SI1937229T1 - Farmacevtski sestavki za inhaliranje v obliki suhih praškov, raztopin ali suspenzij - Google Patents

Farmacevtski sestavki za inhaliranje v obliki suhih praškov, raztopin ali suspenzij

Info

Publication number
SI1937229T1
SI1937229T1 SI200631930T SI200631930T SI1937229T1 SI 1937229 T1 SI1937229 T1 SI 1937229T1 SI 200631930 T SI200631930 T SI 200631930T SI 200631930 T SI200631930 T SI 200631930T SI 1937229 T1 SI1937229 T1 SI 1937229T1
Authority
SI
Slovenia
Prior art keywords
suspensions
solutions
pharmaceutical compositions
dry powders
inhalatory pharmaceutical
Prior art date
Application number
SI200631930T
Other languages
English (en)
Slovenian (sl)
Inventor
Cristina Veneziani
Giovanni Caponetti
Loretta Maggi
Laura Zanellotti
Original Assignee
Eratech S.R.L.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37806135&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI1937229(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Eratech S.R.L. filed Critical Eratech S.R.L.
Publication of SI1937229T1 publication Critical patent/SI1937229T1/sl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SI200631930T 2005-10-21 2006-10-20 Farmacevtski sestavki za inhaliranje v obliki suhih praškov, raztopin ali suspenzij SI1937229T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI20051999 ITMI20051999A1 (it) 2005-10-21 2005-10-21 Formulazioni inalatorie di farmaci in fora di polvere secca per somministrazione come tale o con nebulizzatore e dotate di elevata erogabilita' respirabilita' e stabilita'
PCT/EP2006/067619 WO2007045689A2 (en) 2005-10-21 2006-10-20 Inhalatory pharmaceutical compositions in form of dry powders, solutions or suspensions
EP06807435.0A EP1937229B1 (en) 2005-10-21 2006-10-20 Inhalatory pharmaceutical compositions in form of dry powders, solutions or suspensions

Publications (1)

Publication Number Publication Date
SI1937229T1 true SI1937229T1 (sl) 2015-08-31

Family

ID=37806135

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200631930T SI1937229T1 (sl) 2005-10-21 2006-10-20 Farmacevtski sestavki za inhaliranje v obliki suhih praškov, raztopin ali suspenzij

Country Status (13)

Country Link
US (1) US9138407B2 (enExample)
EP (1) EP1937229B1 (enExample)
JP (1) JP5873616B2 (enExample)
CY (1) CY1116503T1 (enExample)
DK (1) DK1937229T3 (enExample)
ES (1) ES2537777T3 (enExample)
HU (1) HUE026045T2 (enExample)
IT (1) ITMI20051999A1 (enExample)
PL (1) PL1937229T3 (enExample)
PT (1) PT1937229E (enExample)
RU (1) RU2497507C2 (enExample)
SI (1) SI1937229T1 (enExample)
WO (1) WO2007045689A2 (enExample)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
US6923175B2 (en) 2002-03-20 2005-08-02 Mannkind Corporation Inhalation apparatus
CN101010305B (zh) 2004-08-20 2010-08-11 曼金德公司 二酮哌嗪合成的催化反应
BR122019022692B1 (pt) 2004-08-23 2023-01-10 Mannkind Corporation Composição terapêutica em pó seco contendo dicetopiperazina, pelo menos um tipo de cátion e um agente biologicamente ativo
KR101384456B1 (ko) 2005-09-14 2014-04-10 맨카인드 코포레이션 활성제에 대한 결정질 미립자 표면의 친화력의 증가를 기반으로 하는 약물 제제화의 방법
US8497258B2 (en) 2005-11-12 2013-07-30 The Regents Of The University Of California Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract
AU2006335994A1 (en) 2006-01-19 2007-07-26 Optinose As Nasal administration
ES2647080T3 (es) 2006-02-22 2017-12-19 Mannkind Corporation Un método para mejorar las propiedades farmacéuticas de micropartículas que comprenden dicetopiperazina y un agente activo
US8614236B2 (en) * 2006-12-12 2013-12-24 University Of Washington Methods of treating pulmonary disease using acetazolamide and structurally related derivatives
GB2448183A (en) 2007-04-05 2008-10-08 Optinose As Nasal powder delivery device
WO2011163272A1 (en) 2010-06-21 2011-12-29 Mannkind Corporation Dry powder drug delivery system and methods
US20100216754A1 (en) * 2007-11-13 2010-08-26 Meritage Pharma, Inc. Compositions for the treatment of inflammation of the gastrointestinal tract
LT3354276T (lt) 2007-11-13 2020-04-27 Meritage Pharma, Inc. Kompozicijos, skirtos skrandžio ir žarnyno uždegimo gydymui
US9050368B2 (en) * 2007-11-13 2015-06-09 Meritage Pharma, Inc. Corticosteroid compositions
JP5570996B2 (ja) 2007-12-14 2014-08-13 エアロデザインズ インコーポレイテッド エアロゾル化可能な食料品の送達
JP5485879B2 (ja) * 2008-05-15 2014-05-07 株式会社ココカラファインネクスト 異なる物性の薬物の一剤形化
DK2293833T3 (en) 2008-06-13 2016-05-23 Mannkind Corp DRY POWDER INHALER AND MEDICINAL ADMINISTRATION SYSTEM
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
CA2728523C (en) 2008-06-20 2020-03-10 Mannkind Corporation An interactive apparatus and method for real-time profiling of inhalation efforts
TWI532497B (zh) 2008-08-11 2016-05-11 曼凱公司 超快起作用胰島素之用途
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
CA2754595C (en) 2009-03-11 2017-06-27 Mannkind Corporation Apparatus, system and method for measuring resistance of an inhaler
CA2835771C (en) * 2009-03-18 2017-01-24 Incarda Therapeutics, Inc. Unit doses, aerosols, kits, and methods for treating heart conditions by pulmonary administration
US8551528B2 (en) 2009-06-12 2013-10-08 Mannkind Corporation Diketopiperazine microparticles with defined specific surface areas
JP5784622B2 (ja) 2009-11-03 2015-09-24 マンカインド コーポレ−ション 吸入活動をシミュレートするための装置及び方法
RU2445119C2 (ru) * 2010-05-25 2012-03-20 Сергей Викторович Чепур Фармацевтическая композиция и способ ее ингаляционного введения
CN107096014B (zh) 2010-09-29 2022-07-15 普马特里克斯营业公司 吸入用单价金属阳离子干粉剂
GB2488992A (en) * 2011-03-10 2012-09-19 Advanced Ophthalmic Pharma Ltd Medicament dispenser
ES2625858T3 (es) 2011-04-01 2017-07-20 Mannkind Corporation Paquete de tipo blíster para cartuchos farmacéuticos
HRP20161757T1 (hr) * 2011-05-03 2017-02-10 Chiesi Farmaceutici S.P.A. Poboljšana formulacija suspenzije beklometazon-dipropionata za davanje inhalacijom
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
HK1201475A1 (en) 2011-10-24 2015-09-04 Mannkind Corporation Methods and compositions for treating pain
CA3098386C (en) 2012-07-12 2022-11-29 Mannkind Corporation Dry powder drug delivery systems and methods
JP6197515B2 (ja) * 2012-10-19 2017-09-20 大正製薬株式会社 医薬組成物
EP2911690A1 (en) 2012-10-26 2015-09-02 MannKind Corporation Inhalable influenza vaccine compositions and methods
US9757395B2 (en) 2012-12-20 2017-09-12 Otitopic Inc. Dry powder inhaler and methods of use
US9757529B2 (en) 2012-12-20 2017-09-12 Otitopic Inc. Dry powder inhaler and methods of use
KR20180092324A (ko) 2013-03-13 2018-08-20 포레스트 래보러토리즈 홀딩스 리미티드 미분화된 약제학적 조성물
US9452139B2 (en) 2013-03-14 2016-09-27 Novartis Ag Respirable agglomerates of porous carrier particles and micronized drug
MX369136B (es) 2013-03-15 2019-10-30 Mannkind Corp Composiciones de dicetopiperazina microcristalina y metodos.
US11554229B2 (en) 2013-03-26 2023-01-17 OptiNose Inc. Nasal administration
ITMI20130571A1 (it) * 2013-04-10 2014-10-11 Zambon Spa Composizione farmaceutica contenente budesonide e formoterolo
ITMI20130572A1 (it) * 2013-04-10 2014-10-11 Eratech Srl Composizione comprendente almeno due polveri secche ottenute per spray dry per aumentare la stabilita' della formulazione
US10149823B2 (en) 2013-04-30 2018-12-11 Otitopic Inc. Dry powder formulations and methods of use
WO2016004409A1 (en) * 2014-07-03 2016-01-07 Luxena Pharmaceuticals, Inc. Novel aerosol formulations of ondansetron and uses thereof
CN104274426A (zh) 2013-07-03 2015-01-14 陆克塞纳医药公司 昂丹司琼细粉、昂丹司琼气溶胶组合物及其用途
BR122019026637B1 (pt) 2013-07-18 2023-09-26 Mannkind Corporation Formulações farmacêuticas de pó seco e método para a fabricação de uma formulação de pó seco
US11446127B2 (en) 2013-08-05 2022-09-20 Mannkind Corporation Insufflation apparatus and methods
RU2539374C1 (ru) * 2013-11-29 2015-01-20 Федеральное государственное автономное образовательное учреждение высшего образования "Новосибирский национальный исследовательский государственный университет" (Новосибирский государственный университет, НГУ) Высокодисперсная комбинированная фармацевтическая композиция беклометазона и сальбутамола с бета-глицином и способ ее получения
GB201321712D0 (en) * 2013-12-09 2014-01-22 Pharmachemie Bv Dry Powder Inhaler
CN112656780A (zh) 2014-02-20 2021-04-16 奥迪托皮克股份有限公司 用于吸入的干粉制剂
WO2015148905A1 (en) 2014-03-28 2015-10-01 Mannkind Corporation Use of ultrarapid acting insulin
WO2015187356A1 (en) * 2014-06-04 2015-12-10 Quick Joshua Ryan System and method for delivering an inhalable sugar formulation
RU2699995C2 (ru) 2014-09-15 2019-09-12 ВЕРОНА ФАРМА ПиэЛСи Жидкая ингаляционная композиция, содержащая rpl 554
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
KR102462058B1 (ko) 2014-10-08 2022-11-01 잠본쏘시에떼퍼아찌오니 제제의 안정성을 증가시키기 위해 분무 건조에 의해 수득된 1종 이상의 건조 분말을 포함하는 조성물
MX372705B (es) * 2014-10-08 2020-06-18 Zambon Spa Composición farmacéutica que contiene budesonida y formoterol
CN107106641B (zh) 2014-10-31 2021-12-21 葛兰素史密斯克莱知识产权发展有限公司 粉末制剂
WO2017022814A1 (ja) * 2015-08-05 2017-02-09 第一三共株式会社 ネブライザー用組成物
EP3346987A1 (en) * 2015-09-09 2018-07-18 Novartis AG Targeted delivery of spray-dried formulations to the lungs
CN118078742A (zh) 2015-10-20 2024-05-28 斯帕方有限公司 包含丹曲林的水性组合物
CN109069495A (zh) 2016-02-01 2018-12-21 英凯达治疗公司 电子监测联合吸入药理学疗法管理包括心房颤动在内的心律失常
CN109310622A (zh) * 2016-06-30 2019-02-05 菲利普莫里斯生产公司 尼古丁颗粒和组合物
ES3005760T3 (en) * 2016-06-30 2025-03-17 Philip Morris Products Sa Nicotine particles
RU2766086C2 (ru) 2016-10-14 2022-02-07 Пулматрикс Оперэйтинг Компани, Инк. Противогрибковые сухие порошки
RU2770039C2 (ru) * 2017-03-07 2022-04-14 Филип Моррис Продактс С.А. Вдыхаемые составы на основе никотина и способы их получения и применения
CN110869018A (zh) 2017-05-10 2020-03-06 英凯达治疗公司 通过肺部施用治疗心脏病况的单位剂量、气雾剂、试剂盒和方法
AU2018318123B2 (en) 2017-08-15 2024-07-25 Nephron Pharmaceuticals Corporation Aqueous nebulization composition
AU2017432640B2 (en) 2017-09-22 2023-11-30 Aspeya US Inc. Dry powder compositions with magnesium stearate
US10786456B2 (en) 2017-09-22 2020-09-29 Otitopic Inc. Inhaled aspirin and magnesium to treat inflammation
US11278492B2 (en) 2018-01-05 2022-03-22 Impel Neuropharma, Inc. Intranasal delivery of olanzapine by precision olfactory device
WO2019183470A2 (en) 2018-03-22 2019-09-26 Incarda Therapeutics, Inc. A novel method to slow ventricular rate
WO2020150460A1 (en) * 2019-01-18 2020-07-23 Milne Iii Donald A Micronized aspirin formulation
US11007185B2 (en) 2019-08-01 2021-05-18 Incarda Therapeutics, Inc. Antiarrhythmic formulation
RU2730488C1 (ru) * 2019-08-20 2020-08-24 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт биомедицинской химии имени В.Н. Ореховича" (ИБМХ) Фармацевтическая композиция на основе глюкокортикостероида будесонида и фосфатидилхолина для сухой ингаляции
GB201914532D0 (en) * 2019-10-08 2019-11-20 Univ Of Huddersfield Lactose particles and method of production thereof
RU2735502C1 (ru) * 2020-01-09 2020-11-03 Федеральное государственное бюджетное учреждение науки Удмуртский федеральный исследовательский центр Уральского отделения Российской академии наук Аэрозоль для ингаляций при обструктивном бронхите
CN111202723A (zh) * 2020-02-15 2020-05-29 江苏艾立康药业股份有限公司 一种达芦那韦吸入干粉药物组合物及其制备方法
MX2023001201A (es) * 2020-07-31 2023-05-03 Chemo Res S L Terapia combinada para la administracion por inhalacion.
US20250108068A1 (en) * 2023-09-28 2025-04-03 Color Ventures LLC Compositions and methods for alleviating pulmonary ailments

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3009598B2 (ja) 1994-02-18 2000-02-14 武田薬品工業株式会社 プレフィルドシリンジ
GB9501841D0 (en) 1995-01-31 1995-03-22 Co Ordinated Drug Dev Improvements in and relating to carrier particles for use in dry powder inhalers
DE19636150A1 (de) * 1996-09-06 1998-03-12 Asta Medica Ag N-substituierte Indol-3-glyoxylamide mit antiasthmatischer, antiallergischer und immunsuppressiver/immunmodulierender Wirkung
US6309623B1 (en) * 1997-09-29 2001-10-30 Inhale Therapeutic Systems, Inc. Stabilized preparations for use in metered dose inhalers
WO1999016421A1 (en) 1997-09-29 1999-04-08 Inhale Therapeutic Systems, Inc. Stabilized bioactive preparations and methods of use
JP2002518432A (ja) 1998-06-24 2002-06-25 アドバンスト インハレーション リサーチ，インコーポレイテッド 吸入器から放出される大多孔性粒子
EP1210067A2 (en) 1999-08-25 2002-06-05 Advanced Inhalation Research, Inc. Modulation of release from dry powder formulations
EP1666028B1 (en) 1999-10-29 2010-03-24 Novartis AG Dry powder compositions having improved dispersivity
GB9929486D0 (en) 1999-12-15 2000-02-09 Glaxo Group Ltd Inhalation delivery apparatus and method
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
WO2002000197A1 (en) 2000-06-27 2002-01-03 Vectura Limited Method of making particles for use in a pharmaceutical composition
CA2413692C (en) 2000-06-27 2011-10-18 Vectura Limited Method of making particles for use in a pharmaceutical composition
US20020103139A1 (en) 2000-12-01 2002-08-01 M. Weisspapir Solid self-emulsifying controlled release drug delivery system composition for enhanced delivery of water insoluble phytosterols and other hydrophobic natural compounds for body weight and cholestrol level control
US20110123574A1 (en) * 2002-03-20 2011-05-26 Alkermes, Inc. Inhalable sustained therapeutic formulations
CA2478974C (en) 2002-03-20 2014-12-16 Advanced Inhalation Research, Inc. Inhalable sustained therapeutic formulations
CA2488976C (en) 2002-06-28 2009-08-25 Advanced Inhalation Research, Inc. Inhalable epinephrine
EP1556018A1 (en) * 2002-09-30 2005-07-27 Acusphere, Inc. Sustained release porous microparticles for inhalation
JP2006513236A (ja) 2002-12-31 2006-04-20 ネクター セラピューティクス 不溶性活性物質を伴う医薬製剤
EP1617820B1 (en) * 2003-04-14 2018-03-21 Vectura Limited Dry power inhaler devices and dry power formulations for enhancing dosing efficiency
BRPI0414428A (pt) * 2003-09-15 2006-11-14 Vectura Ltd composições farmacêuticas
GB0327723D0 (en) * 2003-09-15 2003-12-31 Vectura Ltd Pharmaceutical compositions
US20060292081A1 (en) 2003-09-15 2006-12-28 Vectura Limited Methods for preparing pharmaceutical compositions
ITMI20040795A1 (it) * 2004-04-23 2004-07-23 Eratech S R L Composizione farmaceutica solida secca suo processo di preparazione e sospensione acquosa stabile ottenuta dalla stessa

Also Published As

Publication number Publication date
PL1937229T3 (pl) 2015-08-31
DK1937229T3 (da) 2015-06-22
ITMI20051999A1 (it) 2007-04-22
US20080226736A1 (en) 2008-09-18
EP1937229B1 (en) 2015-03-11
US9138407B2 (en) 2015-09-22
JP2009512663A (ja) 2009-03-26
EP1937229A2 (en) 2008-07-02
WO2007045689A3 (en) 2007-09-07
HUE026045T2 (hu) 2016-05-30
PT1937229E (pt) 2015-07-16
CY1116503T1 (el) 2017-03-15
ES2537777T3 (es) 2015-06-12
RU2008120018A (ru) 2009-11-27
WO2007045689A2 (en) 2007-04-26
RU2497507C2 (ru) 2013-11-10
JP5873616B2 (ja) 2016-03-01

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