JP5044214B2 - 皮膚状態または癌の処置のためのｓｃｃｅ阻害剤としての縮合複素環化合物の使用 - Google Patents

皮膚状態または癌の処置のためのｓｃｃｅ阻害剤としての縮合複素環化合物の使用 Download PDF

Info

Publication number
JP5044214B2
JP5044214B2 JP2006508134A JP2006508134A JP5044214B2 JP 5044214 B2 JP5044214 B2 JP 5044214B2 JP 2006508134 A JP2006508134 A JP 2006508134A JP 2006508134 A JP2006508134 A JP 2006508134A JP 5044214 B2 JP5044214 B2 JP 5044214B2
Authority
JP
Japan
Prior art keywords
phenyl
oxazin
benzo
aza
thia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2006508134A
Other languages
English (en)
Japanese (ja)
Other versions
JP2006526581A (ja
JP2006526581A5 (en22
Inventor
マルセル・リンショテン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Arexis AB
Original Assignee
Arexis AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arexis AB filed Critical Arexis AB
Publication of JP2006526581A publication Critical patent/JP2006526581A/ja
Publication of JP2006526581A5 publication Critical patent/JP2006526581A5/ja
Application granted granted Critical
Publication of JP5044214B2 publication Critical patent/JP5044214B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/536—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Cosmetics (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2006508134A 2003-06-06 2004-06-07 皮膚状態または癌の処置のためのｓｃｃｅ阻害剤としての縮合複素環化合物の使用 Expired - Fee Related JP5044214B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
DKPA200300844 2003-06-06
DKPA200300842 2003-06-06
DKPA200300840 2003-06-06
DKPA200300840 2003-06-06
DKPA200300843 2003-06-06
DKPA200300844 2003-06-06
DKPA200300843 2003-06-06
DKPA200300842 2003-06-06
PCT/DK2004/000388 WO2004108139A2 (en) 2003-06-06 2004-06-07 Use of fused heterocyclic compounds as scce inhibitors for the treatment of skin conditions or cancer

Publications (3)

Publication Number Publication Date
JP2006526581A JP2006526581A (ja) 2006-11-24
JP2006526581A5 JP2006526581A5 (en22) 2011-05-26
JP5044214B2 true JP5044214B2 (ja) 2012-10-10

Family

ID=33514772

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006508134A Expired - Fee Related JP5044214B2 (ja) 2003-06-06 2004-06-07 皮膚状態または癌の処置のためのｓｃｃｅ阻害剤としての縮合複素環化合物の使用

Country Status (17)

Country Link
US (1) US7872052B2 (en22)
EP (1) EP1631295B1 (en22)
JP (1) JP5044214B2 (en22)
KR (2) KR101099409B1 (en22)
CN (1) CN101152185B (en22)
AT (1) ATE459359T1 (en22)
CA (1) CA2525383C (en22)
CY (1) CY1110084T1 (en22)
DE (1) DE602004025803D1 (en22)
DK (1) DK1631295T3 (en22)
ES (1) ES2341545T3 (en22)
NO (1) NO20060091L (en22)
NZ (1) NZ543636A (en22)
PL (1) PL1631295T3 (en22)
PT (1) PT1631295E (en22)
SI (1) SI1631295T1 (en22)
WO (1) WO2004108139A2 (en22)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10238722A1 (de) 2002-08-23 2004-03-11 Bayer Ag Selektive Phosphodiesterase 9A-Inhibitoren als Arzneimittel zur Verbesserung kognitiver Prozesse
DE10238724A1 (de) 2002-08-23 2004-03-04 Bayer Ag Alkyl-substituierte Pyrazolpyrimidine
DE10320785A1 (de) * 2003-05-09 2004-11-25 Bayer Healthcare Ag 6-Arylmethyl-substituierte Pyrazolopyrimidine
US8044060B2 (en) 2003-05-09 2011-10-25 Boehringer Ingelheim International Gmbh 6-cyclylmethyl- and 6-alkylmethyl pyrazolo[3,4-D]pyrimidines, methods for their preparation and methods for their use to treat impairments of perception, concentration learning and/or memory
DE102004001873A1 (de) * 2004-01-14 2005-09-29 Bayer Healthcare Ag Cyanopyrimidinone
KR101431279B1 (ko) * 2005-07-29 2014-08-20 리스버로직스 코퍼레이션 복합 질환의 예방 및 치료용 약학적 조성물 및 삽입가능한의료 장치에 의한 이의 전달
ZA200902091B (en) 2006-09-21 2010-07-28 Activx Biosciences Inc Serine hydrolase inhibitors
JP2010505811A (ja) 2006-10-04 2010-02-25 ファイザー・プロダクツ・インク カルシウム受容体アンタゴニストとしてのピリド［４，３−ｄ］ピリミジン−４（３Ｈ）−オン誘導体
US8053440B2 (en) 2007-02-01 2011-11-08 Resverlogix Corporation Compounds for the prevention and treatment of cardiovascular diseases
WO2009024528A1 (en) 2007-08-17 2009-02-26 Novartis Ag Use of cyclic depsipeptides to inhibit kallikrein 7
WO2009024527A1 (en) 2007-08-17 2009-02-26 Novartis Ag Cyclic depsipeptides
CA2706018C (en) 2007-11-30 2015-11-24 Boehringer Ingelheim International Gmbh 1, 5-dihydro-pyrazolo [3,4-d]pyrimidin-4-one derivatives and their use as pde9a modulators for the treatment of cns disorders
UA105362C2 (en) 2008-04-02 2014-05-12 Бьорингер Ингельхайм Интернациональ Гмбх 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators
CA2736304A1 (en) 2008-09-08 2010-03-11 Boehringer Ingelheim International Gmbh Pyrazolopyrimidines and their use for the treatment of cns disorders
US8952021B2 (en) 2009-01-08 2015-02-10 Resverlogix Corp. Compounds for the prevention and treatment of cardiovascular disease
US8691828B2 (en) * 2009-03-05 2014-04-08 Takeda Pharmaceutical Company Limited Thienopyrimidine as CDC7 kinase inhibitors
KR101841003B1 (ko) 2009-03-18 2018-03-22 리스버로직스 코퍼레이션 신규한 소염제
UY32531A (es) 2009-03-31 2010-10-29 Boehringer Ingelheim Int Nuevos compuestos para el tratamiento de trastornos del snc
KR20180096823A (ko) 2009-04-22 2018-08-29 리스버로직스 코퍼레이션 신규한 소염제
TWI419884B (zh) * 2010-06-24 2013-12-21 Univ Chang Gung 苯并雜氧嗪酮衍生物，其製備方法以及包含有此等衍生物的藥學組成物
NZ603725A (en) 2010-08-12 2015-04-24 Boehringer Ingelheim Int 6-cycloalkyl-1,5-dihydro-pyrazolo [3,4-d] pyrimidin-4-one derivatives and their use as pde9a inhibitors
WO2012088266A2 (en) 2010-12-22 2012-06-28 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3
US8809345B2 (en) 2011-02-15 2014-08-19 Boehringer Ingelheim International Gmbh 6-cycloalkyl-pyrazolopyrimidinones for the treatment of CNS disorders
US8680054B2 (en) 2011-04-20 2014-03-25 Novartis Ag Suspension type topical formulations comprising cyclic depsipeptide
AR086168A1 (es) 2011-04-20 2013-11-27 Novartis Ag Procesos para la elaboracion de depsipeptidos macrociclicos e intermediarios
TR201909777T4 (tr) 2011-11-01 2019-07-22 Resverlogix Corp Sübsti̇tüe ki̇nazoli̇nonlara yöneli̇k oral çabuk salimli formülasyonlar
CN104334545A (zh) 2012-03-16 2015-02-04 埃克希金医药品有限公司 3,5-二氨基吡唑激酶抑制剂
SMT201700146T1 (it) 2012-06-13 2017-05-08 Incyte Holdings Corp Composti triciclici sostituiti come inibitori di fgfr
US9388185B2 (en) 2012-08-10 2016-07-12 Incyte Holdings Corporation Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors
US8987413B2 (en) 2012-10-09 2015-03-24 Novartis Ag Aldehyde acetal based processes for the manufacture of macrocyclic depsipeptides and new intermediates
US9067978B2 (en) 2012-10-09 2015-06-30 Novartis Ag Solution phase processes for the manufacture of macrocyclic depsipeptides and new intermediates
WO2014080291A2 (en) 2012-11-21 2014-05-30 Rvx Therapeutics Inc. Biaryl derivatives as bromodomain inhibitors
WO2014080290A2 (en) 2012-11-21 2014-05-30 Rvx Therapeutics Inc. Cyclic amines as bromodomain inhibitors
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
EP2935253B1 (en) 2012-12-21 2018-08-01 Zenith Epigenetics Ltd. Novel heterocyclic compounds as bromodomain inhibitors
KR102469849B1 (ko) 2013-04-19 2022-11-23 인사이트 홀딩스 코포레이션 Fgfr 저해제로서 이환식 헤테로사이클
NZ631142A (en) 2013-09-18 2016-03-31 Axikin Pharmaceuticals Inc Pharmaceutically acceptable salts of 3,5-diaminopyrazole kinase inhibitors
HUE051296T2 (hu) * 2014-01-23 2021-03-01 Sixera Pharma Ab Benzoxazinon-származékok bõrbetegségek kezelésére
PT3097084T (pt) 2014-01-23 2020-12-09 Sixera Pharma Ab Novos inibidores de calicreína 7
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
MY191736A (en) 2014-12-23 2022-07-13 Axikin Pharmaceuticals Inc 3,5-diaminopyrazole kinase inhibitors
WO2016134294A1 (en) 2015-02-20 2016-08-25 Incyte Corporation Bicyclic heterocycles as fgfr4 inhibitors
WO2016134320A1 (en) 2015-02-20 2016-08-25 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
EP3268007B1 (en) 2015-03-13 2022-11-09 Resverlogix Corp. Compositions and therapeutic methods for the treatment of complement-associated diseases
AR111960A1 (es) 2017-05-26 2019-09-04 Incyte Corp Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
WO2019074979A1 (en) 2017-10-09 2019-04-18 Girafpharma, Llc HETEROCYCLIC COMPOUNDS AND USES THEREOF
CA3078945A1 (en) * 2017-10-09 2019-04-18 Nuvation Bo Inc. Heterocyclic compounds and uses thereof
CN108421034A (zh) * 2018-04-24 2018-08-21 济南磐升生物技术有限公司 激肽释放酶7在皮肤创伤愈合中的应用
MX2020011639A (es) 2018-05-04 2021-02-15 Incyte Corp Sales de un inhibidor de receptores de factor de crecimiento de fibroblastos (fgfr).
EP3788047B1 (en) 2018-05-04 2024-09-04 Incyte Corporation Solid forms of an fgfr inhibitor and processes for preparing the same
TWI803696B (zh) 2018-09-14 2023-06-01 日商橘生藥品工業股份有限公司 次黃嘌呤化合物
WO2020185532A1 (en) 2019-03-08 2020-09-17 Incyte Corporation Methods of treating cancer with an fgfr inhibitor
US11332473B2 (en) 2019-04-09 2022-05-17 Nuvation Bio Inc. Substituted pyrazolo[3,4-d]pyrimidines as Wee1 inhibitors
US11591329B2 (en) 2019-07-09 2023-02-28 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
WO2021067374A1 (en) 2019-10-01 2021-04-08 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
JP2022551583A (ja) 2019-10-01 2022-12-12 モレキュラー スキン セラピューティクス，インコーポレイティド Ｋｌｋ５／７デュアル阻害剤としてのベンゾキサジノン化合物
TW202128685A (zh) 2019-10-14 2021-08-01 美商英塞特公司 作為ｆｇｆｒ抑制劑之雙環雜環
WO2021076728A1 (en) 2019-10-16 2021-04-22 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
US11897891B2 (en) 2019-12-04 2024-02-13 Incyte Corporation Tricyclic heterocycles as FGFR inhibitors
IL293001A (en) 2019-12-04 2022-07-01 Incyte Corp Derivatives of an fgfr inhibitor
WO2021146424A1 (en) 2020-01-15 2021-07-22 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
JP7502945B2 (ja) 2020-09-08 2024-06-19 花王株式会社 デリケートエリアのかぶれの検査方法
WO2022221170A1 (en) 2021-04-12 2022-10-20 Incyte Corporation Combination therapy comprising an fgfr inhibitor and a nectin-4 targeting agent
WO2022253911A1 (en) 2021-06-01 2022-12-08 Sixera Pharma Ab Oil-in-water emulsion of 6-ethoxy-7-methoxy-2-(2-methylsulfanylphenyl)-3,l-benzoxazin-4-one
US11939331B2 (en) 2021-06-09 2024-03-26 Incyte Corporation Tricyclic heterocycles as FGFR inhibitors
EP4543436A1 (en) * 2022-06-21 2025-04-30 Dana-Farber Cancer Institute, Inc. Fused bicyclic egfr inhibitors and methods of use thereof

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1153994A (en) * 1965-07-21 1969-06-04 Aspro Nicholas Ltd Hydroxyphenyl Anthranilic Acid Derivatives Capable of Absorbing 'Ultra-Violet Light and Compositions containing them
FR2121341A1 (en) 1971-01-04 1972-08-25 Ferlux 2-substd-3,1-benzoxazin-4-ones - antiinflammatories, analgesics sedatives and diuretics
IT1050750B (it) * 1975-12-05 1981-03-20 Erba Carlo Spa Derivati della 3.4 di idro chinazolina
JPS5576868A (en) 1978-12-01 1980-06-10 Hisamitsu Pharmaceut Co Inc Novel 3,1-bezoxazine derivative
GB8817651D0 (en) * 1988-07-25 1988-09-01 Smith Kline French Lab Chemical compounds
FI912995A0 (fi) 1988-12-21 1991-06-19 Upjohn Co Atiaterosklerotiska och antirombotiska 1-benzopyran-4-oner och 2-amino-1,3-benzoxazin-4-oner.
JPH07316056A (ja) * 1990-02-15 1995-12-05 Teijin Ltd エラスターゼ阻害用医薬組成物
CA2051115A1 (en) * 1990-02-15 1991-08-16 Junichi Oshida 4h-3,1-benzoxazin-4-one compounds and their pharmaceutical compositions for inhibiting elastase
JPH05509302A (ja) * 1990-06-20 1993-12-22 ジ・アップジョン・カンパニー 抗アテローム性動脈硬化性および抗血栓性１―ベンゾピラン―４―オン類および２―アミノ―１，３―ベンゾオキサジン―４―オン類
ATE159009T1 (de) * 1991-05-10 1997-10-15 Rhone Poulenc Rorer Int Bis mono- und bicyclische aryl- und heteroarylderivate mit inhibierender wirkung auf die egf und/oder pdgf-rezeptor tyrosinkinase
US5480883A (en) * 1991-05-10 1996-01-02 Rhone-Poulenc Rorer Pharmaceuticals Inc. Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
US5346886A (en) * 1993-11-15 1994-09-13 John Lezdey Topical α-1-antitrypsin, non-aqueous lipid miscible, benzalkonium chloride compositions for treating skin
WO2000030646A1 (en) * 1998-11-26 2000-06-02 Novo Nordisk A/S Heterocyclic compounds regulating clotting
ATE476998T1 (de) * 1999-09-10 2010-08-15 Procter & Gamble Polyoxyalkylen-konjugate als enzyminhibitoren
ATE515940T1 (de) 2001-02-09 2011-07-15 Torbjoern Egelrud Scce transgene mäuse und deren verwendung als modell für menschliche krankheiten
WO2003007955A2 (en) * 2001-07-20 2003-01-30 Cancer Research Technology Limited Biphenyl apurinic/apyrimidinic site endonuclease inhibitors to treat cancer
JP4395073B2 (ja) * 2002-10-03 2010-01-06 株式会社医薬分子設計研究所 キナゾリン−４−オン誘導体
CN1708306A (zh) * 2002-11-04 2005-12-14 Nps制药公司 作为钙阻滞剂的喹唑啉酮化合物
PE20040950A1 (es) * 2003-02-14 2005-01-01 Theravance Inc DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS

Also Published As

Publication number Publication date
HK1120209A1 (en) 2009-03-27
WO2004108139A3 (en) 2005-03-10
DK1631295T3 (da) 2010-06-21
CA2525383A1 (en) 2004-12-16
CY1110084T1 (el) 2015-01-14
KR20110120960A (ko) 2011-11-04
WO2004108139A8 (en) 2005-04-28
EP1631295A2 (en) 2006-03-08
CN101152185B (zh) 2010-12-08
CA2525383C (en) 2012-03-06
ATE459359T1 (de) 2010-03-15
HK1091731A1 (zh) 2007-01-26
KR101205257B1 (ko) 2012-11-27
CN101152185A (zh) 2008-04-02
PL1631295T3 (pl) 2010-09-30
US7872052B2 (en) 2011-01-18
PT1631295E (pt) 2010-05-24
EP1631295B1 (en) 2010-03-03
NZ543636A (en) 2009-07-31
ES2341545T3 (es) 2010-06-22
NO20060091L (no) 2006-03-06
US20060258651A1 (en) 2006-11-16
SI1631295T1 (sl) 2010-06-30
AU2004244704A1 (en) 2004-12-16
JP2006526581A (ja) 2006-11-24
DE602004025803D1 (de) 2010-04-15
KR20060008331A (ko) 2006-01-26
KR101099409B1 (ko) 2011-12-27
WO2004108139A2 (en) 2004-12-16

Similar Documents

Publication Publication Date Title
JP5044214B2 (ja) 皮膚状態または癌の処置のためのｓｃｃｅ阻害剤としての縮合複素環化合物の使用
CN100579518C (zh) Ep4受体配体在制备治疗il-6相关疾病的药物中的应用
AU2004233587B2 (en) Use of a topical medicament comprising Riluzole
JP2010520293A (ja) 複素環式部分を含有するメタロプロテアーゼ阻害剤
JP2003526594A (ja) カッパ・アゴニスト抗掻痒薬学的製剤およびそれにより掻痒を治療する方法
NZ516616A (en) Beta-carboline pharmaceutical compositions
US6180625B1 (en) Heterocyclic compounds regulating clotting
TW201305167A (zh) 使用經鹵芳基取代之胺基嘌呤的治療、改善及預防方法
CA2782472A1 (en) Method of treating scars and beta-catenin-mediated disorders
WO1999048878A1 (en) Heterocyclic compounds regulating clotting
AU2004244704B2 (en) Use of fused heterocyclic compounds as SCCE inhibitors for the treatment of skin conditions or cancer
TWI436767B (zh) 基質金屬蛋白酶－２（ｍｍｐ－２）及／或基質金屬蛋白酶－９（ｍｍｐ－９）抑制劑
CN100518740C (zh) 杂环化合物作为scce抑制剂的制药用途
HK1091731B (en) Pharmaceutical use of fused heterocyclic compounds as scce inhibitors for the treatment of skin conditions or cancer
HK1120209B (en) Use of fused heterocyclic compounds as scce inhibitors
US20180338964A1 (en) 3-(piperidin-4-yl)-isoxazol-3(oh)-ones for treatment of dermatologic disorders
WO2000030646A1 (en) Heterocyclic compounds regulating clotting
US20130203789A1 (en) Novel Inhibitors of LYN Kinase and Methods Using Same
JPH08500120A (ja) 置換アザスピランを用いる乾癬の治療方法
US20130203817A1 (en) Novel Inhibitors of LYN Kinase
EP4448101A1 (en) Neutrophil exocytosis inhibitors
CN119638779A (zh) 一种乏氧响应性蛋白降解靶向嵌合体化合物及其制备方法和应用
TW200403071A (en) Combination therapy

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20070522

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20070522

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20101005

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20101224

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20110106

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20110207

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20110215

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20110307

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20110314

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20110405

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20111227

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20120309

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120327

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20120626

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20120713

R150 Certificate of patent or registration of utility model

Ref document number: 5044214

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20150720

Year of fee payment: 3

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees