PE20070416A1 - Compuestos peptidicos como agonistas del receptor de trombopoyetina - Google Patents
Compuestos peptidicos como agonistas del receptor de trombopoyetinaInfo
- Publication number
- PE20070416A1 PE20070416A1 PE2006000953A PE2006000953A PE20070416A1 PE 20070416 A1 PE20070416 A1 PE 20070416A1 PE 2006000953 A PE2006000953 A PE 2006000953A PE 2006000953 A PE2006000953 A PE 2006000953A PE 20070416 A1 PE20070416 A1 PE 20070416A1
- Authority
- PE
- Peru
- Prior art keywords
- receptor
- trombopoyetin
- agonists
- succinate
- pharmaceutical composition
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
Abstract
SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE UN COMPUESTO PEPTIDICO DE FORMULA (I) DE SECUENCIA SEQ ID Nº: 7, DONDE (2-Nal) ES ß-(2-NAFTIL)ALANINA Y (Sar) ES SARCOSINA, QUE SE ADMINISTRA EN UNA DOSIS DE 0,1 A 5 MG/KG. DICHO COMPUESTO PEPTIDICO ESTA LIGADO COVALENTEMENTE A UN POLIMERO HIDROFILICO DE PREFERENCIA POLIETILENGLICOL SELECCIONADO DE MONOMETOXIPOLIETILENGLICOL, MONOMETOXIPOLIETILENGLICOL-SUCCINATO, MONOMETOXIPOLIETILENGLICOL-TRESILATO, ENTRE OTROS, QUE TIENE UN PESO MOLECULAR DE 5.000 A 20.000 DALTON. LA COMPOSICION FARMACEUTICA ACTUA COMO AGONISTA DEL RECEPTOR DE TROMBOPOYETINA SIENDO UTIL EN EL TRATAMIENTO DE TROMBOCITOPENIA RESULTANTE DE QUIMIOTERAPIA, RADIOTERAPIA, TRANSFUSIONES DE MEDULA OSEA
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/200,416 US7723295B2 (en) | 2003-08-28 | 2005-08-09 | Peptides and compounds that bind to a receptor |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20070416A1 true PE20070416A1 (es) | 2007-06-13 |
Family
ID=37734435
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2006000953A PE20070416A1 (es) | 2005-08-09 | 2006-08-07 | Compuestos peptidicos como agonistas del receptor de trombopoyetina |
Country Status (35)
Country | Link |
---|---|
US (1) | US7723295B2 (es) |
EP (1) | EP1957517B1 (es) |
JP (1) | JP2009504650A (es) |
KR (1) | KR20080048026A (es) |
CN (1) | CN101287749A (es) |
AR (1) | AR055114A1 (es) |
AU (1) | AU2006280230B2 (es) |
BR (1) | BRPI0614647A2 (es) |
CA (1) | CA2618958A1 (es) |
CR (1) | CR9798A (es) |
CY (1) | CY1114032T1 (es) |
DK (1) | DK1957517T3 (es) |
EA (1) | EA200800535A1 (es) |
EC (1) | ECSP088169A (es) |
ES (1) | ES2419005T3 (es) |
GT (1) | GT200600361A (es) |
HK (1) | HK1123811A1 (es) |
HR (1) | HRP20130518T1 (es) |
IL (1) | IL189361A (es) |
JO (1) | JO2859B1 (es) |
MY (1) | MY152177A (es) |
NI (1) | NI200800040A (es) |
NO (1) | NO344405B1 (es) |
NZ (1) | NZ565497A (es) |
PE (1) | PE20070416A1 (es) |
PL (1) | PL1957517T3 (es) |
PT (1) | PT1957517E (es) |
RS (1) | RS52802B (es) |
SI (1) | SI1957517T1 (es) |
SV (1) | SV2008002648A (es) |
TW (1) | TWI400081B (es) |
UA (1) | UA96418C2 (es) |
UY (1) | UY29736A1 (es) |
WO (1) | WO2007021572A2 (es) |
ZA (1) | ZA200802184B (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7091311B2 (en) * | 1996-06-07 | 2006-08-15 | Smithkline Beecham Corporation | Peptides and compounds that bind to a receptor |
AU2003275077B2 (en) | 2002-09-18 | 2010-02-04 | Ortho-Mcneil Pharmaceutical, Inc. | Methods of increasing platelet and hematopoietic stem cell production |
US20040149235A1 (en) * | 2002-10-04 | 2004-08-05 | Pogue Albert S. | Apparatus and method for removal of waste from animal production facilities |
US7615533B2 (en) * | 2004-08-16 | 2009-11-10 | Janssen Pharmaceutica N.V. | TPO peptide compounds for treatment of anemia |
EP1986677A2 (en) * | 2006-01-25 | 2008-11-05 | Amgen Inc. | Thrombopoietic compounds |
MX2010013281A (es) * | 2008-06-03 | 2010-12-21 | Janssen Pharmaceutica Nv | Peptido mimetico de trombopoyetina para prevenir trastornos hematologicos asociados con el tratamiento del cancer. |
JP5709113B2 (ja) * | 2011-06-23 | 2015-04-30 | 株式会社島津製作所 | 分岐型両親媒性ブロックポリマー、それを用いた分子集合体及び薬剤搬送システム |
BR112020001367A2 (pt) | 2017-07-26 | 2020-08-11 | Janssen Pharmaceutica N.V. | métodos de proteção da integridade vascular induzida por terapia de radiação direcionada |
CA3127455A1 (en) | 2019-01-25 | 2020-07-30 | Janssen Pharmaceutica Nv | Methods for mitigating liver injury and promoting liver hypertrophy, regeneration and cell engraftment in conjunction with radiation and/or radiomimetic treatments |
US11273203B2 (en) | 2019-01-25 | 2022-03-15 | Janssen Pharmaceutica Nv | Methods of mitigating toxic effects of vesicants and caustic gas |
WO2020154637A1 (en) | 2019-01-25 | 2020-07-30 | Janssen Pharmaceutica Nv | Methods of enhancing protection against organ and vascular injury, hematopoietic recovery and survival in response to total body radiation/chemical exposure |
US20230104658A1 (en) | 2021-10-01 | 2023-04-06 | Janssen Pharmaceutica Nv | Methods of increasing progenitor cell production |
WO2024095178A1 (en) | 2022-11-01 | 2024-05-10 | Janssen Pharmaceutica Nv | Thrombopoietin mimetic for use in the treatment of acute liver failure |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5143854A (en) * | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
US5326558A (en) * | 1989-08-08 | 1994-07-05 | Genetics Institute, Inc. | Megakaryocytopoietic factor |
IL96477A0 (en) | 1989-12-01 | 1991-08-16 | Amgen Inc | Megakaryocyte production |
DK167813B1 (da) * | 1989-12-07 | 1993-12-20 | Carlbiotech Ltd As | Pentapeptidderivat, farmaceutisk acceptable salte heraf, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende et saadant derivat |
US5571508A (en) | 1989-12-18 | 1996-11-05 | Amrad Corporation Limited | Method for the treatment of thrombocytopenia and pharmaceutical compositions useful therefor |
IT1241395B (it) | 1990-04-02 | 1994-01-10 | Eniricerche Spa | Composti immunogenici,il procedimento per la loro sintesi e loro impiego per la preparazione di vaccini antimalaria |
US5141851A (en) * | 1990-04-18 | 1992-08-25 | Board Of Regents, The University Of Texas System | Isolated farnesyl protein transferase enzyme |
US5250732A (en) * | 1991-07-18 | 1993-10-05 | Genentech, Inc. | Ketamine analogues for treatment of thrombocytopenia |
US5270170A (en) * | 1991-10-16 | 1993-12-14 | Affymax Technologies N.V. | Peptide library and screening method |
ATE222500T1 (de) | 1992-06-11 | 2002-09-15 | Alkermes Inc | Enythropoietin enthaltendes arzneimittelabgabesystem |
EP0945504A3 (en) * | 1992-12-11 | 1999-12-08 | The University Of Florida | Materials and method for control of pests |
WO1995011922A1 (en) | 1993-10-29 | 1995-05-04 | Affymax Technologies N.V. | In vitro peptide and antibody display libraries |
SG47030A1 (en) | 1994-01-03 | 1998-03-20 | Genentech Inc | Thrombopoietin |
NZ281482A (en) | 1994-02-14 | 2000-09-29 | Univ Washington | The stimulation of erythropoiesis using thrombopoietin and erythropoietin |
WO1995021919A2 (en) | 1994-02-14 | 1995-08-17 | Kirin Brewery Company, Limited | Protein having tpo activity |
NZ271230A (en) | 1994-02-14 | 1998-03-25 | Zymogenetics Inc | Hematopoietic proteins, production and use |
SG79882A1 (en) | 1994-02-14 | 2001-04-17 | Kirin Brewery | Protein having tpo activity |
DK0690127T3 (da) | 1994-03-31 | 1999-05-03 | Amgen Inc | Sammensætninger og fremgangsmåder til stimulering af megakaryocytvækst og -differentiering |
US5571686A (en) | 1994-04-14 | 1996-11-05 | Massachusetts Institute Of Technology | Method of using megapoietin for prolonging the survival & viability of platlets |
WO1996017062A1 (en) | 1994-11-30 | 1996-06-06 | Zymogenetics, Inc. | Low molecular weight thrombopoietin |
ES2276401T3 (es) | 1995-04-26 | 2007-06-16 | Kyowa Hakko Kogyo Co., Ltd. | Proteinas de fusion g-csf tpo. |
ES2303338T3 (es) | 1995-06-07 | 2008-08-01 | Glaxo Group Limited | Peptidos y compuestos que se unen a un receptor de trombopoyetina. |
US6251864B1 (en) * | 1995-06-07 | 2001-06-26 | Glaxo Group Limited | Peptides and compounds that bind to a receptor |
US5869451A (en) | 1995-06-07 | 1999-02-09 | Glaxo Group Limited | Peptides and compounds that bind to a receptor |
US6060052A (en) * | 1995-10-30 | 2000-05-09 | Systemix, Inc. | Methods for use of Mpl ligands with primitive human hematopoietic stem cells |
US5932546A (en) * | 1996-10-04 | 1999-08-03 | Glaxo Wellcome Inc. | Peptides and compounds that bind to the thrombopoietin receptor |
AU771460B2 (en) | 1999-09-24 | 2004-03-25 | Smithkline Beecham Corporation | Thrombopoietin mimetics |
WO2002078612A2 (en) | 2001-04-02 | 2002-10-10 | Euro-Celtique S.A. | Thrombopoietin (tpo) synthebody for stimulation of platelet production |
AU2003275077B2 (en) * | 2002-09-18 | 2010-02-04 | Ortho-Mcneil Pharmaceutical, Inc. | Methods of increasing platelet and hematopoietic stem cell production |
RS56387B1 (sr) * | 2003-08-28 | 2017-12-29 | Ortho Mcneil Pharm Inc | Peptidi i jedinjenja koja se vežu za trombopoetinski receptor |
-
2005
- 2005-08-09 US US11/200,416 patent/US7723295B2/en active Active
-
2006
- 2006-08-03 PT PT67893578T patent/PT1957517E/pt unknown
- 2006-08-03 BR BRPI0614647-3A patent/BRPI0614647A2/pt not_active Application Discontinuation
- 2006-08-03 KR KR1020087005576A patent/KR20080048026A/ko not_active Application Discontinuation
- 2006-08-03 ES ES06789357T patent/ES2419005T3/es active Active
- 2006-08-03 CN CNA2006800376102A patent/CN101287749A/zh active Pending
- 2006-08-03 SI SI200631599T patent/SI1957517T1/sl unknown
- 2006-08-03 EP EP06789357A patent/EP1957517B1/en active Active
- 2006-08-03 RS RS20130193A patent/RS52802B/en unknown
- 2006-08-03 DK DK06789357.8T patent/DK1957517T3/da active
- 2006-08-03 NZ NZ565497A patent/NZ565497A/en not_active IP Right Cessation
- 2006-08-03 AU AU2006280230A patent/AU2006280230B2/en active Active
- 2006-08-03 PL PL06789357T patent/PL1957517T3/pl unknown
- 2006-08-03 CA CA002618958A patent/CA2618958A1/en active Pending
- 2006-08-03 UA UAA200801217A patent/UA96418C2/ru unknown
- 2006-08-03 JP JP2008526082A patent/JP2009504650A/ja active Pending
- 2006-08-03 WO PCT/US2006/030359 patent/WO2007021572A2/en active Application Filing
- 2006-08-03 EA EA200800535A patent/EA200800535A1/ru unknown
- 2006-08-07 MY MYPI20063814 patent/MY152177A/en unknown
- 2006-08-07 GT GT200600361A patent/GT200600361A/es unknown
- 2006-08-07 PE PE2006000953A patent/PE20070416A1/es not_active Application Discontinuation
- 2006-08-08 JO JO2006266A patent/JO2859B1/en active
- 2006-08-08 TW TW095128950A patent/TWI400081B/zh active
- 2006-08-08 AR ARP060103451A patent/AR055114A1/es unknown
- 2006-08-09 UY UY29736A patent/UY29736A1/es not_active Application Discontinuation
- 2006-08-09 SV SV2006002648A patent/SV2008002648A/es not_active Application Discontinuation
-
2008
- 2008-02-07 NI NI200800040A patent/NI200800040A/es unknown
- 2008-02-07 IL IL189361A patent/IL189361A/en active IP Right Grant
- 2008-02-08 EC EC2008008169A patent/ECSP088169A/es unknown
- 2008-03-06 CR CR9798A patent/CR9798A/es not_active Application Discontinuation
- 2008-03-07 ZA ZA200802184A patent/ZA200802184B/xx unknown
- 2008-03-10 NO NO20081298A patent/NO344405B1/no unknown
-
2009
- 2009-02-18 HK HK09101574.3A patent/HK1123811A1/xx not_active IP Right Cessation
-
2013
- 2013-06-06 CY CY20131100452T patent/CY1114032T1/el unknown
- 2013-06-11 HR HRP20130518TT patent/HRP20130518T1/hr unknown
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Legal Events
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FC | Refusal | ||
AE | Restoration of lapsed or forfeited application | ||
FC | Refusal |