CA2801778C - Furanyl compounds and the use thereof - Google Patents

Furanyl compounds and the use thereof Download PDF

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Publication number
CA2801778C
CA2801778C CA2801778A CA2801778A CA2801778C CA 2801778 C CA2801778 C CA 2801778C CA 2801778 A CA2801778 A CA 2801778A CA 2801778 A CA2801778 A CA 2801778A CA 2801778 C CA2801778 C CA 2801778C
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CA
Canada
Prior art keywords
cancer
nr5r6
compound
optionally substituted
membered
Prior art date
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Active
Application number
CA2801778A
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English (en)
French (fr)
Other versions
CA2801778A1 (en
Inventor
Leah M. Fung
Kyle W. H. Chan
Cathy A. Swindlehurst
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novomedix LLC
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Novomedix LLC
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Filing date
Publication date
Application filed by Novomedix LLC filed Critical Novomedix LLC
Publication of CA2801778A1 publication Critical patent/CA2801778A1/en
Application granted granted Critical
Publication of CA2801778C publication Critical patent/CA2801778C/en
Active legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
CA2801778A 2010-06-07 2011-06-07 Furanyl compounds and the use thereof Active CA2801778C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35230810P 2010-06-07 2010-06-07
US61/352,308 2010-06-07
PCT/US2011/039377 WO2011156321A1 (en) 2010-06-07 2011-06-07 Furanyl compounds and the use thereof

Publications (2)

Publication Number Publication Date
CA2801778A1 CA2801778A1 (en) 2011-12-15
CA2801778C true CA2801778C (en) 2018-06-05

Family

ID=44210539

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2801778A Active CA2801778C (en) 2010-06-07 2011-06-07 Furanyl compounds and the use thereof

Country Status (11)

Country Link
US (3) US8722731B2 (enExample)
EP (1) EP2576532B1 (enExample)
JP (1) JP5855095B2 (enExample)
CN (2) CN104860907A (enExample)
AU (1) AU2011265047B2 (enExample)
CA (1) CA2801778C (enExample)
MX (2) MX2012014273A (enExample)
NZ (1) NZ604018A (enExample)
SG (1) SG186229A1 (enExample)
WO (1) WO2011156321A1 (enExample)
ZA (1) ZA201209237B (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2576532B1 (en) 2010-06-07 2018-07-18 Novomedix, LLC Furanyl compounds and the use thereof
EP3345596B1 (en) * 2012-09-21 2021-01-20 Rhode Island Hospital Inhibitors of beta-hydrolase for treatment of cancer
WO2014085633A1 (en) 2012-11-30 2014-06-05 Novomedix, Llc Substituted biaryl sulfonamides and the use thereof
WO2015088977A1 (en) * 2013-12-10 2015-06-18 Emory University Targeted protease compositions and uses related thereto
JP2017510552A (ja) 2014-02-07 2017-04-13 イーフェクター セラピューティクス， インコーポレイテッド 線維性疾患を治療するための方法
US10548908B2 (en) * 2016-09-15 2020-02-04 Nostopharma, LLC Compositions and methods for preventing and treating heterotopic ossification and pathologic calcification
AR121506A1 (es) * 2020-03-03 2022-06-08 Pic Therapeutics Inc Inhibidores del eif4e y sus usos

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ZA201209237B (en) 2015-05-27
US20160024040A1 (en) 2016-01-28
CN103108868A (zh) 2013-05-15
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CN103108868B (zh) 2015-11-25
US20130116317A1 (en) 2013-05-09
US9663483B2 (en) 2017-05-30
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US8722731B2 (en) 2014-05-13
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US20140309297A1 (en) 2014-10-16
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US9149527B2 (en) 2015-10-06
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