JP4629334B2 - システインプロテアーゼの阻害因子としてのピロロピリミジン - Google Patents
システインプロテアーゼの阻害因子としてのピロロピリミジン Download PDFInfo
- Publication number
- JP4629334B2 JP4629334B2 JP2003524991A JP2003524991A JP4629334B2 JP 4629334 B2 JP4629334 B2 JP 4629334B2 JP 2003524991 A JP2003524991 A JP 2003524991A JP 2003524991 A JP2003524991 A JP 2003524991A JP 4629334 B2 JP4629334 B2 JP 4629334B2
- Authority
- JP
- Japan
- Prior art keywords
- propyl
- pyrrolo
- dimethyl
- pyrimidine
- carbonitrile
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 CCc([n]1*CC*)cc2c1nc(C#N)nc2 Chemical compound CCc([n]1*CC*)cc2c1nc(C#N)nc2 0.000 description 14
- XBQHHKVUQMLHJZ-UHFFFAOYSA-N Cc1c(NC)nc(C)nc1 Chemical compound Cc1c(NC)nc(C)nc1 XBQHHKVUQMLHJZ-UHFFFAOYSA-N 0.000 description 2
- YSBWXEUHBBTOJF-UHFFFAOYSA-N CC(C)(C)CNc1c(C)[n](C)c(C#N)n1 Chemical compound CC(C)(C)CNc1c(C)[n](C)c(C#N)n1 YSBWXEUHBBTOJF-UHFFFAOYSA-N 0.000 description 1
- NWSNCNVCDPBGAR-UHFFFAOYSA-N CC(C)(C)C[n]1c2nc(C#N)ncc2cc1CN(C(CN(C1)C(OC(C)(C)C)=O)=O)C1=O Chemical compound CC(C)(C)C[n]1c2nc(C#N)ncc2cc1CN(C(CN(C1)C(OC(C)(C)C)=O)=O)C1=O NWSNCNVCDPBGAR-UHFFFAOYSA-N 0.000 description 1
- IQFKMQAIOBWBLW-UHFFFAOYSA-N CC(C)(C)C[n]1c2nc(C#N)ncc2cc1CN(CC1)CCN1c(cc1)ccc1C(C)=O Chemical compound CC(C)(C)C[n]1c2nc(C#N)ncc2cc1CN(CC1)CCN1c(cc1)ccc1C(C)=O IQFKMQAIOBWBLW-UHFFFAOYSA-N 0.000 description 1
- OAINXYLTHFSMMN-UHFFFAOYSA-N CC(C)(C)C[n]1c2nc(C#N)ncc2cc1CN(CC1)CCN1c1c(C)cccc1C Chemical compound CC(C)(C)C[n]1c2nc(C#N)ncc2cc1CN(CC1)CCN1c1c(C)cccc1C OAINXYLTHFSMMN-UHFFFAOYSA-N 0.000 description 1
- PAKPEUHNHWITNS-UHFFFAOYSA-N CC(C)(C)C[n]1c2nc(C#N)ncc2cc1CN/N=N\C(c1ccc(CCl)cc1)=N Chemical compound CC(C)(C)C[n]1c2nc(C#N)ncc2cc1CN/N=N\C(c1ccc(CCl)cc1)=N PAKPEUHNHWITNS-UHFFFAOYSA-N 0.000 description 1
- MMYLURYQLIZURB-UHFFFAOYSA-N CC(C)(C)C[n]1c2nc(C#N)ncc2cc1CN/N=N\C(c1ccc(CN2CCCCC2)cc1)=N Chemical compound CC(C)(C)C[n]1c2nc(C#N)ncc2cc1CN/N=N\C(c1ccc(CN2CCCCC2)cc1)=N MMYLURYQLIZURB-UHFFFAOYSA-N 0.000 description 1
- KIVXZRKUUAEFCO-UHFFFAOYSA-N CC(C)(C)C[n]1c2nc(C#N)ncc2cc1CN/N=N\C(c1ccc(CO)cc1)=N Chemical compound CC(C)(C)C[n]1c2nc(C#N)ncc2cc1CN/N=N\C(c1ccc(CO)cc1)=N KIVXZRKUUAEFCO-UHFFFAOYSA-N 0.000 description 1
- XCLCHALZLMRKMQ-UHFFFAOYSA-N CC(C)(C)C[n]1c2nc(C#N)ncc2cc1COc1cc(Cl)ncn1 Chemical compound CC(C)(C)C[n]1c2nc(C#N)ncc2cc1COc1cc(Cl)ncn1 XCLCHALZLMRKMQ-UHFFFAOYSA-N 0.000 description 1
- LYTIAMDXOVOOHR-UHFFFAOYSA-N CC(C)(C)C[n]1c2nc(C#N)ncc2cc1Cc1ccc(CN/C=N\C=N)cc1 Chemical compound CC(C)(C)C[n]1c2nc(C#N)ncc2cc1Cc1ccc(CN/C=N\C=N)cc1 LYTIAMDXOVOOHR-UHFFFAOYSA-N 0.000 description 1
- KOLRBJXRZQYUDU-UHFFFAOYSA-N CC(C)(C)OC(N(C(C(CC1)(CCN1C(OC(C)(C)C)=O)N1)=O)C1=O)=O Chemical compound CC(C)(C)OC(N(C(C(CC1)(CCN1C(OC(C)(C)C)=O)N1)=O)C1=O)=O KOLRBJXRZQYUDU-UHFFFAOYSA-N 0.000 description 1
- DHJXKTPWDXJQEK-UHFFFAOYSA-N CC(C)(C)OC(N(CC1)CCC1(C(N1)=O)NC1=O)=O Chemical compound CC(C)(C)OC(N(CC1)CCC1(C(N1)=O)NC1=O)=O DHJXKTPWDXJQEK-UHFFFAOYSA-N 0.000 description 1
- ABNALEUMAZTJGU-UHFFFAOYSA-N CC(C)(C)OC(N(CC1)CCC1(C(N1C)=O)N(C)C1=O)=O Chemical compound CC(C)(C)OC(N(CC1)CCC1(C(N1C)=O)N(C)C1=O)=O ABNALEUMAZTJGU-UHFFFAOYSA-N 0.000 description 1
- XCNPCKGQMXHCNS-APXACOEDSA-N CC(C)/N=C(/C#N)\N=C/C Chemical compound CC(C)/N=C(/C#N)\N=C/C XCNPCKGQMXHCNS-APXACOEDSA-N 0.000 description 1
- JKIZQXAGFSTQBD-UHFFFAOYSA-N CC(C)OCCN(C)C Chemical compound CC(C)OCCN(C)C JKIZQXAGFSTQBD-UHFFFAOYSA-N 0.000 description 1
- IFKAOXCGHQLJCX-UHFFFAOYSA-N CC(C)c1c(N(C)CC(C)(C)C)nc(C#N)[nH]1 Chemical compound CC(C)c1c(N(C)CC(C)(C)C)nc(C#N)[nH]1 IFKAOXCGHQLJCX-UHFFFAOYSA-N 0.000 description 1
- LDRPULCXZDDSGE-UHFFFAOYSA-N CCCC(F)(F)F Chemical compound CCCC(F)(F)F LDRPULCXZDDSGE-UHFFFAOYSA-N 0.000 description 1
- SZSUNQBSXSFPDF-UHFFFAOYSA-N CCCC(Nc1ccc(Cc2cc3cnc(C#N)nc3[n]2CC(C)(C)C)cc1)=O Chemical compound CCCC(Nc1ccc(Cc2cc3cnc(C#N)nc3[n]2CC(C)(C)C)cc1)=O SZSUNQBSXSFPDF-UHFFFAOYSA-N 0.000 description 1
- ROOAZSFNNONQFB-UHFFFAOYSA-N CCCN(C(C1(CCN(Cc([n]2CC(C)(C)C)cc3c2nc(C#N)nc3)CC1)N1)=O)C1=O Chemical compound CCCN(C(C1(CCN(Cc([n]2CC(C)(C)C)cc3c2nc(C#N)nc3)CC1)N1)=O)C1=O ROOAZSFNNONQFB-UHFFFAOYSA-N 0.000 description 1
- ZSUBSMFLGXJIBB-UHFFFAOYSA-N CCCN(C(N1C)O)C2(CCN(Cc3cc4cnc(C#N)nc4[n]3CC(C)(C)C)CC2)C1=O Chemical compound CCCN(C(N1C)O)C2(CCN(Cc3cc4cnc(C#N)nc4[n]3CC(C)(C)C)CC2)C1=O ZSUBSMFLGXJIBB-UHFFFAOYSA-N 0.000 description 1
- XRSMROJWIXPQLP-UHFFFAOYSA-N CCCN(C1(CCNCC1)/C(/N1C)=[O]/C)C1=O Chemical compound CCCN(C1(CCNCC1)/C(/N1C)=[O]/C)C1=O XRSMROJWIXPQLP-UHFFFAOYSA-N 0.000 description 1
- ZDJLKHADBWOJQU-UHFFFAOYSA-N CCN(C1(CCN(Cc2cc3cnc(C#N)nc3[n]2CC(C)(C)C)CC1)C(N1)=O)C1=O Chemical compound CCN(C1(CCN(Cc2cc3cnc(C#N)nc3[n]2CC(C)(C)C)CC1)C(N1)=O)C1=O ZDJLKHADBWOJQU-UHFFFAOYSA-N 0.000 description 1
- SZKYYMCBYVBBQI-UHFFFAOYSA-N CCN(CC1)CCC1(C(N1)=O)OC1=O Chemical compound CCN(CC1)CCC1(C(N1)=O)OC1=O SZKYYMCBYVBBQI-UHFFFAOYSA-N 0.000 description 1
- HWGWISRVEWQRIQ-UHFFFAOYSA-N CCc1cnc(N(CC2)CCN2C(OC(C)(C)C)=O)nc1 Chemical compound CCc1cnc(N(CC2)CCN2C(OC(C)(C)C)=O)nc1 HWGWISRVEWQRIQ-UHFFFAOYSA-N 0.000 description 1
- MZQQHYDUINOMDG-UHFFFAOYSA-N CN(C(CN1)=O)C1=O Chemical compound CN(C(CN1)=O)C1=O MZQQHYDUINOMDG-UHFFFAOYSA-N 0.000 description 1
- YJDDYJYAMSGYLO-UHFFFAOYSA-N CN1CCN(Cc(cc2)ccc2OCC#Cc2c(NC3CCCCC3)nc(C#N)nc2)CC1 Chemical compound CN1CCN(Cc(cc2)ccc2OCC#Cc2c(NC3CCCCC3)nc(C#N)nc2)CC1 YJDDYJYAMSGYLO-UHFFFAOYSA-N 0.000 description 1
- JDTNUODODFBTAB-UHFFFAOYSA-N CN1CCN(Cc(cc2)ccc2OCc([n]2C3CCCCC3)cc3c2nc(C#N)nc3)CC1 Chemical compound CN1CCN(Cc(cc2)ccc2OCc([n]2C3CCCCC3)cc3c2nc(C#N)nc3)CC1 JDTNUODODFBTAB-UHFFFAOYSA-N 0.000 description 1
- CHLICZRVGGXEOD-UHFFFAOYSA-N Cc(cc1)ccc1OC Chemical compound Cc(cc1)ccc1OC CHLICZRVGGXEOD-UHFFFAOYSA-N 0.000 description 1
- CAWHJQAVHZEVTJ-UHFFFAOYSA-N Cc1nccnc1 Chemical compound Cc1nccnc1 CAWHJQAVHZEVTJ-UHFFFAOYSA-N 0.000 description 1
- QTYNRNCLRXPYHQ-UHFFFAOYSA-N O=C(C1(CCNCC1)O1)NC1=O Chemical compound O=C(C1(CCNCC1)O1)NC1=O QTYNRNCLRXPYHQ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0121033.5A GB0121033D0 (en) | 2001-08-30 | 2001-08-30 | Organic compounds |
| PCT/EP2002/009663 WO2003020721A1 (en) | 2001-08-30 | 2002-08-29 | Pyrrolo pyrimidines as agents for the inhibition of cystein proteases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005502683A JP2005502683A (ja) | 2005-01-27 |
| JP2005502683A5 JP2005502683A5 (enExample) | 2010-09-09 |
| JP4629334B2 true JP4629334B2 (ja) | 2011-02-09 |
Family
ID=9921234
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003524991A Expired - Fee Related JP4629334B2 (ja) | 2001-08-30 | 2002-08-29 | システインプロテアーゼの阻害因子としてのピロロピリミジン |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US7452886B2 (enExample) |
| EP (1) | EP1423391B8 (enExample) |
| JP (1) | JP4629334B2 (enExample) |
| KR (1) | KR100695845B1 (enExample) |
| CN (1) | CN100372849C (enExample) |
| AR (1) | AR036374A1 (enExample) |
| AT (1) | ATE326469T1 (enExample) |
| AU (1) | AU2002333760B2 (enExample) |
| BR (1) | BR0212226A (enExample) |
| CA (1) | CA2458684C (enExample) |
| CY (1) | CY1105573T1 (enExample) |
| DE (1) | DE60211530T2 (enExample) |
| DK (1) | DK1423391T3 (enExample) |
| EC (1) | ECSP044998A (enExample) |
| ES (1) | ES2262888T3 (enExample) |
| GB (1) | GB0121033D0 (enExample) |
| HU (1) | HUP0401301A3 (enExample) |
| IL (3) | IL160367A0 (enExample) |
| MX (1) | MXPA04001935A (enExample) |
| MY (1) | MY157368A (enExample) |
| NO (1) | NO328890B1 (enExample) |
| NZ (1) | NZ531343A (enExample) |
| PE (1) | PE20030418A1 (enExample) |
| PL (1) | PL368280A1 (enExample) |
| PT (1) | PT1423391E (enExample) |
| RU (1) | RU2331644C2 (enExample) |
| TW (1) | TWI297690B (enExample) |
| WO (1) | WO2003020721A1 (enExample) |
| ZA (1) | ZA200401042B (enExample) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030144234A1 (en) * | 2001-08-30 | 2003-07-31 | Buxton Francis Paul | Methods for the treatment of chronic pain and compositions therefor |
| SE0201980D0 (sv) | 2002-06-24 | 2002-06-24 | Astrazeneca Ab | Novel compounds |
| GB0220187D0 (en) | 2002-08-30 | 2002-10-09 | Novartis Ag | Organic compounds |
| MXPA05003254A (es) | 2002-09-24 | 2005-06-08 | Novartis Ag | Agonistas del receptor de esfingosina-1-fosfato en el tratamiento de trastornos de desmielinacion. |
| AR043692A1 (es) * | 2003-02-06 | 2005-08-10 | Novartis Ag | 2-cianopirrolopirimidinas y sus usos farmaceuticos |
| GB0304640D0 (en) * | 2003-02-28 | 2003-04-02 | Novartis Ag | Organic compounds |
| EP1619193A4 (en) * | 2003-04-18 | 2010-08-11 | Ono Pharmaceutical Co | SPIROPIPERIDINE COMPOUND AND MEDICINAL USE THEREOF |
| WO2004096227A1 (en) * | 2003-04-28 | 2004-11-11 | Novartis Ag | Pharmaceutical compositon comprising a cathepsin s inhibitor and an opioid |
| EP1797883A3 (en) * | 2003-04-28 | 2007-08-01 | Novartis AG | Pharmaceutical composition comprising a cathepsin S inhibitor and an opioid |
| ATE434612T1 (de) * | 2003-04-30 | 2009-07-15 | Bayer Cropscience Ag | Insektizide (dihalopropenyl)phenylalkyl substituierte dihydrobenzofuran- und dihydrobenzopyran-derivate |
| WO2005011703A1 (en) * | 2003-08-04 | 2005-02-10 | Akzo Nobel N.V. | 2-cyano-1,3,5-triazine-4,6-diamine derivatives |
| CA2579609A1 (en) | 2003-09-10 | 2005-03-17 | Virochem Pharma Inc. | Spirohydantoin compounds and methods for the modulation of chemokine receptor activity |
| WO2005080356A1 (en) | 2004-02-18 | 2005-09-01 | Astrazeneca Ab | Tetrazole compounds and their use as metabotropic glutamate receptor antagonits |
| EP1724264A1 (en) * | 2004-03-10 | 2006-11-22 | Ono Pharmaceutical Co., Ltd. | Nitriles and medicinal compositions containing the same as the active ingredient |
| ES2251292B1 (es) * | 2004-04-20 | 2007-07-01 | Inke, S.A. | Procedimiento para la obtencion de un compuesto farmaceuticamente activo y de sus intermedios de sintesis. |
| CA2564953A1 (en) * | 2004-05-03 | 2005-11-24 | Janssen Pharmaceutica N.V. | Novel indole derivatives as selective androgen receptor modulators (sarms) |
| TW200614993A (en) | 2004-06-11 | 2006-05-16 | Akzo Nobel Nv | 4-phenyl-pyrimidine-2-carbonitrile derivatives |
| US7951816B2 (en) | 2004-08-27 | 2011-05-31 | Ono Pharmaceutical Co., Ltd. | Compound containing basic group and use thereof |
| KR100651849B1 (ko) * | 2005-02-01 | 2006-12-01 | 엘지전자 주식회사 | 세탁기 |
| RU2424234C2 (ru) * | 2005-08-05 | 2011-07-20 | Ибриженикс Са | Новые ингибиторы цистеиновых протеаз и их терапевтическое применение |
| EP1933860A2 (en) | 2005-09-01 | 2008-06-25 | Ares Trading S.A. | Treatment of optic neuritis |
| TW200745055A (en) * | 2005-09-23 | 2007-12-16 | Organon Nv | 4-Phenyl-6-substituted-pyrimidine-2-carbonitrile derivatives |
| US7326715B2 (en) | 2005-09-23 | 2008-02-05 | N.V. Organon | 4-Phenyl-6-substituted-pyrimidine-2-carbonitrile derivatives |
| TW200732314A (en) * | 2005-10-26 | 2007-09-01 | Smithkline Beecham Corp | Substituted thiazoles and their use |
| PT1961744E (pt) | 2005-11-18 | 2013-05-15 | Ono Pharmaceutical Co | Composto que contém um grupo básico e sua utilização |
| EA200870019A1 (ru) * | 2005-12-05 | 2008-12-30 | Инсайт Корпорейшн | Лактамовые соединения и способы их применения |
| US7687515B2 (en) | 2006-01-17 | 2010-03-30 | N.V. Organon | 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives |
| US8618122B2 (en) | 2006-05-16 | 2013-12-31 | Ono Pharmaceutical Co., Ltd. | Compound having acidic group which may be protected, and use thereof |
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