JP5829373B2 - Ｎｏｇｏレセプターアンタゴニスト - Google Patents

Ｎｏｇｏレセプターアンタゴニスト Download PDF

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Publication number
JP5829373B2
JP5829373B2 JP2008552443A JP2008552443A JP5829373B2 JP 5829373 B2 JP5829373 B2 JP 5829373B2 JP 2008552443 A JP2008552443 A JP 2008552443A JP 2008552443 A JP2008552443 A JP 2008552443A JP 5829373 B2 JP5829373 B2 JP 5829373B2
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Japan
Prior art keywords
polypeptide
antibody
seq
amino acids
amino acid
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Expired - Fee Related
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JP2008552443A
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Japanese (ja)
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JP2009524429A (ja
JP2009524429A5 (enExample
Inventor
ダニエル エイチ．エス． リー，
ダニエル エイチ．エス． リー，
ディンギ ウェン，
ディンギ ウェン，
ブレーク アール． ペピンスキ，
ブレーク アール． ペピンスキ，
ジェーン ケー． レルトン，
ジェーン ケー． レルトン，
シンチョン ワン，
シンチョン ワン，
アレクセイ ルゴフスコイ，
アレクセイ ルゴフスコイ，
ワーナー マイアー，
ワーナー マイアー，
エレン エー． ガーバー，
エレン エー． ガーバー，
ローラ シルビアン，
ローラ シルビアン，
ポール エイチ． ワインレブ，
ポール エイチ． ワインレブ，
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Biogen MA Inc
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Biogen MA Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A01K2217/054—Animals comprising random inserted nucleic acids (transgenic) inducing loss of function
    • A01K2217/058—Animals comprising random inserted nucleic acids (transgenic) inducing loss of function due to expression of inhibitory nucleic acid, e.g. siRNA, antisense
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0356—Animal model for processes and diseases of the central nervous system, e.g. stress, learning, schizophrenia, pain, epilepsy
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/55—Fab or Fab'
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
    • C—CHEMISTRY; METALLURGY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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JP2008552443A 2006-01-27 2007-01-26 Ｎｏｇｏレセプターアンタゴニスト Expired - Fee Related JP5829373B2 (ja)

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Application Number Priority Date Filing Date Title
US76248706P 2006-01-27 2006-01-27
US60/762,487 2006-01-27
US83165906P 2006-07-19 2006-07-19
US60/831,659 2006-07-19
PCT/US2007/002199 WO2007089601A2 (en) 2006-01-27 2007-01-26 Nogo receptor antagonists

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JP2012266674A Division JP2013048638A (ja) 2006-01-27 2012-12-05 Ｎｏｇｏレセプターアンタゴニスト

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JP2009524429A JP2009524429A (ja) 2009-07-02
JP2009524429A5 JP2009524429A5 (enExample) 2010-03-11
JP5829373B2 true JP5829373B2 (ja) 2015-12-09

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JP2008552443A Expired - Fee Related JP5829373B2 (ja) 2006-01-27 2007-01-26 Ｎｏｇｏレセプターアンタゴニスト
JP2012266674A Pending JP2013048638A (ja) 2006-01-27 2012-12-05 Ｎｏｇｏレセプターアンタゴニスト
JP2014168201A Withdrawn JP2014221076A (ja) 2006-01-27 2014-08-21 Ｎｏｇｏレセプターアンタゴニスト
JP2016040966A Withdrawn JP2016104821A (ja) 2006-01-27 2016-03-03 Ｎｏｇｏレセプターアンタゴニスト

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JP2012266674A Pending JP2013048638A (ja) 2006-01-27 2012-12-05 Ｎｏｇｏレセプターアンタゴニスト
JP2014168201A Withdrawn JP2014221076A (ja) 2006-01-27 2014-08-21 Ｎｏｇｏレセプターアンタゴニスト
JP2016040966A Withdrawn JP2016104821A (ja) 2006-01-27 2016-03-03 Ｎｏｇｏレセプターアンタゴニスト

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US (3) US8669345B2 (enExample)
EP (2) EP2526968A3 (enExample)
JP (4) JP5829373B2 (enExample)
CN (2) CN101420977B (enExample)
BR (1) BRPI0707276B1 (enExample)
CA (2) CA2913655A1 (enExample)
DK (1) DK1981902T3 (enExample)
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EP1981902B1 (en) 2015-07-29
JP2016104821A (ja) 2016-06-09
JP2009524429A (ja) 2009-07-02
EP1981902A4 (en) 2009-12-23
EP2526968A3 (en) 2013-05-22
CA2640423C (en) 2016-03-15
US20140227266A1 (en) 2014-08-14
PT1981902E (pt) 2015-11-02
EP2526968A2 (en) 2012-11-28
CA2640423A1 (en) 2007-08-09
CA2913655A1 (en) 2007-08-09
ES2550099T3 (es) 2015-11-04
US20090099078A1 (en) 2009-04-16
CN103215293B (zh) 2015-10-28
US20160159878A1 (en) 2016-06-09
JP2014221076A (ja) 2014-11-27
HRP20151108T1 (xx) 2015-11-20
WO2007089601A2 (en) 2007-08-09
WO2007089601A3 (en) 2008-11-06
WO2007089601A8 (en) 2008-10-02
BRPI0707276A2 (pt) 2011-04-26
BRPI0707276B1 (pt) 2021-08-31
CN101420977A (zh) 2009-04-29
US9228015B2 (en) 2016-01-05
DK1981902T3 (en) 2015-10-05
US8669345B2 (en) 2014-03-11
CN101420977B (zh) 2016-08-10
WO2007089601A9 (en) 2008-12-18
CN103215293A (zh) 2013-07-24
JP2013048638A (ja) 2013-03-14

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