CN111819181A - 苯并七元杂环类化合物、其制备方法、药物组合物及应用 - Google Patents

苯并七元杂环类化合物、其制备方法、药物组合物及应用 Download PDF

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Publication number
CN111819181A
CN111819181A CN201980018278.2A CN201980018278A CN111819181A CN 111819181 A CN111819181 A CN 111819181A CN 201980018278 A CN201980018278 A CN 201980018278A CN 111819181 A CN111819181 A CN 111819181A
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China
Prior art keywords
methyl
benzo
fluorophenyl
azepin
pyrido
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Pending
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CN201980018278.2A
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English (en)
Inventor
朱久香
胡永韩
蔡冬梅
董加强
王铁林
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Luoxin Biotechnology Shanghai Co ltd
Shandong Luoxin Pharmaceutical Group Co Ltd
Shandong Luoxin Pharmaceutical Co Ltd
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Luoxin Biotechnology Shanghai Co ltd
Shandong Luoxin Pharmaceutical Group Co Ltd
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Publication of CN111819181A publication Critical patent/CN111819181A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

本发明公开了一种如式I所示的苯并七元杂环类化合物、其互变异构体、其溶剂化物、其药学上可接受的盐或其前药，该本发明的苯并七元杂环类化合物具有较好的细胞活性和代谢稳定性，因此可以成为治疗肿瘤的有效药物。

Description

PCT国内申请，说明书已公开。

Claims (15)

  1. PCT国内申请，权利要求书已公开。
CN201980018278.2A 2018-05-10 2019-04-15 苯并七元杂环类化合物、其制备方法、药物组合物及应用 Pending CN111819181A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2018104450180 2018-05-10
CN201810445018 2018-05-10
PCT/CN2019/082610 WO2019214399A1 (zh) 2018-05-10 2019-04-15 苯并七元杂环类化合物、其制备方法、药物组合物及应用

Publications (1)

Publication Number Publication Date
CN111819181A true CN111819181A (zh) 2020-10-23

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CN (1) CN111819181A (zh)
WO (1) WO2019214399A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115477575A (zh) * 2022-10-31 2022-12-16 中南大学 一种二芳基酮的合成方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02229193A (ja) * 1989-02-28 1990-09-11 Yoshitomi Pharmaceut Ind Ltd ベンズアゼピン化合物
US20070197510A1 (en) * 2004-03-10 2007-08-23 Kazuyuki Ohmoto Nitriles and medicinal compositions containing the same as the active ingredient
CN107106547A (zh) * 2014-10-22 2017-08-29 默沙东公司 作为Janus激酶抑制剂的乙基N‑Boc哌啶基吡唑并吡啶酮
CN107548393A (zh) * 2015-03-30 2018-01-05 朱比兰特生物系统有限公司 适用于治疗癌症的1‑(环)烷基吡啶‑2‑酮的三环稠合衍生物
CN108069976A (zh) * 2016-11-10 2018-05-25 山东罗欣药业集团股份有限公司 一种含氮大环类化合物、其制备方法、药物组合物及应用

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02229193A (ja) * 1989-02-28 1990-09-11 Yoshitomi Pharmaceut Ind Ltd ベンズアゼピン化合物
US20070197510A1 (en) * 2004-03-10 2007-08-23 Kazuyuki Ohmoto Nitriles and medicinal compositions containing the same as the active ingredient
CN107106547A (zh) * 2014-10-22 2017-08-29 默沙东公司 作为Janus激酶抑制剂的乙基N‑Boc哌啶基吡唑并吡啶酮
CN107548393A (zh) * 2015-03-30 2018-01-05 朱比兰特生物系统有限公司 适用于治疗癌症的1‑(环)烷基吡啶‑2‑酮的三环稠合衍生物
CN108069976A (zh) * 2016-11-10 2018-05-25 山东罗欣药业集团股份有限公司 一种含氮大环类化合物、其制备方法、药物组合物及应用

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JOHN M.KANE ET AL.: "The reactions of thiosemicarbazides and 5-halovalerophenones", 《JOURNAL OF HETEROCYCLIC CHEMISTRY》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115477575A (zh) * 2022-10-31 2022-12-16 中南大学 一种二芳基酮的合成方法
CN115477575B (zh) * 2022-10-31 2023-10-13 中南大学 一种二芳基酮的合成方法

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