JP4842800B2 - サフィンゴールの医薬組成物およびその使用方法 - Google Patents
サフィンゴールの医薬組成物およびその使用方法 Download PDFInfo
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- JP4842800B2 JP4842800B2 JP2006503721A JP2006503721A JP4842800B2 JP 4842800 B2 JP4842800 B2 JP 4842800B2 JP 2006503721 A JP2006503721 A JP 2006503721A JP 2006503721 A JP2006503721 A JP 2006503721A JP 4842800 B2 JP4842800 B2 JP 4842800B2
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- solution
- cancer
- emulsion
- sphingolipid
- lactic acid
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- PHEDXBVPIONUQT-RGYGYFBISA-N phorbol 13-acetate 12-myristate Chemical compound C([C@]1(O)C(=O)C(C)=C[C@H]1[C@@]1(O)[C@H](C)[C@H]2OC(=O)CCCCCCCCCCCCC)C(CO)=C[C@H]1[C@H]1[C@]2(OC(C)=O)C1(C)C PHEDXBVPIONUQT-RGYGYFBISA-N 0.000 description 1
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- 210000004881 tumor cell Anatomy 0.000 description 1
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/133—Amines having hydroxy groups, e.g. sphingosine
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/739—Lipopolysaccharides
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Dispersion Chemistry (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
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| US44953603P | 2003-02-21 | 2003-02-21 | |
| US60/449,536 | 2003-02-21 | ||
| PCT/US2004/004960 WO2004075834A2 (en) | 2003-02-21 | 2004-02-19 | Stabilized pharmaceutical compositions of safingol and methods of using the same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| JP2010290577A Division JP2011126886A (ja) | 2003-02-21 | 2010-12-27 | サフィンゴールの医薬組成物およびその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006518743A JP2006518743A (ja) | 2006-08-17 |
| JP2006518743A5 JP2006518743A5 (enExample) | 2007-04-05 |
| JP4842800B2 true JP4842800B2 (ja) | 2011-12-21 |
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| JP2006503721A Expired - Fee Related JP4842800B2 (ja) | 2003-02-21 | 2004-02-19 | サフィンゴールの医薬組成物およびその使用方法 |
| JP2010290577A Withdrawn JP2011126886A (ja) | 2003-02-21 | 2010-12-27 | サフィンゴールの医薬組成物およびその使用方法 |
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| Application Number | Title | Priority Date | Filing Date |
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| JP2010290577A Withdrawn JP2011126886A (ja) | 2003-02-21 | 2010-12-27 | サフィンゴールの医薬組成物およびその使用方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7476692B2 (enExample) |
| EP (1) | EP1594488B1 (enExample) |
| JP (2) | JP4842800B2 (enExample) |
| AT (1) | ATE331507T1 (enExample) |
| CA (1) | CA2516399C (enExample) |
| DE (1) | DE602004001393T2 (enExample) |
| ES (1) | ES2270347T3 (enExample) |
| MX (1) | MXPA05008860A (enExample) |
| WO (1) | WO2004075834A2 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2007233155B2 (en) | 2006-03-29 | 2012-04-26 | Scitech Development Llc | Liposomal nanoparticles and other formulations of fenretinide for use in therapy and drug delivery |
| JP2013510878A (ja) * | 2009-11-12 | 2013-03-28 | テキサス テック ユニバーシティー | 高増殖性障害を処置する組成物および方法 |
| EP3024441A4 (en) * | 2013-07-25 | 2017-04-19 | Nemucore Medical Innovations, Inc. | Nanoemulsions of hydrophobic platinum derivative |
| IT201600105201A1 (it) * | 2016-10-19 | 2018-04-19 | Nutrilinea Srl | Uso della fosfatidilserina per la prevenzione e il trattamento dei disturbi della prostata e relative composizioni farmaceutiche e nutraceutiche |
| US10034895B2 (en) * | 2017-11-30 | 2018-07-31 | Joel Steven Goldberg | Local application of D-lactic acid dimer is selectively cytotoxic when applied to cancer cells |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000191496A (ja) * | 1998-12-28 | 2000-07-11 | Kao Corp | 化粧料 |
| JP2001048848A (ja) * | 1999-07-20 | 2001-02-20 | Doosan:Kk | フィトスフィンゴシン水溶液の製造方法及び使用方法 |
| JP2001048721A (ja) * | 1999-07-27 | 2001-02-20 | Doosan:Kk | 皮膚保護用クリーム組成物及びその使用方法 |
| JP2001181169A (ja) * | 1999-12-24 | 2001-07-03 | Kao Corp | 化粧料 |
| JP2002519329A (ja) * | 1998-06-29 | 2002-07-02 | チルドレンズ・ホスピタル・オヴ・ロス・アンジェルス | 過増殖性障害の治療 |
| JP2003171269A (ja) * | 2001-12-10 | 2003-06-17 | Kao Corp | 皮膚外用剤 |
| JP2003171229A (ja) * | 2001-12-10 | 2003-06-17 | Kao Corp | セラミド類乳化物の製造法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0716589A4 (en) * | 1993-07-23 | 1997-06-11 | Morris Herstein | COSMETIC COMPOSITION STIMULATING THE RENEWAL OF THE SKIN WITH A PROLONGED IRRITATION ELIMINATION EFFECT |
| WO1997014412A1 (en) * | 1994-08-26 | 1997-04-24 | Mary Kay Inc. | Topically applied, structural cellulite treatments |
| US5635536A (en) * | 1994-12-07 | 1997-06-03 | Pharmacia & Upjohn Aktiebolag | Emulsion suitable for administering a sphingolipid |
| US6368831B1 (en) * | 1998-06-29 | 2002-04-09 | Childrens Hospital Los Angeles | Treatment of hyperproliferative disorders |
| US6720001B2 (en) * | 1999-10-18 | 2004-04-13 | Lipocine, Inc. | Emulsion compositions for polyfunctional active ingredients |
| EP1287815A1 (en) * | 2001-08-31 | 2003-03-05 | Cosmoferm B.V. | Use of a sphingoid base for inhibiting ceramidase activity |
| CN100340227C (zh) * | 2001-12-10 | 2007-10-03 | 花王株式会社 | 神经酰胺类乳化物 |
| PL373235A1 (en) * | 2002-09-05 | 2005-08-22 | Galderma S.A. | Solution for ungual application |
-
2004
- 2004-02-19 EP EP04712898A patent/EP1594488B1/en not_active Expired - Lifetime
- 2004-02-19 ES ES04712898T patent/ES2270347T3/es not_active Expired - Lifetime
- 2004-02-19 JP JP2006503721A patent/JP4842800B2/ja not_active Expired - Fee Related
- 2004-02-19 CA CA2516399A patent/CA2516399C/en not_active Expired - Fee Related
- 2004-02-19 AT AT04712898T patent/ATE331507T1/de not_active IP Right Cessation
- 2004-02-19 US US10/782,459 patent/US7476692B2/en active Active
- 2004-02-19 WO PCT/US2004/004960 patent/WO2004075834A2/en not_active Ceased
- 2004-02-19 DE DE602004001393T patent/DE602004001393T2/de not_active Expired - Lifetime
- 2004-02-19 MX MXPA05008860A patent/MXPA05008860A/es active IP Right Grant
-
2010
- 2010-12-27 JP JP2010290577A patent/JP2011126886A/ja not_active Withdrawn
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002519329A (ja) * | 1998-06-29 | 2002-07-02 | チルドレンズ・ホスピタル・オヴ・ロス・アンジェルス | 過増殖性障害の治療 |
| JP2000191496A (ja) * | 1998-12-28 | 2000-07-11 | Kao Corp | 化粧料 |
| JP2001048848A (ja) * | 1999-07-20 | 2001-02-20 | Doosan:Kk | フィトスフィンゴシン水溶液の製造方法及び使用方法 |
| JP2001048721A (ja) * | 1999-07-27 | 2001-02-20 | Doosan:Kk | 皮膚保護用クリーム組成物及びその使用方法 |
| JP2001181169A (ja) * | 1999-12-24 | 2001-07-03 | Kao Corp | 化粧料 |
| JP2003171269A (ja) * | 2001-12-10 | 2003-06-17 | Kao Corp | 皮膚外用剤 |
| JP2003171229A (ja) * | 2001-12-10 | 2003-06-17 | Kao Corp | セラミド類乳化物の製造法 |
Also Published As
| Publication number | Publication date |
|---|---|
| DE602004001393D1 (de) | 2006-08-10 |
| DE602004001393T2 (de) | 2007-06-14 |
| ATE331507T1 (de) | 2006-07-15 |
| MXPA05008860A (es) | 2005-10-05 |
| CA2516399C (en) | 2013-05-14 |
| US20050187186A1 (en) | 2005-08-25 |
| WO2004075834A2 (en) | 2004-09-10 |
| EP1594488B1 (en) | 2006-06-28 |
| EP1594488A2 (en) | 2005-11-16 |
| JP2006518743A (ja) | 2006-08-17 |
| JP2011126886A (ja) | 2011-06-30 |
| CA2516399A1 (en) | 2004-09-10 |
| WO2004075834A3 (en) | 2005-03-24 |
| ES2270347T3 (es) | 2007-04-01 |
| US7476692B2 (en) | 2009-01-13 |
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