ECSP088169A - Peptidos y compuestos que se unen a un receptor - Google Patents

Peptidos y compuestos que se unen a un receptor

Info

Publication number
ECSP088169A
ECSP088169A EC2008008169A ECSP088169A ECSP088169A EC SP088169 A ECSP088169 A EC SP088169A EC 2008008169 A EC2008008169 A EC 2008008169A EC SP088169 A ECSP088169 A EC SP088169A EC SP088169 A ECSP088169 A EC SP088169A
Authority
EC
Ecuador
Prior art keywords
compounds
peptides
join
receiver
tpo
Prior art date
Application number
EC2008008169A
Other languages
English (en)
Inventor
Brian R Macdonald
Jeffery Kenneth Weis
Edward John Yurkow
Original Assignee
Ortho Mcneil Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37734435&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP088169(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc
Publication of ECSP088169A publication Critical patent/ECSP088169A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

Se describen compuestos peptídicos que se unen y activan el receptor de trombopoyetina (c-mpl o TPO-R) o actúan de otra forma como un agonista de TPO.
EC2008008169A 2005-08-09 2008-02-08 Peptidos y compuestos que se unen a un receptor ECSP088169A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11/200,416 US7723295B2 (en) 2003-08-28 2005-08-09 Peptides and compounds that bind to a receptor

Publications (1)

Publication Number Publication Date
ECSP088169A true ECSP088169A (es) 2008-03-26

Family

ID=37734435

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2008008169A ECSP088169A (es) 2005-08-09 2008-02-08 Peptidos y compuestos que se unen a un receptor

Country Status (35)

Country Link
US (1) US7723295B2 (es)
EP (1) EP1957517B1 (es)
JP (1) JP2009504650A (es)
KR (1) KR20080048026A (es)
CN (1) CN101287749A (es)
AR (1) AR055114A1 (es)
AU (1) AU2006280230B2 (es)
BR (1) BRPI0614647A2 (es)
CA (1) CA2618958A1 (es)
CR (1) CR9798A (es)
CY (1) CY1114032T1 (es)
DK (1) DK1957517T3 (es)
EA (1) EA200800535A1 (es)
EC (1) ECSP088169A (es)
ES (1) ES2419005T3 (es)
GT (1) GT200600361A (es)
HK (1) HK1123811A1 (es)
HR (1) HRP20130518T1 (es)
IL (1) IL189361A (es)
JO (1) JO2859B1 (es)
MY (1) MY152177A (es)
NI (1) NI200800040A (es)
NO (1) NO344405B1 (es)
NZ (1) NZ565497A (es)
PE (1) PE20070416A1 (es)
PL (1) PL1957517T3 (es)
PT (1) PT1957517E (es)
RS (1) RS52802B (es)
SI (1) SI1957517T1 (es)
SV (1) SV2008002648A (es)
TW (1) TWI400081B (es)
UA (1) UA96418C2 (es)
UY (1) UY29736A1 (es)
WO (1) WO2007021572A2 (es)
ZA (1) ZA200802184B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7091311B2 (en) * 1996-06-07 2006-08-15 Smithkline Beecham Corporation Peptides and compounds that bind to a receptor
US8067367B2 (en) * 2002-09-18 2011-11-29 Janssen Pharmaceutica, N.V. Methods of increasing platelet and hematopoietic stem cell production
US20040149235A1 (en) * 2002-10-04 2004-08-05 Pogue Albert S. Apparatus and method for removal of waste from animal production facilities
US7615533B2 (en) * 2004-08-16 2009-11-10 Janssen Pharmaceutica N.V. TPO peptide compounds for treatment of anemia
US20090053242A1 (en) * 2006-01-25 2009-02-26 Amgen Inc. Thrombopoietic compounds
ES2729622T3 (es) * 2008-06-03 2019-11-05 Janssen Pharmaceutica Nv Péptido mimético de TPO para prevenir el desorden hematológico asociado al tratamiento contra el cáncer
US9295734B2 (en) 2011-06-23 2016-03-29 Shimadzu Corporation Branched amphipathic block polymer and molecular aggregate and drug delivery system using same
CA3070442A1 (en) 2017-07-26 2019-01-31 Janssen Pharmaceutica Nv Methods of protecting vascular integrity induced by targeted radiation therapy
MX2021008943A (es) 2019-01-25 2021-11-04 Janssen Pharmaceutica Nv Metodos para mitigar la lesion hepatica y promover la hipertrofia hepatica, la regeneracion e injerto celular en conjunto con tratamientos de radiacion y/o radiomimeticos.
WO2020209920A2 (en) 2019-01-25 2020-10-15 Janssen Pharmaceutica Nv Methods of mitigating toxic effects of vesicants and caustic gas
US20200237872A1 (en) 2019-01-25 2020-07-30 Janssen Pharmaceutica Nv Methods of enhancing protection against organ and vascular injury, hematopoietic recovery and survival in response to total body radiation/chemical exposure
CN118660955A (zh) 2021-10-01 2024-09-17 詹森药业有限公司 增加祖细胞生产的方法
WO2024095178A1 (en) 2022-11-01 2024-05-10 Janssen Pharmaceutica Nv Thrombopoietin mimetic for use in the treatment of acute liver failure

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5326558A (en) 1989-08-08 1994-07-05 Genetics Institute, Inc. Megakaryocytopoietic factor
IL96477A0 (en) 1989-12-01 1991-08-16 Amgen Inc Megakaryocyte production
DK167813B1 (da) 1989-12-07 1993-12-20 Carlbiotech Ltd As Pentapeptidderivat, farmaceutisk acceptable salte heraf, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende et saadant derivat
US5571508A (en) 1989-12-18 1996-11-05 Amrad Corporation Limited Method for the treatment of thrombocytopenia and pharmaceutical compositions useful therefor
IT1241395B (it) 1990-04-02 1994-01-10 Eniricerche Spa Composti immunogenici,il procedimento per la loro sintesi e loro impiego per la preparazione di vaccini antimalaria
US5141851A (en) 1990-04-18 1992-08-25 Board Of Regents, The University Of Texas System Isolated farnesyl protein transferase enzyme
US5250732A (en) 1991-07-18 1993-10-05 Genentech, Inc. Ketamine analogues for treatment of thrombocytopenia
US5270170A (en) 1991-10-16 1993-12-14 Affymax Technologies N.V. Peptide library and screening method
WO1993025221A1 (en) 1992-06-11 1993-12-23 Alkermes Controlled Therapeutics, Inc. Erythropoietin drug delivery system
ATE184882T1 (de) 1992-12-11 1999-10-15 Univ Florida Materialien und methoden zur schädlingsbekämpfung
AU8124694A (en) 1993-10-29 1995-05-22 Affymax Technologies N.V. In vitro peptide and antibody display libraries
GB2285446B (en) 1994-01-03 1999-07-28 Genentech Inc Thrombopoietin
WO1995021920A1 (en) 1994-02-14 1995-08-17 Zymogenetics, Inc. Hematopoietic protein and materials and methods for making it
WO1995021626A1 (en) 1994-02-14 1995-08-17 University Of Washington Methods for stimulating erythropoiesis using thrombopoietin
EP0668352A1 (en) 1994-02-14 1995-08-23 Kirin Brewery Company, Ltd. Protein having TPO activity
WO1995021919A2 (en) 1994-02-14 1995-08-17 Kirin Brewery Company, Limited Protein having tpo activity
KR100203824B1 (ko) 1994-03-31 1999-06-15 스티븐 엠. 오드리 거핵구 성장 및 분화를 자극하기 위한 조성물 및방법
US5571686A (en) 1994-04-14 1996-11-05 Massachusetts Institute Of Technology Method of using megapoietin for prolonging the survival & viability of platlets
WO1996017062A1 (en) 1994-11-30 1996-06-06 Zymogenetics, Inc. Low molecular weight thrombopoietin
DE69636714T2 (de) 1995-04-26 2007-10-18 Kyowa Hakko Kogyo Co., Ltd. G-CSF TPO Fusionsproteine
US5869451A (en) 1995-06-07 1999-02-09 Glaxo Group Limited Peptides and compounds that bind to a receptor
PL188795B1 (pl) 1995-06-07 2005-04-29 Glaxo Group Ltd Związek wiążący się z receptorem trombopoetyny, kompozycja farmaceutyczna i zastosowanie związku wiążącego się z receptorem trombopoetyny
US6251864B1 (en) * 1995-06-07 2001-06-26 Glaxo Group Limited Peptides and compounds that bind to a receptor
US6060052A (en) 1995-10-30 2000-05-09 Systemix, Inc. Methods for use of Mpl ligands with primitive human hematopoietic stem cells
US5932546A (en) 1996-10-04 1999-08-03 Glaxo Wellcome Inc. Peptides and compounds that bind to the thrombopoietin receptor
AU771460B2 (en) 1999-09-24 2004-03-25 Smithkline Beecham Corporation Thrombopoietin mimetics
AU2002307062A1 (en) 2001-04-02 2002-10-15 Purdue Pharma L.P. Thrombopoietin (tpo) synthebody for stimulation of platelet production
US8067367B2 (en) 2002-09-18 2011-11-29 Janssen Pharmaceutica, N.V. Methods of increasing platelet and hematopoietic stem cell production
HUE032370T2 (en) 2003-08-28 2017-09-28 Janssen Pharmaceuticals Inc Peptides and compounds that bind to thrombopoietin receptors

Also Published As

Publication number Publication date
IL189361A (en) 2015-11-30
CA2618958A1 (en) 2007-02-22
EP1957517A2 (en) 2008-08-20
KR20080048026A (ko) 2008-05-30
ZA200802184B (en) 2009-08-26
TW200744626A (en) 2007-12-16
PT1957517E (pt) 2013-05-28
HK1123811A1 (en) 2009-06-26
GT200600361A (es) 2007-03-14
WO2007021572A3 (en) 2007-06-07
CY1114032T1 (el) 2016-07-27
MY152177A (en) 2014-08-15
NI200800040A (es) 2010-11-25
BRPI0614647A2 (pt) 2011-04-12
UA96418C2 (ru) 2011-11-10
CN101287749A (zh) 2008-10-15
ES2419005T3 (es) 2013-08-19
HRP20130518T1 (hr) 2013-07-31
EP1957517B1 (en) 2013-03-20
UY29736A1 (es) 2006-12-29
PL1957517T3 (pl) 2013-08-30
RS52802B (en) 2013-10-31
SI1957517T1 (sl) 2013-07-31
IL189361A0 (en) 2008-06-05
WO2007021572A2 (en) 2007-02-22
EA200800535A1 (ru) 2008-08-29
PE20070416A1 (es) 2007-06-13
JO2859B1 (en) 2015-03-15
AU2006280230A1 (en) 2007-02-22
US7723295B2 (en) 2010-05-25
NO20081298L (no) 2008-04-23
NO344405B1 (no) 2019-12-02
AU2006280230B2 (en) 2012-11-08
CR9798A (es) 2008-09-09
NZ565497A (en) 2011-10-28
JP2009504650A (ja) 2009-02-05
AR055114A1 (es) 2007-08-08
TWI400081B (zh) 2013-07-01
SV2008002648A (es) 2008-11-28
US20060040866A1 (en) 2006-02-23
DK1957517T3 (da) 2013-04-08

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