PE20160994A1 - Compuestos al receptor-3 del factor de crecimiento del fibroblasto (fgfr3) y metodos de tratamiento - Google Patents

Compuestos al receptor-3 del factor de crecimiento del fibroblasto (fgfr3) y metodos de tratamiento

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Publication number
PE20160994A1
PE20160994A1 PE2016000802A PE2016000802A PE20160994A1 PE 20160994 A1 PE20160994 A1 PE 20160994A1 PE 2016000802 A PE2016000802 A PE 2016000802A PE 2016000802 A PE2016000802 A PE 2016000802A PE 20160994 A1 PE20160994 A1 PE 20160994A1
Authority
PE
Peru
Prior art keywords
seq
fgfr3
conjugate
growth factor
factor receptor
Prior art date
Application number
PE2016000802A
Other languages
English (en)
Inventor
Paul J Balderes
Scott W Eastman
Hans K Erickson
Alan C Rigby
Christopher M Moxham
Gregory D Plowman
Dale L Ludwig
Original Assignee
Imclone Llc
Immunogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imclone Llc, Immunogen Inc filed Critical Imclone Llc
Publication of PE20160994A1 publication Critical patent/PE20160994A1/es

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • A61K31/559—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing hetero atoms other than oxygen
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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    • A61K47/6861—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from kidney or bladder cancer cell
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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Abstract

Se refiere a un compuesto de formula I, el cual es un conjugado de un agente citotoxico con un anticuerpo que se une al receptor 3 del factor de crecimiento del fibroblasto humano (FGFR3); donde n es un numero entero de 1 a 10; R es el anticuerpo anti–FGFR3 humano que comprende: a) una region variable de cadena pesada cuyas CDRH1, CDRH2 y CDRH3 tienen las secuencias GYMFTSYGIS (SEQ ID NO: 1), WVSTYNGDTNYAQKFQG (SEQ ID NO: 2) y VLGYYDSIDGYYYGMDV (SEQ ID NO: 3) respectivamente; y b) una region variable de cadena ligera cuyas CDRL1, CDRL2 y CDRL3 tienen las secuencias GGNNIGDKSVH (SEQ ID NO: 4), LDTERPS (SEQ ID NO: 5) y QVWDSGSDHVV (SEQ ID NO: 6) respectivamente. Tambien se refiere a composiciones farmaceuticas que comprenden dicho conjugado, junto con un portador, diluyente o excipiente farmaceuticamente aceptable. Dicho conjugado proporciona una ventaja en la terapia tumoral de objetivo, al estar disenado y adaptado para dirigirse a una poblacion celular especifica y suministrar una citotoxina potente dentro de la celula
PE2016000802A 2013-12-18 2014-12-11 Compuestos al receptor-3 del factor de crecimiento del fibroblasto (fgfr3) y metodos de tratamiento PE20160994A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361917457P 2013-12-18 2013-12-18
US201461928025P 2014-01-16 2014-01-16

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PE20160994A1 true PE20160994A1 (es) 2016-10-08

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PE2016000802A PE20160994A1 (es) 2013-12-18 2014-12-11 Compuestos al receptor-3 del factor de crecimiento del fibroblasto (fgfr3) y metodos de tratamiento

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US (1) US9375488B2 (es)
EP (1) EP3082873A1 (es)
JP (1) JP6113933B1 (es)
KR (1) KR101708603B1 (es)
CN (1) CN105916523A (es)
AP (1) AP2016009271A0 (es)
AU (1) AU2014366359A1 (es)
BR (1) BR112016013026A2 (es)
CA (1) CA2930599A1 (es)
CL (1) CL2016001496A1 (es)
EA (1) EA201691053A1 (es)
HK (1) HK1224179A1 (es)
IL (1) IL245483A0 (es)
MX (1) MX2016008072A (es)
NZ (1) NZ719936A (es)
PE (1) PE20160994A1 (es)
PH (1) PH12016501185A1 (es)
SG (1) SG11201604119YA (es)
TN (1) TN2016000204A1 (es)
TW (1) TWI541022B (es)
WO (1) WO2015094900A1 (es)

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TWI835880B (zh) * 2018-10-10 2024-03-21 日商安斯泰來製藥股份有限公司 含有標識部－抗人類抗體Ｆａｂ片段複合體之醫藥組成物
MX2023002106A (es) 2020-08-21 2023-03-15 Genzyme Corp Anticuerpos fgfr3 y metodos de uso.
WO2024107759A2 (en) * 2022-11-14 2024-05-23 Regeneron Pharmaceuticals, Inc. Anti-fgfr3 antibodies and antigen-binding fragments and methods of use thereof

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