ATE309543T1 - Natürlicher ligand von gpcr chemr23 und dessen verwendung - Google Patents

Natürlicher ligand von gpcr chemr23 und dessen verwendung

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Publication number
ATE309543T1
ATE309543T1 AT02754857T AT02754857T ATE309543T1 AT E309543 T1 ATE309543 T1 AT E309543T1 AT 02754857 T AT02754857 T AT 02754857T AT 02754857 T AT02754857 T AT 02754857T AT E309543 T1 ATE309543 T1 AT E309543T1
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Austria
Prior art keywords
chemr23
gpcr
coupled receptor
protein coupled
natural ligand
Prior art date
Application number
AT02754857T
Other languages
English (en)
Inventor
Valerie Wittamer
David Communi
Ann Vandenbogaerde
Michel Detheux
Marc Parmentier
Original Assignee
Euroscreen Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euroscreen Sa filed Critical Euroscreen Sa
Application granted granted Critical
Publication of ATE309543T1 publication Critical patent/ATE309543T1/de

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AT02754857T 2001-07-09 2002-07-09 Natürlicher ligand von gpcr chemr23 und dessen verwendung ATE309543T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30385801P 2001-07-09 2001-07-09
US09/905,253 US20030096299A1 (en) 2001-07-09 2001-07-13 Natural ligand of G protein coupled receptor ChemR23 and uses thereof
PCT/EP2002/007647 WO2003006996A2 (en) 2001-07-09 2002-07-09 Natural ligand of gpcr chemr23 and uses thereof

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Publication Number Publication Date
ATE309543T1 true ATE309543T1 (de) 2005-11-15

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US (5) US20030096299A1 (de)
EP (1) EP1405083B1 (de)
JP (2) JP4446737B2 (de)
AT (1) ATE309543T1 (de)
CA (1) CA2450587C (de)
DE (1) DE60207254T2 (de)
DK (1) DK1405083T3 (de)
ES (1) ES2252494T3 (de)
WO (1) WO2003006996A2 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7858755B2 (en) * 2001-07-09 2010-12-28 Euroscreen S.A. Monoclonal antibodies that bind Chemerin polypeptide
US20030096299A1 (en) * 2001-07-09 2003-05-22 Valerie Wittamer Natural ligand of G protein coupled receptor ChemR23 and uses thereof
US7419658B2 (en) * 2001-07-09 2008-09-02 Euroscreen S.A. Isolated ligand of ChemerinR
US7470772B2 (en) * 2001-07-09 2008-12-30 Euroscreen S.A. Antibody that specifically binds to Chemerin receptor ligand precursor
AU2003274076A1 (en) * 2002-10-31 2004-05-25 Ipf Pharmaceuticals Gmbh Human chondroosteomodulin (tig2), production, and use for the treatment or diagnosis of bone diseases, cartilage diseases, obesity, inflammatory diseases, and skin diseases
US20050037946A1 (en) * 2003-01-13 2005-02-17 Millennium Pharmaceuticals, Inc. Methods and compositions for treating cardiovascular disease using 1722, 10280, 59917, 85553, 10653, 9235, 21668, 17794, 2210, 6169, 10102, 21061, 17662, 1468, 12282, 6350, 9035, 1820, 23652, 7301, 8925, 8701, 3533, 9462, 9123, 12788, 17729, 65552, 1261, 21476, 33770, 9380, 2569654, 33556, 53656, 44143, 32612, 10671, 261, 44570, 41922, 2552, 2417, 19319, 43969, 8921, 8993, 955, 32345, 966, 1920, 17318, 1510, 14180, 26005, 554, 16408, 42028, 112091, 13886, 13942, 1673, 54946 or 2419
US8580517B2 (en) * 2003-02-05 2013-11-12 Washington University In St. Louis Biosensor and use thereof to identify therapeutic drug molecules and molecules binding orphan receptors
US20050202029A1 (en) * 2003-10-03 2005-09-15 The Board Of Trustees Of The Leland Stanford Junior University Family of cystatin-related chemoattractant proteins
JP2008502307A (ja) * 2003-10-28 2008-01-31 プロテミックス ディスカバリー リミティド 抗肥満活性及び他の関連用途を有するペプチド
WO2005050212A1 (en) * 2003-11-19 2005-06-02 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with g protein-coupled receptor chemr23 (chemr23)
US8178077B2 (en) * 2004-10-19 2012-05-15 Reverse Proteomics Research Institute Co., Ltd. Drug development target protein and target gene, and method of screening
EP1864131B1 (de) * 2005-03-03 2011-09-28 ChemCom S.A. Natürlicher ligand des g-protein-gekoppelten rezeptors rcc356 und verwendungen davon
JP2006248978A (ja) * 2005-03-10 2006-09-21 Mebiopharm Co Ltd 新規なリポソーム製剤
US20070009961A1 (en) * 2005-07-07 2007-01-11 Academia Sinica Identification of targeting component of herbal medicines from simplified HPLC spectrum using after flowing through immobilized receptor (AFTIR) method
WO2008055313A1 (en) * 2006-11-10 2008-05-15 Dimerix Bioscience Pty Ltd Detection system and uses therefor
GB0705488D0 (en) * 2007-03-22 2007-05-02 Isis Innovation Treatment of inflammation and/or endotoxic shock
CN101848720B (zh) * 2007-10-31 2013-04-24 国立大学法人神户大学 糖尿病治疗剂
CN102816209A (zh) * 2012-07-09 2012-12-12 深圳先进技术研究院 一种趋化素衍生肽及其表达基因和应用
CN103539834B (zh) * 2012-07-09 2016-12-21 深圳先进技术研究院 趋化素衍生肽及其表达基因和应用
US9708413B2 (en) 2012-11-22 2017-07-18 Glytech, Inc. Glycosylated linker, compound containing glycosylated linker moiety and physiologically active substance moiety or salt thereof, and methods for producing said compound or salt thereof
JP6219308B2 (ja) 2012-11-30 2017-10-25 株式会社糖鎖工学研究所 糖鎖付加リンカー、糖鎖付加リンカーと生理活性物質とを含む化合物またはその塩、及びそれらの製造方法
US9144178B2 (en) * 2013-03-01 2015-09-22 International Business Machines Corporation Selective clamping of electronics card to coolant-cooled structure
WO2016020503A1 (en) * 2014-08-08 2016-02-11 Randox Laboratories Limited Method and kit for detecting bacterial infection
CN110609020B (zh) * 2019-08-15 2021-10-01 济南大学 基于回文分子信标检测atp的生物传感器及其制备方法和应用
KR20220087466A (ko) * 2019-10-09 2022-06-24 오제 이뮈노테라프틱스 항-케모킨(anti-chemokin) 유사 수용체 1 사람화된 항체 및 이의 치료학적 적용

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9009548D0 (en) * 1990-04-27 1990-06-20 Celltech Ltd Chimeric antibody and method
US5948664A (en) 1996-02-29 1999-09-07 The Regents Of The University Of California PI 3-kinase polypeptides
AU2205499A (en) 1997-12-31 1999-07-19 Incyte Pharmaceuticals, Inc. Human regulatory proteins
JP2002511259A (ja) 1998-04-09 2002-04-16 ジェンセット 5’estおよびコードされるヒトタンパク質
DK1133559T3 (da) 1998-11-20 2006-04-10 Arena Pharm Inc Human-G-protein-koblet orphan receptor RUP3
US7205146B1 (en) * 2000-06-14 2007-04-17 Oscient Pharmaceuticals Corporation Nucleotide and amino acid sequences relating to respiratory diseases and obesity
AU2001271902A1 (en) * 2000-07-06 2002-01-21 Deltagen, Inc. Transgenic mice containing targeted gpcr gene disruptions
WO2002003798A1 (en) 2000-07-12 2002-01-17 Ocapco, Llc Avermectin pesticide with an organosilicone surfactant
AU2002239409A1 (en) 2000-11-20 2003-11-17 Diadexus, Inc. Compositions and methods relating to colon specific genes and proteins
US20030096299A1 (en) 2001-07-09 2003-05-22 Valerie Wittamer Natural ligand of G protein coupled receptor ChemR23 and uses thereof

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US20090047741A1 (en) 2009-02-19
ES2252494T3 (es) 2006-05-16
WO2003006996A3 (en) 2003-12-04
US20090081729A1 (en) 2009-03-26
JP2005500047A (ja) 2005-01-06
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JP2009148278A (ja) 2009-07-09
US7582734B2 (en) 2009-09-01
EP1405083B1 (de) 2005-11-09
CA2450587C (en) 2011-03-22
WO2003006996A2 (en) 2003-01-23
US20030104478A1 (en) 2003-06-05
CA2450587A1 (en) 2003-01-23
DE60207254D1 (de) 2005-12-15
US8003347B2 (en) 2011-08-23
EP1405083A2 (de) 2004-04-07
US7666401B2 (en) 2010-02-23
US20070238862A1 (en) 2007-10-11
US20030096299A1 (en) 2003-05-22
DK1405083T3 (da) 2006-03-20

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