JP5855095B2 - フラニル化合物およびその使用 - Google Patents

フラニル化合物およびその使用 Download PDF

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Publication number
JP5855095B2
JP5855095B2 JP2013514280A JP2013514280A JP5855095B2 JP 5855095 B2 JP5855095 B2 JP 5855095B2 JP 2013514280 A JP2013514280 A JP 2013514280A JP 2013514280 A JP2013514280 A JP 2013514280A JP 5855095 B2 JP5855095 B2 JP 5855095B2
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Japan
Prior art keywords
cancer
compound
acid
mixture
alkyl
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Japanese (ja)
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JP2013528215A (ja
JP2013528215A5 (enExample
Inventor
ファン，リー，エム．
チャン，カイル，ダブリュー．，エイチ．
スウィンドルハースト，キャシー，エイ．
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Novomedix LLC
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Novomedix LLC
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
JP2013514280A 2010-06-07 2011-06-07 フラニル化合物およびその使用 Active JP5855095B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35230810P 2010-06-07 2010-06-07
US61/352,308 2010-06-07
PCT/US2011/039377 WO2011156321A1 (en) 2010-06-07 2011-06-07 Furanyl compounds and the use thereof

Publications (3)

Publication Number Publication Date
JP2013528215A JP2013528215A (ja) 2013-07-08
JP2013528215A5 JP2013528215A5 (enExample) 2015-09-24
JP5855095B2 true JP5855095B2 (ja) 2016-02-09

Family

ID=44210539

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013514280A Active JP5855095B2 (ja) 2010-06-07 2011-06-07 フラニル化合物およびその使用

Country Status (11)

Country Link
US (3) US8722731B2 (enExample)
EP (1) EP2576532B1 (enExample)
JP (1) JP5855095B2 (enExample)
CN (2) CN104860907A (enExample)
AU (1) AU2011265047B2 (enExample)
CA (1) CA2801778C (enExample)
MX (2) MX367469B (enExample)
NZ (1) NZ604018A (enExample)
SG (1) SG186229A1 (enExample)
WO (1) WO2011156321A1 (enExample)
ZA (1) ZA201209237B (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2576532B1 (en) 2010-06-07 2018-07-18 Novomedix, LLC Furanyl compounds and the use thereof
CN110818660B (zh) * 2012-09-21 2023-09-12 罗得岛医院 用于治疗癌症的β-羟化酶抑制剂
CN104955801B (zh) 2012-11-30 2017-10-31 诺沃梅迪科斯有限公司 取代的二芳基磺酰胺及其用途
WO2015088977A1 (en) * 2013-12-10 2015-06-18 Emory University Targeted protease compositions and uses related thereto
US9993494B2 (en) 2014-02-07 2018-06-12 Effector Therapeutics, Inc. Compositions and methods for treating fibrotic disease
US10548908B2 (en) * 2016-09-15 2020-02-04 Nostopharma, LLC Compositions and methods for preventing and treating heterotopic ossification and pathologic calcification
TW202146393A (zh) * 2020-03-03 2021-12-16 美商皮克醫療公司 Eif4e抑制劑及其用途

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US9663483B2 (en) 2017-05-30
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US8722731B2 (en) 2014-05-13
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