AR055114A1 - Peptidos y compuestos que se fijan a un receptor - Google Patents

Peptidos y compuestos que se fijan a un receptor

Info

Publication number
AR055114A1
AR055114A1 ARP060103451A ARP060103451A AR055114A1 AR 055114 A1 AR055114 A1 AR 055114A1 AR P060103451 A ARP060103451 A AR P060103451A AR P060103451 A ARP060103451 A AR P060103451A AR 055114 A1 AR055114 A1 AR 055114A1
Authority
AR
Argentina
Prior art keywords
peptides
receiver
tpo
cells
compounds fixed
Prior art date
Application number
ARP060103451A
Other languages
English (en)
Original Assignee
Ortho Mcneil Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37734435&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR055114(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc
Publication of AR055114A1 publication Critical patent/AR055114A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

Compuestos peptídicos que se unen y activan el receptor de trombopoyetina (c-mpl o TPO-R) o de otro modo actuan como agonista de TPO. Reivindicacion 1: Un compuesto que se une a un receptor de trombopoyetina, donde dicho compuesto comprende (H- IEGPTLRQ(2-Nal) LAARX10)2K-NH2, donde X10 se selecciona del grupo integrado por sarcosina o beta-alanina. Reivindicacion 17: Un método de acuerdo con la reivindicacion 15 donde dichas células comprenden células dependientes de TPO. Reivindicacion 20: Un método de acuerdo con la reivindicacion 19 donde dicha poblacion de células se obtiene antes de dicha quimioterapia.
ARP060103451A 2005-08-09 2006-08-08 Peptidos y compuestos que se fijan a un receptor AR055114A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11/200,416 US7723295B2 (en) 2003-08-28 2005-08-09 Peptides and compounds that bind to a receptor

Publications (1)

Publication Number Publication Date
AR055114A1 true AR055114A1 (es) 2007-08-08

Family

ID=37734435

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060103451A AR055114A1 (es) 2005-08-09 2006-08-08 Peptidos y compuestos que se fijan a un receptor

Country Status (35)

Country Link
US (1) US7723295B2 (es)
EP (1) EP1957517B1 (es)
JP (1) JP2009504650A (es)
KR (1) KR20080048026A (es)
CN (1) CN101287749A (es)
AR (1) AR055114A1 (es)
AU (1) AU2006280230B2 (es)
BR (1) BRPI0614647A2 (es)
CA (1) CA2618958A1 (es)
CR (1) CR9798A (es)
CY (1) CY1114032T1 (es)
DK (1) DK1957517T3 (es)
EA (1) EA200800535A1 (es)
EC (1) ECSP088169A (es)
ES (1) ES2419005T3 (es)
GT (1) GT200600361A (es)
HK (1) HK1123811A1 (es)
HR (1) HRP20130518T1 (es)
IL (1) IL189361A (es)
JO (1) JO2859B1 (es)
MY (1) MY152177A (es)
NI (1) NI200800040A (es)
NO (1) NO344405B1 (es)
NZ (1) NZ565497A (es)
PE (1) PE20070416A1 (es)
PL (1) PL1957517T3 (es)
PT (1) PT1957517E (es)
RS (1) RS52802B (es)
SI (1) SI1957517T1 (es)
SV (1) SV2008002648A (es)
TW (1) TWI400081B (es)
UA (1) UA96418C2 (es)
UY (1) UY29736A1 (es)
WO (1) WO2007021572A2 (es)
ZA (1) ZA200802184B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7091311B2 (en) * 1996-06-07 2006-08-15 Smithkline Beecham Corporation Peptides and compounds that bind to a receptor
DK1542714T3 (da) * 2002-09-18 2014-05-26 Janssen Pharmaceuticals Inc Fremgangsmåder til forøgelse af produktion af blodplader og hæmatopoietiske stamceller
US20040149235A1 (en) * 2002-10-04 2004-08-05 Pogue Albert S. Apparatus and method for removal of waste from animal production facilities
US7615533B2 (en) * 2004-08-16 2009-11-10 Janssen Pharmaceutica N.V. TPO peptide compounds for treatment of anemia
US20090053242A1 (en) * 2006-01-25 2009-02-26 Amgen Inc. Thrombopoietic compounds
MX2010013281A (es) * 2008-06-03 2010-12-21 Janssen Pharmaceutica Nv Peptido mimetico de trombopoyetina para prevenir trastornos hematologicos asociados con el tratamiento del cancer.
CN103635514B (zh) 2011-06-23 2016-01-20 株式会社岛津制作所 支链型两亲性嵌段聚合物、使用其的分子聚集体及药物输送系统
CA3070442A1 (en) 2017-07-26 2019-01-31 Janssen Pharmaceutica Nv Methods of protecting vascular integrity induced by targeted radiation therapy
CN113905754A (zh) 2019-01-25 2022-01-07 詹森药业有限公司 减轻起疱剂和腐蚀性气体毒性作用的方法
US20200237872A1 (en) 2019-01-25 2020-07-30 Janssen Pharmaceutica Nv Methods of enhancing protection against organ and vascular injury, hematopoietic recovery and survival in response to total body radiation/chemical exposure
CN113766926A (zh) 2019-01-25 2021-12-07 詹森药业有限公司 与放射和/或放射模拟物治疗结合的减轻肝损伤和促进肝肥大、再生和细胞植入的方法
IL311797A (en) 2021-10-01 2024-05-01 Albert Einstein College Of Medicine Methods for increasing stem cell production
WO2024095178A1 (en) 2022-11-01 2024-05-10 Janssen Pharmaceutica Nv Thrombopoietin mimetic for use in the treatment of acute liver failure

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5326558A (en) 1989-08-08 1994-07-05 Genetics Institute, Inc. Megakaryocytopoietic factor
IL96477A0 (en) 1989-12-01 1991-08-16 Amgen Inc Megakaryocyte production
DK167813B1 (da) 1989-12-07 1993-12-20 Carlbiotech Ltd As Pentapeptidderivat, farmaceutisk acceptable salte heraf, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende et saadant derivat
US5571508A (en) 1989-12-18 1996-11-05 Amrad Corporation Limited Method for the treatment of thrombocytopenia and pharmaceutical compositions useful therefor
IT1241395B (it) 1990-04-02 1994-01-10 Eniricerche Spa Composti immunogenici,il procedimento per la loro sintesi e loro impiego per la preparazione di vaccini antimalaria
US5141851A (en) 1990-04-18 1992-08-25 Board Of Regents, The University Of Texas System Isolated farnesyl protein transferase enzyme
US5250732A (en) 1991-07-18 1993-10-05 Genentech, Inc. Ketamine analogues for treatment of thrombocytopenia
US5270170A (en) 1991-10-16 1993-12-14 Affymax Technologies N.V. Peptide library and screening method
ES2181691T5 (es) 1992-06-11 2007-10-01 Alkermes Controlled Therapeutics, Inc. Sistema de distribucion de proteina eritropoyetina.
US5358934A (en) 1992-12-11 1994-10-25 The United States Of America As Represented By The Secretary Of Agriculture Materials and methods for control of pests
WO1995011922A1 (en) 1993-10-29 1995-05-04 Affymax Technologies N.V. In vitro peptide and antibody display libraries
SG47030A1 (en) 1994-01-03 1998-03-20 Genentech Inc Thrombopoietin
CA2169173C (en) 1994-02-14 2002-10-15 Kenneth Kaushansky Methods for stimulating erythropoiesis using thrombopoietin
WO1995021919A2 (en) 1994-02-14 1995-08-17 Kirin Brewery Company, Limited Protein having tpo activity
SG79882A1 (en) 1994-02-14 2001-04-17 Kirin Brewery Protein having tpo activity
PL178384B1 (pl) 1994-02-14 2000-04-28 Univ Washington Wydzielone białko, wydzielone cząsteczki polinukleotydowe, wektor ekspresji, hodowana komórka, kompozycja farmaceutyczna do stymulacji wytwarzania płytek krwi u ssaka, sposób wytwarzania białka homeopoezyjnego, sposób otrzymywania przeciwciał, sposób stymulacji i namnażania komórek
WO1995026746A1 (en) 1994-03-31 1995-10-12 Amgen Inc. Compositions and methods for stimulating megakaryocyte growth and differentiation
US5571686A (en) 1994-04-14 1996-11-05 Massachusetts Institute Of Technology Method of using megapoietin for prolonging the survival & viability of platlets
WO1996017062A1 (en) 1994-11-30 1996-06-06 Zymogenetics, Inc. Low molecular weight thrombopoietin
DE69636714T2 (de) 1995-04-26 2007-10-18 Kyowa Hakko Kogyo Co., Ltd. G-CSF TPO Fusionsproteine
US5869451A (en) 1995-06-07 1999-02-09 Glaxo Group Limited Peptides and compounds that bind to a receptor
EP1961760A3 (en) 1995-06-07 2008-09-03 Glaxo Group Limited Peptides and compounds that bind to a thrombopoietin receptor
US6251864B1 (en) * 1995-06-07 2001-06-26 Glaxo Group Limited Peptides and compounds that bind to a receptor
US6060052A (en) 1995-10-30 2000-05-09 Systemix, Inc. Methods for use of Mpl ligands with primitive human hematopoietic stem cells
US5932546A (en) 1996-10-04 1999-08-03 Glaxo Wellcome Inc. Peptides and compounds that bind to the thrombopoietin receptor
JP2003509462A (ja) 1999-09-24 2003-03-11 スミスクライン・ビーチャム・コーポレイション トロンボポイエチン模倣物
WO2002078612A2 (en) 2001-04-02 2002-10-10 Euro-Celtique S.A. Thrombopoietin (tpo) synthebody for stimulation of platelet production
DK1542714T3 (da) 2002-09-18 2014-05-26 Janssen Pharmaceuticals Inc Fremgangsmåder til forøgelse af produktion af blodplader og hæmatopoietiske stamceller
CN102241742B (zh) 2003-08-28 2014-04-02 奥索-麦克尼尔药品公司 结合血小板生成素受体的肽和化合物

Also Published As

Publication number Publication date
ZA200802184B (en) 2009-08-26
SI1957517T1 (sl) 2013-07-31
UA96418C2 (ru) 2011-11-10
JO2859B1 (en) 2015-03-15
PL1957517T3 (pl) 2013-08-30
NZ565497A (en) 2011-10-28
PE20070416A1 (es) 2007-06-13
NI200800040A (es) 2010-11-25
RS52802B (en) 2013-10-31
CY1114032T1 (el) 2016-07-27
CN101287749A (zh) 2008-10-15
CR9798A (es) 2008-09-09
CA2618958A1 (en) 2007-02-22
DK1957517T3 (da) 2013-04-08
US7723295B2 (en) 2010-05-25
EP1957517B1 (en) 2013-03-20
MY152177A (en) 2014-08-15
TW200744626A (en) 2007-12-16
GT200600361A (es) 2007-03-14
AU2006280230A1 (en) 2007-02-22
AU2006280230B2 (en) 2012-11-08
HRP20130518T1 (hr) 2013-07-31
KR20080048026A (ko) 2008-05-30
HK1123811A1 (en) 2009-06-26
WO2007021572A3 (en) 2007-06-07
TWI400081B (zh) 2013-07-01
ECSP088169A (es) 2008-03-26
NO344405B1 (no) 2019-12-02
EA200800535A1 (ru) 2008-08-29
IL189361A (en) 2015-11-30
US20060040866A1 (en) 2006-02-23
EP1957517A2 (en) 2008-08-20
SV2008002648A (es) 2008-11-28
UY29736A1 (es) 2006-12-29
BRPI0614647A2 (pt) 2011-04-12
PT1957517E (pt) 2013-05-28
NO20081298L (no) 2008-04-23
JP2009504650A (ja) 2009-02-05
ES2419005T3 (es) 2013-08-19
WO2007021572A2 (en) 2007-02-22
IL189361A0 (en) 2008-06-05

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