JP4883220B2 - ロチゴチン含有組成物及びその使用並びにこの組成物を含む経皮貼付剤 - Google Patents

ロチゴチン含有組成物及びその使用並びにこの組成物を含む経皮貼付剤 Download PDF

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JP4883220B2
JP4883220B2 JP2010515339A JP2010515339A JP4883220B2 JP 4883220 B2 JP4883220 B2 JP 4883220B2 JP 2010515339 A JP2010515339 A JP 2010515339A JP 2010515339 A JP2010515339 A JP 2010515339A JP 4883220 B2 JP4883220 B2 JP 4883220B2
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composition
rotigotine
eudragit
mixing system
weight
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JP2010532390A5 (enExample
JP2010532390A (ja
Inventor
▲樹▼ 明 王
慧 勇 ▲シュエ▼
▲麗▼ 王
恩 宏 ▲張▼
▲紅▼ 俊 ▲連▼
▲暁▼ 燕 石
国 ▲華▼ ▲チー▼
玉 成 ▲陸▼
喜 全 ▲劉▼
莉 宋
叙 英 ▲鐘▼
洪 光 杜
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北京康倍得医薬技術開發有限公司
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2010515339A 2007-07-06 2008-07-03 ロチゴチン含有組成物及びその使用並びにこの組成物を含む経皮貼付剤 Active JP4883220B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN200710118491XA CN101147739B (zh) 2007-07-06 2007-07-06 含罗替戈汀的组合物及其制药用途以及含该组合物的透皮贴剂
CN200710118491.X 2007-07-06
PCT/CN2008/001267 WO2009006787A1 (en) 2007-07-06 2008-07-03 Composition comprising rotigotine, its use and transdermal patch comprising the composition

Publications (3)

Publication Number Publication Date
JP2010532390A JP2010532390A (ja) 2010-10-07
JP2010532390A5 JP2010532390A5 (enExample) 2011-07-21
JP4883220B2 true JP4883220B2 (ja) 2012-02-22

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JP2010515339A Active JP4883220B2 (ja) 2007-07-06 2008-07-03 ロチゴチン含有組成物及びその使用並びにこの組成物を含む経皮貼付剤

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US (2) US9265752B2 (enExample)
EP (1) EP2177217B1 (enExample)
JP (1) JP4883220B2 (enExample)
CN (1) CN101147739B (enExample)
DK (1) DK2177217T3 (enExample)
ES (1) ES2655705T3 (enExample)
WO (1) WO2009006787A1 (enExample)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101147739B (zh) 2007-07-06 2010-12-08 北京康倍得医药技术开发有限公司 含罗替戈汀的组合物及其制药用途以及含该组合物的透皮贴剂
TWI541246B (zh) 2008-12-08 2016-07-11 歐陸斯迪公司 二氫羥戊甲嗎啡
WO2011048491A2 (en) 2009-10-19 2011-04-28 Actavis Group Ptc Ehf Amorphous rotigotine co-precipitates
JP5815556B2 (ja) 2009-12-22 2015-11-17 ウーツェーベー ファルマ ゲーエムベーハーＵｃｂ Ｐｈａｒｍａ Ｇｍｂｈ 非結晶形態のロチゴチンの固体分散体を安定化するためのポリビニルピロリドン
WO2012084969A1 (en) 2010-12-22 2012-06-28 Hexal Ag Adhesive composition containing rotigotine and transdermal therapeutic system comprising the adhesive composition
JP5900971B2 (ja) * 2011-02-02 2016-04-06 大日本住友製薬株式会社 経皮吸収促進剤及びそれを含有する経皮吸収型製剤
JP5856424B2 (ja) * 2011-10-05 2016-02-09 祐徳薬品工業株式会社 ロチゴチン含有経皮吸収型貼付剤
DE102012205493A1 (de) * 2012-04-03 2013-10-10 Acino Ag Einen Dopamin-Agonisten enthaltendes transdermales Applikationssystem
KR101558042B1 (ko) * 2012-07-05 2015-10-07 에스케이케미칼주식회사 로티고틴을 함유한 경피흡수제제
CN105247002B (zh) * 2012-11-19 2018-02-06 瀚森公司 压敏粘结剂组合物
TW201431570A (zh) 2012-11-22 2014-08-16 Ucb Pharma Gmbh 用於經皮投服羅替戈汀（Ｒｏｔｉｇｏｔｉｎｅ）之多天式貼片
EP2968201B1 (en) 2013-03-13 2022-12-28 Avery Dennison Corporation Enhanced drug delivery from adhesives
WO2014159798A1 (en) 2013-03-13 2014-10-02 Avery Dennison Corporation Improving adhesive properties
AR095259A1 (es) * 2013-03-15 2015-09-30 Noven Pharma Composiciones y métodos para la administración transdérmica de fármacos de amina terciaria
KR101686987B1 (ko) * 2013-05-30 2016-12-15 에스케이케미칼주식회사 로티고틴과 지방산 및 스티렌 점착제를 함유한 경피치료시스템
GB201309654D0 (en) 2013-05-30 2013-07-17 Euro Celtique Sa Method
WO2015001012A1 (de) 2013-07-03 2015-01-08 Lts Lohmann Therapie-Systeme Ag Transdermales therapeutisches system mit elektronischem bauteil
GB201317718D0 (en) 2013-10-07 2013-11-20 Buzzz Pharmaceuticals Ltd Novel formulation
WO2015168646A1 (en) * 2014-05-02 2015-11-05 The Research Foundation For The State University Of New York Compositions and methods for intradermal vaccine delivery
CA2948220C (en) * 2014-05-20 2023-06-20 Lts Lohmann Therapie-Systeme Ag Transdermal delivery system containing rotigotine
EP3145503A1 (en) 2014-05-20 2017-03-29 LTS Lohmann Therapie-Systeme AG Method for adjusting the release of active agent in a transdermal delivery system
CA2948221C (en) 2014-05-20 2022-11-22 Lts Lohmann Therapie-Systeme Ag Transdermal delivery system including an interface mediator
KR102364378B1 (ko) * 2014-05-21 2022-02-16 에스케이케미칼 주식회사 안정성을 향상시킨 로티고틴 함유 경피흡수제제
DE102014114282A1 (de) * 2014-10-01 2016-04-07 Neuraxpharm Arzneimittel Gmbh Transdermales therapeutisches System mit Rotigotin zur Behandlung von Morbus Parkinson
GB201520647D0 (en) * 2015-11-23 2016-01-06 Buzzz Pharmaceuticals Ltd Transdermal patches
WO2017153441A1 (en) * 2016-03-09 2017-09-14 Tesa Labtec Gmbh Topical composition
WO2018067163A1 (en) 2016-10-07 2018-04-12 Transwell Biotech Co., Ltd. Pramipexole transdermal delivery system and uses thereof
EP3700511A1 (en) 2017-10-17 2020-09-02 Lubrizol Advanced Materials, Inc. Composition and device for delivery of active agents to skin surfaces
CN107823190A (zh) * 2017-11-06 2018-03-23 广州市桐晖药业有限公司 一种盐酸洛哌丁胺贴剂
CN110292576A (zh) * 2019-07-01 2019-10-01 武汉威立得生物医药有限公司 罗替戈汀在制备治疗或预防流感病毒感染的药物中的应用
CN112076177B (zh) * 2020-10-28 2021-08-31 江苏集萃新型药物制剂技术研究所有限公司 一种口腔粘膜给药系统
CN112891324A (zh) * 2021-01-19 2021-06-04 北京亚宝生物药业有限公司 一种透皮贴剂
CN117157044A (zh) * 2021-04-06 2023-12-01 Ddp特种电子材料美国第9有限公司 成膜组合物
CN113368083A (zh) * 2021-06-16 2021-09-10 华健医疗(深圳)有限公司 一种大麻二酚cbd透皮给药系统
CN113384560A (zh) * 2021-07-07 2021-09-14 华健医疗(深圳)有限公司 一种治疗或预防神经系统疾病的罗替戈汀与尼古丁的复方透皮贴片及制备方法
CN114699391B (zh) * 2022-04-07 2023-10-31 北京福元医药股份有限公司 一种罗替高汀透皮吸收贴剂

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5474783A (en) * 1988-03-04 1995-12-12 Noven Pharmaceuticals, Inc. Solubility parameter based drug delivery system and method for altering drug saturation concentration
US5656286A (en) 1988-03-04 1997-08-12 Noven Pharmaceuticals, Inc. Solubility parameter based drug delivery system and method for altering drug saturation concentration
CN1151780C (zh) * 1993-01-02 2004-06-02 诺纹制药股份有限公司 基于溶度参数的药物释放系统和改变药物饱和浓度的方法
DE19814084B4 (de) * 1998-03-30 2005-12-22 Lts Lohmann Therapie-Systeme Ag D2-Agonist enthaltendes transdermales therapeutisches System zur Behandlung des Parkinson-Syndroms und Verfahren zu seiner Herstellung
US20020004065A1 (en) * 2000-01-20 2002-01-10 David Kanios Compositions and methods to effect the release profile in the transdermal administration of active agents
EP1344522A1 (en) 2001-05-08 2003-09-17 Schwarz Pharma Ag Transdermal therapeutic system for Parkinson's disease inducing high plasma levels of rotigotine
TWI277418B (en) * 2001-06-18 2007-04-01 Noven Pharma Enhanced drug delivery in transdermal systems
US20060216336A1 (en) * 2002-05-07 2006-09-28 Hans-Michael Wolff Transdermal therapeutic system for Parkinson's Disease
DE10234673B4 (de) * 2002-07-30 2007-08-16 Schwarz Pharma Ag Heißschmelz-TTS zur Verabreichung von Rotigotin und Verfahren zu seiner Herstellung sowie Verwendung von Rotigotin bei der Herstellung eines TTS im Heißschmelzverfahren
DE10261696A1 (de) * 2002-12-30 2004-07-15 Schwarz Pharma Ag Vorrichtung zur transdermalen Verabreichung von Rotigotin-Base
DE10361259A1 (de) 2003-12-24 2005-07-28 Schwarz Pharma Ag Verwendung von Rotigotine in einem Frühstadium von Morbus Parkinson zur Prävention des weiteren Neuronenverlustes
CN100411692C (zh) 2004-01-13 2008-08-20 北京康倍得医药技术开发有限公司 丙烯酸基粘合剂组合物及其药物组合物和透皮治疗系统
CN101147739B (zh) * 2007-07-06 2010-12-08 北京康倍得医药技术开发有限公司 含罗替戈汀的组合物及其制药用途以及含该组合物的透皮贴剂

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Publication number Publication date
US9265752B2 (en) 2016-02-23
US20160120822A1 (en) 2016-05-05
CN101147739A (zh) 2008-03-26
EP2177217B1 (en) 2017-11-22
EP2177217A4 (en) 2013-12-04
EP2177217A1 (en) 2010-04-21
ES2655705T3 (es) 2018-02-21
JP2010532390A (ja) 2010-10-07
DK2177217T3 (en) 2018-02-05
CN101147739B (zh) 2010-12-08
US20110027345A1 (en) 2011-02-03
WO2009006787A1 (en) 2009-01-15

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