ATE506947T1 - Kondensierte thiophene verbindungen und deren verwendung zur behandlung von chronischen schmerzen - Google Patents

Kondensierte thiophene verbindungen und deren verwendung zur behandlung von chronischen schmerzen

Info

Publication number
ATE506947T1
ATE506947T1 AT02731200T AT02731200T ATE506947T1 AT E506947 T1 ATE506947 T1 AT E506947T1 AT 02731200 T AT02731200 T AT 02731200T AT 02731200 T AT02731200 T AT 02731200T AT E506947 T1 ATE506947 T1 AT E506947T1
Authority
AT
Austria
Prior art keywords
treatment
chronic pain
thiophene compounds
condensed thiophene
compounds
Prior art date
Application number
AT02731200T
Other languages
English (en)
Inventor
Allan Moorman
Romeo Romagnoli
Pier Baraldi
Original Assignee
King Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by King Pharmaceuticals Inc filed Critical King Pharmaceuticals Inc
Application granted granted Critical
Publication of ATE506947T1 publication Critical patent/ATE506947T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4743—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
AT02731200T 2001-03-30 2002-03-29 Kondensierte thiophene verbindungen und deren verwendung zur behandlung von chronischen schmerzen ATE506947T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28041601P 2001-03-30 2001-03-30
PCT/US2002/009943 WO2002083083A2 (en) 2001-03-30 2002-03-29 Pharmaceutically active compounds and methods of use

Publications (1)

Publication Number Publication Date
ATE506947T1 true ATE506947T1 (de) 2011-05-15

Family

ID=23072979

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02731200T ATE506947T1 (de) 2001-03-30 2002-03-29 Kondensierte thiophene verbindungen und deren verwendung zur behandlung von chronischen schmerzen

Country Status (15)

Country Link
US (2) US7101905B2 (de)
EP (1) EP1383463B1 (de)
JP (1) JP4303474B2 (de)
KR (1) KR100888093B1 (de)
AT (1) ATE506947T1 (de)
AU (1) AU2002303191B2 (de)
BR (1) BR0208593A (de)
CA (1) CA2443135C (de)
DE (1) DE60239864D1 (de)
ES (1) ES2365905T3 (de)
IL (2) IL158186A0 (de)
MX (1) MXPA03008936A (de)
NZ (1) NZ528635A (de)
WO (1) WO2002083083A2 (de)
ZA (1) ZA200308020B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60239864D1 (de) * 2001-03-30 2011-06-09 King Pharmaceuticals Inc Kondensierte thiophene verbindungen und deren verwendung zur behandlung von chronischen schmerzen
AR039280A1 (es) * 2002-04-11 2005-02-16 Smithkline Beecham Corp Compuesto de aminotiofeno y su uso para preparar una composicion farmaceutica
US20040087642A1 (en) * 2002-10-24 2004-05-06 Zeldis Jerome B. Methods of using and compositions comprising a JNK inhibitor for the treatment, prevention, management and/or modification of pain
UA95641C2 (en) * 2006-07-06 2011-08-25 Эррей Биофарма Инк. Hydroxylated cyclopenta [d] pyrimidines as akt protein kinase inhibitors
US8063050B2 (en) 2006-07-06 2011-11-22 Array Biopharma Inc. Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
EP3010887A1 (de) * 2013-06-21 2016-04-27 LEK Pharmaceuticals d.d. Herstellung von chiralen 1-methyl-2,3,4,5-1h-benzodiazepinen durch asymmetrische reduktion von alpha-substituierten styrolen
TWI734699B (zh) * 2015-09-09 2021-08-01 美商英塞特公司 Ｐｉｍ激酶抑制劑之鹽
CN116410205A (zh) * 2021-12-29 2023-07-11 上海皓元生物医药科技有限公司 一种3-取代-9-甲基-噻吩并三唑并噁嗪类化合物的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9401499D0 (sv) 1994-05-02 1994-05-02 Item Dev Ab New method of treatment
DE69721794T2 (de) 1996-09-06 2004-03-18 Takeda Chemical Industries, Ltd. Kondensierte 4,5,6,7-tetrahydrobenzo c]thiophene als beschleuniger der wirkung des zelldifferenzierungsinduktionsfaktors
US5939432A (en) 1997-10-29 1999-08-17 Medco Research, Inc. Thiophenes useful for modulating the adenosine receptor
GB9808665D0 (en) 1998-04-23 1998-06-24 Merck Sharp & Dohme Therapeutic compounds
DE60239864D1 (de) * 2001-03-30 2011-06-09 King Pharmaceuticals Inc Kondensierte thiophene verbindungen und deren verwendung zur behandlung von chronischen schmerzen

Also Published As

Publication number Publication date
EP1383463B1 (de) 2011-04-27
EP1383463A2 (de) 2004-01-28
MXPA03008936A (es) 2005-03-07
JP2005500994A (ja) 2005-01-13
AU2002303191B2 (en) 2007-01-18
WO2002083083A2 (en) 2002-10-24
EP1383463A4 (de) 2009-03-25
BR0208593A (pt) 2006-02-21
US20030073733A1 (en) 2003-04-17
US7449490B2 (en) 2008-11-11
IL158186A0 (en) 2004-03-28
CA2443135A1 (en) 2002-10-24
DE60239864D1 (de) 2011-06-09
JP4303474B2 (ja) 2009-07-29
NZ528635A (en) 2006-11-30
WO2002083083A3 (en) 2003-11-06
KR100888093B1 (ko) 2009-03-11
US7101905B2 (en) 2006-09-05
ES2365905T3 (es) 2011-10-13
US20060183921A1 (en) 2006-08-17
ZA200308020B (en) 2007-01-31
KR20040083335A (ko) 2004-10-01
CA2443135C (en) 2010-07-13
IL158186A (en) 2011-03-31

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