ATE334136T1 - Verfahren zur herstellung von azithromycin - Google Patents

Verfahren zur herstellung von azithromycin

Info

Publication number
ATE334136T1
ATE334136T1 AT00943902T AT00943902T ATE334136T1 AT E334136 T1 ATE334136 T1 AT E334136T1 AT 00943902 T AT00943902 T AT 00943902T AT 00943902 T AT00943902 T AT 00943902T AT E334136 T1 ATE334136 T1 AT E334136T1
Authority
AT
Austria
Prior art keywords
azithromycin
producing
producing azithromycin
monohydrate
stable
Prior art date
Application number
AT00943902T
Other languages
German (de)
English (en)
Inventor
Victor Centellas
Rafael Garcia
Marta Poch
Jose Diago
Johannes Ludescher
Immaculada Bosch
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9915218.3A external-priority patent/GB9915218D0/en
Priority claimed from GBGB9915216.7A external-priority patent/GB9915216D0/en
Priority claimed from GBGB9930059.2A external-priority patent/GB9930059D0/en
Application filed by Sandoz Ag filed Critical Sandoz Ag
Application granted granted Critical
Publication of ATE334136T1 publication Critical patent/ATE334136T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT00943902T 1999-06-29 2000-06-27 Verfahren zur herstellung von azithromycin ATE334136T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9915218.3A GB9915218D0 (en) 1999-06-29 1999-06-29 Organic compounds
GBGB9915216.7A GB9915216D0 (en) 1999-06-29 1999-06-29 Organic compounds
GBGB9930059.2A GB9930059D0 (en) 1999-12-20 1999-12-20 Organic compounds

Publications (1)

Publication Number Publication Date
ATE334136T1 true ATE334136T1 (de) 2006-08-15

Family

ID=27269768

Family Applications (2)

Application Number Title Priority Date Filing Date
AT00943902T ATE334136T1 (de) 1999-06-29 2000-06-27 Verfahren zur herstellung von azithromycin
AT06117687T ATE469910T1 (de) 1999-06-29 2000-06-27 Azithromycinmonohydrat

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT06117687T ATE469910T1 (de) 1999-06-29 2000-06-27 Azithromycinmonohydrat

Country Status (10)

Country Link
US (1) US6703372B1 (enExample)
EP (2) EP1712556B1 (enExample)
JP (2) JP4703924B2 (enExample)
KR (1) KR100700475B1 (enExample)
AT (2) ATE334136T1 (enExample)
AU (1) AU5820400A (enExample)
DE (3) DE20023815U1 (enExample)
ES (2) ES2346782T3 (enExample)
HR (1) HRP20010956B1 (enExample)
WO (1) WO2001000640A1 (enExample)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20020231A2 (en) * 2002-03-18 2003-12-31 Pliva D D ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
CA2245398C (en) 1998-08-21 2002-01-29 Apotex Inc. Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
CA2417353C (en) 2000-07-25 2009-09-01 Laboratorio Silanes,S.A. De C.V. Single-step process for preparing 7,16-deoxy-2-aza-10-o-cladinosil-12-o-desosaminil-4,5-dihydroxi-6-ethyl-3,5,9,11,13,15-hexamethylbicycle (11.2.1)hexadeca-1(2)-en-8-one, and obtaining a new form of 9-deoxo-9a-methyl-9a-aza-9a-homoerythromycin a
ES2172417B1 (es) * 2000-07-31 2003-09-16 Sint Quimica Sa Nueva forma mejorada de azitromicina monohidrato de menor higroscopicidad, procedimiento de preparacion y composiciones farmaceuticas que la comprenden.
HU229488B1 (hu) 2000-11-27 2014-01-28 Sandoz Ag Eljárás makrolid hidrátok elõállítására
HRP20010301A2 (en) * 2001-04-27 2001-12-31 Pliva D D New therapeutic indication for azithromycin in the treatment of non-infective inflammatory diseases
US6861413B2 (en) 2001-05-22 2005-03-01 Pfizer Inc. Stable non-dihydrate azithromycin oral suspensions
GEP20084399B (en) 2001-05-22 2008-06-10 Pfizer Prod Inc Crystal forms of azithromycin
EP1652851A1 (en) * 2001-05-22 2006-05-03 Pfizer Products Inc. New crystal form of Azithromycin
AU2002353316A1 (en) * 2001-12-21 2003-07-09 Pfizer Products Inc. Methods for wet granulating azithromycin
US20050209446A1 (en) * 2002-02-26 2005-09-22 Meiji Seika Kaisha Ltd. Novel 15-membered cyclic azalide, novel 16-membered cyclic diazalide derivative, and process for producing these
EP1490382A4 (en) * 2002-04-03 2007-09-12 Hanmi Pharm Ind Co Ltd PROCESS FOR PREPARING AZITHROMYXIN AND HYDRATE CRYSTALLINE 9-DEOXO-9A-HOMOERYTHROMYCIN
ITMI20021209A1 (it) * 2002-06-04 2003-12-04 Chemi Spa Processo di preparazione di azitromicina ad elevata purezza
GB0214277D0 (en) * 2002-06-20 2002-07-31 Biochemie Gmbh Organic compounds
US6855813B2 (en) 2002-07-19 2005-02-15 Alembic Limited Process for the preparation of azithromycin monohydrate
HRP20020614A2 (en) 2002-07-22 2004-06-30 PLIVA-ISTRAŽIVAČKI INSTITUT d.o.o. Rhombic pseudopolymorph of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin a
GB0224197D0 (en) * 2002-10-17 2002-11-27 Biochemie Gmbh Organic compounds
US20050013835A1 (en) * 2003-07-15 2005-01-20 Pfizer Inc. Stable non-dihydrate azithromycin oral suspensions
US20060189800A1 (en) * 2003-07-24 2006-08-24 Mitsuru Ohkubo Indolopyrrolocabazole derivative and antitumor agent
DE602004019288D1 (de) * 2003-07-24 2009-03-19 Pliva Hrvatska D O O Schnellösliches azithromycin in einzeldosisform
US7384921B2 (en) * 2004-02-20 2008-06-10 Enanta Pharmaceuticals, Inc. Polymorphic forms of 6-11 bicyclic ketolide derivatives
US7468428B2 (en) * 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
US20060116336A1 (en) * 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
US7683162B2 (en) * 2004-08-30 2010-03-23 Taro Pharmaceutical Industries Limited Process of preparing a crystalline azithromycin monohydrate
WO2006055663A2 (en) * 2004-11-17 2006-05-26 Smithkline Beecham Corporation The use of novel antibacterial compounds
CN101177441B (zh) * 2007-12-05 2012-05-23 浙江耐司康药业有限公司 一种稳定的阿奇霉素一水合物结晶的制备方法
CN101445532B (zh) * 2008-12-30 2011-09-21 广东东阳光药业有限公司 阿奇霉素一水合物结晶的制备方法
KR20120004448A (ko) 2009-03-13 2012-01-12 다 볼떼라 그람음성 박테리아 제거용 조성물 및 방법
CN102417531B (zh) * 2011-12-20 2014-06-11 浙江国邦药业有限公司 一种阿奇霉素一水合物的制备方法
CN105030704B (zh) * 2015-06-29 2018-09-07 石药集团欧意药业有限公司 阿奇霉素片剂及其制备方法
CN110684056B (zh) * 2018-07-05 2021-07-13 青岛农业大学 一种阿奇霉素中间体的化学合成方法
CN114516895A (zh) * 2020-11-19 2022-05-20 江苏威奇达药业有限公司 一种阿奇霉素胺结晶方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA835204B (en) * 1982-07-19 1985-02-27 Pfizer N-methyl 11-aza-10-deoxo-10-dihydroerythromycin a,intermediates therefor and processes for their preparation
RU2066324C1 (ru) * 1987-07-09 1996-09-10 Пфайзер Инк. Кристаллический дигидрат азитромицина и способ его получения
ES2122905B1 (es) 1996-07-11 1999-11-16 Astur Pharma Sa Sintesis de 11,12-hidrogenoortoborato de 9-desoxo-9a-aza-11,12-desoxi-9a-metil-9a-homoeritromicina a. un procedimiento para la preparacion de 9-desoxo-9a-aza-9a-metil-9a-homoeritromicina a dihidrato (azitromicina dihidrato).
GB9705323D0 (en) * 1997-03-14 1997-04-30 Biochemie Sa Organic compounds
WO1999002541A2 (en) * 1997-07-08 1999-01-21 Biochemie S.A. Erythromycin a oxime solvates
PT102130A (pt) * 1998-03-13 1999-09-30 Hovione Sociedade Quimica S A Processo de preparacao de dihidrato de azitromicina
CA2245398C (en) * 1998-08-21 2002-01-29 Apotex Inc. Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
GB9824580D0 (en) * 1998-11-10 1999-01-06 Biochemie Sa Organic compounds

Also Published As

Publication number Publication date
DE60044515D1 (de) 2010-07-15
US6703372B1 (en) 2004-03-09
ES2346782T3 (es) 2010-10-20
ES2267549T3 (es) 2007-03-16
EP1712556B1 (en) 2010-06-02
HRP20010956B1 (hr) 2010-09-30
DE60029589D1 (de) 2006-09-07
EP1189915B1 (en) 2006-07-26
EP1712556A1 (en) 2006-10-18
DE60029589T2 (de) 2007-07-19
DE20023815U1 (de) 2006-06-08
JP2003503417A (ja) 2003-01-28
HRP20010956A2 (en) 2003-08-31
JP2011126894A (ja) 2011-06-30
JP4703924B2 (ja) 2011-06-15
KR20020016862A (ko) 2002-03-06
ATE469910T1 (de) 2010-06-15
AU5820400A (en) 2001-01-31
WO2001000640A1 (en) 2001-01-04
EP1189915A1 (en) 2002-03-27
KR100700475B1 (ko) 2007-03-28

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