JP2005528894A5 - - Google Patents
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- Publication number
- JP2005528894A5 JP2005528894A5 JP2003584089A JP2003584089A JP2005528894A5 JP 2005528894 A5 JP2005528894 A5 JP 2005528894A5 JP 2003584089 A JP2003584089 A JP 2003584089A JP 2003584089 A JP2003584089 A JP 2003584089A JP 2005528894 A5 JP2005528894 A5 JP 2005528894A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- polypeptide
- receptor
- sample
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 16
- 238000000034 method Methods 0.000 claims 14
- 229920001184 polypeptide Polymers 0.000 claims 13
- 102000004196 processed proteins & peptides Human genes 0.000 claims 13
- 125000003275 alpha amino acid group Chemical group 0.000 claims 7
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 6
- 239000000556 agonist Substances 0.000 claims 6
- 239000005557 antagonist Substances 0.000 claims 6
- 229910052791 calcium Inorganic materials 0.000 claims 6
- 239000011575 calcium Substances 0.000 claims 6
- 239000003446 ligand Substances 0.000 claims 6
- 102000039446 nucleic acids Human genes 0.000 claims 6
- 108020004707 nucleic acids Proteins 0.000 claims 6
- 150000007523 nucleic acids Chemical class 0.000 claims 6
- 102000005962 receptors Human genes 0.000 claims 6
- 108020003175 receptors Proteins 0.000 claims 6
- 230000000890 antigenic effect Effects 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 239000012634 fragment Substances 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 238000013508 migration Methods 0.000 claims 2
- 230000005012 migration Effects 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 1
- 230000027425 release of sequestered calcium ion into cytosol Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37264002P | 2002-04-12 | 2002-04-12 | |
| PCT/US2003/011159 WO2003087134A2 (en) | 2002-04-12 | 2003-04-10 | G-protein coupled receptor ligands and methods |
Related Child Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006103683A Division JP2006254916A (ja) | 2002-04-12 | 2006-04-04 | Ｇタンパク質共役レセプターリガンドおよび方法 |
| JP2010163440A Division JP2010252805A (ja) | 2002-04-12 | 2010-07-20 | Ｇタンパク質共役レセプターリガンドおよび方法 |
| JP2010163439A Division JP5284313B2 (ja) | 2002-04-12 | 2010-07-20 | Ｇタンパク質共役レセプターリガンドおよび方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005528894A JP2005528894A (ja) | 2005-09-29 |
| JP2005528894A5 true JP2005528894A5 (enExample) | 2006-07-06 |
| JP4594623B2 JP4594623B2 (ja) | 2010-12-08 |
Family
ID=29250884
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003584089A Expired - Fee Related JP4594623B2 (ja) | 2002-04-12 | 2003-04-10 | Ｇタンパク質共役レセプターリガンドおよび方法 |
| JP2006103683A Pending JP2006254916A (ja) | 2002-04-12 | 2006-04-04 | Ｇタンパク質共役レセプターリガンドおよび方法 |
| JP2010163440A Withdrawn JP2010252805A (ja) | 2002-04-12 | 2010-07-20 | Ｇタンパク質共役レセプターリガンドおよび方法 |
| JP2010163439A Expired - Fee Related JP5284313B2 (ja) | 2002-04-12 | 2010-07-20 | Ｇタンパク質共役レセプターリガンドおよび方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006103683A Pending JP2006254916A (ja) | 2002-04-12 | 2006-04-04 | Ｇタンパク質共役レセプターリガンドおよび方法 |
| JP2010163440A Withdrawn JP2010252805A (ja) | 2002-04-12 | 2010-07-20 | Ｇタンパク質共役レセプターリガンドおよび方法 |
| JP2010163439A Expired - Fee Related JP5284313B2 (ja) | 2002-04-12 | 2010-07-20 | Ｇタンパク質共役レセプターリガンドおよび方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US7338772B2 (enExample) |
| EP (1) | EP1532446B1 (enExample) |
| JP (4) | JP4594623B2 (enExample) |
| CN (1) | CN1324047C (enExample) |
| AT (1) | ATE545866T1 (enExample) |
| AU (1) | AU2003221878A1 (enExample) |
| CA (1) | CA2481508A1 (enExample) |
| MX (1) | MXPA04009959A (enExample) |
| WO (1) | WO2003087134A2 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1532446B1 (en) * | 2002-04-12 | 2012-02-15 | Schering Corporation | G-protein coupled receptor ligands and methods |
| WO2006039256A1 (en) * | 2004-09-29 | 2006-04-13 | Glaxo Group Limited | Use of gpr103 agonists for modulating feeding behaviour |
| WO2009043524A2 (en) * | 2007-09-11 | 2009-04-09 | Mondobiotech Laboratories Ag | Use of a peptide as therapeutic agent |
| JP5313068B2 (ja) * | 2009-03-09 | 2013-10-09 | 富士フイルム株式会社 | 側視内視鏡装置 |
| US10877036B2 (en) * | 2014-10-14 | 2020-12-29 | Université de Montréal | Biosensor based on Gβγ-interacting proteins to monitor G-protein activation |
| JP6405352B2 (ja) * | 2016-09-16 | 2018-10-17 | 株式会社Ｓｕｂａｒｕ | 直噴内燃機関のピストン |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4447233A (en) | 1981-04-10 | 1984-05-08 | Parker-Hannifin Corporation | Medication infusion pump |
| US4439196A (en) | 1982-03-18 | 1984-03-27 | Merck & Co., Inc. | Osmotic drug delivery system |
| US4447224A (en) | 1982-09-20 | 1984-05-08 | Infusaid Corporation | Variable flow implantable infusion apparatus |
| US4487603A (en) | 1982-11-26 | 1984-12-11 | Cordis Corporation | Implantable microinfusion pump system |
| US5693489A (en) | 1984-03-30 | 1997-12-02 | Associated Universities, Inc. | Cloning and expression of the gene for bacteriophage T7 RNA polymerase |
| US4952496A (en) | 1984-03-30 | 1990-08-28 | Associated Universities, Inc. | Cloning and expression of the gene for bacteriophage T7 RNA polymerase |
| US4596556A (en) | 1985-03-25 | 1986-06-24 | Bioject, Inc. | Hypodermic injection apparatus |
| US5011912A (en) * | 1986-12-19 | 1991-04-30 | Immunex Corporation | Hybridoma and monoclonal antibody for use in an immunoaffinity purification system |
| US4941880A (en) | 1987-06-19 | 1990-07-17 | Bioject, Inc. | Pre-filled ampule and non-invasive hypodermic injection device assembly |
| US4790824A (en) | 1987-06-19 | 1988-12-13 | Bioject, Inc. | Non-invasive hypodermic injection device |
| US5064413A (en) | 1989-11-09 | 1991-11-12 | Bioject, Inc. | Needleless hypodermic injection device |
| US5312335A (en) | 1989-11-09 | 1994-05-17 | Bioject Inc. | Needleless hypodermic injection device |
| US5383851A (en) | 1992-07-24 | 1995-01-24 | Bioject Inc. | Needleless hypodermic injection device |
| CN1167490A (zh) * | 1994-11-10 | 1997-12-10 | 人体基因组科学有限公司 | 人司登尼亚钙蛋白-α |
| SG99290A1 (en) | 1996-04-09 | 2003-10-27 | Nps Pharma Inc | Calcilytic compounds |
| SE9704836D0 (sv) | 1997-12-22 | 1997-12-22 | Astra Pharma Inc | Novel receptor |
| WO2000011015A1 (en) * | 1998-08-24 | 2000-03-02 | Alphagene, Inc. | Secreted proteins and polynucleotides encoding them |
| NZ510712A (en) | 1998-10-13 | 2004-11-26 | Arena Pharm Inc | Non-endogenous, constitutively activated human G protein-coupled receptors |
| ATE301673T1 (de) | 1998-11-20 | 2005-08-15 | Arena Pharm Inc | Menschliche, an ein g-protein gekoppelter rezeptor rup3 ohne bekannten ligand |
| WO2000031256A1 (fr) | 1998-11-20 | 2000-06-02 | Chugai Research Institute For Molecular Medicine, Inc. | Nouveau gene codant une proteine membranaire specifique au cerveau |
| EP1178821B1 (en) | 1999-04-29 | 2005-12-14 | Novo Nordisk A/S | Use of anti-hbp antibodies in the inhibition of bradykinin release |
| WO2000078809A1 (en) | 1999-06-21 | 2000-12-28 | Smithkline Beecham Corporation | Axor16, a g protein coupled receptor |
| CA2311201A1 (en) * | 1999-08-05 | 2001-02-05 | Genset S.A. | Ests and encoded human proteins |
| EP1207201A4 (en) * | 1999-08-27 | 2003-03-12 | Takeda Chemical Industries Ltd | PROTEIN G-COUPLED RECEPTOR AND CORRESPONDING DNA |
| AR025984A1 (es) * | 1999-10-07 | 2002-12-26 | Maxygen Aps | Polipeptidos oligomericos de cadena simple |
| WO2001048189A1 (fr) | 1999-12-28 | 2001-07-05 | Helix Research Institute | Nouveaux recepteurs couples a une proteine de liaison au guanosine triphosphate, genes de ces derniers, et production et utilisation de ces derniers |
| AU2001271838A1 (en) * | 2000-07-06 | 2002-01-21 | Bayer Corporation | Human neuropeptide y-like g protein-coupled receptor |
| EP1424392B1 (en) * | 2001-09-03 | 2012-10-24 | Takeda Pharmaceutical Company Limited | RF-peptide ligands of G-protein coupled receptor |
| EP1532446B1 (en) * | 2002-04-12 | 2012-02-15 | Schering Corporation | G-protein coupled receptor ligands and methods |
-
2003
- 2003-04-10 EP EP03718335A patent/EP1532446B1/en not_active Expired - Lifetime
- 2003-04-10 JP JP2003584089A patent/JP4594623B2/ja not_active Expired - Fee Related
- 2003-04-10 AT AT03718335T patent/ATE545866T1/de active
- 2003-04-10 CA CA002481508A patent/CA2481508A1/en not_active Abandoned
- 2003-04-10 AU AU2003221878A patent/AU2003221878A1/en not_active Abandoned
- 2003-04-10 MX MXPA04009959A patent/MXPA04009959A/es active IP Right Grant
- 2003-04-10 WO PCT/US2003/011159 patent/WO2003087134A2/en not_active Ceased
- 2003-04-10 US US10/411,545 patent/US7338772B2/en not_active Expired - Fee Related
- 2003-04-10 CN CNB038131234A patent/CN1324047C/zh not_active Expired - Fee Related
-
2006
- 2006-04-04 JP JP2006103683A patent/JP2006254916A/ja active Pending
-
2008
- 2008-01-07 US US11/970,276 patent/US7807390B2/en not_active Expired - Fee Related
-
2010
- 2010-07-20 JP JP2010163440A patent/JP2010252805A/ja not_active Withdrawn
- 2010-07-20 JP JP2010163439A patent/JP5284313B2/ja not_active Expired - Fee Related
- 2010-10-01 US US12/896,297 patent/US8133980B2/en not_active Expired - Fee Related
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