JP4703924B2 - マクロライド - Google Patents

マクロライド Download PDF

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Publication number
JP4703924B2
JP4703924B2 JP2001507048A JP2001507048A JP4703924B2 JP 4703924 B2 JP4703924 B2 JP 4703924B2 JP 2001507048 A JP2001507048 A JP 2001507048A JP 2001507048 A JP2001507048 A JP 2001507048A JP 4703924 B2 JP4703924 B2 JP 4703924B2
Authority
JP
Japan
Prior art keywords
compound
azithromycin
formula
sugar
alcohols
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2001507048A
Other languages
English (en)
Japanese (ja)
Other versions
JP2003503417A (ja
Inventor
センテジヤス，ビクトル
ガルシア，ラフアエル
ポツチ，マルタ
デイアゴ，ホセ
ルーデツシヤー，ヨハネス
ボス，インマクラーダ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9915216.7A external-priority patent/GB9915216D0/en
Priority claimed from GBGB9915218.3A external-priority patent/GB9915218D0/en
Priority claimed from GBGB9930059.2A external-priority patent/GB9930059D0/en
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of JP2003503417A publication Critical patent/JP2003503417A/ja
Application granted granted Critical
Publication of JP4703924B2 publication Critical patent/JP4703924B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP2001507048A 1999-06-29 2000-06-27 マクロライド Expired - Fee Related JP4703924B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB9915218.3 1999-06-29
GBGB9915216.7A GB9915216D0 (en) 1999-06-29 1999-06-29 Organic compounds
GBGB9915218.3A GB9915218D0 (en) 1999-06-29 1999-06-29 Organic compounds
GB9915216.7 1999-06-29
GBGB9930059.2A GB9930059D0 (en) 1999-12-20 1999-12-20 Organic compounds
GB9930059.2 1999-12-20
PCT/EP2000/005948 WO2001000640A1 (en) 1999-06-29 2000-06-27 Macrolides

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2011017553A Division JP2011126894A (ja) 1999-06-29 2011-01-31 マクロライド

Publications (2)

Publication Number Publication Date
JP2003503417A JP2003503417A (ja) 2003-01-28
JP4703924B2 true JP4703924B2 (ja) 2011-06-15

Family

ID=27269768

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2001507048A Expired - Fee Related JP4703924B2 (ja) 1999-06-29 2000-06-27 マクロライド
JP2011017553A Pending JP2011126894A (ja) 1999-06-29 2011-01-31 マクロライド

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2011017553A Pending JP2011126894A (ja) 1999-06-29 2011-01-31 マクロライド

Country Status (10)

Country Link
US (1) US6703372B1 (enExample)
EP (2) EP1712556B1 (enExample)
JP (2) JP4703924B2 (enExample)
KR (1) KR100700475B1 (enExample)
AT (2) ATE469910T1 (enExample)
AU (1) AU5820400A (enExample)
DE (3) DE60044515D1 (enExample)
ES (2) ES2346782T3 (enExample)
HR (1) HRP20010956B1 (enExample)
WO (1) WO2001000640A1 (enExample)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20020231A2 (en) * 2002-03-18 2003-12-31 Pliva D D ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
US6245903B1 (en) 1998-08-21 2001-06-12 Apotex, Inc. Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
ES2260047T3 (es) 2000-07-25 2006-11-01 Laboratorio Silanes, S.A. De C.V. Proceso de etapa unica para la preparacion de 7,16-deoxi-2-aza-10-o-cladinosil-12-o-desosaminil-4,5-dihidroxi-6-etil-3,5,9,11,13,15-hexametilbiciclo(11.2.1)hexadeca-1(2)-en-ona y obtencion de una forma nueva de 9-deoxo-9a-metil-9a-homoeritromicina a.
ES2172417B1 (es) * 2000-07-31 2003-09-16 Sint Quimica Sa Nueva forma mejorada de azitromicina monohidrato de menor higroscopicidad, procedimiento de preparacion y composiciones farmaceuticas que la comprenden.
HU229488B1 (hu) 2000-11-27 2014-01-28 Sandoz Ag Eljárás makrolid hidrátok elõállítására
HRP20010301A2 (en) * 2001-04-27 2001-12-31 Pliva D D New therapeutic indication for azithromycin in the treatment of non-infective inflammatory diseases
US6861413B2 (en) 2001-05-22 2005-03-01 Pfizer Inc. Stable non-dihydrate azithromycin oral suspensions
EP1652851A1 (en) * 2001-05-22 2006-05-03 Pfizer Products Inc. New crystal form of Azithromycin
DE60209704T2 (de) 2001-05-22 2006-11-16 Pfizer Products Inc., Groton Neue kristallforme von azithromycin
NZ532063A (en) * 2001-12-21 2006-03-31 Pfizer Prod Inc Methods for wet granulating azithromycin
WO2003072589A1 (fr) * 2002-02-26 2003-09-04 Meiji Seika Kaisha, Ltd. Nouveau compose azalide cyclique a 15 chainons, nouveau derive diazalide cyclique a 16 chainons et procede de production de ceux-ci
CN1276919C (zh) * 2002-04-03 2006-09-27 韩美药品株式会社 阿奇霉素的制备方法及其中使用的结晶9－脱氧－9a－氮杂－9a－同型红霉素A水合物
ITMI20021209A1 (it) * 2002-06-04 2003-12-04 Chemi Spa Processo di preparazione di azitromicina ad elevata purezza
GB0214277D0 (en) * 2002-06-20 2002-07-31 Biochemie Gmbh Organic compounds
US6855813B2 (en) 2002-07-19 2005-02-15 Alembic Limited Process for the preparation of azithromycin monohydrate
HRP20020614A2 (en) 2002-07-22 2004-06-30 PLIVA-ISTRAŽIVAČKI INSTITUT d.o.o. Rhombic pseudopolymorph of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin a
GB0224197D0 (en) * 2002-10-17 2002-11-27 Biochemie Gmbh Organic compounds
US20050013835A1 (en) * 2003-07-15 2005-01-20 Pfizer Inc. Stable non-dihydrate azithromycin oral suspensions
EP1648473B1 (en) * 2003-07-24 2009-01-28 PLIVA HRVATSKA d.o.o. Single dose fast dissolving azithromycin
US20060189800A1 (en) * 2003-07-24 2006-08-24 Mitsuru Ohkubo Indolopyrrolocabazole derivative and antitumor agent
US7384921B2 (en) * 2004-02-20 2008-06-10 Enanta Pharmaceuticals, Inc. Polymorphic forms of 6-11 bicyclic ketolide derivatives
US7468428B2 (en) * 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
US20060116336A1 (en) * 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
US7683162B2 (en) 2004-08-30 2010-03-23 Taro Pharmaceutical Industries Limited Process of preparing a crystalline azithromycin monohydrate
JP2008520686A (ja) * 2004-11-17 2008-06-19 スミスクライン・ビーチャム・コーポレイション 新規な抗菌化合物の使用
CN101177441B (zh) * 2007-12-05 2012-05-23 浙江耐司康药业有限公司 一种稳定的阿奇霉素一水合物结晶的制备方法
CN101445532B (zh) * 2008-12-30 2011-09-21 广东东阳光药业有限公司 阿奇霉素一水合物结晶的制备方法
CN102413826A (zh) 2009-03-13 2012-04-11 达·沃尔泰拉公司 用于消除革兰氏阴性菌的组合物和方法
CN102417531B (zh) * 2011-12-20 2014-06-11 浙江国邦药业有限公司 一种阿奇霉素一水合物的制备方法
CN105030704B (zh) * 2015-06-29 2018-09-07 石药集团欧意药业有限公司 阿奇霉素片剂及其制备方法
CN110684056B (zh) * 2018-07-05 2021-07-13 青岛农业大学 一种阿奇霉素中间体的化学合成方法
CN114516895A (zh) * 2020-11-19 2022-05-20 江苏威奇达药业有限公司 一种阿奇霉素胺结晶方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA835204B (en) * 1982-07-19 1985-02-27 Pfizer N-methyl 11-aza-10-deoxo-10-dihydroerythromycin a,intermediates therefor and processes for their preparation
MX12213A (es) * 1987-07-09 1993-05-01 Pfizer Metodo de preparacion de dihidrato de azitromicina cristalino
ES2122905B1 (es) * 1996-07-11 1999-11-16 Astur Pharma Sa Sintesis de 11,12-hidrogenoortoborato de 9-desoxo-9a-aza-11,12-desoxi-9a-metil-9a-homoeritromicina a. un procedimiento para la preparacion de 9-desoxo-9a-aza-9a-metil-9a-homoeritromicina a dihidrato (azitromicina dihidrato).
GB9705323D0 (en) * 1997-03-14 1997-04-30 Biochemie Sa Organic compounds
EP0994889B1 (en) * 1997-07-08 2004-06-16 Biochemie S.A. Erythromycin a oxime solvates
PT102130A (pt) * 1998-03-13 1999-09-30 Hovione Sociedade Quimica S A Processo de preparacao de dihidrato de azitromicina
US6245903B1 (en) * 1998-08-21 2001-06-12 Apotex, Inc. Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
GB9824580D0 (en) * 1998-11-10 1999-01-06 Biochemie Sa Organic compounds

Also Published As

Publication number Publication date
KR100700475B1 (ko) 2007-03-28
US6703372B1 (en) 2004-03-09
WO2001000640A1 (en) 2001-01-04
ES2346782T3 (es) 2010-10-20
DE60029589D1 (de) 2006-09-07
EP1189915B1 (en) 2006-07-26
ATE334136T1 (de) 2006-08-15
HRP20010956B1 (hr) 2010-09-30
JP2003503417A (ja) 2003-01-28
EP1712556B1 (en) 2010-06-02
AU5820400A (en) 2001-01-31
DE20023815U1 (de) 2006-06-08
ES2267549T3 (es) 2007-03-16
DE60044515D1 (de) 2010-07-15
KR20020016862A (ko) 2002-03-06
EP1712556A1 (en) 2006-10-18
EP1189915A1 (en) 2002-03-27
ATE469910T1 (de) 2010-06-15
JP2011126894A (ja) 2011-06-30
HRP20010956A2 (en) 2003-08-31
DE60029589T2 (de) 2007-07-19

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