HRP20010956B1 - Makrolidi - Google Patents

Makrolidi

Info

Publication number
HRP20010956B1
HRP20010956B1 HR20010956A HRP20010956A HRP20010956B1 HR P20010956 B1 HRP20010956 B1 HR P20010956B1 HR 20010956 A HR20010956 A HR 20010956A HR P20010956 A HRP20010956 A HR P20010956A HR P20010956 B1 HRP20010956 B1 HR P20010956B1
Authority
HR
Croatia
Prior art keywords
compound
iii
formula
macrolides
hydrolyzing
Prior art date
Application number
HR20010956A
Other languages
English (en)
Croatian (hr)
Inventor
Centellas Victor
Garcia Rafael
Poch Marta
Diago Jose
Ludescher Johannes
Bosch Immaculada
Original Assignee
Biochemie S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9915216.7A external-priority patent/GB9915216D0/en
Priority claimed from GBGB9915218.3A external-priority patent/GB9915218D0/en
Priority claimed from GBGB9930059.2A external-priority patent/GB9930059D0/en
Application filed by Biochemie S.A. filed Critical Biochemie S.A.
Publication of HRP20010956A2 publication Critical patent/HRP20010956A2/hr
Publication of HRP20010956B1 publication Critical patent/HRP20010956B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
HR20010956A 1999-06-29 2000-06-27 Makrolidi HRP20010956B1 (hr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9915216.7A GB9915216D0 (en) 1999-06-29 1999-06-29 Organic compounds
GBGB9915218.3A GB9915218D0 (en) 1999-06-29 1999-06-29 Organic compounds
GBGB9930059.2A GB9930059D0 (en) 1999-12-20 1999-12-20 Organic compounds
PCT/EP2000/005948 WO2001000640A1 (en) 1999-06-29 2000-06-27 Macrolides

Publications (2)

Publication Number Publication Date
HRP20010956A2 HRP20010956A2 (en) 2003-08-31
HRP20010956B1 true HRP20010956B1 (hr) 2010-09-30

Family

ID=27269768

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20010956A HRP20010956B1 (hr) 1999-06-29 2000-06-27 Makrolidi

Country Status (10)

Country Link
US (1) US6703372B1 (enExample)
EP (2) EP1712556B1 (enExample)
JP (2) JP4703924B2 (enExample)
KR (1) KR100700475B1 (enExample)
AT (2) ATE469910T1 (enExample)
AU (1) AU5820400A (enExample)
DE (3) DE60044515D1 (enExample)
ES (2) ES2346782T3 (enExample)
HR (1) HRP20010956B1 (enExample)
WO (1) WO2001000640A1 (enExample)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20020231A2 (en) * 2002-03-18 2003-12-31 Pliva D D ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
US6245903B1 (en) 1998-08-21 2001-06-12 Apotex, Inc. Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
ES2260047T3 (es) 2000-07-25 2006-11-01 Laboratorio Silanes, S.A. De C.V. Proceso de etapa unica para la preparacion de 7,16-deoxi-2-aza-10-o-cladinosil-12-o-desosaminil-4,5-dihidroxi-6-etil-3,5,9,11,13,15-hexametilbiciclo(11.2.1)hexadeca-1(2)-en-ona y obtencion de una forma nueva de 9-deoxo-9a-metil-9a-homoeritromicina a.
ES2172417B1 (es) * 2000-07-31 2003-09-16 Sint Quimica Sa Nueva forma mejorada de azitromicina monohidrato de menor higroscopicidad, procedimiento de preparacion y composiciones farmaceuticas que la comprenden.
HU229488B1 (hu) 2000-11-27 2014-01-28 Sandoz Ag Eljárás makrolid hidrátok elõállítására
HRP20010301A2 (en) * 2001-04-27 2001-12-31 Pliva D D New therapeutic indication for azithromycin in the treatment of non-infective inflammatory diseases
US6861413B2 (en) 2001-05-22 2005-03-01 Pfizer Inc. Stable non-dihydrate azithromycin oral suspensions
EP1652851A1 (en) * 2001-05-22 2006-05-03 Pfizer Products Inc. New crystal form of Azithromycin
DE60209704T2 (de) 2001-05-22 2006-11-16 Pfizer Products Inc., Groton Neue kristallforme von azithromycin
NZ532063A (en) * 2001-12-21 2006-03-31 Pfizer Prod Inc Methods for wet granulating azithromycin
WO2003072589A1 (fr) * 2002-02-26 2003-09-04 Meiji Seika Kaisha, Ltd. Nouveau compose azalide cyclique a 15 chainons, nouveau derive diazalide cyclique a 16 chainons et procede de production de ceux-ci
CN1276919C (zh) * 2002-04-03 2006-09-27 韩美药品株式会社 阿奇霉素的制备方法及其中使用的结晶9－脱氧－9a－氮杂－9a－同型红霉素A水合物
ITMI20021209A1 (it) * 2002-06-04 2003-12-04 Chemi Spa Processo di preparazione di azitromicina ad elevata purezza
GB0214277D0 (en) * 2002-06-20 2002-07-31 Biochemie Gmbh Organic compounds
US6855813B2 (en) 2002-07-19 2005-02-15 Alembic Limited Process for the preparation of azithromycin monohydrate
HRP20020614A2 (en) 2002-07-22 2004-06-30 PLIVA-ISTRAŽIVAČKI INSTITUT d.o.o. Rhombic pseudopolymorph of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin a
GB0224197D0 (en) * 2002-10-17 2002-11-27 Biochemie Gmbh Organic compounds
US20050013835A1 (en) * 2003-07-15 2005-01-20 Pfizer Inc. Stable non-dihydrate azithromycin oral suspensions
EP1648473B1 (en) * 2003-07-24 2009-01-28 PLIVA HRVATSKA d.o.o. Single dose fast dissolving azithromycin
US20060189800A1 (en) * 2003-07-24 2006-08-24 Mitsuru Ohkubo Indolopyrrolocabazole derivative and antitumor agent
US7384921B2 (en) * 2004-02-20 2008-06-10 Enanta Pharmaceuticals, Inc. Polymorphic forms of 6-11 bicyclic ketolide derivatives
US7468428B2 (en) * 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
US20060116336A1 (en) * 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
US7683162B2 (en) 2004-08-30 2010-03-23 Taro Pharmaceutical Industries Limited Process of preparing a crystalline azithromycin monohydrate
JP2008520686A (ja) * 2004-11-17 2008-06-19 スミスクライン・ビーチャム・コーポレイション 新規な抗菌化合物の使用
CN101177441B (zh) * 2007-12-05 2012-05-23 浙江耐司康药业有限公司 一种稳定的阿奇霉素一水合物结晶的制备方法
CN101445532B (zh) * 2008-12-30 2011-09-21 广东东阳光药业有限公司 阿奇霉素一水合物结晶的制备方法
CN102413826A (zh) 2009-03-13 2012-04-11 达·沃尔泰拉公司 用于消除革兰氏阴性菌的组合物和方法
CN102417531B (zh) * 2011-12-20 2014-06-11 浙江国邦药业有限公司 一种阿奇霉素一水合物的制备方法
CN105030704B (zh) * 2015-06-29 2018-09-07 石药集团欧意药业有限公司 阿奇霉素片剂及其制备方法
CN110684056B (zh) * 2018-07-05 2021-07-13 青岛农业大学 一种阿奇霉素中间体的化学合成方法
CN114516895A (zh) * 2020-11-19 2022-05-20 江苏威奇达药业有限公司 一种阿奇霉素胺结晶方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0298650A2 (en) * 1987-07-09 1989-01-11 Pfizer Inc. Azithromycin dihydrate
WO1998041532A1 (en) * 1997-03-14 1998-09-24 Biochemie S.A. Erythromycin a oxime dihydrate
EP0941999A2 (en) * 1998-03-13 1999-09-15 Hovione Inter Ltd. Preparation of azithromycin dihydrate
EP0984020A2 (en) * 1998-08-21 2000-03-08 Apotex Inc. Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof.
WO2000027856A1 (en) * 1998-11-10 2000-05-18 Biochemie S.A. Macrolide intermediates

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA835204B (en) * 1982-07-19 1985-02-27 Pfizer N-methyl 11-aza-10-deoxo-10-dihydroerythromycin a,intermediates therefor and processes for their preparation
ES2122905B1 (es) * 1996-07-11 1999-11-16 Astur Pharma Sa Sintesis de 11,12-hidrogenoortoborato de 9-desoxo-9a-aza-11,12-desoxi-9a-metil-9a-homoeritromicina a. un procedimiento para la preparacion de 9-desoxo-9a-aza-9a-metil-9a-homoeritromicina a dihidrato (azitromicina dihidrato).
EP0994889B1 (en) * 1997-07-08 2004-06-16 Biochemie S.A. Erythromycin a oxime solvates

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0298650A2 (en) * 1987-07-09 1989-01-11 Pfizer Inc. Azithromycin dihydrate
WO1998041532A1 (en) * 1997-03-14 1998-09-24 Biochemie S.A. Erythromycin a oxime dihydrate
EP0941999A2 (en) * 1998-03-13 1999-09-15 Hovione Inter Ltd. Preparation of azithromycin dihydrate
EP0984020A2 (en) * 1998-08-21 2000-03-08 Apotex Inc. Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof.
WO2000027856A1 (en) * 1998-11-10 2000-05-18 Biochemie S.A. Macrolide intermediates

Also Published As

Publication number Publication date
KR100700475B1 (ko) 2007-03-28
US6703372B1 (en) 2004-03-09
WO2001000640A1 (en) 2001-01-04
ES2346782T3 (es) 2010-10-20
DE60029589D1 (de) 2006-09-07
EP1189915B1 (en) 2006-07-26
ATE334136T1 (de) 2006-08-15
JP2003503417A (ja) 2003-01-28
EP1712556B1 (en) 2010-06-02
AU5820400A (en) 2001-01-31
DE20023815U1 (de) 2006-06-08
ES2267549T3 (es) 2007-03-16
DE60044515D1 (de) 2010-07-15
JP4703924B2 (ja) 2011-06-15
KR20020016862A (ko) 2002-03-06
EP1712556A1 (en) 2006-10-18
EP1189915A1 (en) 2002-03-27
ATE469910T1 (de) 2010-06-15
JP2011126894A (ja) 2011-06-30
HRP20010956A2 (en) 2003-08-31
DE60029589T2 (de) 2007-07-19

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ARAI Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
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Payment date: 20150506

Year of fee payment: 16

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Effective date: 20160627