CA2516399C - Pharmaceutical compositions of safingol and methods of using the same - Google Patents
Pharmaceutical compositions of safingol and methods of using the same Download PDFInfo
- Publication number
- CA2516399C CA2516399C CA2516399A CA2516399A CA2516399C CA 2516399 C CA2516399 C CA 2516399C CA 2516399 A CA2516399 A CA 2516399A CA 2516399 A CA2516399 A CA 2516399A CA 2516399 C CA2516399 C CA 2516399C
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- CA
- Canada
- Prior art keywords
- cancer
- solution
- emulsion
- dihydrosphingosine
- sphingolipid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 title claims abstract description 38
- OTKJDMGTUTTYMP-UHFFFAOYSA-N dihydrosphingosine Natural products CCCCCCCCCCCCCCCC(O)C(N)CO OTKJDMGTUTTYMP-UHFFFAOYSA-N 0.000 title claims description 121
- OTKJDMGTUTTYMP-ROUUACIJSA-N Safingol ( L-threo-sphinganine) Chemical group CCCCCCCCCCCCCCC[C@H](O)[C@@H](N)CO OTKJDMGTUTTYMP-ROUUACIJSA-N 0.000 title claims description 117
- 229950008902 safingol Drugs 0.000 title description 88
- 239000008194 pharmaceutical composition Substances 0.000 title description 18
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims abstract description 142
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- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
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- 229940093609 tricaprylin Drugs 0.000 description 1
- VLPFTAMPNXLGLX-UHFFFAOYSA-N trioctanoin Chemical compound CCCCCCCC(=O)OCC(OC(=O)CCCCCCC)COC(=O)CCCCCCC VLPFTAMPNXLGLX-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
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- A61K31/133—Amines having hydroxy groups, e.g. sphingosine
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/739—Lipopolysaccharides
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A—HUMAN NECESSITIES
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
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- A—HUMAN NECESSITIES
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- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Dispersion Chemistry (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44953603P | 2003-02-21 | 2003-02-21 | |
| US60/449,536 | 2003-02-21 | ||
| PCT/US2004/004960 WO2004075834A2 (en) | 2003-02-21 | 2004-02-19 | Stabilized pharmaceutical compositions of safingol and methods of using the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2516399A1 CA2516399A1 (en) | 2004-09-10 |
| CA2516399C true CA2516399C (en) | 2013-05-14 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2516399A Expired - Fee Related CA2516399C (en) | 2003-02-21 | 2004-02-19 | Pharmaceutical compositions of safingol and methods of using the same |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7476692B2 (enExample) |
| EP (1) | EP1594488B1 (enExample) |
| JP (2) | JP4842800B2 (enExample) |
| AT (1) | ATE331507T1 (enExample) |
| CA (1) | CA2516399C (enExample) |
| DE (1) | DE602004001393T2 (enExample) |
| ES (1) | ES2270347T3 (enExample) |
| MX (1) | MXPA05008860A (enExample) |
| WO (1) | WO2004075834A2 (enExample) |
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| AU2007233155B2 (en) | 2006-03-29 | 2012-04-26 | Scitech Development Llc | Liposomal nanoparticles and other formulations of fenretinide for use in therapy and drug delivery |
| JP2013510878A (ja) * | 2009-11-12 | 2013-03-28 | テキサス テック ユニバーシティー | 高増殖性障害を処置する組成物および方法 |
| EP3024441A4 (en) * | 2013-07-25 | 2017-04-19 | Nemucore Medical Innovations, Inc. | Nanoemulsions of hydrophobic platinum derivative |
| IT201600105201A1 (it) * | 2016-10-19 | 2018-04-19 | Nutrilinea Srl | Uso della fosfatidilserina per la prevenzione e il trattamento dei disturbi della prostata e relative composizioni farmaceutiche e nutraceutiche |
| US10034895B2 (en) * | 2017-11-30 | 2018-07-31 | Joel Steven Goldberg | Local application of D-lactic acid dimer is selectively cytotoxic when applied to cancer cells |
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| EP0716589A4 (en) * | 1993-07-23 | 1997-06-11 | Morris Herstein | COSMETIC COMPOSITION STIMULATING THE RENEWAL OF THE SKIN WITH A PROLONGED IRRITATION ELIMINATION EFFECT |
| WO1997014412A1 (en) * | 1994-08-26 | 1997-04-24 | Mary Kay Inc. | Topically applied, structural cellulite treatments |
| US5635536A (en) * | 1994-12-07 | 1997-06-03 | Pharmacia & Upjohn Aktiebolag | Emulsion suitable for administering a sphingolipid |
| ATE409486T1 (de) * | 1998-06-29 | 2008-10-15 | Children S Hospital Los Angele | Behandlung hyperproliferativer erkrankungen |
| US6368831B1 (en) * | 1998-06-29 | 2002-04-09 | Childrens Hospital Los Angeles | Treatment of hyperproliferative disorders |
| JP3220434B2 (ja) * | 1998-12-28 | 2001-10-22 | 花王株式会社 | 化粧料 |
| KR100343885B1 (ko) * | 1999-07-20 | 2002-07-19 | 주식회사 두산 | 파이토스핑고신의 수용액의 제조 방법 |
| KR100371491B1 (ko) * | 1999-07-27 | 2003-02-07 | 주식회사 두산 | 피부 보호용 크림조성물 |
| US6720001B2 (en) * | 1999-10-18 | 2004-04-13 | Lipocine, Inc. | Emulsion compositions for polyfunctional active ingredients |
| JP3896234B2 (ja) * | 1999-12-24 | 2007-03-22 | 花王株式会社 | 化粧料 |
| EP1287815A1 (en) * | 2001-08-31 | 2003-03-05 | Cosmoferm B.V. | Use of a sphingoid base for inhibiting ceramidase activity |
| CN100340227C (zh) * | 2001-12-10 | 2007-10-03 | 花王株式会社 | 神经酰胺类乳化物 |
| JP4220698B2 (ja) * | 2001-12-10 | 2009-02-04 | 花王株式会社 | 皮膚外用剤 |
| JP4119646B2 (ja) * | 2001-12-10 | 2008-07-16 | 花王株式会社 | セラミド類乳化物の製造法 |
| PL373235A1 (en) * | 2002-09-05 | 2005-08-22 | Galderma S.A. | Solution for ungual application |
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2004
- 2004-02-19 EP EP04712898A patent/EP1594488B1/en not_active Expired - Lifetime
- 2004-02-19 ES ES04712898T patent/ES2270347T3/es not_active Expired - Lifetime
- 2004-02-19 JP JP2006503721A patent/JP4842800B2/ja not_active Expired - Fee Related
- 2004-02-19 CA CA2516399A patent/CA2516399C/en not_active Expired - Fee Related
- 2004-02-19 AT AT04712898T patent/ATE331507T1/de not_active IP Right Cessation
- 2004-02-19 US US10/782,459 patent/US7476692B2/en active Active
- 2004-02-19 WO PCT/US2004/004960 patent/WO2004075834A2/en not_active Ceased
- 2004-02-19 DE DE602004001393T patent/DE602004001393T2/de not_active Expired - Lifetime
- 2004-02-19 MX MXPA05008860A patent/MXPA05008860A/es active IP Right Grant
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2010
- 2010-12-27 JP JP2010290577A patent/JP2011126886A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| DE602004001393D1 (de) | 2006-08-10 |
| DE602004001393T2 (de) | 2007-06-14 |
| ATE331507T1 (de) | 2006-07-15 |
| MXPA05008860A (es) | 2005-10-05 |
| US20050187186A1 (en) | 2005-08-25 |
| WO2004075834A2 (en) | 2004-09-10 |
| JP4842800B2 (ja) | 2011-12-21 |
| EP1594488B1 (en) | 2006-06-28 |
| EP1594488A2 (en) | 2005-11-16 |
| JP2006518743A (ja) | 2006-08-17 |
| JP2011126886A (ja) | 2011-06-30 |
| CA2516399A1 (en) | 2004-09-10 |
| WO2004075834A3 (en) | 2005-03-24 |
| ES2270347T3 (es) | 2007-04-01 |
| US7476692B2 (en) | 2009-01-13 |
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