NL1031539C2 - Bicyclische [3.1.0] heteroarylamiden als type 1 glycinetransportremmers. - Google Patents

Bicyclische [3.1.0] heteroarylamiden als type 1 glycinetransportremmers. Download PDF

Info

Publication number
NL1031539C2
NL1031539C2 NL1031539A NL1031539A NL1031539C2 NL 1031539 C2 NL1031539 C2 NL 1031539C2 NL 1031539 A NL1031539 A NL 1031539A NL 1031539 A NL1031539 A NL 1031539A NL 1031539 C2 NL1031539 C2 NL 1031539C2
Authority
NL
Netherlands
Prior art keywords
heteroarylamides
bicyclic
type
transport inhibitors
glycine transport
Prior art date
Application number
NL1031539A
Other languages
English (en)
Other versions
NL1031539A1 (nl
Inventor
Stanton Furst Mchardy
John Adams Lowe Iii
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of NL1031539A1 publication Critical patent/NL1031539A1/nl
Application granted granted Critical
Publication of NL1031539C2 publication Critical patent/NL1031539C2/nl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41781,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
NL1031539A 2005-04-08 2006-04-07 Bicyclische [3.1.0] heteroarylamiden als type 1 glycinetransportremmers. NL1031539C2 (nl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US66947205P 2005-04-08 2005-04-08

Publications (2)

Publication Number Publication Date
NL1031539A1 NL1031539A1 (nl) 2006-10-10
NL1031539C2 true NL1031539C2 (nl) 2007-04-10

Family

ID=36649611

Family Applications (1)

Application Number Title Priority Date Filing Date
NL1031539A NL1031539C2 (nl) 2005-04-08 2006-04-07 Bicyclische [3.1.0] heteroarylamiden als type 1 glycinetransportremmers.

Country Status (31)

Country Link
US (2) US20060229455A1 (nl)
EP (1) EP1869019B1 (nl)
JP (1) JP4193949B2 (nl)
KR (1) KR100969402B1 (nl)
CN (1) CN101189228A (nl)
AP (1) AP2007004198A0 (nl)
AR (1) AR056307A1 (nl)
AU (1) AU2006231917B2 (nl)
BR (1) BRPI0608148A2 (nl)
CA (1) CA2603939C (nl)
CR (1) CR9493A (nl)
DK (1) DK1869019T3 (nl)
DO (1) DOP2006000078A (nl)
EA (1) EA014311B1 (nl)
ES (1) ES2520015T3 (nl)
GE (1) GEP20105053B (nl)
GT (1) GT200600136A (nl)
HN (1) HN2006013804A (nl)
IL (1) IL186409A (nl)
MA (1) MA29672B1 (nl)
MX (1) MX2007012463A (nl)
NL (1) NL1031539C2 (nl)
NO (1) NO339422B1 (nl)
NZ (1) NZ563238A (nl)
PE (1) PE20061400A1 (nl)
TN (1) TNSN07380A1 (nl)
TW (1) TW200719890A (nl)
UA (1) UA88518C2 (nl)
UY (1) UY29456A1 (nl)
WO (1) WO2006106425A1 (nl)
ZA (1) ZA200708481B (nl)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008065500A2 (en) * 2006-11-30 2008-06-05 Pfizer Products Inc. Heteroaryl amides as type i glycine transport inhibitors
US20090270398A1 (en) * 2008-04-21 2009-10-29 Institute For Oneworld Health Compounds, Compositions and Methods Comprising Pyridazine Derivatives
WO2009131957A2 (en) 2008-04-21 2009-10-29 Institute For Oneworld Health Compounds, compositions and methods comprising oxadiazole derivatives
US20090264433A1 (en) * 2008-04-21 2009-10-22 Institute For Oneworld Health Compounds, Compositions and Methods Comprising Triazine Derivatives
FR2932479A1 (fr) * 2008-06-13 2009-12-18 Servier Lab Nouveaux derives azabicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
WO2010025890A1 (en) * 2008-09-02 2010-03-11 Ortho-Mcneil-Janssen Pharmaceuticals, Inc 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors
JP2012503005A (ja) * 2008-09-19 2012-02-02 インスティテュート フォア ワンワールド ヘルス イミダゾール誘導体およびトリアゾール誘導体を含む、化合物、組成物ならびに方法。
US8642772B2 (en) * 2008-10-14 2014-02-04 Sk Biopharmaceuticals Co., Ltd. Piperidine compounds, pharmaceutical composition comprising the same and its use
EP2409976A4 (en) * 2009-03-19 2012-09-19 Taisho Pharmaceutical Co Ltd GLYCINTRANSPORTERHEMMER
US8343976B2 (en) 2009-04-20 2013-01-01 Institute For Oneworld Health Compounds, compositions and methods comprising pyrazole derivatives
US20100267706A1 (en) * 2009-04-20 2010-10-21 Institute For Oneworld Health Compounds, Compositions and Methods Comprising Pyridazine Derivatives
US8232315B2 (en) 2009-06-26 2012-07-31 Sk Biopharmaceuticals Co., Ltd. Methods for treating drug addiction and improving addiction-related behavior
AR077472A1 (es) * 2009-07-15 2011-08-31 Taisho Pharmaceutical Co Ltd Inhibidores de transportador de glicina
MX2012005258A (es) 2009-11-06 2012-06-19 Sk Biopharmaceuticals Co Ltd El uso de un compuesto de carbamoilo para el tratamiento del trastorno de deficit de atencion/hiperactividad.
AU2010316172B2 (en) 2009-11-06 2015-11-12 Sk Biopharmaceuticals Co., Ltd. Methods for treating fibromyalgia syndrome
US9610274B2 (en) 2010-06-30 2017-04-04 Sk Biopharmaceuticals Co., Ltd. Methods for treating bipolar disorder
US8623913B2 (en) 2010-06-30 2014-01-07 Sk Biopharmaceuticals Co., Ltd. Methods for treating restless legs syndrome
US20120035156A1 (en) * 2010-08-09 2012-02-09 Daniela Alberati Combination of glyt1 compound with antipsychotics
JP2013249257A (ja) * 2010-09-16 2013-12-12 Taisho Pharmaceutical Co Ltd グリシントランスポーター阻害物質
JP2013249258A (ja) * 2010-09-17 2013-12-12 Taisho Pharmaceutical Co Ltd グリシントランスポーター阻害物質
JPWO2012036278A1 (ja) 2010-09-17 2014-02-03 大正製薬株式会社 グリシントランスポーター阻害物質
JP2013542929A (ja) 2010-09-28 2013-11-28 パナセア バイオテック リミテッド 新規ビシクロ環化合物
ES2644758T3 (es) * 2012-10-16 2017-11-30 Tolero Pharmaceuticals, Inc. Moduladores de PKM2 y métodos para su uso
JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神分裂病を処置するための方法および組成物
MA39888A (fr) 2014-04-24 2017-03-01 Dart Neuroscience Cayman Ltd Composés de 2,4,5,6-tétrahydropyrrolo[3,4-c] pyrazole et 4,5,6,7-tétrahydro-2 h-pyrazolo [4,3-c] pyridine utilisés comme inhibiteurs de glyt1
WO2016073420A1 (en) 2014-11-05 2016-05-12 Dart Neuroscience, Llc Substituted azetidinyl compounds as glyt1 inhibitors
AU2018378348A1 (en) 2017-12-05 2020-06-18 Sunovion Pharmaceuticals Inc. Crystal forms and production methods thereof
WO2019113079A1 (en) 2017-12-05 2019-06-13 Sunovion Pharmaceuticals Inc. Nonracemic mixtures and uses thereof
CA3133460A1 (en) 2019-03-22 2020-10-01 Sumitomo Dainippon Pharma Oncology, Inc. Compositions comprising pkm2 modulators and methods of treatment using the same
MX2021014441A (es) 2019-05-31 2022-01-06 Ikena Oncology Inc Inhibidores del dominio asociado mejorador de la transcripcion (tead) y usos de los mismos.
BR112021024108A2 (pt) 2019-05-31 2022-03-22 Ikena Oncology Inc Inibidores de tead e usos dos mesmos
CA3142355A1 (en) 2019-06-04 2020-12-10 Sunovion Pharmaceuticals Inc. Modified release formulations and uses thereof
WO2021142329A1 (en) * 2020-01-09 2021-07-15 Disc Medicine, Inc. Methods of treating erythropoietic protoporphyria, x-linked protoporphyria, or congenital erythropoietic porphyria with glycine transport inhibitors

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2322136A1 (en) 1998-03-06 1999-09-10 Ludo Edmond Josephine Kennis Glycine transport inhibitors
JP2002212179A (ja) 2001-01-15 2002-07-31 Wakunaga Pharmaceut Co Ltd 新規アニリド誘導体又はその塩及びこれを含有する医薬
CA2468761A1 (en) 2001-10-31 2003-05-08 Morphochem Aktiengesellschaft Fuer Kombinatorische Chemie Novel anticancer compounds
FR2838739B1 (fr) 2002-04-19 2004-05-28 Sanofi Synthelabo Derives de n-[phenyl(piperidin-2-yl)methyl)benzamide, leur preparation et leur application en therapeutique
US7160888B2 (en) * 2003-08-22 2007-01-09 Warner Lambert Company Llc [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia
WO2005037216A2 (en) * 2003-10-14 2005-04-28 Pfizer Products Inc. Bicyclic [3.1.0] derivatives as glycine transporter inhibitors
CN106434833A (zh) 2004-05-23 2017-02-22 杰勒德·M·豪斯 Theramutein调节剂

Also Published As

Publication number Publication date
MA29672B1 (fr) 2008-08-01
IL186409A0 (en) 2008-01-20
UY29456A1 (es) 2006-11-30
MX2007012463A (es) 2007-11-07
CA2603939C (en) 2013-08-27
AU2006231917B2 (en) 2011-07-28
EA014311B1 (ru) 2010-10-29
TW200719890A (en) 2007-06-01
DOP2006000078A (es) 2006-10-15
CN101189228A (zh) 2008-05-28
DK1869019T3 (da) 2014-10-06
AR056307A1 (es) 2007-10-03
US8124639B2 (en) 2012-02-28
CR9493A (es) 2007-12-04
ZA200708481B (en) 2010-05-26
JP4193949B2 (ja) 2008-12-10
KR100969402B1 (ko) 2010-07-14
NZ563238A (en) 2011-01-28
EP1869019A1 (en) 2007-12-26
US20100324020A1 (en) 2010-12-23
GEP20105053B (en) 2010-07-26
UA88518C2 (ru) 2009-10-26
CA2603939A1 (en) 2006-10-12
KR20070120582A (ko) 2007-12-24
BRPI0608148A2 (pt) 2009-11-10
NO20074993L (no) 2007-11-02
NO339422B1 (no) 2016-12-12
EA200701902A1 (ru) 2008-04-28
AU2006231917A1 (en) 2006-10-12
AP2007004198A0 (en) 2007-10-31
WO2006106425A1 (en) 2006-10-12
HN2006013804A (es) 2009-10-30
IL186409A (en) 2012-07-31
JP2008534671A (ja) 2008-08-28
NL1031539A1 (nl) 2006-10-10
PE20061400A1 (es) 2007-01-15
EP1869019B1 (en) 2014-08-27
TNSN07380A1 (fr) 2009-03-17
GT200600136A (es) 2006-11-07
ES2520015T3 (es) 2014-11-11
US20060229455A1 (en) 2006-10-12

Similar Documents

Publication Publication Date Title
NL1031539C2 (nl) Bicyclische [3.1.0] heteroarylamiden als type 1 glycinetransportremmers.
FIC20230027I1 (fi) Tremelimumabi
NL300935I2 (nl) guselkumab.
CY2016009I1 (el) Ενωσεις για την αναστολη του ενζυμου πρωτεασωματος
NL1031385A1 (nl) Gesubstitueerde sulfonylaminoarylmethylcyclopropaancarbonamideverbindingen.
NO20051199L (no) Rorhandteringsutstyr.
NL1031335A1 (nl) Gesubstitueerde N-sulfonylaminofenylethyl-2-fenoxyaceetamideverbindingen.
ITMO20050009A1 (it) Apparato di serraggio.
NL1030382A1 (nl) Gesubstitueerde N-sulfonylaminobenzyl-2-fenoxyaceetamide verbindingen.
NO20053362D0 (no) Syklofuge.
DK1968623T3 (da) Bacteriocin-inducer-peptider
ATE421499T1 (de) Inhibitoren des glycintransports
NL1031705A1 (nl) Aminozuurderivaten.
DE502005002052D1 (de) Transportvorrichtung
NL1028090A1 (nl) Aanvoertransporteur.
ITMO20050280A1 (it) Apparato pulitore
ES1059948Y (es) Transportador de bisectrices.
ES1057865Y (es) Desatascador de desagues.
ITMO20050300A1 (it) Elettrotermopergamena -- e.t.p.
ITVE20050001U1 (it) Borraccia.
ES1061002Y (es) Contenedor armable.
CL2007003633S1 (es) Envase.
ES1057412Y (es) Taburete-contenedor de residuos.
FI20045383A (fi) Kuljetusväline
FI6779U1 (fi) Halkaisulaite

Legal Events

Date Code Title Description
AD1A A request for search or an international type search has been filed
RD2N Patents in respect of which a decision has been taken or a report has been made (novelty report)

Effective date: 20061206

PD2B A search report has been drawn up
V1 Lapsed because of non-payment of the annual fee

Effective date: 20101101