CN1324047C - G蛋白偶联受体的配体与方法 - Google Patents

G蛋白偶联受体的配体与方法 Download PDF

Info

Publication number
CN1324047C
CN1324047C CNB038131234A CN03813123A CN1324047C CN 1324047 C CN1324047 C CN 1324047C CN B038131234 A CNB038131234 A CN B038131234A CN 03813123 A CN03813123 A CN 03813123A CN 1324047 C CN1324047 C CN 1324047C
Authority
CN
China
Prior art keywords
seq
leu
ala
gly
phe
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB038131234A
Other languages
English (en)
Chinese (zh)
Other versions
CN1659438A (zh
Inventor
Y·蒋
F·L·张
N·J·穆尔戈罗
L·罗
J·S·西蒙
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of CN1659438A publication Critical patent/CN1659438A/zh
Application granted granted Critical
Publication of CN1324047C publication Critical patent/CN1324047C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Biotechnology (AREA)
  • Diabetes (AREA)
  • Microbiology (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Neurology (AREA)
  • General Physics & Mathematics (AREA)
CNB038131234A 2002-04-12 2003-04-10 G蛋白偶联受体的配体与方法 Expired - Fee Related CN1324047C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37264002P 2002-04-12 2002-04-12
US60/372,640 2002-04-12

Publications (2)

Publication Number Publication Date
CN1659438A CN1659438A (zh) 2005-08-24
CN1324047C true CN1324047C (zh) 2007-07-04

Family

ID=29250884

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB038131234A Expired - Fee Related CN1324047C (zh) 2002-04-12 2003-04-10 G蛋白偶联受体的配体与方法

Country Status (9)

Country Link
US (3) US7338772B2 (enExample)
EP (1) EP1532446B1 (enExample)
JP (4) JP4594623B2 (enExample)
CN (1) CN1324047C (enExample)
AT (1) ATE545866T1 (enExample)
AU (1) AU2003221878A1 (enExample)
CA (1) CA2481508A1 (enExample)
MX (1) MXPA04009959A (enExample)
WO (1) WO2003087134A2 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4594623B2 (ja) * 2002-04-12 2010-12-08 シェーリング コーポレイション Ｇタンパク質共役レセプターリガンドおよび方法
WO2006039256A1 (en) * 2004-09-29 2006-04-13 Glaxo Group Limited Use of gpr103 agonists for modulating feeding behaviour
WO2009043524A2 (en) * 2007-09-11 2009-04-09 Mondobiotech Laboratories Ag Use of a peptide as therapeutic agent
JP5313068B2 (ja) * 2009-03-09 2013-10-09 富士フイルム株式会社 側視内視鏡装置
CA2963579C (en) * 2014-10-14 2023-10-31 Universite De Montreal Biosensor based on g-beta-gamma-interacting proteins to monitor g-protein activation
JP6405352B2 (ja) * 2016-09-16 2018-10-17 株式会社Ｓｕｂａｒｕ 直噴内燃機関のピストン

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1167490A (zh) * 1994-11-10 1997-12-10 人体基因组科学有限公司 人司登尼亚钙蛋白-α
WO2000011015A1 (en) * 1998-08-24 2000-03-02 Alphagene, Inc. Secreted proteins and polynucleotides encoding them
WO2000066151A1 (en) * 1999-04-29 2000-11-09 Novo Nordisk A/S Use of heparin-binding antagonists in the inhibition of bradykinin release

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4447233A (en) 1981-04-10 1984-05-08 Parker-Hannifin Corporation Medication infusion pump
US4439196A (en) 1982-03-18 1984-03-27 Merck & Co., Inc. Osmotic drug delivery system
US4447224A (en) 1982-09-20 1984-05-08 Infusaid Corporation Variable flow implantable infusion apparatus
US4487603A (en) 1982-11-26 1984-12-11 Cordis Corporation Implantable microinfusion pump system
US4952496A (en) 1984-03-30 1990-08-28 Associated Universities, Inc. Cloning and expression of the gene for bacteriophage T7 RNA polymerase
US5693489A (en) 1984-03-30 1997-12-02 Associated Universities, Inc. Cloning and expression of the gene for bacteriophage T7 RNA polymerase
US4596556A (en) 1985-03-25 1986-06-24 Bioject, Inc. Hypodermic injection apparatus
US5011912A (en) * 1986-12-19 1991-04-30 Immunex Corporation Hybridoma and monoclonal antibody for use in an immunoaffinity purification system
US4790824A (en) 1987-06-19 1988-12-13 Bioject, Inc. Non-invasive hypodermic injection device
US4941880A (en) 1987-06-19 1990-07-17 Bioject, Inc. Pre-filled ampule and non-invasive hypodermic injection device assembly
US5064413A (en) 1989-11-09 1991-11-12 Bioject, Inc. Needleless hypodermic injection device
US5312335A (en) 1989-11-09 1994-05-17 Bioject Inc. Needleless hypodermic injection device
US5383851A (en) 1992-07-24 1995-01-24 Bioject Inc. Needleless hypodermic injection device
WO1997037967A1 (en) 1996-04-09 1997-10-16 Nps Pharmaceuticals, Inc. Calcilytic compounds
SE9704836D0 (sv) 1997-12-22 1997-12-22 Astra Pharma Inc Novel receptor
KR20010080882A (ko) 1998-10-13 2001-08-25 리처드 피. 버군 쥬니어 구성적으로 활성화된 비내생성 인간 ｇ 단백질 결합형수용체
PT1133559E (pt) 1998-11-20 2005-10-31 Arena Pharm Inc Receptor acoplato a proteina g orfao humano, rup3
WO2000031256A1 (fr) 1998-11-20 2000-06-02 Chugai Research Institute For Molecular Medicine, Inc. Nouveau gene codant une proteine membranaire specifique au cerveau
EP1189944A4 (en) 1999-06-21 2002-09-11 Smithkline Beecham Corp AXOR16, R CEPTEUR COUPL UNE PROT INE G
CA2311201A1 (en) * 1999-08-05 2001-02-05 Genset S.A. Ests and encoded human proteins
WO2001016316A1 (fr) 1999-08-27 2001-03-08 Takeda Chemical Industries, Ltd. Proteine recepteur couplee a une proteine g et adn correspondant
AU7645700A (en) * 1999-10-07 2001-05-10 Maxygen Aps Single-chain antagonist polypeptides
WO2001048189A1 (fr) 1999-12-28 2001-07-05 Helix Research Institute Nouveaux recepteurs couples a une proteine de liaison au guanosine triphosphate, genes de ces derniers, et production et utilisation de ces derniers
AU2001271838A1 (en) * 2000-07-06 2002-01-21 Bayer Corporation Human neuropeptide y-like g protein-coupled receptor
WO2003020932A1 (en) * 2001-09-03 2003-03-13 Takeda Chemical Industries, Ltd. Novel secretory proteins and dna thereof
JP4594623B2 (ja) * 2002-04-12 2010-12-08 シェーリング コーポレイション Ｇタンパク質共役レセプターリガンドおよび方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1167490A (zh) * 1994-11-10 1997-12-10 人体基因组科学有限公司 人司登尼亚钙蛋白-α
WO2000011015A1 (en) * 1998-08-24 2000-03-02 Alphagene, Inc. Secreted proteins and polynucleotides encoding them
WO2000066151A1 (en) * 1999-04-29 2000-11-09 Novo Nordisk A/S Use of heparin-binding antagonists in the inhibition of bradykinin release

Also Published As

Publication number Publication date
CA2481508A1 (en) 2003-10-23
EP1532446A4 (en) 2006-06-07
JP4594623B2 (ja) 2010-12-08
JP2010279373A (ja) 2010-12-16
US20030223992A1 (en) 2003-12-04
US7338772B2 (en) 2008-03-04
AU2003221878A1 (en) 2003-10-27
JP2010252805A (ja) 2010-11-11
WO2003087134A3 (en) 2005-03-24
AU2003221878A8 (en) 2003-10-27
JP2006254916A (ja) 2006-09-28
ATE545866T1 (de) 2012-03-15
US8133980B2 (en) 2012-03-13
JP2005528894A (ja) 2005-09-29
JP5284313B2 (ja) 2013-09-11
US7807390B2 (en) 2010-10-05
US20080138348A1 (en) 2008-06-12
MXPA04009959A (es) 2004-12-13
WO2003087134A2 (en) 2003-10-23
EP1532446B1 (en) 2012-02-15
EP1532446A2 (en) 2005-05-25
CN1659438A (zh) 2005-08-24
US20110020354A1 (en) 2011-01-27

Similar Documents

Publication Publication Date Title
CN1324405A (zh) 新型g蛋白偶联型受体蛋白、dna及其配体
CN1310942C (zh) 校正基因
CN1622958A (zh) 促甲状腺素(tsh)受体的表位区域、其用途和针对该区域的抗体
CN1902227A (zh) Tim－3配体及其方法
CN1278183A (zh) 可溶性mhc复合体及其使用方法
CN1729290A (zh) 在分裂停止后的产多巴胺型神经元前体细胞中特异性表达的基因
CN1174845A (zh) 合成甲状旁腺素类似物和甲状旁腺素相关肽的方法
CN1968962A (zh) 新型可溶性cd14抗原
CN1493597A (zh) 分离树突状细胞膜蛋白基因
CN1894409A (zh) 人LXRα变体
CN1341123A (zh) 新型g蛋白偶联型受体蛋白及其dna
CN1324047C (zh) G蛋白偶联受体的配体与方法
CN1297566C (zh) 编码新rg1多肽的dna
CN1333786A (zh) 新的g蛋白偶联型受体蛋白、其dna及其配体
CN1549858A (zh) 内源和非内源型人g蛋白偶联受体
CN1849395A (zh) 来源于Livin的HLA－A24结合性癌抗原肽
CN1171816A (zh) 编码骨形态形成蛋白ii型受体的互补脱氧核糖核酸
CN1241940C (zh) 新型胶原蛋白样蛋白clac、其前体和它们的编码基因
CN1878865A (zh) 无细胞Notch切割分析方法以及药物筛选方法
CN1633498A (zh) 新型胰岛素/胰岛素样生长因子/松弛素家族多肽及其dna
CN101052718A (zh) 变异型淀粉样蛋白质
CN1390256A (zh) 新型蛋白质及其dna
CN1359421A (zh) 新型多肽及其dna
CN1397019A (zh) 筛选方法
CN1795205A (zh) Spex组合物和使用方法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C56 Change in the name or address of the patentee

Owner name: MSD CORP.

Free format text: FORMER NAME: SCHERING CORP (US)

CP01 Change in the name or title of a patent holder

Address after: new jersey

Patentee after: Schering Corporation

Address before: new jersey

Patentee before: SCHERING CORP (US)

CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20070704

Termination date: 20150410

EXPY Termination of patent right or utility model