MA39888A - Composés de 2,4,5,6-tétrahydropyrrolo[3,4-c] pyrazole et 4,5,6,7-tétrahydro-2 h-pyrazolo [4,3-c] pyridine utilisés comme inhibiteurs de glyt1 - Google Patents

Composés de 2,4,5,6-tétrahydropyrrolo[3,4-c] pyrazole et 4,5,6,7-tétrahydro-2 h-pyrazolo [4,3-c] pyridine utilisés comme inhibiteurs de glyt1

Info

Publication number
MA39888A
MA39888A MA039888A MA39888A MA39888A MA 39888 A MA39888 A MA 39888A MA 039888 A MA039888 A MA 039888A MA 39888 A MA39888 A MA 39888A MA 39888 A MA39888 A MA 39888A
Authority
MA
Morocco
Prior art keywords
tetrahydropyrrolo
pyrazolo
pyrazole
tetrahydro
substituted
Prior art date
Application number
MA039888A
Other languages
English (en)
Inventor
Jillian Basinger
Brett Bookser
Mi Chen
Demichael Chung
Varsha Gupta
Andrew Hudson
Alan Kaplan
James Na
Joel Renick
Vincent Santora
Original Assignee
Dart Neuroscience Cayman Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dart Neuroscience Cayman Ltd filed Critical Dart Neuroscience Cayman Ltd
Publication of MA39888A publication Critical patent/MA39888A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Abstract

L'invention concerne une entité chimique de formule (i), dans laquelle r
MA039888A 2014-04-24 2015-04-22 Composés de 2,4,5,6-tétrahydropyrrolo[3,4-c] pyrazole et 4,5,6,7-tétrahydro-2 h-pyrazolo [4,3-c] pyridine utilisés comme inhibiteurs de glyt1 MA39888A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201461983821P 2014-04-24 2014-04-24

Publications (1)

Publication Number Publication Date
MA39888A true MA39888A (fr) 2017-03-01

Family

ID=53373533

Family Applications (1)

Application Number Title Priority Date Filing Date
MA039888A MA39888A (fr) 2014-04-24 2015-04-22 Composés de 2,4,5,6-tétrahydropyrrolo[3,4-c] pyrazole et 4,5,6,7-tétrahydro-2 h-pyrazolo [4,3-c] pyridine utilisés comme inhibiteurs de glyt1

Country Status (5)

Country Link
US (1) US9708334B2 (fr)
EP (1) EP3134406A1 (fr)
MA (1) MA39888A (fr)
TW (1) TW201625608A (fr)
WO (1) WO2015164520A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3215500A1 (fr) 2014-11-05 2017-09-13 Dart NeuroScience (Cayman) Ltd. Composés azétidinyles substitués utilisés comme inhibiteurs de glyt1
US10383335B2 (en) 2015-04-09 2019-08-20 Fmc Corporation Bicyclic pyrazole pesticides
CN110551123A (zh) * 2019-07-23 2019-12-10 常州合全药业有限公司 一种5-(叔丁氧羰基)-2-甲基-4,5,6,7-四氢-2h-吡唑并[4,3-c]吡啶-7-羧酸的制备方法
MX2022008665A (es) * 2020-01-13 2022-08-10 Aptabio Therapeutics Inc Nuevo derivado de pirazol.

Family Cites Families (25)

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US4938949A (en) 1988-09-12 1990-07-03 University Of New York Treatment of damaged bone marrow and dosage units therefor
US9931318B2 (en) 2003-04-08 2018-04-03 Dart Neuroscience (Cayman) Ltd. Phosphodiesterase 4 inhibitors for cognitive and motor rehabilitation
AU2001284792A1 (en) 2000-08-10 2002-02-25 Cold Spring Harbor Laboratory Augmented cognitive training
US7868015B2 (en) 2000-08-10 2011-01-11 Cold Spring Harbor Laboratory Phosphodiesesterase 4 inhibitors for the treatment of a cognitive deficit
DE60206454T2 (de) 2001-08-16 2006-06-29 Pfizer Products Inc., Groton Difluormethylen aromatische Ether und ihre Verwendung als Inhibitoren des Glycin-Typ-1-Transporters
BR0312913A (pt) * 2002-07-25 2005-07-12 Pharmacia Italia Spa Ativo de biciclo-pirazóis como inibidores de cinase, processo para sua preparação e composições farmacêuticas compreendendo o mesmo
PE20040804A1 (es) * 2002-12-19 2004-12-31 Boehringer Ingelheim Pharma DERIVADOS DE CARBOXAMIDAS COMO INHIBIDORES DEL FACTOR Xa
CA2534675C (fr) 2003-08-11 2013-07-23 F. Hoffmann-La Roche Ag Piperazine avec groupe phenyle substitue de type or et leur utilisation comme inhibiteurs de glyt1
MXPA06002672A (es) 2003-09-09 2006-06-06 Hoffmann La Roche Derivados de 1-benzoil-piperazina como inhibidores de absorcion de glicina para el tratamiento de psicosis.
DE602004009323T2 (de) 2003-09-09 2008-07-10 F. Hoffmann-La Roche Ag 1-(2-amino-benzoyl)-piperazin-derivate als glycin-aufnahmehemmer zur behandlung von psychosen
DE602004010419T2 (de) 2003-10-23 2008-10-09 F. Hoffmann-La Roche Ag Triazaspiropiperidinderivate zur verwendung als glyt-1-inhibitoren bei der behandlung von neurologischen und neuropsychiatrischen erkrankungen
CA2544981A1 (fr) 2003-11-12 2005-05-26 Merck & Co., Inc. Inhibiteurs du transporteur de 4-phenyl piperidine sulfonyl glycine
RU2387644C2 (ru) 2004-09-30 2010-04-27 Мерк Энд Ко., Инк. Циклопропилпиперидиновые ингибиторы транспортера глицина
JP5006799B2 (ja) 2005-01-07 2012-08-22 エフ．ホフマン−ラ ロシュ アーゲー 神経疾患及び精神神経疾患の処置用のグリシントランスポーター１（ｇｌｙｔ−１）阻害剤としての［４−（ヘテロアリール）ピペラジン−１−イル］−（２，５−置換フェニル）−メタノン誘導体
GB0505086D0 (en) 2005-03-11 2005-04-20 Glaxo Group Ltd Compounds
UA88518C2 (ru) 2005-04-08 2009-10-26 Пфайзер Продактс Инк. Бицикло[3,1,0]гетероариламиды как ингибиторы транспорта глицина типа i
CA2609969C (fr) 2005-06-06 2015-10-27 Merck Sharp & Dohme Limited Derives de cyclohexanesulfonyle en tant qu'inhibiteurs de glyt1 pour traiter la schizophrenie
JP4937347B2 (ja) 2006-06-22 2012-05-23 エフ．ホフマン−ラ ロシュ アーゲー 置換フェニルメタノン誘導体
EP2947067A1 (fr) 2006-06-28 2015-11-25 Amgen, Inc Inhibiteurs du transporteur 1 de la glycine
ES2392105T3 (es) 2006-08-30 2012-12-04 F. Hoffmann-La Roche Ag Inhibidores de GlyT-1
US7943617B2 (en) * 2006-11-27 2011-05-17 Bristol-Myers Squibb Company Heterobicyclic compounds useful as kinase inhibitors
US20090053140A1 (en) 2007-05-15 2009-02-26 Roderick Euan Milne Scott METHODS OF IDENTIFYING GENES INVOLVED IN MEMORY FORMATION USING SMALL INTERFERING RNA(siRNA)
GB0813694D0 (en) 2008-07-25 2008-09-03 Glaxo Group Ltd Compounds
JP5957525B2 (ja) * 2011-09-16 2016-07-27 サノフイ 置換された、４，５，６，７−テトラヒドロ−１Ｈ−ピラゾロ［４，３−ｃ］ピリジン、医薬としてのそれらの使用、及びそれらを含む医薬製剤
BR112014006180A2 (pt) * 2011-09-16 2017-04-11 Sanofi Sa 4, 5, 6, 7-tetraidro-1h-pirazol [4, 3-c] piridinas substituídas, seu uso como medicamento e preparações farmacêuticas que compreendem as mesmas

Also Published As

Publication number Publication date
TW201625608A (zh) 2016-07-16
EP3134406A1 (fr) 2017-03-01
WO2015164520A4 (fr) 2015-12-17
US9708334B2 (en) 2017-07-18
US20170044167A1 (en) 2017-02-16
WO2015164520A1 (fr) 2015-10-29

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