JP4848277B2 - 受容体に結合するペプチドおよび化合物 - Google Patents

受容体に結合するペプチドおよび化合物 Download PDF

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Publication number
JP4848277B2
JP4848277B2 JP2006524705A JP2006524705A JP4848277B2 JP 4848277 B2 JP4848277 B2 JP 4848277B2 JP 2006524705 A JP2006524705 A JP 2006524705A JP 2006524705 A JP2006524705 A JP 2006524705A JP 4848277 B2 JP4848277 B2 JP 4848277B2
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Prior art keywords
compound
peptide
group
receptor
peptides
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Expired - Lifetime
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JP2006524705A
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English (en)
Japanese (ja)
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JP2007504132A5 (cg-RX-API-DMAC10.html
JP2007504132A (ja
Inventor
マクドナルド，ブライアン・アール
ウエイス，ジエフリー・ケネス
ヤーコウ，エドワード・ジヨン
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オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/524—Thrombopoietin, i.e. C-MPL ligand
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/03—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Polyethers (AREA)
  • Medicinal Preparation (AREA)
JP2006524705A 2003-08-28 2004-08-13 受容体に結合するペプチドおよび化合物 Expired - Lifetime JP4848277B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US49874003P 2003-08-28 2003-08-28
US60/498,740 2003-08-28
PCT/US2004/026422 WO2005023834A2 (en) 2003-08-28 2004-08-13 Peptides and compounds that bind to thrombopoietin receptors

Publications (3)

Publication Number Publication Date
JP2007504132A JP2007504132A (ja) 2007-03-01
JP2007504132A5 JP2007504132A5 (cg-RX-API-DMAC10.html) 2007-09-20
JP4848277B2 true JP4848277B2 (ja) 2011-12-28

Family

ID=34272720

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006524705A Expired - Lifetime JP4848277B2 (ja) 2003-08-28 2004-08-13 受容体に結合するペプチドおよび化合物

Country Status (32)

Country Link
US (1) US7576056B2 (cg-RX-API-DMAC10.html)
EP (1) EP1675606B1 (cg-RX-API-DMAC10.html)
JP (1) JP4848277B2 (cg-RX-API-DMAC10.html)
KR (2) KR20120078742A (cg-RX-API-DMAC10.html)
CN (2) CN1871022B (cg-RX-API-DMAC10.html)
AR (1) AR045530A1 (cg-RX-API-DMAC10.html)
AU (1) AU2004270656B2 (cg-RX-API-DMAC10.html)
BR (1) BRPI0414008B8 (cg-RX-API-DMAC10.html)
CA (1) CA2537421C (cg-RX-API-DMAC10.html)
CY (1) CY1118965T1 (cg-RX-API-DMAC10.html)
DK (1) DK1675606T3 (cg-RX-API-DMAC10.html)
EA (1) EA009286B1 (cg-RX-API-DMAC10.html)
EC (1) ECSP066396A (cg-RX-API-DMAC10.html)
ES (1) ES2626107T3 (cg-RX-API-DMAC10.html)
HR (1) HRP20170810T1 (cg-RX-API-DMAC10.html)
HU (1) HUE032370T2 (cg-RX-API-DMAC10.html)
IL (1) IL173965A (cg-RX-API-DMAC10.html)
IS (1) IS8300A (cg-RX-API-DMAC10.html)
LT (1) LT1675606T (cg-RX-API-DMAC10.html)
ME (1) ME00313B (cg-RX-API-DMAC10.html)
MX (1) MXPA06002292A (cg-RX-API-DMAC10.html)
NO (1) NO344233B1 (cg-RX-API-DMAC10.html)
NZ (1) NZ545455A (cg-RX-API-DMAC10.html)
PL (1) PL1675606T3 (cg-RX-API-DMAC10.html)
PT (1) PT1675606T (cg-RX-API-DMAC10.html)
RS (2) RS20060141A (cg-RX-API-DMAC10.html)
SG (1) SG131110A1 (cg-RX-API-DMAC10.html)
SI (1) SI1675606T1 (cg-RX-API-DMAC10.html)
TW (1) TWI348375B (cg-RX-API-DMAC10.html)
UA (1) UA82710C2 (cg-RX-API-DMAC10.html)
WO (1) WO2005023834A2 (cg-RX-API-DMAC10.html)
ZA (1) ZA200602495B (cg-RX-API-DMAC10.html)

Families Citing this family (19)

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US7091311B2 (en) * 1996-06-07 2006-08-15 Smithkline Beecham Corporation Peptides and compounds that bind to a receptor
ATE348163T1 (de) 1998-10-23 2007-01-15 Amgen Inc Thrombopoietin substitute
DK1542714T3 (da) * 2002-09-18 2014-05-26 Janssen Pharmaceuticals Inc Fremgangsmåder til forøgelse af produktion af blodplader og hæmatopoietiske stamceller
US20040149235A1 (en) * 2002-10-04 2004-08-05 Pogue Albert S. Apparatus and method for removal of waste from animal production facilities
US7723295B2 (en) * 2003-08-28 2010-05-25 Ortho-Mcneil Pharmaceutical, Inc. Peptides and compounds that bind to a receptor
RS20060141A (sr) 2003-08-28 2008-08-07 Ortho-Mcneil Pharmaceutical Inc., Peptidi i jedinjenja koja se vežu za receptor
US7615533B2 (en) 2004-08-16 2009-11-10 Janssen Pharmaceutica N.V. TPO peptide compounds for treatment of anemia
EP1986677A2 (en) * 2006-01-25 2008-11-05 Amgen Inc. Thrombopoietic compounds
AR059573A1 (es) * 2006-02-14 2008-04-16 Janssen Pharmaceutica Nv Uso de compuestos peptidicos de tpo y composiciones farmaceuticas en el tratamiento de la anemia
PT1984014E (pt) * 2006-02-14 2014-11-13 Janssen Pharmaceutica Nv Utilização de compostos de péptidos tpo e composições farmacêuticas no tratamento da anemia
US7981425B2 (en) 2006-06-19 2011-07-19 Amgen Inc. Thrombopoietic compounds
KR20110015448A (ko) * 2008-06-03 2011-02-15 얀센 파마슈티카 엔.브이. 암 치료와 관련된 혈액 질환을 예방하기 위한 ｔｐｏ 모방 펩티드
CN103635514B (zh) 2011-06-23 2016-01-20 株式会社岛津制作所 支链型两亲性嵌段聚合物、使用其的分子聚集体及药物输送系统
JP7481252B2 (ja) * 2017-07-26 2024-05-10 ヤンセン ファーマシューティカ エヌ．ベー． 標的放射線治療誘発性血管完全性を保護する方法
US20200237872A1 (en) 2019-01-25 2020-07-30 Janssen Pharmaceutica Nv Methods of enhancing protection against organ and vascular injury, hematopoietic recovery and survival in response to total body radiation/chemical exposure
US11273203B2 (en) 2019-01-25 2022-03-15 Janssen Pharmaceutica Nv Methods of mitigating toxic effects of vesicants and caustic gas
MA54820A (fr) 2019-01-25 2021-12-01 Janssen Pharmaceutica Nv Méthodes d'atténuation d'une lésion hépatique et de promotion d'une hypertrophie hépatique, de régénération du foie et de prise de greffe de cellules hépatiques conjointement avec des traitements par radiothérapie et/ou radiomimétiques
CN118660955A (zh) 2021-10-01 2024-09-17 詹森药业有限公司 增加祖细胞生产的方法
WO2024095178A1 (en) 2022-11-01 2024-05-10 Janssen Pharmaceutica Nv Thrombopoietin mimetic for use in the treatment of acute liver failure

Citations (2)

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Publication number Priority date Publication date Assignee Title
WO1996014293A1 (en) * 1994-11-04 1996-05-17 Santen Pharmaceutical Co., Ltd. Novel 1,3-dialkylurea derivative having hydroxyl group
WO2002051861A2 (en) * 2000-12-22 2002-07-04 Kinerton Limited Process for the synthesis of a peptide having a tryptophan residue

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US5326558A (en) * 1989-08-08 1994-07-05 Genetics Institute, Inc. Megakaryocytopoietic factor
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DK167813B1 (da) * 1989-12-07 1993-12-20 Carlbiotech Ltd As Pentapeptidderivat, farmaceutisk acceptable salte heraf, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende et saadant derivat
US5571508A (en) 1989-12-18 1996-11-05 Amrad Corporation Limited Method for the treatment of thrombocytopenia and pharmaceutical compositions useful therefor
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US5571686A (en) 1994-04-14 1996-11-05 Massachusetts Institute Of Technology Method of using megapoietin for prolonging the survival & viability of platlets
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CN1966520B (zh) * 1995-06-07 2012-07-11 葛兰素集团有限公司 结合血小板生成素受体的肽和化合物
US6251864B1 (en) * 1995-06-07 2001-06-26 Glaxo Group Limited Peptides and compounds that bind to a receptor
US5869451A (en) 1995-06-07 1999-02-09 Glaxo Group Limited Peptides and compounds that bind to a receptor
US6060052A (en) * 1995-10-30 2000-05-09 Systemix, Inc. Methods for use of Mpl ligands with primitive human hematopoietic stem cells
US5932546A (en) * 1996-10-04 1999-08-03 Glaxo Wellcome Inc. Peptides and compounds that bind to the thrombopoietin receptor
AU771460B2 (en) 1999-09-24 2004-03-25 Smithkline Beecham Corporation Thrombopoietin mimetics
AU2002307062A1 (en) 2001-04-02 2002-10-15 Purdue Pharma L.P. Thrombopoietin (tpo) synthebody for stimulation of platelet production
DK1542714T3 (da) * 2002-09-18 2014-05-26 Janssen Pharmaceuticals Inc Fremgangsmåder til forøgelse af produktion af blodplader og hæmatopoietiske stamceller
RS20060141A (sr) 2003-08-28 2008-08-07 Ortho-Mcneil Pharmaceutical Inc., Peptidi i jedinjenja koja se vežu za receptor

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996014293A1 (en) * 1994-11-04 1996-05-17 Santen Pharmaceutical Co., Ltd. Novel 1,3-dialkylurea derivative having hydroxyl group
WO2002051861A2 (en) * 2000-12-22 2002-07-04 Kinerton Limited Process for the synthesis of a peptide having a tryptophan residue

Also Published As

Publication number Publication date
SI1675606T1 (sl) 2017-07-31
EA009286B1 (ru) 2007-12-28
MEP48508A (en) 2011-02-10
HUE032370T2 (en) 2017-09-28
WO2005023834A2 (en) 2005-03-17
TW200517103A (en) 2005-06-01
CA2537421C (en) 2011-09-27
RS56387B1 (sr) 2017-12-29
CN1871022B (zh) 2011-07-06
SG131110A1 (en) 2007-04-26
CY1118965T1 (el) 2018-01-10
AR045530A1 (es) 2005-11-02
NZ545455A (en) 2009-02-28
IL173965A (en) 2015-10-29
RS20060141A (sr) 2008-08-07
CN102241742A (zh) 2011-11-16
TWI348375B (en) 2011-09-11
KR101183875B1 (ko) 2012-09-27
BRPI0414008B8 (pt) 2021-05-25
EA200600477A1 (ru) 2007-02-27
PT1675606T (pt) 2017-05-22
LT1675606T (lt) 2017-11-10
PL1675606T3 (pl) 2017-08-31
BRPI0414008B1 (pt) 2018-05-15
WO2005023834A3 (en) 2005-05-06
NO344233B1 (no) 2019-10-14
AU2004270656A1 (en) 2005-03-17
IS8300A (is) 2006-02-14
NO20061346L (no) 2006-05-22
EP1675606B1 (en) 2017-04-05
ZA200602495B (en) 2007-06-27
CA2537421A1 (en) 2005-03-17
HRP20170810T1 (hr) 2017-08-11
JP2007504132A (ja) 2007-03-01
EP1675606A2 (en) 2006-07-05
MXPA06002292A (es) 2006-09-04
CN102241742B (zh) 2014-04-02
UA82710C2 (uk) 2008-05-12
IL173965A0 (en) 2006-07-05
DK1675606T3 (en) 2017-06-19
EP1675606A4 (en) 2009-09-30
KR20070017942A (ko) 2007-02-13
US7576056B2 (en) 2009-08-18
ES2626107T3 (es) 2017-07-24
KR20120078742A (ko) 2012-07-10
US20050137133A1 (en) 2005-06-23
ECSP066396A (es) 2006-08-30
AU2004270656B2 (en) 2011-03-10
HK1096873A1 (en) 2007-06-15
BRPI0414008A (pt) 2006-10-24
CN1871022A (zh) 2006-11-29
ME00313B (me) 2011-05-10

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