JP5837498B2 - 抗菌医療用包帯及び、創傷及びカテーテル部位の保護 - Google Patents
抗菌医療用包帯及び、創傷及びカテーテル部位の保護 Download PDFInfo
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- MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 description 1
- 229960003165 vancomycin Drugs 0.000 description 1
- MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 description 1
- 231100000925 very toxic Toxicity 0.000 description 1
- 230000003253 viricidal effect Effects 0.000 description 1
- 230000004572 zinc-binding Effects 0.000 description 1
- 150000003952 β-lactams Chemical class 0.000 description 1
Images
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- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/02—Holding devices, e.g. on the body
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- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/02—Holding devices, e.g. on the body
- A61M2025/0266—Holding devices, e.g. on the body using pads, patches, tapes or the like
- A61M2025/0273—Holding devices, e.g. on the body using pads, patches, tapes or the like having slits to place the pad around a catheter puncturing site
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- A61M2205/00—General characteristics of the apparatus
- A61M2205/02—General characteristics of the apparatus characterised by a particular materials
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Description
本出願は、2010年9月1日出願の米国特許出願第12/874,188号の優先権、また、2009年9月2日出願の「Antimicrobial Medical Dressings and Methods of Protecting Wounds and Catheter Sites」を名称とする、米国特許仮出願第61/239,130号の優先権を主張する。米国特許出願第12/874,188号及び米国特許仮出願第61/239,130号は、その全体が参考として本明細書に援用される。
概要
感染阻害溶液は実施形態に記載され、また、抗菌剤の組み合わせを伴う抗菌医療用包帯は、別の実施形態に記載される。感染阻害溶液もまた、抗菌剤を含む。溶液における抗菌剤、及び包帯における抗菌剤の組み合わせは、微生物からの防護、滲出液の吸収、及び/または治癒を促進するため、種々な濃度で使用される。感染阻害溶液及び抗菌医療用包帯で使用される抗菌剤は、過酸化水素、過酸化カルバミド、エチレンジアミン四酢酸、クエン酸ナトリウム、またはアルコールを種々の濃度で含むことができる。
抗菌医療用包帯、傷の感染を防止する方法、カテーテル部位にて感染を防止する方法、及び感染阻害溶液または感染防止溶液が、本明細書中に記載される。抗菌医療用包帯の例は、ほとんどの場合図1−9を参照して記載される。
加えて、抗菌性包帯は負傷部位、血管内のラインポートなどの洗浄に使用される感染阻害溶液を含む。例えば、感染阻害溶液は、抗菌性包帯10の膜20において、注入され、浸透され、またはコーティングされ得る。一般に、感染阻害溶液は様々な濃度で、水、エチレンジアミン四酢酸(EDTA)、エタノール及び過酸化水素を含む。感染阻害溶液は水(すなわちH20)、EDTAのような強力で非毒性のキレート剤、短鎖一価アルコール(例えば、分子式C2H5OH、実験式C2H6Oのエタノール)、過酸化水素(すなわちH2O2)のような強力で小さな分子の酸化剤を含み得る。特定の態様において、好ましくは、溶液は本質的に、水、EDTA、エタノール、及び過酸化水素からなり得る。
エステルの加水分解:R−COOEt+H2O→R−COOH+EtOH
(式中、Rはカルボン酸炭素鎖を表す。)
これを特定のAHLの事例に適用し、AHLの加水分解を示すと、
AHL−COOR+H20→AHL−COOH+R−OH(新しいカルボン酸)(式1)
a.AHLのエステル交換反応:
b.AHL−COOR+EtOH→AHL−COOEt+HOH(水)
である。
LPS加水分解:LPS+H20→L−H+PS−OH
脂質 多糖類
LPSエタノール分解:LPS+EtOH→L−OEt+PS−H
脂質エステル 多糖類
キレート化:EDTA-2+Ca+2→EDTA−Ca(EDTA−一カルシウム複合体)
鉄(Fe+2)イオンのキレート化:
Fe+2−クロリド+EDTA→Fe+2−EDTA複合体+クロリド-2
細菌または真菌の増殖はない。
Mn+2+EDTA→Mn+2-EDTA複合体
細菌または真菌の胞子形成はない。
MMPにおけるZnイオンのキレート化:
−S−S−結合の酸化:
エステルの加水分解:R−COOEt+H20→R−C02H+EtOH
再エステル化:R−C02H+EtOH→R−COOEt+H20 (式2)
SuA−CH(OH)−SuB+H202→SuA−CO−SuB+H20→AHLなし
ケトン糖誘導体
アルデヒド生成物への糖の酸化:
SuA−CH2OH+H202 →SuA−CHO+H20→AHLなし
アルデヒド糖誘導体
本主題は、言語的に特定の構造的特徴及び/または組成物で記載されているが、添付の特許請求の範囲に定義されている本主題は、必ずしも記載された特定の特徴または組成物に限定されないことを理解されたい。むしろ、特定の特徴及び組成物は、特許請求の範囲を実施するための例示的な形態として開示される。
Claims (15)
- 蒸気障壁を含み、少なくとも1つ以上のアルミ箔、酸化アルミニウム、または酸化シリコンコーティングされたポリマーフィルム、ポリエチレン、またはポリプロピレンを含む下層と、
前記下層一面にあり、ヒトの皮膚と接触するよう構成される上側表面を有するガス透過性膜層と、
前記ガス透過性膜層内に配置され、少なくとも1つ以上の過酸化水素、過酸化カルバミド、エチレンジアミン四酢酸、クエン酸塩、またはアルコールを含む防腐剤と、
を含む医療用包帯。 - 少なくとも1つ以上のアルミ箔、酸化アルミニウム、酸化シリコンコーティングされたポリマーフィルム、ポリエチレン、ポリプロピレン、ポリシリコン、ポリ塩化ビニル、ポリテトラフルオロエチレンまたはマイラを含む蒸気障壁を含む着脱可能な上層をさらに含む請求項1に記載の医療用包帯。
- 前記着脱可能な上層及び前記下層が同一物質で形成される請求項2に記載の医療用包帯。
- 前記着脱可能な上層が前記下層に着脱可能に接続され、前記着脱可能な上層が前記下層と前記着脱可能な上層との間の穿孔線で裂けることにより着脱するよう構成される請求項2に記載の医療用包帯。
- 前記上層の周囲に粘着性物質領域をさらに含む請求項2に記載の医療用包帯。
- 蒸気障壁を含み、少なくとも1つ以上のアルミ箔、酸化アルミニウム、酸化シリコンコーティングされたポリマーフィルム、ポリエチレン、ポリプロピレン、ポリシリコン、ポリ塩化ビニル、ポリテトラフルオロエチレン、またはマイラを含む下層と、
前記下層一面にあるガス透過性膜層と、
前記ガス透過性膜層内に配置され、少なくとも1つ以上の過酸化水素、過酸化カルバミド、エチレンジアミン四酢酸、クエン酸塩、アルコールを含む防腐剤と、
前記ガス透過性膜層一面にあり、ヒトの皮膚と接触するように構成される上側表面を有する吸収物質層と、
を含む医療用包帯。 - 前記医療用包帯が、前記医療用包帯を貫通する中央開口部及び前記中央開口部から前記医療用包帯の外縁を通り伸長するスリットを有する請求項6に記載の医療用包帯。
- 前記医療用包帯の周囲に粘着物質領域をさらに含む請求項6に記載の医療用包帯。
- 前記上側表面が少なくとも透明物質、半透過性物質、または半透明物質の一つを含む請求項6に記載の医療用包帯。
- 前記医療用包帯がヒトの皮膚上の部位の進行を視覚的に観察することを可能にする部分的な開口部を含む請求項6に記載の医療用包帯。
- 5〜50mg/mlのエチレンジアミン四酢酸(EDTA)、
5〜30体積%のエタノール、
0.5〜5体積%の過酸化水素、及び
水
からなる感染阻害溶液。 - 3体積%の過酸化水素を含む請求項11に記載の溶液。
- 医療用包帯、綿棒、高分子発泡体、または手洗浄剤のうち少なくとも1つにおける適用を含む請求項11に記載の溶液。
- 過酸化水素の存在により可能となる安定でない量の各々相互濃度のEDTA及びエタノールを含む請求項11に記載の溶液。
- 5〜50mg/mlのエチレンジアミン四酢酸(EDTA)、5〜30体積%のエタノール、0.5〜5体積%の過酸化水素および水を混合して、感染阻害溶液を形成する工程を含む、感染阻害溶液を調製する方法。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23913009P | 2009-09-02 | 2009-09-02 | |
US61/239,130 | 2009-09-02 | ||
US12/874,188 | 2010-09-01 | ||
US12/874,188 US8778387B2 (en) | 2009-09-02 | 2010-09-01 | Antimicrobial medical dressings and protecting wounds and catheter sites |
PCT/US2010/047756 WO2011028965A2 (en) | 2009-09-02 | 2010-09-02 | Antimicrobial medical dressings and protecting wounds and catheter sites |
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JP (1) | JP5837498B2 (ja) |
CN (1) | CN102625686B (ja) |
AU (1) | AU2010289415B2 (ja) |
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CA (1) | CA2772042C (ja) |
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Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USD342022S (en) * | 1991-05-28 | 1993-12-07 | Beecham, Inc. | Combined compartmented bottle and closure |
US7846141B2 (en) | 2002-09-03 | 2010-12-07 | Bluesky Medical Group Incorporated | Reduced pressure treatment system |
GB0224986D0 (en) | 2002-10-28 | 2002-12-04 | Smith & Nephew | Apparatus |
GB0325129D0 (en) | 2003-10-28 | 2003-12-03 | Smith & Nephew | Apparatus in situ |
AU2006287463A1 (en) | 2005-09-06 | 2007-03-15 | Tyco Healthcare Group Lp | Self contained wound dressing with micropump |
CA2684150C (en) | 2007-05-14 | 2016-10-04 | Research Foundation Of State University Of New York | Decenoic acid dispersion inducers in the treatment of biofilms |
US8778387B2 (en) | 2009-09-02 | 2014-07-15 | Hyprotek, Inc. | Antimicrobial medical dressings and protecting wounds and catheter sites |
CN103108643B (zh) * | 2010-01-22 | 2016-10-26 | 希普罗特克有限公司 | 包含过氧化物、醇和螯合剂的抗菌剂 |
US9061095B2 (en) | 2010-04-27 | 2015-06-23 | Smith & Nephew Plc | Wound dressing and method of use |
CN107252383A (zh) | 2011-07-14 | 2017-10-17 | 史密夫及内修公开有限公司 | 伤口敷料和治疗方法 |
AU2012346030A1 (en) | 2011-11-28 | 2014-06-05 | Hyprotek, Inc. | Catheter devices and techniques |
US9192443B2 (en) * | 2012-02-06 | 2015-11-24 | Hyprotek, Inc. | Combined cap applicators |
EP3708196A1 (en) | 2012-03-12 | 2020-09-16 | Smith & Nephew PLC | Reduced pressure apparatus and methods |
AU346291S (en) | 2012-05-15 | 2013-01-09 | Smith & Nephew | Medical dressing |
EP3354293B1 (en) | 2012-05-23 | 2019-12-11 | Smith & Nephew plc | Apparatuses for negative pressure wound therapy |
HUE033329T2 (en) | 2012-08-01 | 2017-11-28 | Smith & Nephew | dressing |
CN104661626B (zh) | 2012-08-01 | 2018-04-06 | 史密夫及内修公开有限公司 | 伤口敷料 |
DE102012015483B3 (de) | 2012-08-07 | 2014-01-16 | Otto Bock Healthcare Gmbh | Elektrodenanordnung für eine Plasmabehandlung und Vorrichtung zur Herstellung einer transkutanen Verbindung |
EP2752176B1 (de) | 2013-01-08 | 2024-03-20 | BSN medical GmbH | Antimikrobiell aktive Wundauflage für Katheterfixierungen |
EP3245871A1 (en) | 2014-04-30 | 2017-11-22 | Matoke Holdings Limited | Antimicrobial compositions |
JP6586431B2 (ja) | 2014-06-18 | 2019-10-02 | スミス アンド ネフュー ピーエルシーSmith & Nephew Public Limited Company | 創傷包帯および治療方法 |
WO2016100847A2 (en) | 2014-12-20 | 2016-06-23 | Northwestern University | Polymer metal-organic framework composites |
US9527660B2 (en) * | 2014-12-31 | 2016-12-27 | Hyprotek, Inc. | Individually sealed antiseptic applicators |
US10485892B2 (en) | 2015-03-10 | 2019-11-26 | Covalon Technologies Inc. | Method for local reduction of microbial skin flora |
CN105311669B (zh) * | 2015-11-02 | 2018-03-02 | 江苏千泽健康科技有限公司 | 抑菌卫生巾 |
CN105935459A (zh) * | 2016-04-27 | 2016-09-14 | 广东百合医疗科技股份有限公司 | 一种抗感染的管体、静脉留置针及该管体的其制备方法 |
US10835717B2 (en) | 2016-06-27 | 2020-11-17 | Vlv Associates, Inc. | Dressing |
US10773008B2 (en) * | 2016-08-08 | 2020-09-15 | Universiti Brunei Darussalam | Medicated patch for preventing exit site infections during peritoneal dialysis |
GB2555584B (en) | 2016-10-28 | 2020-05-27 | Smith & Nephew | Multi-layered wound dressing and method of manufacture |
WO2018170132A1 (en) | 2017-03-14 | 2018-09-20 | University Of Connecticut | Biodegradable pressure sensor |
WO2019060229A1 (en) * | 2017-09-15 | 2019-03-28 | Bard Access Systems, Inc. | ANTIMICROBIAL DRESSING WITH LINING FOR MEDICAL DEVICE |
GB201716986D0 (en) | 2017-10-16 | 2017-11-29 | Matoke Holdings Ltd | Antimicrobial compositions |
US20190298882A1 (en) * | 2018-03-27 | 2019-10-03 | Kevin M. Nelson | Hydrogel bandage |
US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
AU201817459S (en) * | 2018-06-12 | 2019-01-17 | HATCH Collection LLC | Abdominal sheet mask |
US11826495B2 (en) | 2019-03-01 | 2023-11-28 | University Of Connecticut | Biodegradable piezoelectric ultrasonic transducer system |
KR102219436B1 (ko) * | 2019-05-09 | 2021-02-23 | 가톨릭대학교 산학협력단 | 튜브 고정 패드 |
WO2021050931A1 (en) * | 2019-09-12 | 2021-03-18 | Lansinoh Laboratories, Inc. | Freezable pad for pain relief |
CN110812620B (zh) * | 2019-11-14 | 2022-04-05 | 南京医科大学附属逸夫医院 | 一种轮换皮下注射卡及其使用方法 |
US11745001B2 (en) | 2020-03-10 | 2023-09-05 | University Of Connecticut | Therapeutic bandage |
WO2022150407A1 (en) * | 2021-01-05 | 2022-07-14 | Sanders Mitchell C | Purified and enhanced hydrogen peroxide disinfecting solution for the rapid inactivation of covid-19 and other pathogens |
CN115487340B (zh) * | 2022-10-31 | 2023-11-17 | 振德医疗用品股份有限公司 | 一种负载活性氧的细菌纤维素敷料及其制备方法 |
Family Cites Families (145)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB350384A (en) | 1929-03-04 | 1931-06-04 | John Barnard Kirsch | Dressing for wounds ready for use |
US4188234A (en) | 1965-08-24 | 1980-02-12 | Plains Chemical Development Co. | Chelation |
US3607760A (en) | 1969-06-09 | 1971-09-21 | Edna M Mcintyre | Cleaning composition for pet stains |
US3851649A (en) | 1973-03-21 | 1974-12-03 | Kendall & Co | Catheterization package |
US3860348A (en) | 1973-06-06 | 1975-01-14 | Schick Inc | Applicator package for fluid products |
US4291697A (en) | 1980-04-18 | 1981-09-29 | Stephen Georgevich | Cleaning and application device for medical purposes |
US5046608A (en) | 1981-10-19 | 1991-09-10 | Laipply Thomas C | Combined fluid storage container and applicator device and method |
US4696393A (en) | 1981-10-19 | 1987-09-29 | Laipply Thomas C | Applicator wipe for inviscid fluids |
US4446967A (en) | 1982-05-07 | 1984-05-08 | Halkyard Douglas R | Germicide sleeve for dental and medical instruments |
US4440207A (en) | 1982-05-14 | 1984-04-03 | Baxter Travenol Laboratories, Inc. | Antibacterial protective cap for connectors |
JPS59500801A (ja) | 1982-05-14 | 1984-05-10 | バクスタ−、インターナショナル インコ−ポレイテッド | コネクタ−のための抗バクテリア性保護キャップ |
US4588400A (en) * | 1982-12-16 | 1986-05-13 | Johnson & Johnson Products, Inc. | Liquid loaded pad for medical applications |
DE3485126D1 (de) | 1984-01-23 | 1991-10-31 | Thomas C Laipply | Alkoholwischer und verfahren. |
US4564010A (en) * | 1984-04-18 | 1986-01-14 | Daubert Coated Products Inc. | Pressure sensitive adhesive film for medical use |
JPS6274364A (ja) | 1985-09-27 | 1987-04-06 | 株式会社 ニツシヨ− | 医療用具 |
GB8622698D0 (en) | 1986-09-20 | 1986-10-29 | Smith & Nephew Ass | Dispenser |
US4830856A (en) | 1987-01-27 | 1989-05-16 | Peppers James M | Chelation product |
US5009652A (en) | 1987-10-16 | 1991-04-23 | Morgan Cheryle I | Medical sponges and wipes with a barrier impermeable to infectious agents |
US4811847A (en) | 1988-03-14 | 1989-03-14 | Reif Thomas H | Urinary catheter package |
US4954239A (en) | 1988-04-15 | 1990-09-04 | Mueller Louis H | Prefilled catheter tip syringe kit |
US5438984A (en) * | 1988-09-08 | 1995-08-08 | Sudor Partners | Apparatus and method for the collection of analytes on a dermal patch |
US5171523A (en) | 1988-10-03 | 1992-12-15 | Williams Robert M | Method and apparatus for disinfecting objects |
US5041264A (en) | 1988-10-03 | 1991-08-20 | Williams Robert M | Method and apparatus for disinfecting objects |
US4893956A (en) | 1988-11-18 | 1990-01-16 | Blistex Inc. | Packaging for medicaments |
JP2563538B2 (ja) | 1988-11-30 | 1996-12-11 | 松下電器産業株式会社 | 電気湯沸し器 |
US5015228A (en) | 1989-06-05 | 1991-05-14 | Eastman Kodak Company | Sterilizing dressing device and method for skin puncture |
JPH06501857A (ja) * | 1990-09-17 | 1994-03-03 | メディプロ・サイエンシズ・リミテッド | 二層包帯剤 |
JP2978601B2 (ja) | 1991-07-30 | 1999-11-15 | 山中産業株式会社 | 抽出バッグ用タッグ糸および抽出用バッグ |
ES2133332T3 (es) * | 1991-11-06 | 1999-09-16 | Bioderm Inc | Apositos para heridas oclusivos y medio aplicador. |
US5222600A (en) | 1992-07-28 | 1993-06-29 | Stoddard James T | Autoclave pouch |
CA2151144A1 (en) * | 1992-12-07 | 1994-06-23 | Masaru Saita | Diagnostic patch and method for diagnosis using the same |
AU6716294A (en) * | 1993-05-04 | 1994-11-21 | Lisa Fernandez Geng | Wound dressing |
US5454798A (en) | 1993-05-14 | 1995-10-03 | Mentor Corporation | Disposable urine bag |
AU7256194A (en) | 1993-07-06 | 1995-02-06 | Leo J. Utecht | Personal protection apparatus |
DE4332093C2 (de) * | 1993-09-22 | 1995-07-13 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System mit dem Wirkstoff Acetylsalicylsäure und Verfahren zu seiner Herstellung |
US5731275A (en) | 1994-04-05 | 1998-03-24 | Universite De Montreal | Synergistic detergent and disinfectant combinations for decontaminating biofilm-coated surfaces |
GB9411429D0 (en) * | 1994-06-08 | 1994-07-27 | Seton Healthcare Group Plc | Wound dressings |
US5556375A (en) * | 1994-06-16 | 1996-09-17 | Hercules Incorporated | Wound dressing having a fenestrated base layer |
US5569207A (en) | 1994-10-13 | 1996-10-29 | Quinton Instrument Company | Hydrocolloid dressing |
US5554135A (en) | 1995-02-17 | 1996-09-10 | Menyhay; Steve Z. | Sterile medical injection port and cover method and apparatus |
AU5543196A (en) | 1995-04-12 | 1996-10-30 | Robert B. Hopp | Skin patch for use in contact immunotherapy |
JP3605437B2 (ja) | 1995-05-19 | 2004-12-22 | 大日本印刷株式会社 | 貼着体 |
MX9601936A (es) | 1995-07-07 | 1997-01-31 | Becton Dickinson Co | Una bandeja mejorada para la preparacion de la piel para uso en procedimientos quirurgicos. |
US5976117A (en) * | 1996-09-25 | 1999-11-02 | 3M Innovative Properties Company | Wound dressing |
JPH10110268A (ja) * | 1996-10-03 | 1998-04-28 | Nissin Electric Co Ltd | 医療用被覆材 |
US5975082A (en) | 1997-03-10 | 1999-11-02 | Kimberly-Clark Worldwide, Inc. | Tear-away surgical drape |
US20030007939A1 (en) * | 1998-07-31 | 2003-01-09 | Howard Murad | Pharmaceutical compositions and methods for managing dermatological conditions |
US6071541A (en) * | 1998-07-31 | 2000-06-06 | Murad; Howard | Pharmaceutical compositions and methods for managing skin conditions |
US6168800B1 (en) * | 1998-08-20 | 2001-01-02 | Medwrap Corporation | Antimcrobial multi-layer island dressing |
JP2002529545A (ja) | 1998-11-06 | 2002-09-10 | ユニベルシテ ドゥ モントリオール | バイオフィルムを除去するための改良型の殺菌性及び非殺菌性溶液 |
US6274232B1 (en) | 1999-06-18 | 2001-08-14 | The Procter & Gamble Company | Absorbent sheet material having cut-resistant layer and method for making the same |
FR2804601B1 (fr) | 2000-02-04 | 2002-04-26 | 3X Engineering | Dispositif d'application de principes actifs utilisables dans le domaine pharmaceutique ou cosmetique |
US6455066B1 (en) * | 2000-03-10 | 2002-09-24 | Epicept Corporation | Intradermal-penetration agents for topical local anesthetic administration |
AU2001264256B2 (en) * | 2000-06-13 | 2006-05-11 | Hisamitsu Pharmaceutical Co, Inc | Plaster |
JP3601593B2 (ja) | 2001-03-06 | 2004-12-15 | 日本電気株式会社 | 移動通信グループ暗号鍵配送方法 |
WO2002083021A1 (en) | 2001-04-13 | 2002-10-24 | I-Flow Corporation | Sterile container for medical applications |
US7482021B1 (en) | 2001-05-11 | 2009-01-27 | Tison Kelley H | Two-sided wipe for cleaning and drying a skin surface |
CN2511272Y (zh) | 2001-10-09 | 2002-09-18 | 韩平 | 伤口促愈贴 |
US8541472B2 (en) * | 2001-12-05 | 2013-09-24 | Aseptica, Inc. | Antiseptic compositions, methods and systems |
GB2382775B (en) * | 2001-12-06 | 2005-05-25 | Johnson & Johnson Medical Ltd | Controlled release therapeutic wound dressings |
JP4132911B2 (ja) | 2002-03-25 | 2008-08-13 | 日東電工株式会社 | 貼付製剤 |
CN2546003Y (zh) * | 2002-04-29 | 2003-04-23 | 康乐保(中国)有限公司 | 一种方便护理插引流管伤口的自粘敷料 |
US6769546B2 (en) | 2002-07-03 | 2004-08-03 | L. John Busch | Epidural anesthesia kit |
JP2004049540A (ja) * | 2002-07-19 | 2004-02-19 | Chisso Corp | 抗菌性粘着フィルム及びそれを用いた救急絆創膏 |
EP1393710A1 (en) | 2002-08-21 | 2004-03-03 | The Procter & Gamble Company | A method of applying an oral composition |
US8112973B2 (en) | 2002-10-04 | 2012-02-14 | Ethicon, Inc. | Method of making a packaged antimicrobial suture |
US9597067B2 (en) | 2002-10-04 | 2017-03-21 | Ethicon, Inc. | Packaged antimicrobial medical device and method of preparing same |
US8100872B2 (en) * | 2002-10-23 | 2012-01-24 | Tyco Healthcare Group Lp | Medical dressing containing antimicrobial agent |
US20040129581A1 (en) | 2002-11-22 | 2004-07-08 | Janet Tompkins | Barium swallowing kit |
AU2003294366B2 (en) | 2002-12-31 | 2009-11-05 | Bsn Medical Gmbh | Wound dressing |
WO2004066876A1 (en) | 2003-01-27 | 2004-08-12 | Medtronic Vascular Connaught | Improved packaging for stent delivery systems |
US20060142684A1 (en) * | 2003-04-11 | 2006-06-29 | Shanbrom Technologies, Llc | Oxygen releasing material |
JP2004351632A (ja) | 2003-05-27 | 2004-12-16 | Meisei Sansho Kk | 薬液含浸シート |
HUE045608T2 (hu) | 2003-06-06 | 2020-01-28 | Univ Texas | Antimikrobiális öblítõoldatok |
US7282186B2 (en) * | 2003-06-20 | 2007-10-16 | Lake Jr Robert F | Decontamination device |
US20040261196A1 (en) | 2003-06-27 | 2004-12-30 | The Procter & Gamble Company | Fabric care compositions for lipophilic fluid systems incorporating an antimicrobial agent |
DE10331192A1 (de) | 2003-07-10 | 2005-02-03 | Paul Hartmann Ag | Hautfreundliches Einwegprodukt |
US20050034731A1 (en) * | 2003-08-13 | 2005-02-17 | Rousseau Robert A. | Surgical wound closure device |
CA2538617A1 (en) * | 2003-09-13 | 2005-03-24 | Boots Healthcare International Limited | Skincare compositions comprising salicylic acid |
US7118545B2 (en) | 2003-10-14 | 2006-10-10 | Boyde Sandra M | Wound dressing retainer and fastening device |
JP4476593B2 (ja) | 2003-10-16 | 2010-06-09 | 日東電工株式会社 | 医療用粘着性抗菌シート |
EP1689416A1 (en) * | 2003-11-11 | 2006-08-16 | Veckis Industries Ltd. | Disinfecting composition and methods of making and using same |
GB2408207A (en) | 2003-11-24 | 2005-05-25 | Johnson & Johnson Medical Ltd | Wound dressing for the controlled release of therapeutic agents comprising also an inhibitor of a protease enzyme & a linker group cleavable by such an enzyme |
US20050129897A1 (en) | 2003-12-11 | 2005-06-16 | Kimberly-Clark Worldwide, Inc. | Disposable scrubbing product |
EP1699397A4 (en) | 2003-12-23 | 2012-02-15 | Hemcon Inc | TISSUE ASSEMBLY, SYSTEMS AND METHODS FROM HYDROPHILIC POLYMER SPONGES, SUCH AS CHITOSAN |
US7204368B2 (en) | 2003-12-29 | 2007-04-17 | Cheaure Sarah F | Resealable package |
JP2005350571A (ja) | 2004-06-10 | 2005-12-22 | Sekisui Chem Co Ltd | 熱可塑性樹脂発泡体シート及び熱可塑性樹脂発泡体シートの製造方法 |
CN2705167Y (zh) * | 2004-02-20 | 2005-06-22 | 佟刚 | 胶原贴敷料 |
WO2005089341A2 (en) | 2004-03-16 | 2005-09-29 | Bull Brian S | Method and device for coronary artery bypass |
US20050249791A1 (en) * | 2004-05-07 | 2005-11-10 | 3M Innovative Properties Company | Antimicrobial articles |
EP1765081B8 (en) | 2004-05-14 | 2018-08-15 | Virox Technologies Inc. | Hydrogen peroxide-based skin disinfectant |
FR2870828B1 (fr) | 2004-05-26 | 2006-08-18 | Oreal | Dispositif de conditionnement et d'application d'un produit |
US7478962B2 (en) | 2004-05-26 | 2009-01-20 | L'oreal | Device for packaging and application of a product |
US20050281890A1 (en) * | 2004-06-18 | 2005-12-22 | San Chandan K | Methods and compositions for wound healing |
CN1711845A (zh) | 2004-06-25 | 2005-12-28 | 殷生章 | 一种可杀灭非典肺炎冠状病毒的消毒剂 |
US8017826B2 (en) | 2004-09-16 | 2011-09-13 | Dsu Medical Corporation | Injection and hemostasis site |
RU2393876C2 (ru) | 2004-09-17 | 2010-07-10 | Дэвид М. ДИКСОН | Перевязочный материал для ухода за раной и способ его использования |
US7506760B2 (en) | 2005-01-10 | 2009-03-24 | Grossman Victor A | Packaging and dispensers for adhesive backed elements |
US8999357B2 (en) | 2005-02-07 | 2015-04-07 | Sishield Technologies, Inc. | Methods and compositions for biocidal treatments |
WO2006089139A2 (en) * | 2005-02-15 | 2006-08-24 | Lab39, Llc | Oral care cleaning compositions and methods |
JP4756497B2 (ja) | 2005-02-25 | 2011-08-24 | 株式会社吉野工業所 | 容器用パッキン |
US7749453B2 (en) * | 2005-05-04 | 2010-07-06 | Bionostics, Inc. | Devices, systems, and methods for the containment and use of liquid solutions |
US20070014685A1 (en) | 2005-07-15 | 2007-01-18 | Halt Gerald B Sr | Personal sanitation device |
JP2007044258A (ja) | 2005-08-10 | 2007-02-22 | Transcutaneous Technologies Inc | 注射針挿入孔付き経皮吸収用パッチ |
WO2007044624A2 (en) | 2005-10-06 | 2007-04-19 | Stickley Robert F | Wearable stethoscope sanitizing device |
GB0525504D0 (en) * | 2005-12-14 | 2006-01-25 | Bristol Myers Squibb Co | Antimicrobial composition |
US20070179373A1 (en) * | 2005-12-22 | 2007-08-02 | Provex Technologies, Llc. | Integrated patch and assay device with visual detection means |
US7799965B2 (en) | 2006-04-11 | 2010-09-21 | Tyco Healthcare Group Lp | Wound dressings with anti-microbial and zinc-containing agents |
US8162899B2 (en) | 2006-05-18 | 2012-04-24 | Hyprotek, Inc. | Intravascular line and port cleaning methods, methods of administering an agent intravascularly, methods of obtaining/testing blood, and devices for performing such methods |
WO2007146820A2 (en) | 2006-06-08 | 2007-12-21 | Hollister Incorporated | Catheter product package and method of forming same |
US20090324508A1 (en) | 2006-07-06 | 2009-12-31 | Centennial Ventures B.V. | Broad Spectrum and Skin Friendly Disinfecting Composition |
GB0614278D0 (en) * | 2006-07-19 | 2006-08-30 | Insense Ltd | Hydrogen peroxide delivery system |
US7780794B2 (en) | 2006-07-21 | 2010-08-24 | Ivera Medical Corporation | Medical implement cleaning device |
CA2600249C (en) | 2006-09-12 | 2014-05-20 | Tyco Healthcare Group Lp | Thin film dressing |
US8403898B2 (en) | 2006-11-21 | 2013-03-26 | Mark R. Moore | Apparatus and method for deploying a surgical preparation |
US8647326B2 (en) | 2007-01-16 | 2014-02-11 | Catheter Connections, Inc. | System for cleaning luer connectors |
US8343536B2 (en) | 2007-01-25 | 2013-01-01 | Cook Biotech Incorporated | Biofilm-inhibiting medical products |
US8065773B2 (en) | 2007-04-02 | 2011-11-29 | Bard Access Systems, Inc. | Microbial scrub brush |
US8336152B2 (en) | 2007-04-02 | 2012-12-25 | C. R. Bard, Inc. | Insert for a microbial scrubbing device |
US20100240799A1 (en) | 2007-06-13 | 2010-09-23 | 3M Innovative Properties Company | Antimicrobial film-forming composition, antimicrobial film, and method of verifying the presence of an antimicrobial film |
US20090010998A1 (en) | 2007-07-03 | 2009-01-08 | Marchitto Kevin S | Drug-delivery patch comprising a dissolvable layer and uses thereof |
US20090028750A1 (en) | 2007-07-23 | 2009-01-29 | Ryan Dana Wm | Cleaning and Disinfection Swabbing Device for Needle-Free Intravenous (IV) Connectors |
US20090036541A1 (en) | 2007-08-02 | 2009-02-05 | Donald David Mardis | Applicator and chemical combination for better topical anesthesia |
CN101969768A (zh) | 2007-12-17 | 2011-02-09 | 澳大利亚诺万芬研究公司 | 杀病毒组合物 |
US8388894B2 (en) | 2008-03-20 | 2013-03-05 | Psi Medical Catheter Care, Llc | Apparatus and method for sterilizing a tubular medical line port |
US8273303B2 (en) | 2008-05-06 | 2012-09-25 | Michael J. Ferlic | Universal sterilizing tool |
US8777504B2 (en) | 2008-07-03 | 2014-07-15 | Retractable Technologies, Inc. | Cleaning tool |
US20100030170A1 (en) | 2008-08-01 | 2010-02-04 | Keith Alan Keller | Absorptive Pad |
WO2010128554A1 (ja) | 2009-05-08 | 2010-11-11 | 日昭クインズ株式会社 | 医療具用容器及び医療キット |
WO2010131253A2 (en) | 2009-05-13 | 2010-11-18 | Hadasit Medical Research Services And Development Ltd. | Stethoscope disinfection device |
US8486004B1 (en) | 2009-07-02 | 2013-07-16 | Centurion Medical Products Corporation | Dressing having integral antimicrobial |
CN201481841U (zh) | 2009-08-07 | 2010-05-26 | 刘书光 | 一种重症监护室专用消毒箱 |
WO2011019132A1 (ko) | 2009-08-14 | 2011-02-17 | 중앙대학교 산학협력단 | 도전성 접착제, 이를 이용한 반도체의 실장방법 및 웨이퍼 레벨 패키지 |
US20110184382A1 (en) | 2009-08-20 | 2011-07-28 | Cady Timothy B | Multi-purpose articles for sanitizing and capping luer access valves |
US8778387B2 (en) | 2009-09-02 | 2014-07-15 | Hyprotek, Inc. | Antimicrobial medical dressings and protecting wounds and catheter sites |
JP2011056183A (ja) | 2009-09-14 | 2011-03-24 | Olympus Corp | 医療用シート状部材 |
JP5370844B2 (ja) | 2009-09-30 | 2013-12-18 | レンゴー株式会社 | アリルイソチオシアネート揮散製剤 |
CN103108643B (zh) * | 2010-01-22 | 2016-10-26 | 希普罗特克有限公司 | 包含过氧化物、醇和螯合剂的抗菌剂 |
US8496625B2 (en) | 2010-05-26 | 2013-07-30 | Nxstage Medical, Inc. | Safe needle methods, apparatus, and systems |
WO2011163124A1 (en) | 2010-06-23 | 2011-12-29 | Medical Components, Inc. | Cleaner for medical device |
WO2012007929A1 (en) | 2010-07-14 | 2012-01-19 | Hemcon Medical Technologies (Ip) Limited | A dressing device for use with a cannula or a catheter |
CN102133421B (zh) | 2011-03-17 | 2013-11-20 | 山东赛克赛斯药业科技有限公司 | 一种快速止血创伤敷料及其制备方法与应用 |
AU2012346030A1 (en) | 2011-11-28 | 2014-06-05 | Hyprotek, Inc. | Catheter devices and techniques |
US9522001B2 (en) | 2012-04-12 | 2016-12-20 | Operating Room Innovations, Inc. | Surgical appliance kit and system for releasably securing a surgical appliance to a surgical field and method of assembling the surgical applicance kit |
WO2014025994A1 (en) | 2012-08-08 | 2014-02-13 | Board Of Regents, The University Of Texas System | Antimicrobial compositions comprising glyceryl nitrates |
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CN102625686A (zh) | 2012-08-01 |
EP2482772A4 (en) | 2014-05-21 |
CA2772042C (en) | 2018-09-25 |
AU2010289415B2 (en) | 2014-08-14 |
WO2011028965A2 (en) | 2011-03-10 |
MX2012002746A (es) | 2012-07-04 |
IN2012DN01869A (ja) | 2015-08-21 |
EP2482772B1 (en) | 2018-10-31 |
EP2482772A2 (en) | 2012-08-08 |
AU2010289415A1 (en) | 2012-03-15 |
CA2772042A1 (en) | 2011-03-10 |
BR112012004695A2 (pt) | 2016-04-12 |
CN102625686B (zh) | 2015-11-25 |
US8778387B2 (en) | 2014-07-15 |
US20140243725A1 (en) | 2014-08-28 |
US9789005B2 (en) | 2017-10-17 |
JP2013503713A (ja) | 2013-02-04 |
WO2011028965A3 (en) | 2011-07-21 |
SG178583A1 (en) | 2012-03-29 |
US20110052664A1 (en) | 2011-03-03 |
HK1169302A1 (zh) | 2013-01-25 |
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