ATE545866T1 - Liganden von g-protein-gekoppelten rezeptoren und verfahren - Google Patents

Liganden von g-protein-gekoppelten rezeptoren und verfahren

Info

Publication number
ATE545866T1
ATE545866T1 AT03718335T AT03718335T ATE545866T1 AT E545866 T1 ATE545866 T1 AT E545866T1 AT 03718335 T AT03718335 T AT 03718335T AT 03718335 T AT03718335 T AT 03718335T AT E545866 T1 ATE545866 T1 AT E545866T1
Authority
AT
Austria
Prior art keywords
methods
protein
ligands
coupled receptors
relates
Prior art date
Application number
AT03718335T
Other languages
English (en)
Inventor
Ying Jiang
Fang Zhang
Nicholas Murgolo
Lin Luo
Jason Simon
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ATE545866T1 publication Critical patent/ATE545866T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Pulmonology (AREA)
  • General Physics & Mathematics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
AT03718335T 2002-04-12 2003-04-10 Liganden von g-protein-gekoppelten rezeptoren und verfahren ATE545866T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37264002P 2002-04-12 2002-04-12
PCT/US2003/011159 WO2003087134A2 (en) 2002-04-12 2003-04-10 G-protein coupled receptor ligands and methods

Publications (1)

Publication Number Publication Date
ATE545866T1 true ATE545866T1 (de) 2012-03-15

Family

ID=29250884

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03718335T ATE545866T1 (de) 2002-04-12 2003-04-10 Liganden von g-protein-gekoppelten rezeptoren und verfahren

Country Status (9)

Country Link
US (3) US7338772B2 (de)
EP (1) EP1532446B1 (de)
JP (4) JP4594623B2 (de)
CN (1) CN1324047C (de)
AT (1) ATE545866T1 (de)
AU (1) AU2003221878A1 (de)
CA (1) CA2481508A1 (de)
MX (1) MXPA04009959A (de)
WO (1) WO2003087134A2 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4594623B2 (ja) * 2002-04-12 2010-12-08 シェーリング コーポレイション Ｇタンパク質共役レセプターリガンドおよび方法
WO2006039256A1 (en) * 2004-09-29 2006-04-13 Glaxo Group Limited Use of gpr103 agonists for modulating feeding behaviour
WO2009043524A2 (en) * 2007-09-11 2009-04-09 Mondobiotech Laboratories Ag Use of a peptide as therapeutic agent
JP5313068B2 (ja) * 2009-03-09 2013-10-09 富士フイルム株式会社 側視内視鏡装置
SG11201701895VA (en) * 2014-10-14 2017-04-27 Univ Montreal BIOSENSOR BASED ON GβΥ-INTERACTING PROTEINS TO MONITOR G-PROTEIN ACTIVATION
JP6405352B2 (ja) * 2016-09-16 2018-10-17 株式会社Ｓｕｂａｒｕ 直噴内燃機関のピストン

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4447233A (en) 1981-04-10 1984-05-08 Parker-Hannifin Corporation Medication infusion pump
US4439196A (en) 1982-03-18 1984-03-27 Merck & Co., Inc. Osmotic drug delivery system
US4447224A (en) 1982-09-20 1984-05-08 Infusaid Corporation Variable flow implantable infusion apparatus
US4487603A (en) 1982-11-26 1984-12-11 Cordis Corporation Implantable microinfusion pump system
US4952496A (en) 1984-03-30 1990-08-28 Associated Universities, Inc. Cloning and expression of the gene for bacteriophage T7 RNA polymerase
US5693489A (en) 1984-03-30 1997-12-02 Associated Universities, Inc. Cloning and expression of the gene for bacteriophage T7 RNA polymerase
US4596556A (en) 1985-03-25 1986-06-24 Bioject, Inc. Hypodermic injection apparatus
US5011912A (en) * 1986-12-19 1991-04-30 Immunex Corporation Hybridoma and monoclonal antibody for use in an immunoaffinity purification system
US4941880A (en) 1987-06-19 1990-07-17 Bioject, Inc. Pre-filled ampule and non-invasive hypodermic injection device assembly
US4790824A (en) 1987-06-19 1988-12-13 Bioject, Inc. Non-invasive hypodermic injection device
US5312335A (en) 1989-11-09 1994-05-17 Bioject Inc. Needleless hypodermic injection device
US5064413A (en) 1989-11-09 1991-11-12 Bioject, Inc. Needleless hypodermic injection device
US5383851A (en) 1992-07-24 1995-01-24 Bioject Inc. Needleless hypodermic injection device
CN1167490A (zh) * 1994-11-10 1997-12-10 人体基因组科学有限公司 人司登尼亚钙蛋白-α
AU726659B2 (en) 1996-04-09 2000-11-16 Nps Pharmaceuticals, Inc. Calcilytic compounds
SE9704836D0 (sv) 1997-12-22 1997-12-22 Astra Pharma Inc Novel receptor
EP1107978A1 (de) * 1998-08-24 2001-06-20 Alphagene, Inc. Sekretierte proteine und polynukleotide die sie kodieren
CA2348688A1 (en) 1998-10-13 2000-04-20 Arena Pharmaceuticals, Inc. Non-endogenous, constitutively activated human g protein-coupled receptors
ATE301673T1 (de) 1998-11-20 2005-08-15 Arena Pharm Inc Menschliche, an ein g-protein gekoppelter rezeptor rup3 ohne bekannten ligand
AU1183200A (en) 1998-11-20 2000-06-13 Chugai Research Institute For Molecular Medicine, Inc. Novel gene encoding brain-specific membrane protein
ATE312622T1 (de) 1999-04-29 2005-12-15 Novo Nordisk As Verwendung von anti-hbp antikörper zur inhibierung der freisetzung von bradykinin
WO2000078809A1 (en) 1999-06-21 2000-12-28 Smithkline Beecham Corporation Axor16, a g protein coupled receptor
CA2311201A1 (en) * 1999-08-05 2001-02-05 Genset S.A. Ests and encoded human proteins
WO2001016316A1 (fr) 1999-08-27 2001-03-08 Takeda Chemical Industries, Ltd. Proteine recepteur couplee a une proteine g et adn correspondant
WO2001025277A1 (en) * 1999-10-07 2001-04-12 Maxygen Aps Single-chain antagonist polypeptides
AU2230401A (en) 1999-12-28 2001-07-09 Helix Research Institute Novel guanosine triphosphate-binding protein-coupled receptors, genes thereof and production and use of the same
US6927041B2 (en) * 2000-07-06 2005-08-09 Bayer Corporation Human neuropeptide Y-like G protein-coupled receptor
US20040248790A1 (en) * 2001-09-03 2004-12-09 Shuji Hinuma Novel secretory proteins and dna thereof
JP4594623B2 (ja) * 2002-04-12 2010-12-08 シェーリング コーポレイション Ｇタンパク質共役レセプターリガンドおよび方法

Also Published As

Publication number Publication date
WO2003087134A2 (en) 2003-10-23
US20030223992A1 (en) 2003-12-04
US20080138348A1 (en) 2008-06-12
EP1532446B1 (de) 2012-02-15
EP1532446A2 (de) 2005-05-25
CA2481508A1 (en) 2003-10-23
AU2003221878A1 (en) 2003-10-27
JP4594623B2 (ja) 2010-12-08
US20110020354A1 (en) 2011-01-27
US7338772B2 (en) 2008-03-04
JP2006254916A (ja) 2006-09-28
US7807390B2 (en) 2010-10-05
JP2010252805A (ja) 2010-11-11
JP5284313B2 (ja) 2013-09-11
JP2010279373A (ja) 2010-12-16
EP1532446A4 (de) 2006-06-07
MXPA04009959A (es) 2004-12-13
CN1659438A (zh) 2005-08-24
AU2003221878A8 (en) 2003-10-27
JP2005528894A (ja) 2005-09-29
CN1324047C (zh) 2007-07-04
WO2003087134A3 (en) 2005-03-24
US8133980B2 (en) 2012-03-13

Similar Documents

Publication Publication Date Title
DE60328870D1 (de) Verfahren zur modulierung von cd200-rezeptoren
BR9710988A (pt) Método e compostos moduladores receptores de androgênio
BR0315167A (pt) Métodos para tratar a da dor administrando-se um antagonista do fator de crescimento de nervos e um analgésico opióide e composições contendo os mesmos
DE60039783D1 (de) Lfa-1 antagonisten und tnf-alpha antagonisten zur
DE60025368D1 (de) Verfahren zum identifizieren von prostaglandin d2 rezeptor modulatoren
ATE302194T1 (de) Metabotrope glutamatrezeptorantagonisten zur behandlung von krankheiten des zentralen nervensystems
BR0205829A (pt) Novas aminas como ligantes dos receptores de histamina-3 e suas aplicações terapêuticas
PT800519E (pt) Compostos moduladores de receptores de esteroides e metodos
ATE309543T1 (de) Natürlicher ligand von gpcr chemr23 und dessen verwendung
ATE400653T1 (de) Chimäre rezeptoren und verfahren zur identifizieren verbindungen mit einem aktivität als metabotropischen glutamatrezeptoren sowie verwendung solcher verbindungen in der behandlung von neurologischer erkrankungen und neurologischenstörrungen
ATE539768T1 (de) Kombinationen von metabotropische-glutamat- rezeptor-antagonisten und ihre verwendung zur behandlung von suchtstörungen
WO2002024222A3 (en) Ligands for g protein coupled receptors and methods of using them
ATE504600T1 (de) Verwendung von antikörpern gegen tweak zur behandlung von schlaganfall
ATE545866T1 (de) Liganden von g-protein-gekoppelten rezeptoren und verfahren
EA200700951A1 (ru) БЕЛКИ, СОДЕРЖАЩИЕ ДОМЕНЫ vWFA И/ИЛИ ANT_IG
DE60033576D1 (de) Methoden zum screening knochenmorphogenetishemimetika
WO2003088904A3 (en) Screening and therapeutic methods for treating circadian rhythm disorders
EP1940407A4 (de) N-(4-oxo-3,4-dihydrochinazolin-2-yl)butanamide als androgenrezeptormodulatoren
WO2002018941A3 (en) Screen for glutamate reuptake inhibitors, stimulators, and modulators
DE60325695D1 (de) Der eaat2-promotor und dessen verwendung
ATE230263T1 (de) At1 rezeptor antagonist zur anregung von apoptosis
ATE506947T1 (de) Kondensierte thiophene verbindungen und deren verwendung zur behandlung von chronischen schmerzen
WO2005038006A3 (en) Chimeric metabotropic glutamate receptors and uses thereof
ATE422506T1 (de) Verwendung von löslichem t-cadherin zur behandlung von stoffwechselkrankheiten
WO2006083873A3 (en) Screening and therapeutic methods for treating circadian rhythm disorders