 약제학적 조성물 |
| US9452139B2 (en) | 2013-03-14 | 2016-09-27 | Novartis Ag | Respirable agglomerates of porous carrier particles and micronized drug |
| BR112015023168B1 (pt) | 2013-03-15 | 2021-08-10 | Mannkind Corporation | Composição de 3,6-bis(n-fumaril-4-aminobutil)-2,5-dicetopiperazina cristalina, método de produção de partículas de 3,6-bis(n-fumaril-4-aminobutil)-2,5-dicetopiperazina e uso de uma composição de dicetopiperazina cristalina |
| US11554229B2 (en) | 2013-03-26 | 2023-01-17 | OptiNose Inc. | Nasal administration |
| ITMI20130572A1 (it) * | 2013-04-10 | 2014-10-11 | Eratech Srl | Composizione comprendente almeno due polveri secche ottenute per spray dry per aumentare la stabilita' della formulazione |
| ITMI20130571A1 (it) * | 2013-04-10 | 2014-10-11 | Zambon Spa | Composizione farmaceutica contenente budesonide e formoterolo |
| CN105473133A (zh) | 2013-04-30 | 2016-04-06 | 欧缇托匹克公司 | 干粉制剂及使用方法 |
| CN104274426A (zh) | 2013-07-03 | 2015-01-14 | 陆克塞纳医药公司 | 昂丹司琼细粉、昂丹司琼气溶胶组合物及其用途 |
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| RU2539374C1 (ru) * | 2013-11-29 | 2015-01-20 | Федеральное государственное автономное образовательное учреждение высшего образования "Новосибирский национальный исследовательский государственный университет" (Новосибирский государственный университет, НГУ) | Высокодисперсная комбинированная фармацевтическая композиция беклометазона и сальбутамола с бета-глицином и способ ее получения |
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| WO2015187356A1 (en) * | 2014-06-04 | 2015-12-10 | Quick Joshua Ryan | System and method for delivering an inhalable sugar formulation |
| LT3193835T (lt) | 2014-09-15 | 2018-06-11 | Verona Pharma Plc | Skysta inhaliuojama vaisto forma, apimanti rpl554 |
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| KR102462058B1 (ko) * | 2014-10-08 | 2022-11-01 | 잠본쏘시에떼퍼아찌오니 | 제제의 안정성을 증가시키기 위해 분무 건조에 의해 수득된 1종 이상의 건조 분말을 포함하는 조성물 |
| ES2971768T3 (es) * | 2014-10-08 | 2024-06-06 | Zambon Spa | Composición farmacéutica que contiene budesonida y formoterol |
| AU2015338717B2 (en) | 2014-10-31 | 2018-12-20 | Glaxosmithkline Intellectual Property Development Limited | Powder formulation |
| HK1252798A1 (zh) * | 2015-08-05 | 2019-06-06 | Daiichi Sankyo Company, Limited | 喷雾器用组合物 |
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| JP7680823B2 (ja) * | 2017-03-07 | 2025-05-21 | フィリップ・モーリス・プロダクツ・ソシエテ・アノニム | 吸入可能なニコチン製剤、およびその作製および使用方法 |
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| CA3073195A1 (en) | 2017-08-15 | 2019-02-21 | Nephron Pharmaceuticals Corporation | Aqueous nebulization composition |
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| US10786456B2 (en) | 2017-09-22 | 2020-09-29 | Otitopic Inc. | Inhaled aspirin and magnesium to treat inflammation |
| EP3735223A4 (en) | 2018-01-05 | 2021-10-13 | Impel Neuropharma Inc. | INTRANASAL ADMINISTRATION OF OLANZAPINE BY A PRECISION OLFACTORY DEVICE |
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| WO2020150460A1 (en) * | 2019-01-18 | 2020-07-23 | Milne Iii Donald A | Micronized aspirin formulation |
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| RU2730488C1 (ru) * | 2019-08-20 | 2020-08-24 | Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт биомедицинской химии имени В.Н. Ореховича" (ИБМХ) | Фармацевтическая композиция на основе глюкокортикостероида будесонида и фосфатидилхолина для сухой ингаляции |
| GB201914532D0 (en) * | 2019-10-08 | 2019-11-20 | Univ Of Huddersfield | Lactose particles and method of production thereof |
| RU2735502C1 (ru) * | 2020-01-09 | 2020-11-03 | Федеральное государственное бюджетное учреждение науки Удмуртский федеральный исследовательский центр Уральского отделения Российской академии наук | Аэрозоль для ингаляций при обструктивном бронхите |
| CN111202723A (zh) * | 2020-02-15 | 2020-05-29 | 江苏艾立康药业股份有限公司 | 一种达芦那韦吸入干粉药物组合物及其制备方法 |
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| JP3009598B2 (ja) | 1994-02-18 | 2000-02-14 | 武田薬品工業株式会社 | プレフィルドシリンジ |
| GB9501841D0 (en) | 1995-01-31 | 1995-03-22 | Co Ordinated Drug Dev | Improvements in and relating to carrier particles for use in dry powder inhalers |
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| HUP0500846A3 (en) * | 2002-12-31 | 2008-10-28 | Nektar Therapeutics | Pharmaceutical formulation with an insoluble active agent for pulmonary administration |
| JP2006522634A (ja) | 2003-04-14 | 2006-10-05 | ベクトゥラ・リミテッド | 投与効率を向上させるデバイス及び製薬組成 |
| GB0327723D0 (en) * | 2003-09-15 | 2003-12-31 | Vectura Ltd | Pharmaceutical compositions |
| EP1663164A2 (en) | 2003-09-15 | 2006-06-07 | Vectura Limited | Methods for preparing pharmaceutical compositions |
| KR20060117909A (ko) * | 2003-09-15 | 2006-11-17 | 벡투라 리미티드 | 폐 흡입에 의한 조루 치료용 제약학적 조성물 |
| ITMI20040795A1 (it) | 2004-04-23 | 2004-07-23 | Eratech S R L | Composizione farmaceutica solida secca suo processo di preparazione e sospensione acquosa stabile ottenuta dalla stessa |
-
2005
- 2005-10-21 IT ITMI20051999 patent/ITMI20051999A1/it unknown
-
2006
- 2006-10-20 JP JP2008536060A patent/JP5873616B2/ja active Active
- 2006-10-20 EP EP06807435.0A patent/EP1937229B1/en active Active
- 2006-10-20 PL PL06807435T patent/PL1937229T3/pl unknown
- 2006-10-20 WO PCT/EP2006/067619 patent/WO2007045689A2/en not_active Ceased
- 2006-10-20 PT PT68074350T patent/PT1937229E/pt unknown
- 2006-10-20 RU RU2008120018/15A patent/RU2497507C2/ru not_active Application Discontinuation
- 2006-10-20 ES ES06807435.0T patent/ES2537777T3/es active Active
- 2006-10-20 SI SI200631930T patent/SI1937229T1/sl unknown
- 2006-10-20 US US12/090,899 patent/US9138407B2/en active Active
- 2006-10-20 DK DK06807435.0T patent/DK1937229T3/da active
- 2006-10-20 HU HUE06807435A patent/HUE026045T2/hu unknown
-
2015
- 2015-06-10 CY CY20151100506T patent/CY1116503T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007045689A3 (en) | 2007-09-07 |
| PL1937229T3 (pl) | 2015-08-31 |
| SI1937229T1 (sl) | 2015-08-31 |
| US20080226736A1 (en) | 2008-09-18 |
| JP2009512663A (ja) | 2009-03-26 |
| HUE026045T2 (hu) | 2016-05-30 |
| US9138407B2 (en) | 2015-09-22 |
| WO2007045689A2 (en) | 2007-04-26 |
| ITMI20051999A1 (it) | 2007-04-22 |
| CY1116503T1 (el) | 2017-03-15 |
| EP1937229B1 (en) | 2015-03-11 |
| PT1937229E (pt) | 2015-07-16 |
| ES2537777T3 (es) | 2015-06-12 |
| RU2497507C2 (ru) | 2013-11-10 |
| DK1937229T3 (da) | 2015-06-22 |
| EP1937229A2 (en) | 2008-07-02 |
| RU2008120018A (ru) | 2009-11-27 |
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