JP5406040B2 - 医薬使用のためのリパーゼ変異体 - Google Patents

医薬使用のためのリパーゼ変異体 Download PDF

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JP5406040B2
JP5406040B2 JP2009543078A JP2009543078A JP5406040B2 JP 5406040 B2 JP5406040 B2 JP 5406040B2 JP 2009543078 A JP2009543078 A JP 2009543078A JP 2009543078 A JP2009543078 A JP 2009543078A JP 5406040 B2 JP5406040 B2 JP 5406040B2
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lipase
seq
enzyme
amino acids
activity
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JP2010512795A (ja
JP2010512795A5 (https=
Inventor
スベンセン，アラン
スクヨエット，ミシェル
ヤバー，デビー
レーマン ヒュリング クリステンセン，ラーズ
エスキルセン ラーセン，シグネ
ルンディン，ニーナ
ランサ，マイケル
コリン グレゴリー，ピーター
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ノボザイムス アクティーゼルスカブ
ノボザイムス，インコーポレイティド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/54—Mixtures of enzymes or proenzymes covered by more than a single one of groups A61K38/44 - A61K38/46 or A61K38/51 - A61K38/53
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/01—Carboxylic ester hydrolases (3.1.1)
    • C12Y301/01003—Triacylglycerol lipase (3.1.1.3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Nutrition Science (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Detergent Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2009543078A 2006-12-21 2007-12-12 医薬使用のためのリパーゼ変異体 Active JP5406040B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87119606P 2006-12-21 2006-12-21
US60/871,196 2006-12-21
PCT/US2007/087168 WO2008079685A2 (en) 2006-12-21 2007-12-12 Lipase variants for pharmaceutical use

Publications (3)

Publication Number Publication Date
JP2010512795A JP2010512795A (ja) 2010-04-30
JP2010512795A5 JP2010512795A5 (https=) 2011-02-03
JP5406040B2 true JP5406040B2 (ja) 2014-02-05

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JP2009543078A Active JP5406040B2 (ja) 2006-12-21 2007-12-12 医薬使用のためのリパーゼ変異体

Country Status (16)

Country Link
US (3) US8273348B2 (https=)
EP (6) EP2261328B1 (https=)
JP (1) JP5406040B2 (https=)
KR (1) KR20090101930A (https=)
CN (2) CN105112386A (https=)
AR (1) AR064494A1 (https=)
AU (1) AU2007337150A1 (https=)
BR (1) BRPI0721103A2 (https=)
CA (3) CA2961041C (https=)
IL (1) IL198893A0 (https=)
MX (1) MX2009006597A (https=)
NO (1) NO20092729L (https=)
RU (1) RU2009128067A (https=)
TW (1) TW200829698A (https=)
WO (1) WO2008079685A2 (https=)
ZA (1) ZA200903598B (https=)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2560613C (en) 2004-03-22 2015-11-24 Solvay Pharmaceuticals Gmbh Oral pharmaceutical compositions of lipase-containing products, in particular of pancreatin, containing surfactants
KR101555058B1 (ko) 2005-07-29 2015-09-22 애보트 래버러토리즈 게엠베하 살균된 판크레아틴 분말의 제조방법
US11266607B2 (en) 2005-08-15 2022-03-08 AbbVie Pharmaceuticals GmbH Process for the manufacture and use of pancreatin micropellet cores
US9198871B2 (en) 2005-08-15 2015-12-01 Abbott Products Gmbh Delayed release pancreatin compositions
US10072256B2 (en) 2006-05-22 2018-09-11 Abbott Products Gmbh Process for separating and determining the viral load in a pancreatin sample
RU2009128067A (ru) 2006-12-21 2011-01-27 Новозимс А/С (Dk) Варианты липаз для их применения в фармацевтике
AU2009218457B2 (en) 2008-02-29 2013-10-24 Dsm Ip Assets B.V. Lipases with high specificity towards short chain fatty acids and uses thereof
CN101990573B (zh) * 2008-02-29 2014-01-22 诺维信公司 具有改进的稳定性的脂肪分解酶变体及编码该变体的多核苷酸
MX2010009457A (es) * 2008-02-29 2010-09-24 Procter & Gamble Composicion detergente que comprende lipasa.
MX2012006616A (es) 2009-12-09 2012-06-21 Procter & Gamble Productos para el cuidado de las telas y el hogar.
EP2734633B1 (en) 2011-07-22 2019-05-01 Novozymes North America, Inc. Processes for pretreating cellulosic material and improving hydrolysis thereof
US8268305B1 (en) 2011-09-23 2012-09-18 Bio-Cat, Inc. Method and compositions to reduce serum levels of triacylglycerides in human beings using a fungal lipase
US9809787B2 (en) * 2011-12-29 2017-11-07 Novozymes A/S Detergent compositions comprising lipase
EP2809779B1 (en) 2012-02-03 2017-09-13 Novozymes A/S Lipase variants and polynucleotides encoding same
CN107988181A (zh) 2012-04-02 2018-05-04 诺维信公司 脂肪酶变体以及编码其的多核苷酸
HK1209785A1 (en) * 2012-10-12 2016-04-08 Danisco Us Inc. Compositions and methods comprising a lipolytic enzyme variant
AR096270A1 (es) * 2013-05-14 2015-12-16 Novozymes As Composiciones detergentes
WO2015010009A2 (en) * 2013-07-19 2015-01-22 Danisco Us Inc. Compositions and methods comprising a lipolytic enzyme variant
US10287562B2 (en) * 2014-11-20 2019-05-14 Novoszymes A/S Alicyclobacillus variants and polynucleotides encoding same
EP4067485A3 (en) * 2014-12-05 2023-01-04 Novozymes A/S Lipase variants and polynucleotides encoding same
EP3230442B1 (en) * 2014-12-09 2019-05-22 Novozymes A/S Lipase variants and polynucleotides encoding same
CN107864658A (zh) 2015-04-07 2018-03-30 诺维信公司 用于选择具有脂肪酶活性的酶的方法
CN107922930A (zh) * 2015-07-01 2018-04-17 诺维信公司 减少气味的方法
CN107995922B (zh) * 2015-07-03 2021-12-28 诺维信公司 在亚硫酸盐的存在下具有改进的稳定性的洗涤剂组合物
EP3485008B1 (en) 2016-07-18 2024-01-31 Novozymes A/S Lipase variants, polynucleotides encoding same and the use thereof
WO2018139634A1 (ja) * 2017-01-30 2018-08-02 学校法人日本医科大学 アデノ随伴ウイルス（ａａｖ）キャプシドタンパク質の変異体
EP3461892A3 (en) 2017-09-27 2019-06-12 The Procter & Gamble Company Detergent compositions comprising lipases
JP7317811B2 (ja) * 2017-09-27 2023-07-31 ノボザイムス アクティーゼルスカブ リパーゼ変異体及びかかるリパーゼ変異体を含むマイクロカプセル組成物
WO2019154952A1 (en) * 2018-02-08 2019-08-15 Novozymes A/S Lipase variants and compositions thereof
US12269847B2 (en) * 2018-08-16 2025-04-08 Donaldson Company, Inc. Genetically encoded polypeptide for affinity capture and purification of biologics
CN111334369B (zh) * 2020-03-11 2022-10-21 陕西科技大学 一种酶法制备卵磷脂型pufa的方法
US12467042B2 (en) * 2020-06-24 2025-11-11 Dermapharm Aktiengesellschaft Lipase enzyme
BR112023008326A2 (pt) * 2020-10-29 2023-12-12 Novozymes As Variantes de lipase e composições compreendendo tais variantes de lipase
CN113846074B (zh) * 2021-10-20 2022-10-21 南京林业大学 一种疏棉状嗜热丝孢菌脂肪酶突变体g91c及其应用
CN116732002A (zh) * 2022-03-01 2023-09-12 中国科学院天津工业生物技术研究所 一种耐受表面活性剂的脂肪酶变体及其应用
CN119630280A (zh) 2022-05-14 2025-03-14 诺维信公司 用于预防、处理、抑制和/或消除植物病原性侵染和感染的组合物和方法
EP4544015A2 (en) * 2022-06-24 2025-04-30 Novozymes A/S Lipase variants and compositions comprising such lipase variants
CN120082537B (zh) * 2023-12-01 2026-03-17 青岛蔚蓝生物集团有限公司 一种脂肪酶突变体
TWI903491B (zh) * 2024-05-09 2025-11-01 國立高雄科技大學 水體與沉積物通量培養系統

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK173590D0 (da) 1990-06-06 1990-07-19 Novo Nordisk As Rekombinante terapeutiske lipaser
DK46693D0 (https=) 1993-04-23 1993-04-23 Novo Nordisk As
DE69129988T2 (de) 1990-09-13 1999-03-18 Novo Nordisk A/S, Bagsvaerd Lipase-varianten
US5869438A (en) 1990-09-13 1999-02-09 Novo Nordisk A/S Lipase variants
WO1992010755A1 (en) 1990-12-05 1992-06-25 Novo Nordisk A/S Proteins with changed epitopes and methods for the production thereof
DE69226636T2 (de) 1991-05-01 1999-05-06 Novo Nordisk A/S, Bagsvaerd Stabilisierte enzyme
DK39693D0 (da) 1993-04-02 1993-04-02 Novo Nordisk As Enzym
CN1134726A (zh) 1993-10-04 1996-10-30 诺沃挪第克公司 一种包含修饰酶的酶制剂
EP0746618B1 (en) * 1994-02-22 2002-08-21 Novozymes A/S A method of preparing a variant of a lipolytic enzyme
JPH10509324A (ja) 1994-11-24 1998-09-14 ノボ ノルディスク アクティーゼルスカブ 抑制されたアレルゲン性を有するポリペプチドの製造のための方法
FI972443L (fi) 1994-12-07 1997-06-09 Novo Nordisk As Polypeptidi, jonka allergeenisuus on vähentynyt
EP0805856B2 (en) 1995-01-26 2009-04-01 Novozymes A/S Animal feed additives comprising xylanase
WO1997007202A1 (en) 1995-08-11 1997-02-27 Novo Nordisk A/S Novel lipolytic enzymes
AU6414196A (en) 1995-07-14 1997-02-18 Novo Nordisk A/S A modified enzyme with lipolytic activity
US6495357B1 (en) * 1995-07-14 2002-12-17 Novozyme A/S Lipolytic enzymes
WO1998030682A1 (en) 1997-01-10 1998-07-16 Novo Nordisk A/S Enzyme coupled with polymeric molecules for skin care
WO1998035026A1 (en) 1997-02-06 1998-08-13 Novo Nordisk A/S Polypeptide-polymer conjugates having added and/or removed attachment groups
CA2294567A1 (en) 1997-06-25 1999-01-07 Novo Nordisk A/S A modified polypeptide
CN1247776C (zh) * 1998-02-17 2006-03-29 诺维信公司 脂肪酶变体
AU3247699A (en) 1998-02-17 1999-09-06 Novo Nordisk A/S Lipase variant
AU6078899A (en) 1998-10-13 2000-05-01 Novozymes A/S A modified polypeptide with reduced immune response
DE69936351T2 (de) 1998-10-30 2008-02-21 Novozymes A/S Glykosylierte proteine mit reduzierter allergenität
ATE390441T1 (de) 1998-10-30 2008-04-15 Novozymes As Niedrigallergene proteinvarianten
EP1131416B1 (en) 1998-11-27 2009-09-02 Novozymes A/S Lipolytic enzyme variants
US7312062B2 (en) * 1998-11-27 2007-12-25 Novozymes A/S Lipolytic enzyme variants
BR0009012A (pt) 1999-03-17 2001-12-26 Solvay Pharm Gmbh Medicamento para o tratamento de diabete
US6939702B1 (en) * 1999-03-31 2005-09-06 Novozymes A/S Lipase variant
ES2498823T3 (es) * 1999-03-31 2014-09-25 Novozymes A/S Variante de lipasa
PL203212B1 (pl) 2000-02-08 2009-09-30 Dsm Ip Assets Bv Zastosowanie trwałej w kwasie proteazy w karmie zwierzęcej oraz w wytwarzaniu kompozycji do stosowania w karmie zwierzęcej, dodatek do karmy zwierzęcej, kompozycja karmy zwierzęcej i sposób obróbki białek roślinnych
EP2258835A1 (en) 2000-04-28 2010-12-08 Novozymes A/S Lipolytic enzyme variant
CA2431972C (en) 2001-01-10 2012-10-23 Novozymes A/S Thermostable lipolytic enzyme variant
AR032392A1 (es) 2001-01-19 2003-11-05 Solvay Pharm Gmbh Mezcla de enzimas, preparado farmaceutico y utilizacion de dicho preparado.
CN1491278A (zh) 2001-02-07 2004-04-21 ŵά�Ź�˾ 脂酶变体
DK2295556T3 (en) * 2002-01-16 2015-01-26 Novozymes As Lipolytic Enzyme Variants and Method of Preparation thereof.
WO2004069872A1 (en) 2003-02-06 2004-08-19 Novozymes A/S Human heavy chain antibody expression in filamentous fungi
DK2270140T3 (en) * 2003-05-09 2016-03-14 Novozymes As Lipolytic enzyme variants
US20060251763A1 (en) 2003-06-19 2006-11-09 Patkar Shamkant A Phospholipase variants
US20060236414A1 (en) 2003-06-19 2006-10-19 Novozymes A/S Proteases and methods for producing them
AR047440A1 (es) 2004-01-21 2006-01-18 Novozymes As Produccion de un anticuerpo monoclonal en un hongo heterocarion o una celula huesped fungal
CA2560613C (en) 2004-03-22 2015-11-24 Solvay Pharmaceuticals Gmbh Oral pharmaceutical compositions of lipase-containing products, in particular of pancreatin, containing surfactants
WO2006044529A1 (en) 2004-10-14 2006-04-27 Altus Pharmaceuticals Inc. Compositions containing lipase; protease and amylase for treating pancreatic insufficiency
WO2006084470A2 (en) 2005-02-10 2006-08-17 Novozymes A/S Enzymatic enantioselective ester or amide hydrolysis or synthesis
US20080317726A1 (en) 2005-06-24 2008-12-25 Novozymes A/S Proteases for Pharmaceutical Use
CN101208429A (zh) * 2005-06-24 2008-06-25 诺维信公司 用于药物用途的脂肪酶
MX2007015471A (es) 2005-06-24 2008-04-04 Novozymes As Amilasas para uso farmaceutico.
WO2007080197A2 (en) * 2006-01-16 2007-07-19 Novozymes A/S Immobilised enzymes
AR059154A1 (es) * 2006-01-23 2008-03-12 Procter & Gamble Una composicion que comprende una lipasa y un catalizador de blanqueador
US8187854B2 (en) * 2006-01-23 2012-05-29 Novozymes A/S Lipase variants
RU2009128067A (ru) * 2006-12-21 2011-01-27 Новозимс А/С (Dk) Варианты липаз для их применения в фармацевтике

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Publication number Publication date
EP2455461B1 (en) 2016-03-16
IL198893A0 (en) 2010-02-17
CA2670643A1 (en) 2008-07-03
EP2261328A1 (en) 2010-12-15
AR064494A1 (es) 2009-04-08
US8273348B2 (en) 2012-09-25
EP2455459B1 (en) 2016-03-16
EP2455459A2 (en) 2012-05-23
WO2008079685A2 (en) 2008-07-03
EP2455459A3 (en) 2013-04-24
JP2010512795A (ja) 2010-04-30
WO2008079685A3 (en) 2008-11-06
CN101743308A (zh) 2010-06-16
MX2009006597A (es) 2009-07-02
EP2261328B1 (en) 2013-11-20
US9029115B2 (en) 2015-05-12
CA2670643C (en) 2017-04-25
CA2961041A1 (en) 2008-07-03
EP2455461A2 (en) 2012-05-23
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KR20090101930A (ko) 2009-09-29
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EP2455462B1 (en) 2016-03-16
US9539311B2 (en) 2017-01-10
RU2009128067A (ru) 2011-01-27
CA2961041C (en) 2020-07-14
US20120308543A1 (en) 2012-12-06
US20100034797A1 (en) 2010-02-11
EP2455460A2 (en) 2012-05-23
CN101743308B (zh) 2015-09-16
BRPI0721103A2 (pt) 2014-03-04
TW200829698A (en) 2008-07-16
ZA200903598B (en) 2010-04-28
US20150209414A1 (en) 2015-07-30
CA3081308A1 (en) 2008-07-03
AU2007337150A1 (en) 2008-07-03
EP2455460A3 (en) 2012-12-26
EP2099907A2 (en) 2009-09-16
CA3081308C (en) 2024-02-20
CN105112386A (zh) 2015-12-02
NO20092729L (no) 2009-09-18
EP2455462A3 (en) 2013-05-29

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