JP5453609B2 - 可鍛性タンパク質マトリクス及びその使用 - Google Patents
可鍛性タンパク質マトリクス及びその使用 Download PDFInfo
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- JP5453609B2 JP5453609B2 JP2003553926A JP2003553926A JP5453609B2 JP 5453609 B2 JP5453609 B2 JP 5453609B2 JP 2003553926 A JP2003553926 A JP 2003553926A JP 2003553926 A JP2003553926 A JP 2003553926A JP 5453609 B2 JP5453609 B2 JP 5453609B2
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| US7323204B2 (en) | 2004-06-25 | 2008-01-29 | Kraft Foods Holdings, Inc. | Stabilization of fresh mozzarella cheese using fermented whey |
| US20090130072A1 (en) * | 2005-02-11 | 2009-05-21 | Pierre Lemieux | Use of Lactobacillus Kefiranofaciens as a Probiotic and a Synbiotic |
| US20060182705A1 (en) * | 2005-02-11 | 2006-08-17 | Cruse Maria K | Composition for reduction and prevention of wrinkles on the skin |
| CN100450375C (zh) * | 2006-06-09 | 2009-01-14 | 大连轻工业学院 | 一种复合微生态饲料添加剂及其生产方法 |
| FR2906442B1 (fr) * | 2006-10-02 | 2010-12-17 | Gervais Danone Sa | Utilisation de la gomme arabique pour ameliorer la croissance et la survie des bifidobacteries. |
| WO2008047391A1 (en) * | 2006-10-17 | 2008-04-24 | S.I.F.Fr.A. Farmaceutici Srl | Nutriceutic composition comprising lactoferrin and proteasic probiotics |
| TW200904340A (en) * | 2007-05-11 | 2009-02-01 | Mannatech Inc | Processing of natural polysaccharides by selected non-pathogenic microorganisms and methods of making and using the same |
| EP2205259B1 (en) * | 2007-10-02 | 2014-12-10 | Institut National de la Recherche Scientifique | Mpm (malleable protein matrix) for use in the treatment of arthritis, obesity, insulin resistance, type 2 diabetes, autoimmune disease, hypertension, and hyperlipidemia |
| WO2009127057A1 (en) * | 2008-04-15 | 2009-10-22 | Innovactiv Inc. | Cosmetic compositions comprising exopolysaccharides derived from microbial mats, and use thereof |
| US8241690B2 (en) | 2008-11-14 | 2012-08-14 | Kraft Foods Global Brands Llc | Method of making fresh cheese with enhanced microbiological safety |
| EP2295535A1 (en) * | 2009-09-11 | 2011-03-16 | Mead Johnson Nutrition Company | Probiotic material |
| US20130029906A1 (en) * | 2009-12-04 | 2013-01-31 | Eric Simard | Method of regulating ppar, obesity related pathways and their associated metabolic impact |
| CA2799452A1 (en) * | 2010-05-14 | 2011-11-17 | Lactoscience Inc. | Fermentation process of a substrate using a mixed culture for the production of an edible biomass for animal and/or human consumption |
| WO2012057636A1 (en) * | 2010-10-27 | 2012-05-03 | Fonterra Corporate Research And Development Limited | Modulation of th1 and th2 immune response by lactic acid whey |
| US20120258230A1 (en) * | 2011-04-08 | 2012-10-11 | Tic Gums, Inc. | Thickening and emulsifying guar gum and guar blends conjugated with endogenous and exogenous proteins |
| CN102396688B (zh) * | 2011-11-02 | 2013-05-08 | 华南理工大学 | 呈味活性肽及其制备方法与应用 |
| BR112015003239B1 (pt) | 2012-08-22 | 2020-10-27 | Kraft Foods Group Brands Llc | queijo processado incluindo antimicrobianos naturais e método para produção de um queijo processado tendo antimicrobianos naturais |
| US9808493B2 (en) | 2012-08-31 | 2017-11-07 | University College Cork—National University of Ireland, Cork | Exopolysaccharide-producing bacteria, and uses thereof for protecting heart health |
| WO2014149468A1 (en) * | 2013-03-15 | 2014-09-25 | Halliburton Energy Services, Inc. | Methods of biosynthesizing bacterial extracellular galactomannan polysaccharides and subunits thereof for use in subterranean formation operations |
| AU2014364034B2 (en) * | 2013-12-10 | 2018-09-13 | Kraft Foods Group Brands Llc | Processed cheese with natural antibacterial and antimycotic components and method of manufacturing |
| CN107629119B (zh) * | 2016-07-18 | 2021-05-14 | 河南工业大学 | 一种麦胚抗肿瘤活性蛋白的修饰方法 |
| CA3036967A1 (en) * | 2016-09-14 | 2018-03-22 | Glanbia Nutritionals (Ireland) Ltd. | Agglomerated protein products and method for making |
| FR3065623B1 (fr) | 2017-04-28 | 2021-07-09 | Roquette Freres | Albumines de pois ameliorees, procede d'obtention et leurs applications |
| CN108617770A (zh) * | 2018-05-14 | 2018-10-09 | 戴来花 | 低乳糖杀菌羊奶及其制作方法 |
| CN108740012A (zh) * | 2018-06-04 | 2018-11-06 | 安徽安亳食品有限公司 | 一种黄秋葵酸奶及其制备方法 |
| CN109497558A (zh) * | 2018-11-13 | 2019-03-22 | 南京中医药大学 | 苦参药渣多糖合生元及其制备方法与应用 |
| KR102112949B1 (ko) * | 2019-02-12 | 2020-05-19 | 남현규 | 복합 효모 발효로 불용 단백질을 가용화하여 화장품원료를 추출하는 화장품원료 제조방법 |
| MX2019002435A (es) * | 2019-02-28 | 2020-09-01 | Bioactivos Y Nutraceuticos De Mexico S A De C V | Formulaciones proteicas conjugadas con efecto nutracéutico y su método de preparación. |
| KR102283326B1 (ko) * | 2019-05-27 | 2021-07-29 | 주식회사 단정바이오 | 락토바실러스발효물, 락토코쿠스발효물, 효모폴리펩타이드, 락토바실러스 아시도필루스 포도발효물을 유효성분으로 하는 화장료 조성물 |
| CN111793584B (zh) * | 2020-08-05 | 2021-11-02 | 四川省农业科学院农产品加工研究所 | 鼠李糖乳杆菌菌株d2及其制备方法和用途 |
| CN114886087A (zh) * | 2021-01-26 | 2022-08-12 | 苏州乐卡食品有限公司 | 一种益生菌发酵豆乳及制备方法 |
| CN113088479B (zh) * | 2021-05-08 | 2022-08-26 | 河北农业大学 | 一种促进雪莲菌增殖的复合添加剂 |
| CN113403228A (zh) * | 2021-06-09 | 2021-09-17 | 南昌大学 | 一株产热稳定和pH稳定细菌素的乳酸乳球菌及其筛选方法和应用 |
| CN113388511A (zh) * | 2021-07-02 | 2021-09-14 | 泉州市嗣家名茶发展有限公司 | 一种束萃法提取秋葵果实中植物蛋白质的装置及方法 |
| CN114796001B (zh) * | 2022-04-17 | 2023-11-14 | 上海佰莱美生物科技有限公司 | 抗氧化组合物及其制备和在食品/化妆品中的应用 |
| CN117683117B (zh) * | 2023-12-11 | 2025-10-28 | 厦门元之道生物科技有限公司 | 一种具有减肥、抗糖化及抗炎活性的弹性蛋白肽及其制备方法、功能产品 |
| CN118743634A (zh) * | 2024-07-22 | 2024-10-08 | 广州迷紫化妆品有限公司 | 一种美白洁面组合物 |
Family Cites Families (24)
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|---|---|---|---|---|
| US4209389A (en) * | 1974-07-29 | 1980-06-24 | Hartkorn Karl Heinz | Microbiological method for removing pathogenic microbes and dissolved organic materials from liquids |
| US4073688A (en) * | 1975-12-29 | 1978-02-14 | Vysoka Skola Chemicko-Technologicka | Process for the preparation of a proteinaceous concentrate |
| GB1549573A (en) * | 1977-02-25 | 1979-08-08 | British Petroleum Co | Fermentation process for the production of a protein rich animal feedstuff from liquid dairy by-products |
| US4183966A (en) * | 1978-04-14 | 1980-01-15 | The Board of Regents of the Oklahoma Agricultural & Mechanical Colleges acting for and on behalf of Oklahoma State University of Agriculture and Applied Science | Method of manufacturing a high protein snack food |
| US4444793A (en) * | 1981-08-07 | 1984-04-24 | Stauffer Chemical Company | Fermentation of whey to produce a thickening agent |
| US4741337A (en) * | 1985-07-17 | 1988-05-03 | Ethicon, Inc. | Surgical fastener made from glycolide-rich polymer blends |
| JPS62151155A (ja) * | 1985-09-17 | 1987-07-06 | Ajinomoto Co Inc | チ−ズホエ−を原料とする調味料の製造方法 |
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| US5456924A (en) | 1988-12-23 | 1995-10-10 | Immunotec Research Corporation Ltd. | Method of treatment of HIV-seropositive individuals with dietary whey proteins |
| US5888552A (en) * | 1988-04-29 | 1999-03-30 | Immunotec Research Corporation Ltd. | Anti-cancer therapeutic compositions containing whey protein concentrate |
| US5230902A (en) * | 1988-04-29 | 1993-07-27 | Immunotec Research Corporation | Undenatured whey protein concentrate to improve active systemic humoral immune response |
| CA1333471C (en) * | 1988-04-29 | 1994-12-13 | Gustavo Bounous | Whey protein concentrate as food supplement |
| JP2811316B2 (ja) * | 1989-02-20 | 1998-10-15 | 協同乳業株式会社 | 乳酸菌飲料とその製造方法 |
| WO1992006598A1 (en) * | 1990-10-23 | 1992-04-30 | Kraft General Foods, Inc. | Non-fat natural cheese |
| JPH0771448B2 (ja) * | 1990-11-22 | 1995-08-02 | 雪印乳業株式会社 | ノンファットアイスクリーム及びその製造法 |
| FR2672613B1 (fr) * | 1991-02-08 | 1994-05-27 | Rochade Soc Civ | Procede de fabrication d'un nouveau levain lactique, nouveau levain obtenu, fabrication d'additif alimentaire notamment probiotique a partir de ce levain et produit obtenu. |
| JPH07104A (ja) * | 1993-06-14 | 1995-01-06 | Morinaga Milk Ind Co Ltd | 発酵乳及びその製造方法 |
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| WO2003053158A2 (en) | 2003-07-03 |
| WO2003053158A9 (en) | 2004-04-08 |
| ES2451618T3 (es) | 2014-03-28 |
| WO2003053158A3 (en) | 2003-08-28 |
| US20060057131A1 (en) | 2006-03-16 |
| CA2470776A1 (en) | 2003-07-03 |
| AU2002351606A8 (en) | 2003-07-09 |
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