JP4594623B2 - Ｇタンパク質共役レセプターリガンドおよび方法 - Google Patents

Ｇタンパク質共役レセプターリガンドおよび方法 Download PDF

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Publication number
JP4594623B2
JP4594623B2 JP2003584089A JP2003584089A JP4594623B2 JP 4594623 B2 JP4594623 B2 JP 4594623B2 JP 2003584089 A JP2003584089 A JP 2003584089A JP 2003584089 A JP2003584089 A JP 2003584089A JP 4594623 B2 JP4594623 B2 JP 4594623B2
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JP
Japan
Prior art keywords
seq
amino acid
receptor
polypeptide
acid sequence
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Expired - Fee Related
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JP2003584089A
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English (en)
Japanese (ja)
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JP2005528894A5 (enExample
JP2005528894A (ja
Inventor
イン ジャン，
ファン リャン ザン，
ニコラス ジェイ． ムーゴロ，
リン ルオ，
ジェイソン エス． サイモン，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
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Schering Corp
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Publication of JP4594623B2 publication Critical patent/JP4594623B2/ja
Anticipated expiration legal-status Critical
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Biotechnology (AREA)
  • Diabetes (AREA)
  • Microbiology (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Neurology (AREA)
  • General Physics & Mathematics (AREA)
JP2003584089A 2002-04-12 2003-04-10 Ｇタンパク質共役レセプターリガンドおよび方法 Expired - Fee Related JP4594623B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37264002P 2002-04-12 2002-04-12
PCT/US2003/011159 WO2003087134A2 (en) 2002-04-12 2003-04-10 G-protein coupled receptor ligands and methods

Related Child Applications (3)

Application Number Title Priority Date Filing Date
JP2006103683A Division JP2006254916A (ja) 2002-04-12 2006-04-04 Ｇタンパク質共役レセプターリガンドおよび方法
JP2010163440A Division JP2010252805A (ja) 2002-04-12 2010-07-20 Ｇタンパク質共役レセプターリガンドおよび方法
JP2010163439A Division JP5284313B2 (ja) 2002-04-12 2010-07-20 Ｇタンパク質共役レセプターリガンドおよび方法

Publications (3)

Publication Number Publication Date
JP2005528894A JP2005528894A (ja) 2005-09-29
JP2005528894A5 JP2005528894A5 (enExample) 2006-07-06
JP4594623B2 true JP4594623B2 (ja) 2010-12-08

Family

ID=29250884

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2003584089A Expired - Fee Related JP4594623B2 (ja) 2002-04-12 2003-04-10 Ｇタンパク質共役レセプターリガンドおよび方法
JP2006103683A Pending JP2006254916A (ja) 2002-04-12 2006-04-04 Ｇタンパク質共役レセプターリガンドおよび方法
JP2010163440A Withdrawn JP2010252805A (ja) 2002-04-12 2010-07-20 Ｇタンパク質共役レセプターリガンドおよび方法
JP2010163439A Expired - Fee Related JP5284313B2 (ja) 2002-04-12 2010-07-20 Ｇタンパク質共役レセプターリガンドおよび方法

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2006103683A Pending JP2006254916A (ja) 2002-04-12 2006-04-04 Ｇタンパク質共役レセプターリガンドおよび方法
JP2010163440A Withdrawn JP2010252805A (ja) 2002-04-12 2010-07-20 Ｇタンパク質共役レセプターリガンドおよび方法
JP2010163439A Expired - Fee Related JP5284313B2 (ja) 2002-04-12 2010-07-20 Ｇタンパク質共役レセプターリガンドおよび方法

Country Status (9)

Country Link
US (3) US7338772B2 (enExample)
EP (1) EP1532446B1 (enExample)
JP (4) JP4594623B2 (enExample)
CN (1) CN1324047C (enExample)
AT (1) ATE545866T1 (enExample)
AU (1) AU2003221878A1 (enExample)
CA (1) CA2481508A1 (enExample)
MX (1) MXPA04009959A (enExample)
WO (1) WO2003087134A2 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4594623B2 (ja) * 2002-04-12 2010-12-08 シェーリング コーポレイション Ｇタンパク質共役レセプターリガンドおよび方法
WO2006039256A1 (en) * 2004-09-29 2006-04-13 Glaxo Group Limited Use of gpr103 agonists for modulating feeding behaviour
WO2009043524A2 (en) * 2007-09-11 2009-04-09 Mondobiotech Laboratories Ag Use of a peptide as therapeutic agent
JP5313068B2 (ja) * 2009-03-09 2013-10-09 富士フイルム株式会社 側視内視鏡装置
CA2963579C (en) * 2014-10-14 2023-10-31 Universite De Montreal Biosensor based on g-beta-gamma-interacting proteins to monitor g-protein activation
JP6405352B2 (ja) * 2016-09-16 2018-10-17 株式会社Ｓｕｂａｒｕ 直噴内燃機関のピストン

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US4952496A (en) 1984-03-30 1990-08-28 Associated Universities, Inc. Cloning and expression of the gene for bacteriophage T7 RNA polymerase
US5693489A (en) 1984-03-30 1997-12-02 Associated Universities, Inc. Cloning and expression of the gene for bacteriophage T7 RNA polymerase
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US5011912A (en) * 1986-12-19 1991-04-30 Immunex Corporation Hybridoma and monoclonal antibody for use in an immunoaffinity purification system
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Also Published As

Publication number Publication date
CN1324047C (zh) 2007-07-04
CA2481508A1 (en) 2003-10-23
EP1532446A4 (en) 2006-06-07
JP2010279373A (ja) 2010-12-16
US20030223992A1 (en) 2003-12-04
US7338772B2 (en) 2008-03-04
AU2003221878A1 (en) 2003-10-27
JP2010252805A (ja) 2010-11-11
WO2003087134A3 (en) 2005-03-24
AU2003221878A8 (en) 2003-10-27
JP2006254916A (ja) 2006-09-28
ATE545866T1 (de) 2012-03-15
US8133980B2 (en) 2012-03-13
JP2005528894A (ja) 2005-09-29
JP5284313B2 (ja) 2013-09-11
US7807390B2 (en) 2010-10-05
US20080138348A1 (en) 2008-06-12
MXPA04009959A (es) 2004-12-13
WO2003087134A2 (en) 2003-10-23
EP1532446B1 (en) 2012-02-15
EP1532446A2 (en) 2005-05-25
CN1659438A (zh) 2005-08-24
US20110020354A1 (en) 2011-01-27

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