JP4673839B2 - ガンの処置で使用するためのキナゾリン誘導体 - Google Patents

ガンの処置で使用するためのキナゾリン誘導体 Download PDF

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Publication number
JP4673839B2
JP4673839B2 JP2006506187A JP2006506187A JP4673839B2 JP 4673839 B2 JP4673839 B2 JP 4673839B2 JP 2006506187 A JP2006506187 A JP 2006506187A JP 2006506187 A JP2006506187 A JP 2006506187A JP 4673839 B2 JP4673839 B2 JP 4673839B2
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JP
Japan
Prior art keywords
alkyl
chloro
pyrrolidin
group
methyl
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Expired - Fee Related
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JP2006506187A
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Japanese (ja)
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JP2006525296A (ja
JP2006525296A5 (https=
Inventor
ヘンネキン，ローレント・フランコイス・アンドレ
プロウライト，アレイン
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AstraZeneca AB
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AstraZeneca AB
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2006506187A 2003-04-30 2004-04-27 ガンの処置で使用するためのキナゾリン誘導体 Expired - Fee Related JP4673839B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0309850.6A GB0309850D0 (en) 2003-04-30 2003-04-30 Quinazoline derivatives
PCT/GB2004/001799 WO2004096226A1 (en) 2003-04-30 2004-04-27 Quinazoline derivatives and their use in the treatment of cancer

Publications (3)

Publication Number Publication Date
JP2006525296A JP2006525296A (ja) 2006-11-09
JP2006525296A5 JP2006525296A5 (https=) 2007-05-31
JP4673839B2 true JP4673839B2 (ja) 2011-04-20

Family

ID=9957316

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006506187A Expired - Fee Related JP4673839B2 (ja) 2003-04-30 2004-04-27 ガンの処置で使用するためのキナゾリン誘導体

Country Status (8)

Country Link
US (1) US7659279B2 (https=)
EP (1) EP1622620B1 (https=)
JP (1) JP4673839B2 (https=)
AT (1) ATE386530T1 (https=)
DE (1) DE602004011924T2 (https=)
ES (1) ES2300767T3 (https=)
GB (1) GB0309850D0 (https=)
WO (1) WO2004096226A1 (https=)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005515176A (ja) * 2001-11-03 2005-05-26 アストラゼネカ アクチボラグ 抗腫瘍剤としてのキナゾリン誘導体
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GB0309009D0 (en) * 2003-04-22 2003-05-28 Astrazeneca Ab Quinazoline derivatives
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AU2004272345A1 (en) * 2003-09-16 2005-03-24 Astrazeneca Ab Quinazoline derivatives
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US20070032508A1 (en) * 2003-09-16 2007-02-08 Bradbury Robert H Quinazoline derivatives as tyrosine kinase inhibitors
GB0322409D0 (en) * 2003-09-25 2003-10-29 Astrazeneca Ab Quinazoline derivatives
GB0326459D0 (en) 2003-11-13 2003-12-17 Astrazeneca Ab Quinazoline derivatives
JP5032851B2 (ja) 2004-02-03 2012-09-26 アストラゼネカ アクチボラグ キナゾリン誘導体
AU2005250224A1 (en) * 2004-06-04 2005-12-15 Astrazeneca Ab Quinazoline derivatives as ERBB receptor tyrosine kinases
EP1838712B8 (en) * 2004-12-14 2011-10-12 AstraZeneca AB Pyrazolopyrimidine compounds as antitumor agents
GB0427697D0 (en) * 2004-12-17 2005-01-19 Astrazeneca Ab Chemical process
GB0504475D0 (en) * 2005-03-04 2005-04-13 Astrazeneca Ab Chemical compounds
GB0504474D0 (en) * 2005-03-04 2005-04-13 Astrazeneca Ab Chemical compounds
GB0508717D0 (en) * 2005-04-29 2005-06-08 Astrazeneca Ab Chemical compounds
GB0508715D0 (en) * 2005-04-29 2005-06-08 Astrazeneca Ab Chemical compounds
JP2009508917A (ja) * 2005-09-20 2009-03-05 アストラゼネカ アクチボラグ 抗癌剤としてのキナゾリン誘導体
WO2007034144A1 (en) * 2005-09-20 2007-03-29 Astrazeneca Ab 4- (ih-indazol-s-yl-amino)-quinazoline compounds as erbb receptor tyrosine kinase inhibitors for the treatment of cancer
JP2009517450A (ja) * 2005-12-02 2009-04-30 アストラゼネカ アクチボラグ チロシンキナーゼ阻害薬としての４−アニリノ置換キナゾリン誘導体
JP2009517451A (ja) * 2005-12-02 2009-04-30 アストラゼネカ アクチボラグ Ｅｒｂｂチロシンキナーゼの阻害剤として使用されるキナゾリン誘導体
EP2303276B1 (en) 2008-05-13 2013-11-13 AstraZeneca AB Fumarate salt of 4-(3-chloro-2-fluoroanilino)-7-methoxy-6-{[1-(n-methylcarbamoylmethyl)piperidin-4-yl]oxy}quinazoline
CA3081553C (en) 2017-11-17 2022-11-15 Cellix Bio Private Limited Compositions and methods for the treatment of eye disorders

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JP2005515176A (ja) * 2001-11-03 2005-05-26 アストラゼネカ アクチボラグ 抗腫瘍剤としてのキナゾリン誘導体
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GB0309009D0 (en) * 2003-04-22 2003-05-28 Astrazeneca Ab Quinazoline derivatives
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AU2004272346A1 (en) * 2003-09-16 2005-03-24 Astrazeneca Ab Quinazoline derivatives
ES2305844T3 (es) * 2003-09-16 2008-11-01 Astrazeneca Ab Derivados de quinazolina como inhibidores de tirosina cinasa.
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GB0322409D0 (en) * 2003-09-25 2003-10-29 Astrazeneca Ab Quinazoline derivatives
GB0326459D0 (en) * 2003-11-13 2003-12-17 Astrazeneca Ab Quinazoline derivatives
JP5032851B2 (ja) * 2004-02-03 2012-09-26 アストラゼネカ アクチボラグ キナゾリン誘導体
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Also Published As

Publication number Publication date
WO2004096226A1 (en) 2004-11-11
EP1622620B1 (en) 2008-02-20
US7659279B2 (en) 2010-02-09
DE602004011924D1 (de) 2008-04-03
DE602004011924T2 (de) 2009-01-08
EP1622620A1 (en) 2006-02-08
ATE386530T1 (de) 2008-03-15
US20060211714A1 (en) 2006-09-21
JP2006525296A (ja) 2006-11-09
HK1087613A1 (en) 2006-10-20
GB0309850D0 (en) 2003-06-04
ES2300767T3 (es) 2008-06-16

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