CN101124228B - 用作抗肿瘤药物的吡唑并嘧啶化合物 - Google Patents

用作抗肿瘤药物的吡唑并嘧啶化合物 Download PDF

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Publication number
CN101124228B
CN101124228B CN2005800483311A CN200580048331A CN101124228B CN 101124228 B CN101124228 B CN 101124228B CN 2005800483311 A CN2005800483311 A CN 2005800483311A CN 200580048331 A CN200580048331 A CN 200580048331A CN 101124228 B CN101124228 B CN 101124228B
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China
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pyrazolo
phenyl
ethyl
oxygen base
amino
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Chinese (zh)
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CN101124228A (zh
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B·C·巴拉姆
R·杜克雷
J·G·凯特尔
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AstraZeneca AB
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN2005800483311A 2004-12-14 2005-12-12 用作抗肿瘤药物的吡唑并嘧啶化合物 Expired - Fee Related CN101124228B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP04292982.8 2004-12-14
EP04292982 2004-12-14
EP05291158 2005-05-30
EP05291158.3 2005-05-30
PCT/GB2005/004770 WO2006064196A1 (en) 2004-12-14 2005-12-12 Pyrazolopyrimidine compounds as antitumor agents

Publications (2)

Publication Number Publication Date
CN101124228A CN101124228A (zh) 2008-02-13
CN101124228B true CN101124228B (zh) 2011-06-15

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN2005800483311A Expired - Fee Related CN101124228B (zh) 2004-12-14 2005-12-12 用作抗肿瘤药物的吡唑并嘧啶化合物

Country Status (7)

Country Link
US (1) US7947676B2 (https=)
EP (1) EP1838712B8 (https=)
JP (1) JP4881875B2 (https=)
CN (1) CN101124228B (https=)
AT (1) ATE501148T1 (https=)
DE (1) DE602005026865D1 (https=)
WO (1) WO2006064196A1 (https=)

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JP2008231004A (ja) * 2007-03-19 2008-10-02 Sumitomo Seika Chem Co Ltd アルコキシ−２−メルカプトベンゾチアゾールの製造方法
MD20150037A2 (ro) 2012-11-08 2015-11-30 Pfizer Inc. Compuşi heteroaromatici şi utilizarea lor ca liganzi de dopamină D1
CN105829296A (zh) 2013-12-18 2016-08-03 巴斯夫欧洲公司 带有亚胺衍生的取代基的唑类化合物
US9616063B2 (en) * 2014-12-01 2017-04-11 Astrazeneca Ab 1-[2-(aminomethyl)benzyl]-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-ones as inhibitors of myeloperoxidase
US20190119284A1 (en) * 2016-04-19 2019-04-25 The Regents Of The University Of California ErbB Inhibitors and Uses Thereof

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Also Published As

Publication number Publication date
JP2008523134A (ja) 2008-07-03
EP1838712A1 (en) 2007-10-03
ATE501148T1 (de) 2011-03-15
HK1112462A1 (en) 2008-09-05
JP4881875B2 (ja) 2012-02-22
WO2006064196A1 (en) 2006-06-22
EP1838712B1 (en) 2011-03-09
US7947676B2 (en) 2011-05-24
DE602005026865D1 (de) 2011-04-21
EP1838712B8 (en) 2011-10-12
US20080108613A1 (en) 2008-05-08
CN101124228A (zh) 2008-02-13

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Termination date: 20121212