HK1248686A1 - 適用於治療癌症的1-(環)烷基吡啶-2-酮的三環稠合衍生物 - Google Patents
適用於治療癌症的1-(環)烷基吡啶-2-酮的三環稠合衍生物Info
- Publication number
- HK1248686A1 HK1248686A1 HK18108222.3A HK18108222A HK1248686A1 HK 1248686 A1 HK1248686 A1 HK 1248686A1 HK 18108222 A HK18108222 A HK 18108222A HK 1248686 A1 HK1248686 A1 HK 1248686A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- cyclo
- cancer
- useful
- treatment
- tricyclic fused
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1636CH2015 | 2015-03-30 | ||
| PCT/IN2016/050098 WO2016157221A1 (en) | 2015-03-30 | 2016-03-30 | Tricyclic fused derivatives of 1-(cyclo)alkyl pyridin-2-one useful for the treatment of cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1248686A1 true HK1248686A1 (zh) | 2018-10-19 |
Family
ID=56015058
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK18108222.3A HK1248686A1 (zh) | 2015-03-30 | 2018-06-26 | 適用於治療癌症的1-(環)烷基吡啶-2-酮的三環稠合衍生物 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US10689390B2 (zh) |
| EP (1) | EP3277683B1 (zh) |
| JP (1) | JP6764877B2 (zh) |
| KR (1) | KR102588109B1 (zh) |
| CN (1) | CN107548393B (zh) |
| AU (1) | AU2016242473B2 (zh) |
| BR (1) | BR112017020739B1 (zh) |
| CA (1) | CA2980266A1 (zh) |
| DK (1) | DK3277683T3 (zh) |
| ES (1) | ES2911886T3 (zh) |
| HK (1) | HK1248686A1 (zh) |
| IL (1) | IL254528B (zh) |
| MX (1) | MX2017012387A (zh) |
| PL (1) | PL3277683T3 (zh) |
| PT (1) | PT3277683T (zh) |
| RU (1) | RU2721120C2 (zh) |
| WO (1) | WO2016157221A1 (zh) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2016319638B2 (en) * | 2015-09-09 | 2021-02-11 | Jubilant Biosys Limited | Tricyclic fused pyridin-2-one derivatives and their use as BRD4 inhibitors |
| CN108069976A (zh) * | 2016-11-10 | 2018-05-25 | 山东罗欣药业集团股份有限公司 | 一种含氮大环类化合物、其制备方法、药物组合物及应用 |
| WO2019214399A1 (zh) * | 2018-05-10 | 2019-11-14 | 罗欣药业(上海)有限公司 | 苯并七元杂环类化合物、其制备方法、药物组合物及应用 |
| CN110172068A (zh) * | 2019-06-05 | 2019-08-27 | 河南龙湖生物技术有限公司 | 具有抗肿瘤活性的苯并噻唑类化合物及其制备方法和应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1545767A (en) * | 1976-06-30 | 1979-05-16 | Aspro Nicholas Ltd | Isoquinoline derivatives |
| TW200904403A (en) | 2007-04-25 | 2009-02-01 | Daiichi Sankyo Co Ltd | Tricyclic aryl compounds |
| CL2009000780A1 (es) | 2008-03-31 | 2010-01-15 | Genentech Inc | Compuestos derivados de heterociclil-pirano-heterociclilo, heterociclil-oxepina-heterociclilo, benzopirano-heterociclilo y benzoxepina-heterociclilo sustituidos; composicion farmaceutica; procedimiento de preparacion de la composicion; kit farmaceutico; y su uso en el tratamiento del cancer, mediado por la inhibicion de pi3k. |
| ES2526671T3 (es) | 2010-06-22 | 2015-01-14 | Glaxosmithkline Llc | Compuestos de benzotriazoldiazepina inhibidores de bromodominios |
| AR084070A1 (es) * | 2010-12-02 | 2013-04-17 | Constellation Pharmaceuticals Inc | Inhibidores del bromodominio y usos de los mismos |
| KR20150119926A (ko) * | 2013-02-19 | 2015-10-26 | 바이엘 파마 악티엔게젤샤프트 | 비시클로 2,3-벤조디아제핀 및 스피로시클릭 치환된 2,3-벤조디아제핀 |
| CN105026403B (zh) | 2013-03-12 | 2018-05-18 | 艾伯维公司 | 四环布罗莫结构域抑制剂 |
| WO2015018520A1 (en) | 2013-08-06 | 2015-02-12 | Oncoethix Sa | A bet-brd inhibitor represents a novel agent for alk positive anaplastic large cell lymphoma |
| US9814728B2 (en) | 2013-09-20 | 2017-11-14 | Saint Louis University | Inhibition of DUX4 expression using bromodomain and extra-terminal domain protein inhibitors (BETi) |
-
2016
- 2016-03-30 CN CN201680020269.3A patent/CN107548393B/zh active Active
- 2016-03-30 CA CA2980266A patent/CA2980266A1/en active Pending
- 2016-03-30 DK DK16723536.5T patent/DK3277683T3/da active
- 2016-03-30 EP EP16723536.5A patent/EP3277683B1/en active Active
- 2016-03-30 ES ES16723536T patent/ES2911886T3/es active Active
- 2016-03-30 US US15/562,381 patent/US10689390B2/en active Active
- 2016-03-30 BR BR112017020739-7A patent/BR112017020739B1/pt active IP Right Grant
- 2016-03-30 PT PT167235365T patent/PT3277683T/pt unknown
- 2016-03-30 KR KR1020177031273A patent/KR102588109B1/ko active IP Right Grant
- 2016-03-30 WO PCT/IN2016/050098 patent/WO2016157221A1/en active Application Filing
- 2016-03-30 PL PL16723536T patent/PL3277683T3/pl unknown
- 2016-03-30 MX MX2017012387A patent/MX2017012387A/es active IP Right Grant
- 2016-03-30 RU RU2017135205A patent/RU2721120C2/ru active
- 2016-03-30 AU AU2016242473A patent/AU2016242473B2/en active Active
- 2016-03-30 JP JP2017551712A patent/JP6764877B2/ja active Active
-
2017
- 2017-09-17 IL IL254528A patent/IL254528B/en active IP Right Grant
-
2018
- 2018-06-26 HK HK18108222.3A patent/HK1248686A1/zh unknown
-
2020
- 2020-05-07 US US16/869,517 patent/US11319326B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20200331926A1 (en) | 2020-10-22 |
| US10689390B2 (en) | 2020-06-23 |
| RU2017135205A3 (zh) | 2019-07-17 |
| MX2017012387A (es) | 2018-06-11 |
| JP6764877B2 (ja) | 2020-10-07 |
| AU2016242473B2 (en) | 2020-06-25 |
| CN107548393B (zh) | 2021-03-02 |
| JP2018510203A (ja) | 2018-04-12 |
| KR20170132278A (ko) | 2017-12-01 |
| IL254528B (en) | 2020-11-30 |
| US11319326B2 (en) | 2022-05-03 |
| AU2016242473A1 (en) | 2017-10-26 |
| RU2721120C2 (ru) | 2020-05-15 |
| CN107548393A (zh) | 2018-01-05 |
| KR102588109B1 (ko) | 2023-10-12 |
| IL254528A0 (en) | 2017-11-30 |
| US20180282345A1 (en) | 2018-10-04 |
| ES2911886T3 (es) | 2022-05-23 |
| WO2016157221A1 (en) | 2016-10-06 |
| EP3277683A1 (en) | 2018-02-07 |
| PT3277683T (pt) | 2022-06-28 |
| BR112017020739A2 (pt) | 2018-07-17 |
| RU2017135205A (ru) | 2019-04-10 |
| DK3277683T3 (en) | 2022-05-02 |
| EP3277683B1 (en) | 2022-03-09 |
| BR112017020739B1 (pt) | 2023-03-14 |
| PL3277683T3 (pl) | 2022-05-23 |
| CA2980266A1 (en) | 2016-10-06 |
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