JP5026958B2 - リコンビナーゼポリメラーゼ増幅 - Google Patents

リコンビナーゼポリメラーゼ増幅 Download PDF

Info

Publication number
JP5026958B2
JP5026958B2 JP2007514201A JP2007514201A JP5026958B2 JP 5026958 B2 JP5026958 B2 JP 5026958B2 JP 2007514201 A JP2007514201 A JP 2007514201A JP 2007514201 A JP2007514201 A JP 2007514201A JP 5026958 B2 JP5026958 B2 JP 5026958B2
Authority
JP
Japan
Prior art keywords
dna
recombinase
polymerase
primer
amplification
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP2007514201A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008500831A (ja
JP2008500831A5 (OSRAM
Inventor
オラフ ピーペンブルク，
コリン エイチ． ウィリアムズ，
ニアル エー． アームズ，
デレク エル． ステンプル，
Original Assignee
アリーア サン ディエゴ， インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/931,916 external-priority patent/US7399590B2/en
Application filed by アリーア サン ディエゴ， インコーポレイテッド filed Critical アリーア サン ディエゴ， インコーポレイテッド
Publication of JP2008500831A publication Critical patent/JP2008500831A/ja
Publication of JP2008500831A5 publication Critical patent/JP2008500831A5/ja
Application granted granted Critical
Publication of JP5026958B2 publication Critical patent/JP5026958B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5023—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures with a sample being transported to, and subsequently stored in an absorbent for analysis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y10/00—Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Nanotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Medical Informatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
JP2007514201A 2004-06-01 2005-04-11 リコンビナーゼポリメラーゼ増幅 Expired - Lifetime JP5026958B2 (ja)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US57616204P 2004-06-01 2004-06-01
US57614804P 2004-06-01 2004-06-01
US60/576,148 2004-06-01
US60/576,162 2004-06-01
US10/931,916 US7399590B2 (en) 2002-02-21 2004-09-01 Recombinase polymerase amplification
US10/931,916 2004-09-01
US62229104P 2004-10-26 2004-10-26
US60/622,291 2004-10-26
US63274604P 2004-12-02 2004-12-02
US60/632,746 2004-12-02
PCT/IB2005/001560 WO2005118853A2 (en) 2004-06-01 2005-04-11 Recombinase polymerase amplification

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2008096623A Division JP5089466B2 (ja) 2004-06-01 2008-04-02 リコンビナーゼポリメラーゼ増幅
JP2011044524A Division JP2011103900A (ja) 2004-06-01 2011-03-01 リコンビナーゼポリメラーゼ増幅

Publications (3)

Publication Number Publication Date
JP2008500831A JP2008500831A (ja) 2008-01-17
JP2008500831A5 JP2008500831A5 (OSRAM) 2008-05-22
JP5026958B2 true JP5026958B2 (ja) 2012-09-19

Family

ID=35463460

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2007514201A Expired - Lifetime JP5026958B2 (ja) 2004-06-01 2005-04-11 リコンビナーゼポリメラーゼ増幅
JP2008096623A Expired - Lifetime JP5089466B2 (ja) 2004-06-01 2008-04-02 リコンビナーゼポリメラーゼ増幅
JP2011044524A Pending JP2011103900A (ja) 2004-06-01 2011-03-01 リコンビナーゼポリメラーゼ増幅
JP2013029664A Expired - Lifetime JP5856576B2 (ja) 2004-06-01 2013-02-19 リコンビナーゼポリメラーゼ増幅

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2008096623A Expired - Lifetime JP5089466B2 (ja) 2004-06-01 2008-04-02 リコンビナーゼポリメラーゼ増幅
JP2011044524A Pending JP2011103900A (ja) 2004-06-01 2011-03-01 リコンビナーゼポリメラーゼ増幅
JP2013029664A Expired - Lifetime JP5856576B2 (ja) 2004-06-01 2013-02-19 リコンビナーゼポリメラーゼ増幅

Country Status (6)

Country Link
EP (4) EP1759012B1 (OSRAM)
JP (4) JP5026958B2 (OSRAM)
AU (1) AU2005250233B2 (OSRAM)
CA (1) CA2569512C (OSRAM)
ES (2) ES2425354T3 (OSRAM)
WO (1) WO2005118853A2 (OSRAM)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000040715A2 (en) 1999-01-05 2000-07-13 Trustees Of Boston University Improved nucleic acid cloning
US7435562B2 (en) 2000-07-21 2008-10-14 Modular Genetics, Inc. Modular vector systems
DK1499738T3 (da) * 2002-02-21 2008-11-17 Asm Scient Inc Recombinase-polymerease-amplifikation
US7399590B2 (en) 2002-02-21 2008-07-15 Asm Scientific, Inc. Recombinase polymerase amplification
US8030000B2 (en) 2002-02-21 2011-10-04 Alere San Diego, Inc. Recombinase polymerase amplification
EP1753774B1 (en) 2004-06-02 2008-09-10 ASM Scientific, Inc. 2"-nitrobenzyl-modified ribonucleotides
JP2008519602A (ja) 2004-11-11 2008-06-12 モジュラー ジェネティクス， インコーポレイテッド 多様性を生じるためのラダーアセンブリおよびシステム
ES2420831T3 (es) 2005-07-25 2013-08-27 Alere San Diego, Inc. Procedimientos para multiplexar la ampliación de la recombinasa polimerasa
US8071308B2 (en) * 2006-05-04 2011-12-06 Alere San Diego, Inc. Recombinase polymerase amplification
AU2016204451B2 (en) * 2006-05-04 2017-05-11 Abbott Diagnostics Scarborough, Inc. Recombinase Polymerase Amplification
US7501254B2 (en) 2006-07-20 2009-03-10 Ghc Technologies, Inc. Methods and compositions for amplification and capture of nucleic acid sequences
JP4918409B2 (ja) 2006-07-26 2012-04-18 西川ゴム工業株式会社 核酸配列の増幅方法
DE102006054562A1 (de) * 2006-11-20 2008-05-21 Bayer Healthcare Ag Verfahren zum Nachweis von Pyrophosphat mit Biolumineszenz Detektion
US9689031B2 (en) 2007-07-14 2017-06-27 Ionian Technologies, Inc. Nicking and extension amplification reaction for the exponential amplification of nucleic acids
SI2660336T1 (sl) * 2008-06-11 2017-11-30 Orion Pharma (Uk) Limited Izotermna ojačitev nukleinske kisline
US9309557B2 (en) 2010-12-17 2016-04-12 Life Technologies Corporation Nucleic acid amplification
US9334531B2 (en) 2010-12-17 2016-05-10 Life Technologies Corporation Nucleic acid amplification
JP5847076B2 (ja) 2009-05-20 2016-01-20 バイオサイト インコーポレイテッド Ｄｎａグリコシラーゼ／リアーゼおよびａｐエンドヌクレアーゼ基質
ES3022638T3 (en) 2009-06-05 2025-05-28 Abbott Diagnostics Scarborough Inc Recombinase polymerase amplification reagents
CN102666872A (zh) * 2009-09-25 2012-09-12 艾利尔圣迭戈公司 粗基质中的核酸的检测
US9399217B2 (en) 2010-10-04 2016-07-26 Genapsys, Inc. Chamber free nanoreactor system
US9184099B2 (en) 2010-10-04 2015-11-10 The Board Of Trustees Of The Leland Stanford Junior University Biosensor devices, systems and methods therefor
GB2499340B (en) 2010-10-04 2015-10-28 Genapsys Inc Methods for sequencing nucleic acids
CN103370425B (zh) 2010-12-17 2019-03-19 生命技术公司 用于核酸扩增的方法、组合物、系统、仪器和试剂盒
JP5961247B2 (ja) * 2011-04-07 2016-08-02 アリーア サン ディエゴ， インコーポレイテッド リコンビナーゼポリメラーゼ増幅混合物のモニタリング
US9926596B2 (en) 2011-05-27 2018-03-27 Genapsys, Inc. Systems and methods for genetic and biological analysis
US9352312B2 (en) 2011-09-23 2016-05-31 Alere Switzerland Gmbh System and apparatus for reactions
JP6193252B2 (ja) 2011-12-01 2017-09-06 ジナプシス インコーポレイテッド 高効率電子配列決定及び検出のためのシステム並びに方法
JP5958034B2 (ja) * 2012-04-11 2016-07-27 富士レビオ株式会社 分子ビーコン型プローブを用いた標的核酸の検出方法
EP2839029B1 (en) 2012-04-19 2017-11-15 Life Technologies Corporation Method of performing digital pcr
EP2871244A4 (en) * 2012-07-05 2016-03-23 Ngk Insulators Ltd NUCLEIC ACID CHROMATOGRAPHY METHOD, COMPOSITION FOR NUCLEIC ACID CHROMATOGRAPHY AND KIT CONTAINING THE SAME
CN102816756B (zh) * 2012-09-07 2014-04-16 江苏奇天基因生物科技有限公司 等温核酸扩增反应试剂及等温核酸扩增方法
EP2971141B1 (en) 2013-03-15 2018-11-28 Genapsys, Inc. Systems for biological analysis
JP5904153B2 (ja) * 2013-03-29 2016-04-13 ソニー株式会社 核酸増幅反応用試料の調製方法、核酸増幅方法、固相状核酸増幅反応用試薬及びマイクロチップ
CA2912307C (en) * 2013-06-11 2022-01-11 Biocartis Nv Biomolecule drying process for long-term storage
EP3792921A1 (en) 2013-12-11 2021-03-17 Genapsys, Inc. Systems and methods for biological analysis and computation
US9822401B2 (en) 2014-04-18 2017-11-21 Genapsys, Inc. Methods and systems for nucleic acid amplification
EP2966177A1 (en) 2014-07-09 2016-01-13 Vetgenomics, S.L. Methods for detecting target DNA sequences
CN104232622B (zh) * 2014-09-24 2016-09-14 中国人民解放军疾病预防控制所 一种用聚合酶螺旋反应恒温扩增核酸的方法及其应用
WO2016156529A1 (en) * 2015-03-31 2016-10-06 Qiagen Gmbh Efficiency improving ligation methods
GB201519565D0 (en) 2015-11-05 2015-12-23 Alere San Diego Inc Sample preparation device
CN114645100A (zh) * 2016-01-29 2022-06-21 中国动物卫生与流行病学中心 一种检测h7亚型禽流感病毒的引物对及其引用、检测h7亚型禽流感病毒的方法
US20190048415A1 (en) * 2016-02-10 2019-02-14 The Regents Of The University Of Michigan Detection of nucleic acids
CN105543402B (zh) * 2016-03-02 2019-07-02 刘国宪 等温核酸扩增反应试剂及等温核酸扩增方法
BR112018067739A2 (pt) * 2016-03-04 2019-01-08 Alere San Diego Inc. amplificação da polimerase recombinase nested automatizada
US9617587B1 (en) 2016-04-04 2017-04-11 Nat Diagnostics, Inc. Isothermal amplification components and processes
US11299777B2 (en) 2016-04-04 2022-04-12 Nat Diagnostics, Inc. Isothermal amplification components and processes
DE102016108115B4 (de) 2016-05-02 2019-05-09 Agilent Technologies, Inc. - A Delaware Corporation - Probenpuffer mit niedermolekularem Farbstoffstabilisator für Gelelektrophorese
GB201611469D0 (en) 2016-06-30 2016-08-17 Lumiradx Tech Ltd Improvements in or relating to nucleic acid amplification processes
WO2018017884A1 (en) 2016-07-20 2018-01-25 Genapsys, Inc. Systems and methods for nucleic acid sequencing
CN106399590B (zh) * 2016-10-31 2019-12-13 中国人民解放军军事医学科学院微生物流行病研究所 呼吸道感染相关腺病毒的通用型核酸等温检测试剂
AU2018227436A1 (en) * 2017-02-28 2019-09-12 Abbott Diagnostics Scarborough, Inc. Microfluidic devices and related methods
JP7145517B2 (ja) 2017-03-08 2022-10-03 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 分析物の検出
CN111566224A (zh) 2017-09-21 2020-08-21 吉纳普赛斯股份有限公司 用于核酸测序的系统和方法
CN108130369A (zh) * 2017-12-29 2018-06-08 博迪泰（厦门）生物科技有限公司 一种检测乳牛短脊椎综合症的引物、试剂盒及检测方法
GB2569965A (en) 2018-01-04 2019-07-10 Lumiradx Uk Ltd Improvements in or relating to amplification of nucleic acids
AU2019211356B2 (en) * 2018-01-24 2023-08-17 Revvity Health Sciences, Inc. Purification of nucleic acids in a microfluidic chip by separation
JP7491576B2 (ja) 2018-06-12 2024-05-28 キージーン ナムローゼ フェンノートシャップ 核酸増幅法
DE102018222357A1 (de) * 2018-12-19 2020-06-25 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. In-vitro-Verfahren zum Nachweis von mindestens einer Nukleinsäure, die sich bei einem Lebewesen im Vollblut außerhalb der Blutzellen befindet und Vorrichtung und Kit hierzu
EP4047091A4 (en) 2019-10-18 2023-11-15 Epigeneron, Inc. METHOD FOR DETECTING TARGET NUCLEIC ACID, METHOD FOR DETECTING NUCLEIC ACID BINDING MOLECULE, AND METHOD FOR EVALUATING NUCLEIC ACID BINDING CAPACITY
CN111197110A (zh) * 2020-01-16 2020-05-26 浙江农林大学 用于检测猫泛白细胞减少症病毒的rpa-fld方法
CN111518669A (zh) * 2020-05-07 2020-08-11 安徽科技学院 一种核酸检测微流控芯片及其应用
WO2021226754A1 (zh) * 2020-05-09 2021-11-18 杭州梓晶生物有限公司 一种病毒重组酶-聚合酶扩增检测方法
WO2021250617A1 (en) 2020-06-10 2021-12-16 King Abdullah University Of Science And Technology A rapid multiplex rpa based nanopore sequencing method for real-time detection and sequencing of multiple viral pathogens
CN111979303A (zh) * 2020-08-11 2020-11-24 上海奕谱生物科技有限公司 一种核酸检测试剂盒、方法及其应用
EP3985128A1 (en) 2020-10-14 2022-04-20 midge medical GmbH Isothermal nucleic acid amplification methods for point-of-need diagnosis of emerging infectious diseases
EP3995592A1 (en) 2020-11-09 2022-05-11 midge medical GmbH Multimeric isothermal nucleic acid amplification methods for point-of-need diagnosis
WO2022078775A1 (en) 2020-10-14 2022-04-21 Midge Medical Gmbh Isothermal nucleic acid amplification methods for point-of-need diagnosis
CN112501262A (zh) * 2020-12-15 2021-03-16 苏州点晶生物科技有限公司 一种基于双重多酶介导的核酸扩增检测方法及试剂
CN112708662B (zh) * 2020-12-28 2021-08-31 阅尔基因技术（苏州）有限公司 抑制生物dna样本中非目标区域的核苷酸组合物及其应用
EP4053293A1 (en) 2021-03-03 2022-09-07 midge medical GmbH Protected isothermal nucleic acid amplification (pina) methods for point-of-need diagnosis of emerging infectious diseases
CN114085891A (zh) * 2021-11-23 2022-02-25 广州达安基因股份有限公司 基于重组酶聚合酶扩增技术的逆转录扩增系统和方法
CN113981045B (zh) * 2021-11-23 2025-09-16 广州达安基因股份有限公司 制备恒温扩增混合酶系的方法
CN114262697B (zh) * 2021-12-30 2022-12-13 南京巨匠生物科技有限公司 融合Bsu DNA聚合酶和Bsu DNA聚合酶突变体及其基因、质粒、基因工程菌
CN116004773B (zh) * 2022-09-30 2025-04-08 华南农业大学 一种线性置换等温扩增方法及其应用
CN115747187B (zh) * 2022-12-09 2023-06-20 厦门康基生物科技有限公司 一种重组酶UvsX及其表达基因和应用
EP4477663A1 (en) 2023-06-14 2024-12-18 midge medical GmbH Proteins for isothermal amplification
CN119534585B (zh) * 2024-12-06 2025-11-28 安徽工业大学 用于检测微囊藻毒素mc-lr的ecl生物传感器
CN119776321B (zh) * 2025-02-05 2025-11-04 北洋酶(天津)生物科技有限公司 UvsY蛋白突变体及其应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5273881A (en) 1990-05-07 1993-12-28 Daikin Industries, Ltd. Diagnostic applications of double D-loop formation
CA2116215C (en) * 1990-05-07 1998-12-22 Tapestry Pharmaceuticals, Inc. Diagnostic applications of double d-loop formation
US5223414A (en) * 1990-05-07 1993-06-29 Sri International Process for nucleic acid hybridization and amplification
CA2095624C (en) 1990-11-09 2000-06-13 Rafael D. Camerini-Otero Method of targeting dna
US6117679A (en) * 1994-02-17 2000-09-12 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US5705366A (en) * 1994-09-15 1998-01-06 Johnson & Johnson Clinical Diagnostics, Inc. Coamplification of target nucleic acids using volume exclusion agent in reaction composition, test kit and test device useful therefor
US20040110167A1 (en) * 1995-07-13 2004-06-10 Gerdes John C. Lateral flow system for nucleic acid detection
US20010036634A1 (en) * 2000-03-08 2001-11-01 Timothy Chow Lateral flow PCR with amplicon concentration and detection
ES2305289T3 (es) 2001-04-20 2008-11-01 The Penn State Research Foundation Metodo de manipulacion de acidos nucleicos.
AU2002341898A2 (en) * 2001-09-28 2003-04-07 University Of Delaware Polymorphism detection and separation
US7244562B2 (en) * 2001-11-01 2007-07-17 Gene Check, Inc. RecA assisted detection of mutations, single nucleotide polymorphisms and specific sequences
DK1499738T3 (da) * 2002-02-21 2008-11-17 Asm Scient Inc Recombinase-polymerease-amplifikation
EP1525055A1 (en) * 2002-07-12 2005-04-27 British Biocell International Limited Lateral flow assay device and method
DE60324810D1 (de) * 2002-09-20 2009-01-02 New England Biolabs Inc HELICASE-ABHuNGIGE AMPLIFIKATION VON NUKLEINSUREN
EP1403379A1 (en) * 2002-09-24 2004-03-31 QIAGEN GmbH Enhanced coamplification of nucleic acids
JP2008018820A (ja) * 2006-07-12 2008-01-31 Nsk Ltd 衝撃吸収式ステアリングコラム装置

Also Published As

Publication number Publication date
JP5856576B2 (ja) 2016-02-10
WO2005118853A2 (en) 2005-12-15
JP2008188020A (ja) 2008-08-21
EP2336361B1 (en) 2019-01-23
EP3540073B1 (en) 2021-08-25
WO2005118853A3 (en) 2006-06-15
CA2569512A1 (en) 2005-12-15
EP2336361A2 (en) 2011-06-22
EP3985125A1 (en) 2022-04-20
EP2336361A3 (en) 2011-07-06
JP5089466B2 (ja) 2012-12-05
JP2011103900A (ja) 2011-06-02
AU2005250233B2 (en) 2011-03-17
ES2425354T3 (es) 2013-10-14
EP3540073A1 (en) 2019-09-18
JP2008500831A (ja) 2008-01-17
ES2718482T3 (es) 2019-07-02
CA2569512C (en) 2016-05-31
JP2013102769A (ja) 2013-05-30
EP1759012B1 (en) 2013-05-22
AU2005250233A1 (en) 2005-12-15
EP1759012A2 (en) 2007-03-07

Similar Documents

Publication Publication Date Title
JP5026958B2 (ja) リコンビナーゼポリメラーゼ増幅
US10329603B2 (en) Recombinase polymerase amplification
US7666598B2 (en) Recombinase polymerase amplification
JP4340543B2 (ja) リコンビナーゼポリメラーゼ増幅
AU2013201222B2 (en) Recombinase Polymerase Amplification
CA2921988C (en) Recombinase polymerase amplification
AU2015203225B2 (en) Recombinase Polymerase Amplification
Class et al. Patent application title: Recombinase Polymerase Amplification Inventors: Olaf Piepenburg (Essex, GB) Colin H. Williams (Waltham, MA, US) Niall A. Armes (Suffolk, GB) Derek L. Stemple (Hertfordshire, GB)

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20080402

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20080402

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20101202

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110301

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20111207

A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A712

Effective date: 20120328

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120405

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20120530

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20120619

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20120621

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20150629

Year of fee payment: 3

R150 Certificate of patent or registration of utility model

Ref document number: 5026958

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: R3D04

RD02 Notification of acceptance of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: R3D02

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

S111 Request for change of ownership or part of ownership

Free format text: JAPANESE INTERMEDIATE CODE: R313113

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

EXPY Cancellation because of completion of term