BRPI0721103A2 - Lipase, método de determinação do desempenho da digestão in vitro de uma lipase em comparação com uma lipase de referência, uso de uma lipase ou de uma mistura de lipases, composição farmacêutica, e, método para o tratamento de doença - Google Patents
Lipase, método de determinação do desempenho da digestão in vitro de uma lipase em comparação com uma lipase de referência, uso de uma lipase ou de uma mistura de lipases, composição farmacêutica, e, método para o tratamento de doença Download PDFInfo
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- BRPI0721103A2 BRPI0721103A2 BRPI0721103-1A BRPI0721103A BRPI0721103A2 BR PI0721103 A2 BRPI0721103 A2 BR PI0721103A2 BR PI0721103 A BRPI0721103 A BR PI0721103A BR PI0721103 A2 BRPI0721103 A2 BR PI0721103A2
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- lipase
- seq
- protease
- amylase
- activity
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Classifications
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- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
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- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/54—Mixtures of enzymes or proenzymes covered by more than a single one of groups A61K38/44 - A61K38/46 or A61K38/51 - A61K38/53
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
- C12N9/20—Triglyceride splitting, e.g. by means of lipase
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- C—CHEMISTRY; METALLURGY
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- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
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Landscapes
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- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Nutrition Science (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Detergent Compositions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US87119606P | 2006-12-21 | 2006-12-21 | |
| US60/871196 | 2006-12-21 | ||
| PCT/US2007/087168 WO2008079685A2 (en) | 2006-12-21 | 2007-12-12 | Lipase variants for pharmaceutical use |
Publications (1)
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| BRPI0721103A2 true BRPI0721103A2 (pt) | 2014-03-04 |
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| BRPI0721103-1A BRPI0721103A2 (pt) | 2006-12-21 | 2007-12-12 | Lipase, método de determinação do desempenho da digestão in vitro de uma lipase em comparação com uma lipase de referência, uso de uma lipase ou de uma mistura de lipases, composição farmacêutica, e, método para o tratamento de doença |
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| CA2560613C (en) | 2004-03-22 | 2015-11-24 | Solvay Pharmaceuticals Gmbh | Oral pharmaceutical compositions of lipase-containing products, in particular of pancreatin, containing surfactants |
| KR101555058B1 (ko) | 2005-07-29 | 2015-09-22 | 애보트 래버러토리즈 게엠베하 | 살균된 판크레아틴 분말의 제조방법 |
| US11266607B2 (en) | 2005-08-15 | 2022-03-08 | AbbVie Pharmaceuticals GmbH | Process for the manufacture and use of pancreatin micropellet cores |
| US9198871B2 (en) | 2005-08-15 | 2015-12-01 | Abbott Products Gmbh | Delayed release pancreatin compositions |
| US10072256B2 (en) | 2006-05-22 | 2018-09-11 | Abbott Products Gmbh | Process for separating and determining the viral load in a pancreatin sample |
| RU2009128067A (ru) | 2006-12-21 | 2011-01-27 | Новозимс А/С (Dk) | Варианты липаз для их применения в фармацевтике |
| AU2009218457B2 (en) | 2008-02-29 | 2013-10-24 | Dsm Ip Assets B.V. | Lipases with high specificity towards short chain fatty acids and uses thereof |
| CN101990573B (zh) * | 2008-02-29 | 2014-01-22 | 诺维信公司 | 具有改进的稳定性的脂肪分解酶变体及编码该变体的多核苷酸 |
| MX2010009457A (es) * | 2008-02-29 | 2010-09-24 | Procter & Gamble | Composicion detergente que comprende lipasa. |
| MX2012006616A (es) | 2009-12-09 | 2012-06-21 | Procter & Gamble | Productos para el cuidado de las telas y el hogar. |
| EP2734633B1 (en) | 2011-07-22 | 2019-05-01 | Novozymes North America, Inc. | Processes for pretreating cellulosic material and improving hydrolysis thereof |
| US8268305B1 (en) | 2011-09-23 | 2012-09-18 | Bio-Cat, Inc. | Method and compositions to reduce serum levels of triacylglycerides in human beings using a fungal lipase |
| US9809787B2 (en) * | 2011-12-29 | 2017-11-07 | Novozymes A/S | Detergent compositions comprising lipase |
| EP2809779B1 (en) | 2012-02-03 | 2017-09-13 | Novozymes A/S | Lipase variants and polynucleotides encoding same |
| CN107988181A (zh) | 2012-04-02 | 2018-05-04 | 诺维信公司 | 脂肪酶变体以及编码其的多核苷酸 |
| HK1209785A1 (en) * | 2012-10-12 | 2016-04-08 | Danisco Us Inc. | Compositions and methods comprising a lipolytic enzyme variant |
| AR096270A1 (es) * | 2013-05-14 | 2015-12-16 | Novozymes As | Composiciones detergentes |
| WO2015010009A2 (en) * | 2013-07-19 | 2015-01-22 | Danisco Us Inc. | Compositions and methods comprising a lipolytic enzyme variant |
| US10287562B2 (en) * | 2014-11-20 | 2019-05-14 | Novoszymes A/S | Alicyclobacillus variants and polynucleotides encoding same |
| EP4067485A3 (en) * | 2014-12-05 | 2023-01-04 | Novozymes A/S | Lipase variants and polynucleotides encoding same |
| EP3230442B1 (en) * | 2014-12-09 | 2019-05-22 | Novozymes A/S | Lipase variants and polynucleotides encoding same |
| CN107864658A (zh) | 2015-04-07 | 2018-03-30 | 诺维信公司 | 用于选择具有脂肪酶活性的酶的方法 |
| CN107922930A (zh) * | 2015-07-01 | 2018-04-17 | 诺维信公司 | 减少气味的方法 |
| CN107995922B (zh) * | 2015-07-03 | 2021-12-28 | 诺维信公司 | 在亚硫酸盐的存在下具有改进的稳定性的洗涤剂组合物 |
| EP3485008B1 (en) | 2016-07-18 | 2024-01-31 | Novozymes A/S | Lipase variants, polynucleotides encoding same and the use thereof |
| WO2018139634A1 (ja) * | 2017-01-30 | 2018-08-02 | 学校法人日本医科大学 | アデノ随伴ウイルス（ａａｖ）キャプシドタンパク質の変異体 |
| EP3461892A3 (en) | 2017-09-27 | 2019-06-12 | The Procter & Gamble Company | Detergent compositions comprising lipases |
| JP7317811B2 (ja) * | 2017-09-27 | 2023-07-31 | ノボザイムス アクティーゼルスカブ | リパーゼ変異体及びかかるリパーゼ変異体を含むマイクロカプセル組成物 |
| WO2019154952A1 (en) * | 2018-02-08 | 2019-08-15 | Novozymes A/S | Lipase variants and compositions thereof |
| US12269847B2 (en) * | 2018-08-16 | 2025-04-08 | Donaldson Company, Inc. | Genetically encoded polypeptide for affinity capture and purification of biologics |
| CN111334369B (zh) * | 2020-03-11 | 2022-10-21 | 陕西科技大学 | 一种酶法制备卵磷脂型pufa的方法 |
| US12467042B2 (en) * | 2020-06-24 | 2025-11-11 | Dermapharm Aktiengesellschaft | Lipase enzyme |
| BR112023008326A2 (pt) * | 2020-10-29 | 2023-12-12 | Novozymes As | Variantes de lipase e composições compreendendo tais variantes de lipase |
| CN113846074B (zh) * | 2021-10-20 | 2022-10-21 | 南京林业大学 | 一种疏棉状嗜热丝孢菌脂肪酶突变体g91c及其应用 |
| CN116732002A (zh) * | 2022-03-01 | 2023-09-12 | 中国科学院天津工业生物技术研究所 | 一种耐受表面活性剂的脂肪酶变体及其应用 |
| CN119630280A (zh) | 2022-05-14 | 2025-03-14 | 诺维信公司 | 用于预防、处理、抑制和/或消除植物病原性侵染和感染的组合物和方法 |
| EP4544015A2 (en) * | 2022-06-24 | 2025-04-30 | Novozymes A/S | Lipase variants and compositions comprising such lipase variants |
| CN120082537B (zh) * | 2023-12-01 | 2026-03-17 | 青岛蔚蓝生物集团有限公司 | 一种脂肪酶突变体 |
| TWI903491B (zh) * | 2024-05-09 | 2025-11-01 | 國立高雄科技大學 | 水體與沉積物通量培養系統 |
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| DK173590D0 (da) | 1990-06-06 | 1990-07-19 | Novo Nordisk As | Rekombinante terapeutiske lipaser |
| DK46693D0 (https=) | 1993-04-23 | 1993-04-23 | Novo Nordisk As | |
| DE69129988T2 (de) | 1990-09-13 | 1999-03-18 | Novo Nordisk A/S, Bagsvaerd | Lipase-varianten |
| US5869438A (en) | 1990-09-13 | 1999-02-09 | Novo Nordisk A/S | Lipase variants |
| WO1992010755A1 (en) | 1990-12-05 | 1992-06-25 | Novo Nordisk A/S | Proteins with changed epitopes and methods for the production thereof |
| DE69226636T2 (de) | 1991-05-01 | 1999-05-06 | Novo Nordisk A/S, Bagsvaerd | Stabilisierte enzyme |
| DK39693D0 (da) | 1993-04-02 | 1993-04-02 | Novo Nordisk As | Enzym |
| CN1134726A (zh) | 1993-10-04 | 1996-10-30 | 诺沃挪第克公司 | 一种包含修饰酶的酶制剂 |
| EP0746618B1 (en) * | 1994-02-22 | 2002-08-21 | Novozymes A/S | A method of preparing a variant of a lipolytic enzyme |
| JPH10509324A (ja) | 1994-11-24 | 1998-09-14 | ノボ ノルディスク アクティーゼルスカブ | 抑制されたアレルゲン性を有するポリペプチドの製造のための方法 |
| FI972443L (fi) | 1994-12-07 | 1997-06-09 | Novo Nordisk As | Polypeptidi, jonka allergeenisuus on vähentynyt |
| EP0805856B2 (en) | 1995-01-26 | 2009-04-01 | Novozymes A/S | Animal feed additives comprising xylanase |
| WO1997007202A1 (en) | 1995-08-11 | 1997-02-27 | Novo Nordisk A/S | Novel lipolytic enzymes |
| AU6414196A (en) | 1995-07-14 | 1997-02-18 | Novo Nordisk A/S | A modified enzyme with lipolytic activity |
| US6495357B1 (en) * | 1995-07-14 | 2002-12-17 | Novozyme A/S | Lipolytic enzymes |
| WO1998030682A1 (en) | 1997-01-10 | 1998-07-16 | Novo Nordisk A/S | Enzyme coupled with polymeric molecules for skin care |
| WO1998035026A1 (en) | 1997-02-06 | 1998-08-13 | Novo Nordisk A/S | Polypeptide-polymer conjugates having added and/or removed attachment groups |
| CA2294567A1 (en) | 1997-06-25 | 1999-01-07 | Novo Nordisk A/S | A modified polypeptide |
| CN1247776C (zh) * | 1998-02-17 | 2006-03-29 | 诺维信公司 | 脂肪酶变体 |
| AU3247699A (en) | 1998-02-17 | 1999-09-06 | Novo Nordisk A/S | Lipase variant |
| AU6078899A (en) | 1998-10-13 | 2000-05-01 | Novozymes A/S | A modified polypeptide with reduced immune response |
| DE69936351T2 (de) | 1998-10-30 | 2008-02-21 | Novozymes A/S | Glykosylierte proteine mit reduzierter allergenität |
| ATE390441T1 (de) | 1998-10-30 | 2008-04-15 | Novozymes As | Niedrigallergene proteinvarianten |
| EP1131416B1 (en) | 1998-11-27 | 2009-09-02 | Novozymes A/S | Lipolytic enzyme variants |
| US7312062B2 (en) * | 1998-11-27 | 2007-12-25 | Novozymes A/S | Lipolytic enzyme variants |
| BR0009012A (pt) | 1999-03-17 | 2001-12-26 | Solvay Pharm Gmbh | Medicamento para o tratamento de diabete |
| US6939702B1 (en) * | 1999-03-31 | 2005-09-06 | Novozymes A/S | Lipase variant |
| ES2498823T3 (es) * | 1999-03-31 | 2014-09-25 | Novozymes A/S | Variante de lipasa |
| PL203212B1 (pl) | 2000-02-08 | 2009-09-30 | Dsm Ip Assets Bv | Zastosowanie trwałej w kwasie proteazy w karmie zwierzęcej oraz w wytwarzaniu kompozycji do stosowania w karmie zwierzęcej, dodatek do karmy zwierzęcej, kompozycja karmy zwierzęcej i sposób obróbki białek roślinnych |
| EP2258835A1 (en) | 2000-04-28 | 2010-12-08 | Novozymes A/S | Lipolytic enzyme variant |
| CA2431972C (en) | 2001-01-10 | 2012-10-23 | Novozymes A/S | Thermostable lipolytic enzyme variant |
| AR032392A1 (es) | 2001-01-19 | 2003-11-05 | Solvay Pharm Gmbh | Mezcla de enzimas, preparado farmaceutico y utilizacion de dicho preparado. |
| CN1491278A (zh) | 2001-02-07 | 2004-04-21 | ŵά�Ź�˾ | 脂酶变体 |
| DK2295556T3 (en) * | 2002-01-16 | 2015-01-26 | Novozymes As | Lipolytic Enzyme Variants and Method of Preparation thereof. |
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| AR047440A1 (es) | 2004-01-21 | 2006-01-18 | Novozymes As | Produccion de un anticuerpo monoclonal en un hongo heterocarion o una celula huesped fungal |
| CA2560613C (en) | 2004-03-22 | 2015-11-24 | Solvay Pharmaceuticals Gmbh | Oral pharmaceutical compositions of lipase-containing products, in particular of pancreatin, containing surfactants |
| WO2006044529A1 (en) | 2004-10-14 | 2006-04-27 | Altus Pharmaceuticals Inc. | Compositions containing lipase; protease and amylase for treating pancreatic insufficiency |
| WO2006084470A2 (en) | 2005-02-10 | 2006-08-17 | Novozymes A/S | Enzymatic enantioselective ester or amide hydrolysis or synthesis |
| US20080317726A1 (en) | 2005-06-24 | 2008-12-25 | Novozymes A/S | Proteases for Pharmaceutical Use |
| CN101208429A (zh) * | 2005-06-24 | 2008-06-25 | 诺维信公司 | 用于药物用途的脂肪酶 |
| MX2007015471A (es) | 2005-06-24 | 2008-04-04 | Novozymes As | Amilasas para uso farmaceutico. |
| WO2007080197A2 (en) * | 2006-01-16 | 2007-07-19 | Novozymes A/S | Immobilised enzymes |
| AR059154A1 (es) * | 2006-01-23 | 2008-03-12 | Procter & Gamble | Una composicion que comprende una lipasa y un catalizador de blanqueador |
| US8187854B2 (en) * | 2006-01-23 | 2012-05-29 | Novozymes A/S | Lipase variants |
| RU2009128067A (ru) * | 2006-12-21 | 2011-01-27 | Новозимс А/С (Dk) | Варианты липаз для их применения в фармацевтике |
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2007
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- 2007-12-12 CA CA2961041A patent/CA2961041C/en active Active
- 2007-12-12 EP EP10172609.9A patent/EP2261328B1/en active Active
- 2007-12-12 EP EP12155317.6A patent/EP2455461B1/en active Active
- 2007-12-12 CN CN201510504893.8A patent/CN105112386A/zh active Pending
- 2007-12-12 AU AU2007337150A patent/AU2007337150A1/en not_active Abandoned
- 2007-12-12 WO PCT/US2007/087168 patent/WO2008079685A2/en not_active Ceased
- 2007-12-12 MX MX2009006597A patent/MX2009006597A/es not_active Application Discontinuation
- 2007-12-12 EP EP07869130A patent/EP2099907A2/en not_active Withdrawn
- 2007-12-12 BR BRPI0721103-1A patent/BRPI0721103A2/pt not_active IP Right Cessation
- 2007-12-12 EP EP12155315A patent/EP2455460A3/en not_active Withdrawn
- 2007-12-12 KR KR1020097014850A patent/KR20090101930A/ko not_active Withdrawn
- 2007-12-12 EP EP12155294.7A patent/EP2455459B1/en active Active
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- 2007-12-12 JP JP2009543078A patent/JP5406040B2/ja active Active
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- 2007-12-12 CN CN200780051638.6A patent/CN101743308B/zh active Active
- 2007-12-18 TW TW096148377A patent/TW200829698A/zh unknown
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- 2009-05-25 ZA ZA200903598A patent/ZA200903598B/xx unknown
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