JP4958380B2 - 臓器の生存力を維持及び／又は回復する装置及び方法 - Google Patents
臓器の生存力を維持及び／又は回復する装置及び方法 Download PDFInfo
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- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/14—Mechanical aspects of preservation; Apparatus or containers therefor
- A01N1/146—Non-refrigerated containers specially adapted for transporting or storing living parts whilst preserving
- A01N1/148—Non-refrigerated containers specially adapted for transporting or storing living parts whilst preserving with provisions specially adapted for transporting
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/14—Mechanical aspects of preservation; Apparatus or containers therefor
- A01N1/142—Apparatus
- A01N1/143—Apparatus for organ perfusion
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|---|---|---|---|---|
| US8409846B2 (en) | 1997-09-23 | 2013-04-02 | The United States Of America As Represented By The Department Of Veteran Affairs | Compositions, methods and devices for maintaining an organ |
| US6977140B1 (en) | 1998-09-29 | 2005-12-20 | Organ Recovery Systems, Inc. | Method for maintaining and/or restoring viability of organs |
| US7749693B2 (en) * | 1998-09-29 | 2010-07-06 | Lifeline Scientific, Inc. | Method of determining that an organ is not suitable for transplantation and using it for testing substances |
| US6673594B1 (en) | 1998-09-29 | 2004-01-06 | Organ Recovery Systems | Apparatus and method for maintaining and/or restoring viability of organs |
| FR2807827B1 (fr) * | 2000-04-12 | 2002-07-05 | Technomed Medical Systems | Systeme de manipulation de fluide pour appareil de therapie |
| US7176849B1 (en) * | 2000-08-15 | 2007-02-13 | Agere Systems Inc. | Wireless security badge |
| US20050026132A1 (en) * | 2000-11-03 | 2005-02-03 | University Of Rochester | Warm intermittent perfusion |
| US6677150B2 (en) * | 2001-09-14 | 2004-01-13 | Organ Transport Systems, Inc. | Organ preservation apparatus and methods |
| US20030149401A1 (en) * | 2002-02-06 | 2003-08-07 | Benetti Diaz De Brito Juan Ignacio | Systems and methods for monitoring and controlling the temperature of an organ during surgery |
| US7572622B2 (en) * | 2002-08-14 | 2009-08-11 | Transmedic, Inc. | Heart preservation chamber |
| US8361091B2 (en) | 2002-08-23 | 2013-01-29 | Organ Recovery Systems, Inc. | Cannulas, cannula mount assemblies, and clamping methods using such cannulas and cannula mount assemblies |
| US7790443B2 (en) * | 2002-08-27 | 2010-09-07 | Vanderbilt University | Bioreactors with substance injection capacity |
| AU2003268202A1 (en) * | 2002-08-27 | 2004-03-19 | Vanderbilt University | Bioreactors with an array of chambers and a common feed line |
| EP1613152B1 (en) * | 2003-04-04 | 2018-07-04 | Organ Recovery Systems, Inc. | Device for separating gas from a liquid path |
| PL1613153T3 (pl) * | 2003-04-04 | 2021-11-29 | Organ Recovery Systems, Inc. | Sposoby i aparat do perfuzji, diagnostyki, przechowywania i/lub transportu narządu lub tkanek |
| USD531319S1 (en) * | 2003-04-04 | 2006-10-31 | Organ Recovery Systems | Tube frame for organ transporter |
| US20040202993A1 (en) * | 2003-04-10 | 2004-10-14 | Poo Ramon E. | Apparatus and method for organ preservation and transportation |
| US7897327B2 (en) * | 2003-06-02 | 2011-03-01 | Organ Recovery Systems, Inc. | Method and apparatus for pressure control for maintaining viability of organs |
| NL1024022C2 (nl) * | 2003-07-30 | 2005-02-01 | Technologiestichting Stw | Draagbare preservatie-inrichting voor een donororgaan. |
| DE10340487B4 (de) * | 2003-09-03 | 2007-07-12 | Technische Universität Dresden | Perfusionskreislauf |
| EP1533597A1 (en) * | 2003-11-20 | 2005-05-25 | Millipore Corporation | Fluid dispensing device |
| US20050153271A1 (en) * | 2004-01-13 | 2005-07-14 | Wenrich Marshall S. | Organ preservation apparatus and methods |
| US7504201B2 (en) * | 2004-04-05 | 2009-03-17 | Organ Recovery Systems | Method for perfusing an organ and for isolating cells from the organ |
| US8741555B2 (en) * | 2004-05-14 | 2014-06-03 | Organ Recovery Systems, Inc. | Apparatus and method for perfusion and determining the viability of an organ |
| US8304181B2 (en) | 2004-10-07 | 2012-11-06 | Transmedics, Inc. | Method for ex-vivo organ care and for using lactate as an indication of donor organ status |
| US12010987B2 (en) | 2004-10-07 | 2024-06-18 | Transmedics, Inc. | Systems and methods for ex-vivo organ care and for using lactate as an indication of donor organ status |
| ES2348736T3 (es) * | 2004-10-07 | 2010-12-13 | Transmedics, Inc. | Sistemas yh metodos para cuidado de organos ex-vivo. |
| US9301519B2 (en) * | 2004-10-07 | 2016-04-05 | Transmedics, Inc. | Systems and methods for ex-vivo organ care |
| US7713686B2 (en) * | 2004-12-03 | 2010-05-11 | Biorep Technologies, Inc. | Organ preservation container and method |
| US20060148080A1 (en) * | 2004-12-30 | 2006-07-06 | Paul Diamond | Methods for supporting and producing human cells and tissues in non-human mammal hosts |
| US20060147429A1 (en) * | 2004-12-30 | 2006-07-06 | Paul Diamond | Facilitated cellular reconstitution of organs and tissues |
| US20070148038A1 (en) * | 2005-04-25 | 2007-06-28 | Sundhar Shaam P | Plug-In Oxygenator |
| EP1879997A2 (en) * | 2005-04-29 | 2008-01-23 | Transplan, Inc. | Method and device for organ perfusion |
| US20070032774A1 (en) * | 2005-05-17 | 2007-02-08 | Clifford Glade | Container for transporting blood and blood products |
| US20060276768A1 (en) * | 2005-05-17 | 2006-12-07 | Miller Randal H | Container for transporting blood and blood products |
| US9078428B2 (en) | 2005-06-28 | 2015-07-14 | Transmedics, Inc. | Systems, methods, compositions and solutions for perfusing an organ |
| EP1937059A2 (en) | 2005-07-27 | 2008-07-02 | University Of North Carolina At Charlotte | Composition and method for the restoration and preservation of transplant organs procured from dcd donors |
| US10176887B1 (en) | 2005-11-14 | 2019-01-08 | Organ Recovery Systems, Inc. | Ex vivo methods for drug discovery, development and testing |
| US8834399B2 (en) * | 2010-12-07 | 2014-09-16 | Zoll Lifebridge Gmbh | Cardiopulmonary apparatus and methods for preserving organ viability |
| ES2772676T3 (es) | 2006-04-19 | 2020-07-08 | Transmedics Inc | Sistema de cuidado de órganos ex vivo |
| DE102006032435A1 (de) * | 2006-07-13 | 2008-01-17 | Sixt, Bernhard, Dr. | Transportbehälter zur Kühlhaltung von gefrorenem Gut |
| WO2008034138A1 (en) * | 2006-09-15 | 2008-03-20 | The Ohio State University Research Foundation | Methods and compositions for the topical oxygenation of hypoxic tissue |
| US7790437B2 (en) * | 2006-12-14 | 2010-09-07 | Biorep Technologies, Inc. | Organ transportation device |
| US20080145919A1 (en) * | 2006-12-18 | 2008-06-19 | Franklin Thomas D | Portable organ and tissue preservation apparatus, kit and methods |
| JP5704818B2 (ja) * | 2007-03-01 | 2015-04-22 | ライフライン サイエンティフィック インコーポレイテッド | 潅流調節 |
| US9457179B2 (en) | 2007-03-20 | 2016-10-04 | Transmedics, Inc. | Systems for monitoring and applying electrical currents in an organ perfusion system |
| AU2016201793B2 (en) * | 2007-04-25 | 2017-11-23 | Transmedics, Inc. | Systems and methods for ex-vivo organ care using lactate as an indicator |
| AU2013216566B2 (en) * | 2007-04-25 | 2016-04-21 | Transmedics, Inc. | Systems and methods for ex-vivo organ care using lactate as an indicator |
| US8771930B2 (en) * | 2007-05-18 | 2014-07-08 | Lifeline Scientific, Inc. | Ex vivo methods for testing toxicity of substances using donated human organs or tissues |
| US8765364B2 (en) * | 2007-05-18 | 2014-07-01 | Lifeline Scientific, Inc. | Ex vivo methods for validating substance testing with human organs and/or tissues |
| SE531453C2 (sv) * | 2007-07-06 | 2009-04-07 | Xenodevice Ab | System för organevaluering och -preservation |
| FR2919785B1 (fr) * | 2007-08-09 | 2017-10-20 | Hemarina Sa | Utilisation d'une globine, d'un protomere de globine ou d'une hemoglobine extracellulaire pour la preservation d'organes, de tissus, ou de cellules d'organes ou de tissus, ou de culture de cellules |
| US8485387B2 (en) | 2008-05-13 | 2013-07-16 | Tokitae Llc | Storage container including multi-layer insulation composite material having bandgap material |
| US20090145912A1 (en) * | 2007-12-11 | 2009-06-11 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Temperature-stabilized storage containers |
| US9205969B2 (en) * | 2007-12-11 | 2015-12-08 | Tokitae Llc | Temperature-stabilized storage systems |
| US8377030B2 (en) | 2007-12-11 | 2013-02-19 | Tokitae Llc | Temperature-stabilized storage containers for medicinals |
| US8215518B2 (en) * | 2007-12-11 | 2012-07-10 | Tokitae Llc | Temperature-stabilized storage containers with directed access |
| US8211516B2 (en) * | 2008-05-13 | 2012-07-03 | Tokitae Llc | Multi-layer insulation composite material including bandgap material, storage container using same, and related methods |
| US8603598B2 (en) * | 2008-07-23 | 2013-12-10 | Tokitae Llc | Multi-layer insulation composite material having at least one thermally-reflective layer with through openings, storage container using the same, and related methods |
| US20110127273A1 (en) * | 2007-12-11 | 2011-06-02 | TOKITAE LLC, a limited liability company of the State of Delaware | Temperature-stabilized storage systems including storage structures configured for interchangeable storage of modular units |
| US8069680B2 (en) | 2007-12-11 | 2011-12-06 | Tokitae Llc | Methods of manufacturing temperature-stabilized storage containers |
| US9140476B2 (en) | 2007-12-11 | 2015-09-22 | Tokitae Llc | Temperature-controlled storage systems |
| US8215835B2 (en) * | 2007-12-11 | 2012-07-10 | Tokitae Llc | Temperature-stabilized medicinal storage systems |
| US9174791B2 (en) * | 2007-12-11 | 2015-11-03 | Tokitae Llc | Temperature-stabilized storage systems |
| US8887944B2 (en) | 2007-12-11 | 2014-11-18 | Tokitae Llc | Temperature-stabilized storage systems configured for storage and stabilization of modular units |
| US9462802B2 (en) | 2008-01-31 | 2016-10-11 | Transmedics, Inc. | Systems and methods for ex vivo lung care |
| US8734382B2 (en) * | 2008-02-07 | 2014-05-27 | University of Pittsburgh—of the Commonwealth System of Higher Education | Intracorporeal gas exchange devices, systems and methods |
| EP2278874B1 (en) * | 2008-04-22 | 2019-03-20 | The Board of Regents of The University of Texas System | Fluidics-based pulsatile perfusion organ preservation device |
| WO2009136907A1 (en) * | 2008-05-05 | 2009-11-12 | Wilson Wolf Manufacturing Corporation | Cell container |
| RU2512939C2 (ru) | 2008-06-11 | 2014-04-10 | Бракко Дайэгностикс Инк. | Инфузионные системы с компьютеризированным техническим обслуживанием и/или эксплуатацией и способы применения |
| US8317674B2 (en) | 2008-06-11 | 2012-11-27 | Bracco Diagnostics Inc. | Shielding assemblies for infusion systems |
| US8176749B2 (en) * | 2008-06-19 | 2012-05-15 | Kool Innovations, Inc. | Cooler adapted for use in marine environment |
| US8697430B2 (en) | 2008-07-29 | 2014-04-15 | Kyoto University | Tissue-derived biomaterial carrier device |
| US10328103B2 (en) | 2009-01-03 | 2019-06-25 | Ray C. Wasielewski | Medical treatment composition comprising mammalian dental pulp stem cells |
| US8470308B2 (en) * | 2009-01-03 | 2013-06-25 | Ray C. Wasielewski | Enhanced medical implant comprising disrupted tooth pulp and tooth particles |
| US10091985B2 (en) * | 2009-06-18 | 2018-10-09 | Giner, Inc. | Perfusing an organ with an in situ generated gas |
| US9357764B2 (en) | 2009-06-18 | 2016-06-07 | Giner, Inc. | System for fluid perfusion of biological matter comprising tissue |
| US20130323708A1 (en) | 2009-07-01 | 2013-12-05 | Massachusetts Institute Of Technology | Isolated adult cells, artificial organs, rehabilitated organs, research tools, organ encasements, organ perfusion systems, and methods for preparing and utilizing the same |
| EP2482646A4 (en) | 2009-09-25 | 2017-07-26 | Vivoline Medical AB | Container and supporting structure for housing an organ |
| EP2480069A1 (en) * | 2009-09-25 | 2012-08-01 | Board of Regents, The University of Texas System | Fluidics based pulsatile perfusion preservation device and method |
| US9320269B2 (en) | 2009-09-25 | 2016-04-26 | John Brassil | Organ preservation system |
| FR2951951A1 (fr) * | 2009-11-05 | 2011-05-06 | Centre Nat Rech Scient | Systeme de perfusion securise et procede de mise en oeuvre |
| US9447995B2 (en) | 2010-02-08 | 2016-09-20 | Tokitac LLC | Temperature-stabilized storage systems with integral regulated cooling |
| US9372016B2 (en) | 2013-05-31 | 2016-06-21 | Tokitae Llc | Temperature-stabilized storage systems with regulated cooling |
| US10575515B2 (en) | 2010-05-04 | 2020-03-03 | The General Hospital Corporation | Methods and compositions for preserving tissues and organs |
| US20110294108A1 (en) * | 2010-05-28 | 2011-12-01 | Tyco Healthcare Group Lp | System and Method for an Ex Vivo Body Organ Electrosurgical Research Device |
| US9060507B2 (en) * | 2010-09-01 | 2015-06-23 | Perfusion Fluid Technologies Inc | Perfusion solution |
| WO2013086505A1 (en) * | 2011-12-09 | 2013-06-13 | Vanderbilt University | Integrated organ-on-chip system and applications of the same |
| US20120148542A1 (en) | 2010-12-10 | 2012-06-14 | Lifeline Scientific, Inc. | Machine perfusion with complement inhibitors |
| WO2012125782A2 (en) | 2011-03-15 | 2012-09-20 | Paragonix Technologies, Inc. | Apparatus for oxygenation and perfusion of tissue for organ preservation |
| US11178866B2 (en) | 2011-03-15 | 2021-11-23 | Paragonix Technologies, Inc. | System for hypothermic transport of samples |
| US8828710B2 (en) | 2011-03-15 | 2014-09-09 | Paragonix Technologies, Inc. | System for hypothermic transport of samples |
| US9426979B2 (en) | 2011-03-15 | 2016-08-30 | Paragonix Technologies, Inc. | Apparatus for oxygenation and perfusion of tissue for organ preservation |
| US9253976B2 (en) | 2011-03-15 | 2016-02-09 | Paragonix Technologies, Inc. | Methods and devices for preserving tissues |
| US12279610B2 (en) | 2011-03-15 | 2025-04-22 | Paragonix Technonogies, Inc. | System for hypothermic transport of samples |
| US9867368B2 (en) | 2011-03-15 | 2018-01-16 | Paragonix Technologies, Inc. | System for hypothermic transport of samples |
| US12096765B1 (en) | 2011-03-15 | 2024-09-24 | Paragonix Technologies, Inc. | System for hypothermic transport of samples |
| EP2704560B1 (en) | 2011-04-14 | 2022-04-06 | Transmedics, Inc. | Organ care solution for ex-vivo machine perfusion of donor lungs |
| US9642625B2 (en) | 2011-04-29 | 2017-05-09 | Lifeline Scientific, Inc. | Cannula for a donor organ with or without an aortic cuff or patch |
| US9955682B2 (en) | 2011-04-29 | 2018-05-01 | Lifeline Scientific, Inc. | Portable organ transportation system |
| US9022978B2 (en) | 2011-04-29 | 2015-05-05 | Lifeline Scientific, Inc. | Universal sealring cannula |
| US8828034B2 (en) | 2011-04-29 | 2014-09-09 | Lifeline Scientific, Inc. | Cannula |
| US11490615B2 (en) | 2011-06-09 | 2022-11-08 | Lifeline Scientific, Inc. | Assessing, maintaining and/or restoring viability of organs/tissues |
| CA2846590A1 (en) * | 2011-08-25 | 2013-02-28 | Breonics, Inc. | Organ chamber for ex vivo warm perfusion |
| JP2013075888A (ja) * | 2011-09-15 | 2013-04-25 | Tokyo Metropolitan Univ | 臓器保存装置 |
| ES2681229T3 (es) | 2011-11-10 | 2018-09-12 | Organox Limited | Sistema de perfusión de órganos |
| GB201119420D0 (en) * | 2011-11-10 | 2011-12-21 | Organox Ltd | Oxygen supply for organ perfusion systems |
| ES2685328T3 (es) | 2011-11-10 | 2018-10-08 | Organox Limited | Sistemas de perfusión de órganos |
| US10258032B2 (en) | 2012-01-11 | 2019-04-16 | Lifeline Scientific, Inc. | Transportation bag for use with an organ transporter |
| CA3133545C (en) * | 2012-05-25 | 2023-08-08 | Cellectis | Use of pre t alpha or functional variant thereof for expanding tcr alpha deficient t cells |
| US10602740B2 (en) * | 2012-07-10 | 2020-03-31 | Lifeline Scientific, Inc. | Organ perfusion apparatus with downstream flow control |
| US9357766B2 (en) * | 2012-07-10 | 2016-06-07 | Lifeline Scientific, Inc. | Organ transport apparatus with a document compartment and a tamper evident seal |
| USD685498S1 (en) * | 2012-07-10 | 2013-07-02 | Lifeline Scientific, Inc. | Organ or tissue cradle |
| USD691734S1 (en) * | 2012-07-10 | 2013-10-15 | Lifeline Scientific, Inc. | Coolant container |
| US9119393B2 (en) | 2012-07-10 | 2015-09-01 | Lifeline Scientific, Inc. | Organ transporter with tilt and/or shock sensing |
| US20140017665A1 (en) | 2012-07-10 | 2014-01-16 | Lifeline Scientific, Inc. | Organ transporter with oxygen generation |
| US9357767B2 (en) * | 2012-07-10 | 2016-06-07 | Lifeline Scientific, Inc. | Organ transporter |
| US9402389B2 (en) * | 2012-07-10 | 2016-08-02 | Lifeline Scientific, Inc. | Organ transport apparatus with sample compartments |
| US11439143B2 (en) * | 2012-07-10 | 2022-09-13 | Lifeline Scientific, Inc. | Temperature sensing in organ preservation apparatus |
| US20140017666A1 (en) * | 2012-07-10 | 2014-01-16 | Lifeline Scientific, Inc. | Filtration in organ perfusion apparatus |
| US8785116B2 (en) | 2012-08-10 | 2014-07-22 | Paragonix Technologies, Inc. | Methods for evaluating the suitability of an organ for transplant |
| BR112015002576A2 (pt) * | 2012-08-10 | 2017-07-04 | Paragonix Tech Inc | sistema de transporte hipotérmico de amostras |
| US9560846B2 (en) | 2012-08-10 | 2017-02-07 | Paragonix Technologies, Inc. | System for hypothermic transport of biological samples |
| KR101404369B1 (ko) | 2012-08-14 | 2014-06-09 | 경희대학교 산학협력단 | 심장 허혈 및 재관류에 따른 실시간 생체신호 측정 장치 |
| ITMI20122051A1 (it) * | 2012-11-30 | 2014-05-31 | N G C Medical Spa | Dispositivo per il trasporto isotermico di organi e/o tessuti umani, e metodo ed apparato di controllo del trasporto stesso |
| DE102013200363A1 (de) * | 2013-01-14 | 2014-07-31 | Robert Bosch Gmbh | Mikrofluidisches Kanalsystem mit Blasenfängereinrichtung und Verfahren zum Entfernen von Gasblasen |
| US10420337B2 (en) | 2013-03-15 | 2019-09-24 | Lifeline Scientific, Inc. | Transporter with a glucose sensor for determining viability of an organ or tissue |
| US20140278468A1 (en) | 2013-03-15 | 2014-09-18 | I.D. Therapeutics Llc | Apparatus and method for optimizing treatment using medication compliance patterns and glucose sensor |
| JP6249816B2 (ja) | 2013-03-28 | 2017-12-20 | アークレイ株式会社 | 細胞培養装置、細胞培養システム、及び細胞培養方法 |
| ITMI20131501A1 (it) * | 2013-09-11 | 2015-03-12 | Avionord Srl | Dispositivo per il trasporto isotermico di organi e/o tessuti umani, e metodo ed apparato di controllo del trasporto stesso |
| US10231817B2 (en) | 2013-09-24 | 2019-03-19 | Giner Life Sciences, Inc. | System for gas treatment of a cell implant |
| JP2017508984A (ja) * | 2014-01-20 | 2017-03-30 | ブルックス オートメーション インコーポレイテッド | 持ち運び可能な低温ワークステーション |
| CN116171981A (zh) * | 2014-01-20 | 2023-05-30 | 布鲁克斯自动化公司 | 便携式低温工作站 |
| EP3107080A4 (en) * | 2014-02-12 | 2017-07-26 | Olympus Corporation | Pseudo-human body device |
| US10918102B2 (en) | 2014-03-13 | 2021-02-16 | The General Hospital Corporation | Devices and methods to improve and assess viability of human livers |
| JP6580329B2 (ja) * | 2014-03-31 | 2019-09-25 | シスメックス株式会社 | 未分化細胞から分化細胞および／または分化細胞の産生物を取得する方法 |
| WO2015187737A1 (en) | 2014-06-02 | 2015-12-10 | Transmedics, Inc. | Ex vivo organ care system |
| US10391425B2 (en) * | 2014-06-16 | 2019-08-27 | Siemens Healthcare Diagnostics Inc. | Fluidic device and degassing method |
| FR3023714A1 (fr) * | 2014-07-18 | 2016-01-22 | Lab Francais Du Fractionnement | Emballage de medicament de therapie innovante |
| USD765874S1 (en) | 2014-10-10 | 2016-09-06 | Paragonix Technologies, Inc. | Transporter for a tissue transport system |
| EP3229588B1 (en) | 2014-12-12 | 2025-04-23 | TransMedics, Inc. | Apparatus and method for organ perfusion |
| JP2018501257A (ja) * | 2014-12-19 | 2018-01-18 | インスティテュート ドゥインベスティゲーションズ バイオメディクス オーガスト ピーアイ アイ スーニア （アイディーアイビーエーピーエス） | 超音波の適用を含むエクスビボ生体試料の保存および輸送 |
| ITUB20153042A1 (it) * | 2015-08-10 | 2017-02-10 | Lavorarea Soc Coop Sociale | Dispositivo di regolazione e controllo temperatura per trasporti biologici e relativo metodo di monitoraggio |
| ES2853027T3 (es) | 2015-09-09 | 2021-09-14 | Transmedics Inc | Cánula aórtica para sistema de cuidado de órganos ex vivo |
| US10443904B2 (en) * | 2015-10-23 | 2019-10-15 | Patrick Alan Tatom | Device for cooling substances |
| AU2016381502A1 (en) | 2015-12-29 | 2018-07-19 | Zuta-Core Ltd. | Vacuum-based thermal management system |
| DE102016106097B3 (de) | 2016-04-04 | 2017-05-18 | Leibniz-Institut Für Polymerforschung Dresden E.V. | Gewebe- und Organtransportvorrichtung |
| US10091986B2 (en) | 2016-05-09 | 2018-10-09 | Xor-Labs Toronto Inc. | Organ perfusion device and method |
| BR112018074537B1 (pt) | 2016-05-30 | 2023-04-11 | Tevosol, Inc | Método de ventilar um pulmão extraído |
| DK3516665T3 (da) | 2016-09-20 | 2021-07-12 | Bracco Diagnostics Inc | Afskærmningsanordning til et radioisotopindgivelsessystem med flere strålingsdetektorer |
| JP6814593B2 (ja) * | 2016-10-14 | 2021-01-20 | 株式会社 バイオミメティクスシンパシーズ | 幹細胞及び投与システム |
| CN106508890A (zh) * | 2016-10-28 | 2017-03-22 | 中山大学附属第医院 | 多器官保存装置 |
| US11033666B2 (en) | 2016-11-15 | 2021-06-15 | Giner Life Sciences, Inc. | Percutaneous gas diffusion device suitable for use with a subcutaneous implant |
| RU2019114843A (ru) | 2016-11-15 | 2020-11-16 | Джинер Лайф Сайенс, Инк. | Саморегулируемый электролитический газогенератор и содержащая его имплантационная система |
| ES2675882B1 (es) * | 2017-01-12 | 2019-04-26 | Ebers Medical Tech S L | Equipo de perfusion de organos |
| CA3050111A1 (en) | 2017-01-19 | 2018-07-26 | Coolsystems, Inc. | Systems and methods for rapid contrast therapy |
| EP3614836B1 (en) | 2017-04-28 | 2025-12-03 | Lifeline Scientific, Inc. | Organ transporter with supplemental oxygenation system |
| US11166452B2 (en) | 2017-06-07 | 2021-11-09 | Paragonix Technologies, Inc. | Apparatus for tissue transport and preservation |
| FR3067220B1 (fr) | 2017-06-13 | 2019-07-26 | Centre National De La Recherche Scientifique | Dispositif de perfusion d'un organe |
| US12058996B2 (en) | 2017-06-14 | 2024-08-13 | The General Hospital Corporation | High subzero cryopreservation |
| CN107467011B (zh) * | 2017-08-14 | 2020-04-10 | 武汉大学 | 一种肝脏携氧机械灌注装置 |
| WO2019044354A1 (ja) * | 2017-08-29 | 2019-03-07 | 株式会社Ｓｃｒｅｅｎホールディングス | 臓器保存容器および灌流装置 |
| JP7240832B2 (ja) * | 2017-08-29 | 2023-03-16 | 株式会社Ｓｃｒｅｅｎホールディングス | 臓器保存容器および灌流装置 |
| JP2019048776A (ja) * | 2017-09-08 | 2019-03-28 | 株式会社ジェイ・エム・エス | 臓器及び生体組織の輸送装置 |
| US10543863B2 (en) | 2017-09-28 | 2020-01-28 | Lifeline Scientific, Inc. | Mobile cart for an organ container |
| RU179217U1 (ru) * | 2017-12-27 | 2018-05-04 | Акционерное общество "Научно-производственное объединение "СПЛАВ" | Автоматизированное устройство для нормотермической перфузии изолированной донорской печени |
| US12025276B2 (en) | 2018-01-09 | 2024-07-02 | Cryoport, Inc. | Cryosphere |
| US11268655B2 (en) | 2018-01-09 | 2022-03-08 | Cryoport, Inc. | Cryosphere |
| CA3088986A1 (en) * | 2018-01-19 | 2019-07-25 | University Of Maryland, Baltimore | Techniques for handling human organ during transport |
| EP3749091A4 (en) * | 2018-02-09 | 2022-01-12 | Yale University | Methods, systems and compositions for normothermic ex vivo restoration and preservation of intact organs |
| US10817825B2 (en) * | 2018-03-22 | 2020-10-27 | Maxq Research Llc | Remote integration of cloud services and transportable perishable products active monitor |
| US10342737B1 (en) * | 2018-03-22 | 2019-07-09 | Maxq Research Llc | Active monitoring system for thermally-managed transportation and storage of specific perishable products |
| KR102733368B1 (ko) | 2018-03-28 | 2024-11-21 | 브라코 다이어그노스틱스 아이엔씨. | 방사성 동위 원소 생성기의 종료 수명의 조기 검출 |
| KR102687320B1 (ko) | 2018-03-28 | 2024-07-19 | 브라코 다이어그노스틱스 아이엔씨. | 감마 검출기를 사용하여 방사성 동위 원소 전달 시스템을 교정하는 시스템 및 기술 |
| CA3100192C (en) | 2018-05-17 | 2023-03-14 | Giner Life Sciences, Inc. | Electrolytic gas generator with combined lead and gas port terminals |
| US12167729B2 (en) | 2018-05-30 | 2024-12-17 | The General Hospital Corporation | Cryopreservation of tissues and organs |
| EP3620233A1 (en) * | 2018-09-06 | 2020-03-11 | InSphero AG | Transport device with an inner container |
| US11116206B2 (en) * | 2018-10-01 | 2021-09-14 | Cook Medical Technologies Llc | Cryocontainer |
| US12356982B2 (en) | 2019-03-14 | 2025-07-15 | Lifeline Scientific, Inc. | Oxygenator device |
| WO2020252148A1 (en) | 2019-06-11 | 2020-12-17 | Paragonix Technologies, Inc. | Organ transport container with antiviral therapy |
| US11596146B2 (en) * | 2019-06-20 | 2023-03-07 | Joseph Mario Bernaudo | Speed controlled centrifugal pump embalming systems and method of using the same |
| JP7190398B2 (ja) * | 2019-06-26 | 2022-12-15 | 株式会社Ｓｃｒｅｅｎホールディングス | フレームおよび臓器保持具 |
| JP2021017433A (ja) * | 2019-07-24 | 2021-02-15 | 株式会社Ｓｃｒｅｅｎホールディングス | 臓器収容容器 |
| CA3150915A1 (en) * | 2019-08-15 | 2021-02-18 | Jeremy KWARCINSKI | An insulating medical device for protecting a graft for transplant |
| US20210068389A1 (en) * | 2019-09-11 | 2021-03-11 | Bridge To Life Ltd. | Organ Preservation Perfusion Pump with Spectral Imaging |
| JP7667777B2 (ja) | 2019-09-13 | 2025-04-23 | ライフライン サイエンティフィック インコーポレイテッド | 酸素化オプションを備えた臓器容器 |
| IT201900020498A1 (it) | 2019-11-06 | 2021-05-06 | Univ Degli Studi Di Firenze | Dispositivo per la perfusione extracorporea di un organo |
| US11632951B2 (en) | 2020-01-31 | 2023-04-25 | Paragonix Technologies, Inc. | Apparatus for tissue transport and preservation |
| IL304985A (en) * | 2020-02-20 | 2023-10-01 | Deka Products Lp | System and method for maintaining and transferring a body part |
| EP4118181A1 (en) * | 2020-03-12 | 2023-01-18 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Systems, methods, and devices for ex vivo analysis of resected tissue samples |
| ES2869454A1 (es) * | 2020-04-24 | 2021-10-25 | Ebers Medical Tech S L | Dispositivo de perfusion normotermica adaptado para mantener en condiciones fisiologicas optimas un higado o un rinon |
| US11700847B2 (en) | 2020-06-06 | 2023-07-18 | MediGO, Inc. | Systems and methods for vital asset transport |
| WO2022087049A1 (en) * | 2020-10-21 | 2022-04-28 | The Trustees Of The University Of Pennsylvania | Systems and methods for ex vivo perfusion of vertebrate tissue |
| EP4369928A1 (en) * | 2021-07-15 | 2024-05-22 | Sorin Group Italia S.r.l. | Organ perfusion and preservation system and method |
| CN113686072B (zh) * | 2021-08-17 | 2022-08-19 | 王正昕 | 一种便于转运的肝移植恒温冰箱 |
| JP2023045552A (ja) | 2021-09-22 | 2023-04-03 | 株式会社Ｓｃｒｅｅｎホールディングス | 臓器載置台、臓器保存容器、および臓器載置方法 |
| USD1031028S1 (en) | 2022-09-08 | 2024-06-11 | Paragonix Technologies, Inc. | Tissue suspension adaptor |
| US20240090495A1 (en) * | 2022-09-21 | 2024-03-21 | Daris LLC | Apparatus, system, and method for organ perfusion |
| USD1021129S1 (en) * | 2022-10-28 | 2024-04-02 | Ruben Oganesyan | Organ chamber |
| WO2024119172A2 (en) * | 2022-12-02 | 2024-06-06 | The Johns Hopkins University | Methods for assessing viability of donor organs that undergo perfusion |
| WO2024127882A1 (ja) * | 2022-12-13 | 2024-06-20 | 株式会社島津製作所 | 臓器灌流装置 |
| EP4658070A1 (en) * | 2023-01-31 | 2025-12-10 | DEKA Products Limited Partnership | Cannula for connecting to and interfacing with an organ |
| WO2024182232A2 (en) * | 2023-02-27 | 2024-09-06 | Life Express Llc | Modular hyperbaric organ preservation and transport system |
| USD1078083S1 (en) * | 2023-05-31 | 2025-06-03 | X-Therma, Inc. | Organ and tissue transport device |
| WO2025049335A1 (en) | 2023-08-25 | 2025-03-06 | Paragonix Technologies, Inc. | Systems and methods for maintaining organ pressure |
| WO2025128811A1 (en) * | 2023-12-12 | 2025-06-19 | The General Hospital Corporation | Device and system for managing a bodily tissue ex vivo |
| US20250248390A1 (en) * | 2024-02-02 | 2025-08-07 | Paragonix Technologies, Inc. | System for perfusion of an organ |
| WO2025213152A1 (en) * | 2024-04-06 | 2025-10-09 | The Board Of Trustees Of The Leland Stanford Junior University | Cardiac ex vivo preservation system compatible for use with any oxygenator and pump |
| USD1087382S1 (en) | 2025-01-30 | 2025-08-05 | Paragonix Technologies, Inc. | Device for transporting a biological sample |
Family Cites Families (141)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1682344A (en) | 1928-08-28 | lesieur | ||
| US39318A (en) | 1863-07-21 | Improvement in revolving fire-arms | ||
| FR545332A (fr) | 1921-12-29 | 1922-10-10 | Cie Ingersoll Rand | Raccord à montage instantané pour tuyauteries |
| US1916658A (en) | 1931-10-09 | 1933-07-04 | Louis R Davidson | Pneumothorax apparatus |
| US3406531A (en) | 1964-08-25 | 1968-10-22 | Emil S. Swenson | Apparatus for maintaining organs in a completely viable state |
| US3545221A (en) | 1967-05-22 | 1970-12-08 | Swenko Research & Dev Inc | Apparatus for maintaining organs in vitro in a completely viable state |
| FR1577356A (enExample) | 1968-04-04 | 1969-08-08 | ||
| US3521743A (en) | 1968-11-05 | 1970-07-28 | Carlo J Sposito Jr | Cushion package |
| SE323475B (enExample) | 1968-11-26 | 1970-05-04 | Aga Ab | |
| DE1938275A1 (de) * | 1969-03-11 | 1970-10-08 | Baxter Laboratories Inc | Perfusionseinheit fuer ein Organ od.dgl. |
| US3772153A (en) | 1969-04-02 | 1973-11-13 | Air Liquide | Apparatus for the preservation of animal or human organs in living condition |
| US3632473A (en) | 1969-04-21 | 1972-01-04 | Univ California | Method and apparatus for preserving human organs extracorporeally |
| US3892628A (en) | 1969-10-06 | 1975-07-01 | Baxter Laboratories Inc | Preservation of organs |
| BE755423A (fr) * | 1969-10-06 | 1971-02-01 | Baxter Laboratories Inc | Procede et appareil pour la conservation d'organes |
| US3660241A (en) | 1970-01-12 | 1972-05-02 | Baxter Laboratories Inc | Container for organ perfusion or the like |
| US3639084A (en) | 1970-04-06 | 1972-02-01 | Baxter Laboratories Inc | Mechanism for control pulsatile fluid flow |
| US3810367A (en) | 1970-07-16 | 1974-05-14 | W Peterson | Container for cooling, storage, and shipping of human organ for transplant |
| US3712583A (en) | 1971-01-25 | 1973-01-23 | Ametek Inc | Valved for lines carrying extreme temperature fluids |
| US3753865A (en) | 1971-03-12 | 1973-08-21 | Univ California | Method and apparatus for preserving human organs extracorporeally |
| AT313466B (de) | 1971-06-09 | 1974-02-25 | Waagner Biro Ag | Organperfusionsapparat |
| DE2241698C2 (de) | 1971-09-02 | 1982-08-26 | Roland Dr.med. Zürich Doerig | Verfahren zur Organerhaltung sowie Vorrichtung zum Durchführen dieses Verfahrens |
| US3935065A (en) | 1971-09-02 | 1976-01-27 | Roland Karl Doerig | Procedure for conservation of living organs and apparatus for the execution of this procedure |
| US3881990A (en) | 1971-11-24 | 1975-05-06 | Waters Instr Inc | Method of transporting and storing organs while retaining the organs in a viable condition |
| US3777507A (en) | 1971-11-24 | 1973-12-11 | Waters Instr Inc | Renal preservation system |
| FR2169488A5 (enExample) | 1972-01-27 | 1973-09-07 | Air Liquide | |
| US3843455A (en) | 1972-09-13 | 1974-10-22 | M Bier | Apparatus and technique for preservation of isolated organs through perfusion |
| US3877843A (en) | 1973-05-21 | 1975-04-15 | Baxter Laboratories Inc | Pulsatile pumping system |
| GB1442356A (en) * | 1973-09-21 | 1976-07-14 | Vos Nii Ogneupornoi Promy | Solid electrolytes |
| JPS5331209B2 (enExample) | 1973-10-05 | 1978-09-01 | ||
| US3931898A (en) | 1974-01-21 | 1976-01-13 | Karnobatsky Eduard Konstantino | Machine for conditioning ore heat-treating furnace throat |
| US3944398A (en) | 1974-04-30 | 1976-03-16 | Frank Rutherford Bell | Method of forming an abrasive compact of cubic boron nitride |
| US3995444A (en) | 1974-11-08 | 1976-12-07 | American Hospital Supply Corporation | Organ perfusion system |
| SU760972A1 (ru) | 1976-03-18 | 1980-09-07 | Ir G Med Inst | Устройство для гипотермии 1 |
| US4186565A (en) | 1978-05-19 | 1980-02-05 | Henry Ford Hospital | Perfusion system for organ preservation |
| US4231354A (en) | 1978-07-14 | 1980-11-04 | Howmedica, Incorporated | Pulsatile blood pumping apparatus and method |
| US4243883A (en) | 1979-01-19 | 1981-01-06 | Midwest Cardiovascular Institute Foundation | Blood hematocrit monitoring system |
| US4242883A (en) | 1979-04-02 | 1981-01-06 | Henry Ford Hospital | Liver preservation |
| US4657532A (en) | 1985-07-19 | 1987-04-14 | Thomas Jefferson University | Intra-peritoneal perfusion of oxygenated fluorocarbon |
| US4445500A (en) | 1982-03-03 | 1984-05-01 | Thomas Jefferson University | Stroke treatment utilizing extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders |
| US4393863A (en) | 1980-04-14 | 1983-07-19 | Thomas Jefferson University | Extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders |
| US5085630A (en) | 1980-04-14 | 1992-02-04 | Thomas Jefferson University | Oxygenated fluorocarbon nutrient solution |
| US4378797A (en) | 1980-04-14 | 1983-04-05 | Thomas Jefferson University | Extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders |
| US4717548A (en) | 1980-06-09 | 1988-01-05 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Analytically controlled blood perfusion system |
| US4629686A (en) | 1982-02-19 | 1986-12-16 | Endotronics, Inc. | Apparatus for delivering a controlled dosage of a chemical substance |
| US4451251A (en) | 1982-03-03 | 1984-05-29 | Thomas Jefferson University | Stroke treatment utilizing extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders |
| DE3366419D1 (en) | 1982-06-04 | 1986-10-30 | Hoxan Kk | Method of preserving organ and apparatus for preserving the same |
| US4473637A (en) | 1982-11-10 | 1984-09-25 | Guibert, Colman & Associates | System for processing an organ preparatory to transplant |
| US4559298A (en) | 1982-11-23 | 1985-12-17 | American National Red Cross | Cryopreservation of biological materials in a non-frozen or vitreous state |
| US4474016A (en) | 1983-03-04 | 1984-10-02 | Baxter Travenol Laboratories, Inc. | Sterile cooling system |
| US4618586A (en) | 1983-04-08 | 1986-10-21 | Endotronics, Inc. | Apparatus for administering a controlled dosage of a chemical substance having an improved culture chamber |
| US4837390A (en) | 1983-05-11 | 1989-06-06 | Keyes Offshore, Inc. | Hyperbaric organ preservation apparatus and method for preserving living organs |
| US4462215A (en) | 1983-05-31 | 1984-07-31 | Hoxan Corporation | Method of preserving organ and apparatus for preserving the same |
| US4471629A (en) | 1983-05-31 | 1984-09-18 | Mount Carmel Research And Education Corporation | Method of freezing and transplant of kidneys and apparatus |
| US4801299A (en) | 1983-06-10 | 1989-01-31 | University Patents, Inc. | Body implants of extracellular matrix and means and methods of making and using such implants |
| JPS6061502A (ja) * | 1983-09-14 | 1985-04-09 | Hoxan Corp | 臓器保存処理のための潅流方法と潅流装置 |
| US4502295A (en) | 1984-02-21 | 1985-03-05 | Mount Carmel Research And Education Corporation | Organ hypothermic storage unit |
| US4596250A (en) | 1984-11-14 | 1986-06-24 | Genetic Laboratories, Inc. | Moldable cooling/heating device with directional cooling/heating |
| US4723974A (en) | 1985-07-26 | 1988-02-09 | Ammerman Stephen W | Transporting container for an amputated extremity |
| US4879283A (en) | 1985-10-03 | 1989-11-07 | Wisconsin Alumni Research Foundation | Solution for the preservation of organs |
| US4666425A (en) | 1985-12-17 | 1987-05-19 | The Dis Corporation | Device for perfusing an animal head |
| US4704029A (en) | 1985-12-26 | 1987-11-03 | Research Corporation | Blood glucose monitor |
| FR2592306A1 (fr) | 1985-12-30 | 1987-07-03 | Couegnas Jacques | Appareil de perfusion a debit reglable ne provoquant pas de modification du liquide perfuse. |
| EP0256653A3 (en) | 1986-07-10 | 1990-01-17 | Haemonetics Corporation | Blood compatible heat exchanger |
| GB8619437D0 (en) | 1986-08-08 | 1986-09-17 | Bradley L | Storage & refrigeration |
| CA1296591C (en) | 1986-12-03 | 1992-03-03 | Meddiss, Inc. | Pulsatile flow delivery apparatus |
| US4745759A (en) | 1986-12-23 | 1988-05-24 | Bauer Dan O | Kidney preservation machine |
| WO1988005261A1 (en) | 1987-01-16 | 1988-07-28 | Tops Systems, Inc. | Total organ perfusion system |
| GB8711614D0 (en) | 1987-05-16 | 1987-06-24 | Medical Res Council | Proteins |
| AU618531B2 (en) | 1987-05-29 | 1992-01-02 | Retroperfusion Systems, Inc. | Retroperfusion and retroinfusion control apparatus, system and method |
| SU1632428A1 (ru) | 1987-08-03 | 1991-03-07 | Одесский Медицинский Институт Им.Н.И.Пирогова | Способ лечени т желой черепно-мозговой травмы в острый период заболевани |
| US5051352A (en) | 1987-10-07 | 1991-09-24 | The Regents Of The University Of California | Apparatus and method of preserving the viability of animal organs |
| FR2628077B1 (fr) | 1988-03-07 | 1990-08-03 | Guilhem Jacques | Conteneur pour le transport de greffons |
| DE3808942A1 (de) | 1988-03-17 | 1989-09-28 | Bio Med Gmbh Ges Fuer Biotechn | Inkubator, insbes. fuer die polymerase-ketten-methode |
| US5130230A (en) | 1988-05-02 | 1992-07-14 | Cryomedical Sciences, Inc. | Blood substitute |
| JPH0499701A (ja) * | 1988-10-26 | 1992-03-31 | Mckelvey Karen | 移植に使用するヒトの臓器の輸送用装置 |
| EP0376763A3 (en) | 1988-10-26 | 1992-04-01 | McKelvey, Karen | A device for transportation of human organs used for transplantation |
| US5013303A (en) | 1988-11-03 | 1991-05-07 | Yehuda Tamari | Constant pressure infusion device |
| US4951482A (en) | 1988-12-21 | 1990-08-28 | Gilbert Gary L | Hypothermic organ transport apparatus |
| US5110721A (en) | 1989-02-10 | 1992-05-05 | The Research Foundation Of State University Of New York | Method for hypothermic organ protection during organ retrieval |
| JPH02295901A (ja) * | 1989-05-09 | 1990-12-06 | Olympus Optical Co Ltd | 臓器保存装置 |
| US5326706A (en) | 1989-07-17 | 1994-07-05 | Research Foundation Of State University Of New York | Homeostatic organ preservation system |
| RU2079273C1 (ru) | 1989-07-27 | 1997-05-20 | И.Джост Леонора | Транспортабельный контейнер закрытой системы для хранения биологического материала |
| JPH0653160B2 (ja) | 1989-08-18 | 1994-07-20 | 呉羽化学工業株式会社 | 拍動発生方法及び装置 |
| US5200176A (en) | 1989-10-06 | 1993-04-06 | Genentech, Inc. | Method for protection of ischemic tissues using tumor nerosis factor |
| US5036097A (en) | 1989-10-17 | 1991-07-30 | Oklahoma Medical Research Foundation | Phenylbutyl nitrone compositions and methods for prevention of gastric ulceration |
| US5066578A (en) | 1989-12-21 | 1991-11-19 | The Regents Of The University Of California | Long-term preservation of organs for transplantation |
| US5003787A (en) | 1990-01-18 | 1991-04-02 | Savant Instruments | Cell preservation system |
| WO1991014364A1 (en) * | 1990-03-28 | 1991-10-03 | Waters Instruments, Inc. | Microperfusion apparatus |
| US5145771A (en) | 1990-04-12 | 1992-09-08 | The University Of North Carolina At Chapel Hill | Rinse solution for organs and tissues |
| US5047395A (en) | 1990-07-17 | 1991-09-10 | Nagase Co., Ltd. | Reduction of oxyradical damage in biomedical applications |
| FR2667297B1 (fr) | 1990-09-28 | 1994-05-27 | Electrolux Sarl | Conteneur medical climatise. |
| US5584804A (en) | 1990-10-10 | 1996-12-17 | Life Resuscitation Technologies, Inc. | Brain resuscitation and organ preservation device and method for performing the same |
| US5395314A (en) | 1990-10-10 | 1995-03-07 | Life Resuscitation Technologies, Inc. | Brain resuscitation and organ preservation device and method for performing the same |
| US5149321A (en) | 1990-10-10 | 1992-09-22 | Klatz Ronald M | Brain resuscitation device and method for performing the same |
| US5308320A (en) | 1990-12-28 | 1994-05-03 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Portable and modular cardiopulmonary bypass apparatus and associated aortic balloon catheter and associated method |
| US5157930A (en) | 1991-04-22 | 1992-10-27 | Mcghee Samuel C | Organ preservation apparatus |
| US5723282A (en) | 1991-07-08 | 1998-03-03 | The American National Red Cross | Method of preparing organs for vitrification |
| US5856081A (en) | 1991-07-08 | 1999-01-05 | The American National Red Cross | Computer controlled cryoprotectant perfusion apparatus |
| US5217860A (en) | 1991-07-08 | 1993-06-08 | The American National Red Cross | Method for preserving organs for transplantation by vitrification |
| US5150706A (en) | 1991-08-15 | 1992-09-29 | Cox James L | Cooling net for cardiac or transplant surgery |
| US5216032A (en) | 1991-09-30 | 1993-06-01 | The University Of North Carolina At Chapel Hill | Selective aortic arch perfusion using perfluorochemical and alpha adrenergic agonist to treat cardiac arrest |
| US5328821A (en) | 1991-12-12 | 1994-07-12 | Robyn Fisher | Cold and cryo-preservation methods for human tissue slices |
| US5338662A (en) | 1992-09-21 | 1994-08-16 | Bio-Preserve Medical Corporation | Organ perfusion device |
| DE4301524A1 (de) | 1993-01-21 | 1994-07-28 | Jostra Medizintechnik | Medizinisches Aggregat oder Gerät für Operationssäle, insbesondere Herz-Lungen-Maschine |
| US5356771A (en) | 1993-03-11 | 1994-10-18 | Board Of Regents, The University Of Texas System | Combined perfusion and oxygenation organ preservation apparatus |
| US5362622A (en) | 1993-03-11 | 1994-11-08 | Board Of Regents, The University Of Texas System | Combined perfusion and oxygenation apparatus |
| US5599659A (en) | 1993-03-11 | 1997-02-04 | Breonics, Inc. | Preservation solution for ex vivo, warm preservation of tissues, explants,organs and vascular endothelial cells comprising retinal-derived fibroblast growth factor, cyclodextrin and chondroitin sulfate |
| WO1994021116A1 (en) | 1993-03-16 | 1994-09-29 | Alliance Pharmaceutical Corp. | Preservation solution and method for warm organ preservation |
| US5451524A (en) | 1994-02-01 | 1995-09-19 | The Gillette Company | In vitro chamber for human organ tissue samples |
| US5437633A (en) | 1994-03-30 | 1995-08-01 | The University Of North Carolina At Chapel Hill | Selective aortic arch perfusion |
| FR2718643B1 (fr) * | 1994-04-13 | 1996-06-14 | Fondation Transplantation | Hépato-dialyseur extra-corporel utilisant le foie prélevé d'un être vivant. |
| US5643712A (en) | 1994-05-20 | 1997-07-01 | Brasile; Lauren | Method for treating and rendering grafts nonthrombogenic and substantially nonimmunogenic using an extracellular matrix coating |
| DE69535920D1 (de) | 1994-05-20 | 2009-04-09 | Breonics Inc | Verfahren zur überwachung der lebensfähigkeit transplantabler organe |
| US5823986A (en) | 1995-02-08 | 1998-10-20 | Medtronic, Inc. | Perfusion system |
| US5586438A (en) * | 1995-03-27 | 1996-12-24 | Organ, Inc. | Portable device for preserving organs by static storage or perfusion |
| AU5375496A (en) * | 1995-03-27 | 1996-10-16 | American National Red Cross, The | Organ evaluation and resuscitation device and method |
| US5681740A (en) * | 1995-06-05 | 1997-10-28 | Cytotherapeutics, Inc. | Apparatus and method for storage and transporation of bioartificial organs |
| US6238908B1 (en) | 1995-06-07 | 2001-05-29 | Aastrom Biosciences, Inc. | Apparatus and method for maintaining and growth biological cells |
| US5730720A (en) | 1995-08-18 | 1998-03-24 | Ip Scientific, Inc. | Perfusion hyperthermia treatment system and method |
| US5712084A (en) | 1995-09-08 | 1998-01-27 | Research Corporation Technologies, Inc. | Donor kidney viability test for improved preservation |
| GB2305568A (en) | 1995-09-25 | 1997-04-09 | Gps Genetic Ltd | Remote location monitoring |
| US5843024A (en) | 1996-05-17 | 1998-12-01 | Breonics, Inc. | Solution and process for resuscitation and preparation of ischemically damaged tissue |
| US5965433A (en) | 1996-05-29 | 1999-10-12 | Trans D.A.T.A. Service, Inc. | Portable perfusion/oxygenation module having mechanically linked dual pumps and mechanically actuated flow control for pulsatile cycling of oxygenated perfusate |
| US5894266A (en) | 1996-05-30 | 1999-04-13 | Micron Technology, Inc. | Method and apparatus for remote monitoring |
| US5716378A (en) | 1996-06-06 | 1998-02-10 | Medtronic, Inc. | Heart preservation and transportation apparatus and method employing low rate cardiac pacing for improved removal of catabolites from the myocardium |
| US5879329A (en) | 1997-01-22 | 1999-03-09 | Radiant Medical, Inc. | Infusion systems and methods for introducing fluids into the body within a desired temperature range |
| US6642045B1 (en) * | 1997-04-14 | 2003-11-04 | Breonics, Inc. | System for exsanguinous metabolic support of an organ or tissue |
| US5928182A (en) | 1997-07-02 | 1999-07-27 | Johnson & Johnson Professional, Inc. | Pediatric programmable hydrocephalus valve |
| US6100082A (en) | 1997-09-23 | 2000-08-08 | Hassanein; Waleed H. | Perfusion apparatus and method including chemical compositions for maintaining an organ |
| DE69819759T2 (de) * | 1997-09-23 | 2004-09-23 | Hassanein, Waleed H., Malden | Zusammensetzungen, verfahren und vorrichtungen zur aufrechterhaltung eines organs |
| US6014864A (en) * | 1998-03-16 | 2000-01-18 | Life Science Holdings, Inc. | Cryogenic fluid heat exchanger method and apparatus |
| US6977140B1 (en) | 1998-09-29 | 2005-12-20 | Organ Recovery Systems, Inc. | Method for maintaining and/or restoring viability of organs |
| EP2308296A3 (en) * | 1998-09-29 | 2011-08-24 | Organ Recovery Systems, Inc. | System and method for holding an organ |
| US6673594B1 (en) | 1998-09-29 | 2004-01-06 | Organ Recovery Systems | Apparatus and method for maintaining and/or restoring viability of organs |
| US7045279B1 (en) | 1998-10-22 | 2006-05-16 | Medtronic, Inc. | Isolated perfused heart preparation and method of use |
| GB9908335D0 (en) | 1999-04-12 | 1999-06-09 | Univ Cambridge Tech | Methods and means for extracorporeal organ perfusion |
| KR20020059255A (ko) | 1999-06-17 | 2002-07-12 | 린다 에스. 스티븐슨 | 저온 저장을 개선하기 위한 ＰＥＧ-Ｈｂ를 사용하는 연속심장 관류 보존 |
| EP1208748A4 (en) | 1999-08-31 | 2002-11-20 | Fujisawa Pharmaceutical Co | PRESERVATIVES FOR ORGANS |
| FR2798141B1 (fr) | 1999-09-07 | 2003-04-04 | Rhodia Chimie Sa | Procede de production d'exopolysaccharides |
| US6300875B1 (en) | 1999-11-22 | 2001-10-09 | Mci Worldcom, Inc. | Method and apparatus for high efficiency position information reporting |
| PL1613153T3 (pl) | 2003-04-04 | 2021-11-29 | Organ Recovery Systems, Inc. | Sposoby i aparat do perfuzji, diagnostyki, przechowywania i/lub transportu narządu lub tkanek |
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