AR045530A1 - Peptidos y compuestos que se unen al receptor de trombopoyetina - Google Patents

Peptidos y compuestos que se unen al receptor de trombopoyetina

Info

Publication number
AR045530A1
AR045530A1 ARP040103101A ARP040103101A AR045530A1 AR 045530 A1 AR045530 A1 AR 045530A1 AR P040103101 A ARP040103101 A AR P040103101A AR P040103101 A ARP040103101 A AR P040103101A AR 045530 A1 AR045530 A1 AR 045530A1
Authority
AR
Argentina
Prior art keywords
compound
peptides
compounds
laarx10
iegptlrq
Prior art date
Application number
ARP040103101A
Other languages
English (en)
Original Assignee
Dimensional Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34272720&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR045530(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Dimensional Pharm Inc filed Critical Dimensional Pharm Inc
Publication of AR045530A1 publication Critical patent/AR045530A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/524—Thrombopoietin, i.e. C-MPL ligand
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/03—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Polyethers (AREA)
  • Medicinal Preparation (AREA)

Abstract

Se describen péptidos y compuestos que se unen a, y activan, al receptor de trombopoyetina (c-mpl o TPO-R) o de algún otro modo actúan como un agonista de TPO. Reivindicación 1: Un compuesto que se une a un receptor de trombopoyetina, en donde dicho compuesto comprende (H-IEGPTLRQ(2-Nal)LAARX10)2K-NH2, donde X10 se selecciona del grupo formado por sarcosina o beta-alanina. Reivindicación 2: El compuesto de acuerdo con la reivindicación 1, en donde dicho compuesto está covalentemente unido a un polímero hidrófilo. Reivindicación 8: Una composición farmacéutica que comprende un compuesto de acuerdo con la reivindicación 1 en combinación con un portador farmacéuticamente aceptable. Reivindicación 23: Un método para tratar a un paciente que sufre de trombocitopenia, que comprende administrar a dicho paciente una dosis terapéuticamente efectiva de un compuesto el cual comprende (H-IEGPTLRQ(2-Nal)LAARX10)2K-NH2, donde X10 se selecciona del grupo formado por sarcosina o beta- alanina. Reivindicación 28: Un método de acuerdo con la reivindicación 27 donde dicho compuesto es administrado antes del transplanta de médula ósea, quimioterapia o terapia de radiación.
ARP040103101A 2003-08-28 2004-08-27 Peptidos y compuestos que se unen al receptor de trombopoyetina AR045530A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US49874003P 2003-08-28 2003-08-28

Publications (1)

Publication Number Publication Date
AR045530A1 true AR045530A1 (es) 2005-11-02

Family

ID=34272720

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP040103101A AR045530A1 (es) 2003-08-28 2004-08-27 Peptidos y compuestos que se unen al receptor de trombopoyetina

Country Status (33)

Country Link
US (1) US7576056B2 (es)
EP (1) EP1675606B1 (es)
JP (1) JP4848277B2 (es)
KR (2) KR20120078742A (es)
CN (2) CN102241742B (es)
AR (1) AR045530A1 (es)
AU (1) AU2004270656B2 (es)
BR (1) BRPI0414008B8 (es)
CA (1) CA2537421C (es)
CY (1) CY1118965T1 (es)
DK (1) DK1675606T3 (es)
EA (1) EA009286B1 (es)
EC (1) ECSP066396A (es)
ES (1) ES2626107T3 (es)
HK (1) HK1096873A1 (es)
HR (1) HRP20170810T1 (es)
HU (1) HUE032370T2 (es)
IL (1) IL173965A (es)
IS (1) IS8300A (es)
LT (1) LT1675606T (es)
ME (1) ME00313B (es)
MX (1) MXPA06002292A (es)
NO (1) NO344233B1 (es)
NZ (1) NZ545455A (es)
PL (1) PL1675606T3 (es)
PT (1) PT1675606T (es)
RS (2) RS20060141A (es)
SG (1) SG131110A1 (es)
SI (1) SI1675606T1 (es)
TW (1) TWI348375B (es)
UA (1) UA82710C2 (es)
WO (1) WO2005023834A2 (es)
ZA (1) ZA200602495B (es)

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US7091311B2 (en) * 1996-06-07 2006-08-15 Smithkline Beecham Corporation Peptides and compounds that bind to a receptor
HU228582B1 (en) 1998-10-23 2013-04-29 Kirin Amgen Inc Dimeric thrombopoietin peptide mimetics binding to mp1 receptor and having thrombopoietic activity
ES2462916T3 (es) 2002-09-18 2014-05-26 Janssen Pharmaceuticals, Inc. Métodos para aumentar la producción de células madre hematopoyéticas y plaquetas
US20040149235A1 (en) * 2002-10-04 2004-08-05 Pogue Albert S. Apparatus and method for removal of waste from animal production facilities
US7723295B2 (en) * 2003-08-28 2010-05-25 Ortho-Mcneil Pharmaceutical, Inc. Peptides and compounds that bind to a receptor
SI1675606T1 (sl) 2003-08-28 2017-07-31 Janssen Pharmaceuticals, Inc. Peptidi in spojine, ki se vežejo na trombopoietinske receptorje
US7615533B2 (en) 2004-08-16 2009-11-10 Janssen Pharmaceutica N.V. TPO peptide compounds for treatment of anemia
AU2007208226A1 (en) * 2006-01-25 2007-08-02 Amgen Inc. Thrombopoietic compounds
JP2009526841A (ja) * 2006-02-14 2009-07-23 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｔｐｏペプチド化合物及び薬学的組成物の貧血症の処置における使用
MY151332A (en) * 2006-02-14 2014-05-15 Janssen Pharmaceutica Nv Use of tpo peptide compounds and pharmaceutical compositions in the treatment of anemia
US7981425B2 (en) 2006-06-19 2011-07-19 Amgen Inc. Thrombopoietic compounds
MX2010013281A (es) * 2008-06-03 2010-12-21 Janssen Pharmaceutica Nv Peptido mimetico de trombopoyetina para prevenir trastornos hematologicos asociados con el tratamiento del cancer.
EP2725053B1 (en) 2011-06-23 2016-02-10 Shimadzu Corporation Branched amphipathic block polymer and molecular aggregate and drug delivery system using same
EP3658191A1 (en) * 2017-07-26 2020-06-03 Janssen Pharmaceutica NV Methods of protecting vascular integrity induced by targeted radiation therapy
CA3127378A1 (en) 2019-01-25 2020-10-15 Janssen Pharmaceutica Nv Methods of mitigating toxic effects of vesicants and caustic gas
MA54821A (fr) * 2019-01-25 2021-12-01 Janssen Pharmaceutica Nv Méthodes pour augmenter la protection contre les lésions des organes et des vaisseaux, la récupération hématopoïétique et la survie en réponse à une exposition à une irradiation corporelle totale ou à des agents chimiques
MA54820A (fr) 2019-01-25 2021-12-01 Janssen Pharmaceutica Nv Méthodes d'atténuation d'une lésion hépatique et de promotion d'une hypertrophie hépatique, de régénération du foie et de prise de greffe de cellules hépatiques conjointement avec des traitements par radiothérapie et/ou radiomimétiques
WO2023056444A1 (en) 2021-10-01 2023-04-06 Janssen Pharmaceutica N.V. Methods of increasing progenitor cell production
WO2024095178A1 (en) 2022-11-01 2024-05-10 Janssen Pharmaceutica Nv Thrombopoietin mimetic for use in the treatment of acute liver failure

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SI1675606T1 (sl) 2003-08-28 2017-07-31 Janssen Pharmaceuticals, Inc. Peptidi in spojine, ki se vežejo na trombopoietinske receptorje

Also Published As

Publication number Publication date
HRP20170810T1 (hr) 2017-08-11
CY1118965T1 (el) 2018-01-10
ECSP066396A (es) 2006-08-30
HUE032370T2 (en) 2017-09-28
RS56387B1 (sr) 2017-12-29
CA2537421C (en) 2011-09-27
CN1871022B (zh) 2011-07-06
CN102241742B (zh) 2014-04-02
WO2005023834A3 (en) 2005-05-06
PL1675606T3 (pl) 2017-08-31
EP1675606B1 (en) 2017-04-05
BRPI0414008A (pt) 2006-10-24
EA009286B1 (ru) 2007-12-28
ES2626107T3 (es) 2017-07-24
CA2537421A1 (en) 2005-03-17
US20050137133A1 (en) 2005-06-23
TWI348375B (en) 2011-09-11
IS8300A (is) 2006-02-14
DK1675606T3 (en) 2017-06-19
EP1675606A4 (en) 2009-09-30
AU2004270656A1 (en) 2005-03-17
CN102241742A (zh) 2011-11-16
ZA200602495B (en) 2007-06-27
LT1675606T (lt) 2017-11-10
KR101183875B1 (ko) 2012-09-27
PT1675606T (pt) 2017-05-22
JP4848277B2 (ja) 2011-12-28
IL173965A (en) 2015-10-29
EA200600477A1 (ru) 2007-02-27
CN1871022A (zh) 2006-11-29
KR20120078742A (ko) 2012-07-10
SI1675606T1 (sl) 2017-07-31
NZ545455A (en) 2009-02-28
US7576056B2 (en) 2009-08-18
TW200517103A (en) 2005-06-01
KR20070017942A (ko) 2007-02-13
EP1675606A2 (en) 2006-07-05
NO20061346L (no) 2006-05-22
HK1096873A1 (en) 2007-06-15
UA82710C2 (uk) 2008-05-12
IL173965A0 (en) 2006-07-05
ME00313B (me) 2011-05-10
BRPI0414008B8 (pt) 2021-05-25
JP2007504132A (ja) 2007-03-01
RS20060141A (en) 2008-08-07
SG131110A1 (en) 2007-04-26
NO344233B1 (no) 2019-10-14
MEP48508A (en) 2011-02-10
BRPI0414008B1 (pt) 2018-05-15
AU2004270656B2 (en) 2011-03-10
MXPA06002292A (es) 2006-09-04
WO2005023834A2 (en) 2005-03-17

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