EA200600477A1 - Пептиды и соединения, которые связываются с рецептором - Google Patents

Пептиды и соединения, которые связываются с рецептором

Info

Publication number
EA200600477A1
EA200600477A1 EA200600477A EA200600477A EA200600477A1 EA 200600477 A1 EA200600477 A1 EA 200600477A1 EA 200600477 A EA200600477 A EA 200600477A EA 200600477 A EA200600477 A EA 200600477A EA 200600477 A1 EA200600477 A1 EA 200600477A1
Authority
EA
Eurasian Patent Office
Prior art keywords
peptides
receptor
associate
connections
tpo
Prior art date
Application number
EA200600477A
Other languages
English (en)
Other versions
EA009286B1 (ru
Inventor
Брайан Р. Макдональд
Джеффери Кеннет Вейс
Эдвард Джон Юрков
Original Assignee
Орто-Макнейл Фармасьютикал, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34272720&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200600477(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Орто-Макнейл Фармасьютикал, Инк. filed Critical Орто-Макнейл Фармасьютикал, Инк.
Publication of EA200600477A1 publication Critical patent/EA200600477A1/ru
Publication of EA009286B1 publication Critical patent/EA009286B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/524—Thrombopoietin, i.e. C-MPL ligand
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/03—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Polyethers (AREA)
  • Medicinal Preparation (AREA)

Abstract

Пептиды и соединения, которые связываются с рецептором тромбопоэтина (с-mpl или TPO-R) и активируют его или каким-либо иным образом действуют как агонисты ТРО.
EA200600477A 2003-08-28 2004-08-13 Пептиды и соединения, которые связываются с рецептором EA009286B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49874003P 2003-08-28 2003-08-28
PCT/US2004/026422 WO2005023834A2 (en) 2003-08-28 2004-08-13 Peptides and compounds that bind to thrombopoietin receptors

Publications (2)

Publication Number Publication Date
EA200600477A1 true EA200600477A1 (ru) 2007-02-27
EA009286B1 EA009286B1 (ru) 2007-12-28

Family

ID=34272720

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200600477A EA009286B1 (ru) 2003-08-28 2004-08-13 Пептиды и соединения, которые связываются с рецептором

Country Status (33)

Country Link
US (1) US7576056B2 (ru)
EP (1) EP1675606B1 (ru)
JP (1) JP4848277B2 (ru)
KR (2) KR20120078742A (ru)
CN (2) CN1871022B (ru)
AR (1) AR045530A1 (ru)
AU (1) AU2004270656B2 (ru)
BR (1) BRPI0414008B8 (ru)
CA (1) CA2537421C (ru)
CY (1) CY1118965T1 (ru)
DK (1) DK1675606T3 (ru)
EA (1) EA009286B1 (ru)
EC (1) ECSP066396A (ru)
ES (1) ES2626107T3 (ru)
HK (1) HK1096873A1 (ru)
HR (1) HRP20170810T1 (ru)
HU (1) HUE032370T2 (ru)
IL (1) IL173965A (ru)
IS (1) IS8300A (ru)
LT (1) LT1675606T (ru)
ME (1) ME00313B (ru)
MX (1) MXPA06002292A (ru)
NO (1) NO344233B1 (ru)
NZ (1) NZ545455A (ru)
PL (1) PL1675606T3 (ru)
PT (1) PT1675606T (ru)
RS (2) RS56387B1 (ru)
SG (1) SG131110A1 (ru)
SI (1) SI1675606T1 (ru)
TW (1) TWI348375B (ru)
UA (1) UA82710C2 (ru)
WO (1) WO2005023834A2 (ru)
ZA (1) ZA200602495B (ru)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7091311B2 (en) 1996-06-07 2006-08-15 Smithkline Beecham Corporation Peptides and compounds that bind to a receptor
SI2319928T1 (sl) 1998-10-23 2013-08-30 Kirin-Amgen, Inc. Dimerni trombopoietinski peptidni mimetiki, ki se veĺ˝ejo na receptor mp1 in imajo trombopoietinsko aktivnost
AU2003275077B2 (en) * 2002-09-18 2010-02-04 Ortho-Mcneil Pharmaceutical, Inc. Methods of increasing platelet and hematopoietic stem cell production
US20040149235A1 (en) * 2002-10-04 2004-08-05 Pogue Albert S. Apparatus and method for removal of waste from animal production facilities
US7723295B2 (en) * 2003-08-28 2010-05-25 Ortho-Mcneil Pharmaceutical, Inc. Peptides and compounds that bind to a receptor
RS56387B1 (sr) 2003-08-28 2017-12-29 Ortho Mcneil Pharm Inc Peptidi i jedinjenja koja se vežu za trombopoetinski receptor
US7615533B2 (en) 2004-08-16 2009-11-10 Janssen Pharmaceutica N.V. TPO peptide compounds for treatment of anemia
EP1986677A2 (en) * 2006-01-25 2008-11-05 Amgen Inc. Thrombopoietic compounds
JP2009526841A (ja) * 2006-02-14 2009-07-23 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｔｐｏペプチド化合物及び薬学的組成物の貧血症の処置における使用
TWI458488B (zh) * 2006-02-14 2014-11-01 Janssen Pharmaceutica Nv Ｔｐｏ胜肽化合物及醫藥組成物於治療貧血之用途
US7981425B2 (en) 2006-06-19 2011-07-19 Amgen Inc. Thrombopoietic compounds
MX2010013281A (es) * 2008-06-03 2010-12-21 Janssen Pharmaceutica Nv Peptido mimetico de trombopoyetina para prevenir trastornos hematologicos asociados con el tratamiento del cancer.
JP5709113B2 (ja) 2011-06-23 2015-04-30 株式会社島津製作所 分岐型両親媒性ブロックポリマー、それを用いた分子集合体及び薬剤搬送システム
BR112020001367A2 (pt) * 2017-07-26 2020-08-11 Janssen Pharmaceutica N.V. métodos de proteção da integridade vascular induzida por terapia de radiação direcionada
CA3127455A1 (en) 2019-01-25 2020-07-30 Janssen Pharmaceutica Nv Methods for mitigating liver injury and promoting liver hypertrophy, regeneration and cell engraftment in conjunction with radiation and/or radiomimetic treatments
US11273203B2 (en) 2019-01-25 2022-03-15 Janssen Pharmaceutica Nv Methods of mitigating toxic effects of vesicants and caustic gas
WO2020154637A1 (en) 2019-01-25 2020-07-30 Janssen Pharmaceutica Nv Methods of enhancing protection against organ and vascular injury, hematopoietic recovery and survival in response to total body radiation/chemical exposure
US20230104658A1 (en) 2021-10-01 2023-04-06 Janssen Pharmaceutica Nv Methods of increasing progenitor cell production
WO2024095178A1 (en) 2022-11-01 2024-05-10 Janssen Pharmaceutica Nv Thrombopoietin mimetic for use in the treatment of acute liver failure

Family Cites Families (33)

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US5143854A (en) * 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5326558A (en) * 1989-08-08 1994-07-05 Genetics Institute, Inc. Megakaryocytopoietic factor
IL96477A0 (en) 1989-12-01 1991-08-16 Amgen Inc Megakaryocyte production
DK167813B1 (da) * 1989-12-07 1993-12-20 Carlbiotech Ltd As Pentapeptidderivat, farmaceutisk acceptable salte heraf, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende et saadant derivat
US5571508A (en) 1989-12-18 1996-11-05 Amrad Corporation Limited Method for the treatment of thrombocytopenia and pharmaceutical compositions useful therefor
IT1241395B (it) 1990-04-02 1994-01-10 Eniricerche Spa Composti immunogenici,il procedimento per la loro sintesi e loro impiego per la preparazione di vaccini antimalaria
US5141851A (en) * 1990-04-18 1992-08-25 Board Of Regents, The University Of Texas System Isolated farnesyl protein transferase enzyme
US5250732A (en) * 1991-07-18 1993-10-05 Genentech, Inc. Ketamine analogues for treatment of thrombocytopenia
US5270170A (en) * 1991-10-16 1993-12-14 Affymax Technologies N.V. Peptide library and screening method
ATE222500T1 (de) 1992-06-11 2002-09-15 Alkermes Inc Enythropoietin enthaltendes arzneimittelabgabesystem
EP0945504A3 (en) * 1992-12-11 1999-12-08 The University Of Florida Materials and method for control of pests
WO1995011922A1 (en) 1993-10-29 1995-05-04 Affymax Technologies N.V. In vitro peptide and antibody display libraries
SG47030A1 (en) 1994-01-03 1998-03-20 Genentech Inc Thrombopoietin
SG79882A1 (en) 1994-02-14 2001-04-17 Kirin Brewery Protein having tpo activity
NZ281482A (en) 1994-02-14 2000-09-29 Univ Washington The stimulation of erythropoiesis using thrombopoietin and erythropoietin
WO1995021919A2 (en) 1994-02-14 1995-08-17 Kirin Brewery Company, Limited Protein having tpo activity
NZ271230A (en) 1994-02-14 1998-03-25 Zymogenetics Inc Hematopoietic proteins, production and use
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US5571686A (en) 1994-04-14 1996-11-05 Massachusetts Institute Of Technology Method of using megapoietin for prolonging the survival & viability of platlets
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AU771460B2 (en) 1999-09-24 2004-03-25 Smithkline Beecham Corporation Thrombopoietin mimetics
BR0116447B1 (pt) * 2000-12-22 2014-04-29 Ipsen Mfg Ireland Ltd Processo para a síntese de peptídeos análogos de LHRH tendo um resíduo de triptofano
WO2002078612A2 (en) 2001-04-02 2002-10-10 Euro-Celtique S.A. Thrombopoietin (tpo) synthebody for stimulation of platelet production
AU2003275077B2 (en) * 2002-09-18 2010-02-04 Ortho-Mcneil Pharmaceutical, Inc. Methods of increasing platelet and hematopoietic stem cell production
RS56387B1 (sr) 2003-08-28 2017-12-29 Ortho Mcneil Pharm Inc Peptidi i jedinjenja koja se vežu za trombopoetinski receptor

Also Published As

Publication number Publication date
CA2537421A1 (en) 2005-03-17
US20050137133A1 (en) 2005-06-23
BRPI0414008B8 (pt) 2021-05-25
RS56387B1 (sr) 2017-12-29
EP1675606A4 (en) 2009-09-30
HRP20170810T1 (hr) 2017-08-11
CA2537421C (en) 2011-09-27
TW200517103A (en) 2005-06-01
IL173965A (en) 2015-10-29
DK1675606T3 (en) 2017-06-19
UA82710C2 (ru) 2008-05-12
NO344233B1 (no) 2019-10-14
NO20061346L (no) 2006-05-22
KR20070017942A (ko) 2007-02-13
CN1871022A (zh) 2006-11-29
MEP48508A (en) 2011-02-10
CN1871022B (zh) 2011-07-06
MXPA06002292A (es) 2006-09-04
NZ545455A (en) 2009-02-28
HK1096873A1 (en) 2007-06-15
AR045530A1 (es) 2005-11-02
WO2005023834A2 (en) 2005-03-17
HUE032370T2 (en) 2017-09-28
EA009286B1 (ru) 2007-12-28
KR20120078742A (ko) 2012-07-10
ZA200602495B (en) 2007-06-27
ES2626107T3 (es) 2017-07-24
KR101183875B1 (ko) 2012-09-27
CN102241742A (zh) 2011-11-16
EP1675606B1 (en) 2017-04-05
BRPI0414008A (pt) 2006-10-24
PT1675606T (pt) 2017-05-22
SG131110A1 (en) 2007-04-26
JP2007504132A (ja) 2007-03-01
PL1675606T3 (pl) 2017-08-31
BRPI0414008B1 (pt) 2018-05-15
ME00313B (me) 2011-05-10
CN102241742B (zh) 2014-04-02
AU2004270656A1 (en) 2005-03-17
RS20060141A (en) 2008-08-07
IS8300A (is) 2006-02-14
SI1675606T1 (sl) 2017-07-31
AU2004270656B2 (en) 2011-03-10
US7576056B2 (en) 2009-08-18
LT1675606T (lt) 2017-11-10
TWI348375B (en) 2011-09-11
CY1118965T1 (el) 2018-01-10
EP1675606A2 (en) 2006-07-05
WO2005023834A3 (en) 2005-05-06
ECSP066396A (es) 2006-08-30
JP4848277B2 (ja) 2011-12-28
IL173965A0 (en) 2006-07-05

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