JP4881875B2 - 抗腫瘍剤としてのピラゾロピリミジン化合物 - Google Patents

抗腫瘍剤としてのピラゾロピリミジン化合物 Download PDF

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Publication number
JP4881875B2
JP4881875B2 JP2007546165A JP2007546165A JP4881875B2 JP 4881875 B2 JP4881875 B2 JP 4881875B2 JP 2007546165 A JP2007546165 A JP 2007546165A JP 2007546165 A JP2007546165 A JP 2007546165A JP 4881875 B2 JP4881875 B2 JP 4881875B2
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JP
Japan
Prior art keywords
alkyl
pyrazolo
oxy
amino
phenyl
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Expired - Fee Related
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Japanese (ja)
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JP2008523134A5 (https=
JP2008523134A (ja
Inventor
バーラーム，ベルナール・クリストフ
デュクレ，リシャール
ケトル，ジェイソン・グラント
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AstraZeneca AB
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AstraZeneca AB
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2007546165A 2004-12-14 2005-12-12 抗腫瘍剤としてのピラゾロピリミジン化合物 Expired - Fee Related JP4881875B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP04292982 2004-12-14
EP04292982.8 2004-12-14
EP05291158 2005-05-30
EP05291158.3 2005-05-30
PCT/GB2005/004770 WO2006064196A1 (en) 2004-12-14 2005-12-12 Pyrazolopyrimidine compounds as antitumor agents

Publications (3)

Publication Number Publication Date
JP2008523134A JP2008523134A (ja) 2008-07-03
JP2008523134A5 JP2008523134A5 (https=) 2011-12-22
JP4881875B2 true JP4881875B2 (ja) 2012-02-22

Family

ID=35826513

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007546165A Expired - Fee Related JP4881875B2 (ja) 2004-12-14 2005-12-12 抗腫瘍剤としてのピラゾロピリミジン化合物

Country Status (7)

Country Link
US (1) US7947676B2 (https=)
EP (1) EP1838712B8 (https=)
JP (1) JP4881875B2 (https=)
CN (1) CN101124228B (https=)
AT (1) ATE501148T1 (https=)
DE (1) DE602005026865D1 (https=)
WO (1) WO2006064196A1 (https=)

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DE602005010824D1 (de) 2004-02-03 2008-12-18 Astrazeneca Ab Chinazolinderivate
JP2008231004A (ja) * 2007-03-19 2008-10-02 Sumitomo Seika Chem Co Ltd アルコキシ−２−メルカプトベンゾチアゾールの製造方法
AU2013343105B2 (en) 2012-11-08 2016-04-14 Pfizer Inc. Heteroaromatic compounds as dopamine D1 ligands
WO2015091645A1 (en) 2013-12-18 2015-06-25 Basf Se Azole compounds carrying an imine-derived substituent
US9616063B2 (en) * 2014-12-01 2017-04-11 Astrazeneca Ab 1-[2-(aminomethyl)benzyl]-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-ones as inhibitors of myeloperoxidase
WO2017184775A1 (en) * 2016-04-19 2017-10-26 The Regents Of The University Of California Erbb inhibitors and uses thereof

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EP1664030A1 (en) * 2003-09-16 2006-06-07 AstraZeneca AB Quinazoline derivatives
GB0321648D0 (en) * 2003-09-16 2003-10-15 Astrazeneca Ab Quinazoline derivatives
EP1664028A1 (en) 2003-09-16 2006-06-07 AstraZeneca AB Quinazoline derivatives as tyrosine kinase inhibitors
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GB0322409D0 (en) 2003-09-25 2003-10-29 Astrazeneca Ab Quinazoline derivatives
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BRPI0511741A (pt) 2004-06-04 2008-01-02 Astrazeneca Ab derivado de quinazolina ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, processo para a preparação de um derivado de quinazolina ou de um sal farmaceuticamente aceitável do mesmo
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Also Published As

Publication number Publication date
CN101124228B (zh) 2011-06-15
EP1838712B1 (en) 2011-03-09
ATE501148T1 (de) 2011-03-15
EP1838712A1 (en) 2007-10-03
CN101124228A (zh) 2008-02-13
US20080108613A1 (en) 2008-05-08
WO2006064196A1 (en) 2006-06-22
JP2008523134A (ja) 2008-07-03
HK1112462A1 (en) 2008-09-05
US7947676B2 (en) 2011-05-24
EP1838712B8 (en) 2011-10-12
DE602005026865D1 (de) 2011-04-21

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