JP2003511670A5 - - Google Patents
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- Publication number
- JP2003511670A5 JP2003511670A5 JP2001528704A JP2001528704A JP2003511670A5 JP 2003511670 A5 JP2003511670 A5 JP 2003511670A5 JP 2001528704 A JP2001528704 A JP 2001528704A JP 2001528704 A JP2001528704 A JP 2001528704A JP 2003511670 A5 JP2003511670 A5 JP 2003511670A5
- Authority
- JP
- Japan
- Prior art keywords
- peptide
- cell
- sequence
- cytokine
- celiac disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108090000765 processed proteins & peptides Proteins 0.000 description 41
- 238000000034 method Methods 0.000 description 27
- 210000004027 cell Anatomy 0.000 description 18
- 241000196324 Embryophyta Species 0.000 description 13
- 102000004127 Cytokines Human genes 0.000 description 12
- 108090000695 Cytokines Proteins 0.000 description 12
- 210000001744 T-lymphocyte Anatomy 0.000 description 12
- 208000015943 Coeliac disease Diseases 0.000 description 10
- 108091033319 polynucleotide Proteins 0.000 description 9
- 102000040430 polynucleotide Human genes 0.000 description 9
- 239000002157 polynucleotide Substances 0.000 description 9
- 108010061711 Gliadin Proteins 0.000 description 8
- 108091026890 Coding region Proteins 0.000 description 6
- 150000001413 amino acids Chemical group 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- 230000009261 transgenic effect Effects 0.000 description 6
- 241000209140 Triticum Species 0.000 description 5
- 239000008194 pharmaceutical composition Substances 0.000 description 5
- 230000001105 regulatory effect Effects 0.000 description 5
- 235000007319 Avena orientalis Nutrition 0.000 description 4
- 244000075850 Avena orientalis Species 0.000 description 4
- 240000005979 Hordeum vulgare Species 0.000 description 4
- 235000007340 Hordeum vulgare Nutrition 0.000 description 4
- 241000209056 Secale Species 0.000 description 4
- 235000007238 Secale cereale Nutrition 0.000 description 4
- 235000019714 Triticale Nutrition 0.000 description 4
- 235000021307 Triticum Nutrition 0.000 description 4
- 241000228158 x Triticosecale Species 0.000 description 4
- 108091008874 T cell receptors Proteins 0.000 description 3
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 description 3
- 238000000338 in vitro Methods 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 208000032309 susceptibility to 1 celiac disease Diseases 0.000 description 3
- 235000007558 Avena sp Nutrition 0.000 description 2
- 206010020649 Hyperkeratosis Diseases 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 125000000404 glutamine group Chemical group N[C@@H](CCC(N)=O)C(=O)* 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 210000004962 mammalian cell Anatomy 0.000 description 2
- 230000035772 mutation Effects 0.000 description 2
- 210000001236 prokaryotic cell Anatomy 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 241000894007 species Species 0.000 description 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical group OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical group NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical group C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical group OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Chemical group NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Chemical group 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Chemical group OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
- 240000000111 Saccharum officinarum Species 0.000 description 1
- 235000007201 Saccharum officinarum Nutrition 0.000 description 1
- 240000006394 Sorghum bicolor Species 0.000 description 1
- 235000011684 Sorghum saccharatum Nutrition 0.000 description 1
- 230000005867 T cell response Effects 0.000 description 1
- 108060008539 Transglutaminase Proteins 0.000 description 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Chemical group C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 235000013312 flour Nutrition 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 108020001507 fusion proteins Proteins 0.000 description 1
- 102000037865 fusion proteins Human genes 0.000 description 1
- 235000011868 grain product Nutrition 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- 102000003601 transglutaminase Human genes 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Chemical group OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9923306.6A GB9923306D0 (en) | 1999-10-01 | 1999-10-01 | Diagnostic and therapeutic epitope, and transgenic plant |
| GB9923306.6 | 1999-10-01 | ||
| PCT/GB2000/003760 WO2001025793A2 (en) | 1999-10-01 | 2000-10-02 | Diagnosis of coeliac disease using a gliadin epitope |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010135844A Division JP5371890B2 (ja) | 1999-10-01 | 2010-06-15 | 診断及び治療用エピトープ並びにトランスジェニック植物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003511670A JP2003511670A (ja) | 2003-03-25 |
| JP2003511670A5 true JP2003511670A5 (enExample) | 2007-11-22 |
| JP4932112B2 JP4932112B2 (ja) | 2012-05-16 |
Family
ID=10861989
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001528704A Expired - Lifetime JP4932112B2 (ja) | 1999-10-01 | 2000-10-02 | 診断及び治療用エピトープ並びにトランスジェニック植物 |
| JP2010135844A Expired - Lifetime JP5371890B2 (ja) | 1999-10-01 | 2010-06-15 | 診断及び治療用エピトープ並びにトランスジェニック植物 |
| JP2013018731A Expired - Lifetime JP6139154B2 (ja) | 1999-10-01 | 2013-02-01 | 診断及び治療用エピトープ並びにトランスジェニック植物 |
| JP2016053617A Pending JP2016164169A (ja) | 1999-10-01 | 2016-03-17 | 診断及び治療用エピトープ並びにトランスジェニック植物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010135844A Expired - Lifetime JP5371890B2 (ja) | 1999-10-01 | 2010-06-15 | 診断及び治療用エピトープ並びにトランスジェニック植物 |
| JP2013018731A Expired - Lifetime JP6139154B2 (ja) | 1999-10-01 | 2013-02-01 | 診断及び治療用エピトープ並びにトランスジェニック植物 |
| JP2016053617A Pending JP2016164169A (ja) | 1999-10-01 | 2016-03-17 | 診断及び治療用エピトープ並びにトランスジェニック植物 |
Country Status (14)
| Country | Link |
|---|---|
| US (5) | US7144569B1 (enExample) |
| EP (2) | EP1672368B1 (enExample) |
| JP (4) | JP4932112B2 (enExample) |
| AT (2) | ATE449965T1 (enExample) |
| AU (1) | AU782262B2 (enExample) |
| CA (1) | CA2386089C (enExample) |
| CY (2) | CY1105282T1 (enExample) |
| DE (2) | DE60043402D1 (enExample) |
| DK (2) | DK1672368T3 (enExample) |
| ES (2) | ES2335895T3 (enExample) |
| GB (1) | GB9923306D0 (enExample) |
| MX (1) | MXPA02003295A (enExample) |
| PT (2) | PT1218751E (enExample) |
| WO (1) | WO2001025793A2 (enExample) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9923306D0 (en) * | 1999-10-01 | 1999-12-08 | Isis Innovation | Diagnostic and therapeutic epitope, and transgenic plant |
| US7303871B2 (en) * | 2002-02-14 | 2007-12-04 | The Board Of Trustees Of The Leland Stanford Junior University | Enzyme treatment of foodstuffs for Celiac Sprue |
| US8143210B2 (en) | 2002-02-14 | 2012-03-27 | The Board Of Trustees Of The Leland Stanford Junior University | Enzyme treatment of foodstuffs for celiac sprue |
| US7320788B2 (en) | 2002-02-14 | 2008-01-22 | The Board Of Trustees Of The Leland Stanford Junior University | Enzyme treatment of foodstuffs for Celiac Sprue |
| US7462688B2 (en) * | 2002-05-14 | 2008-12-09 | The Board Of Trustees Of The Leland Stanford Junior University | Peptides for diagnostic and therapeutic methods for celiac sprue |
| US7202216B2 (en) | 2002-05-14 | 2007-04-10 | The Board Of Trustees Of The Leland Stanford Junior University | Drug therapy for celiac sprue |
| US7265093B2 (en) * | 2002-05-14 | 2007-09-04 | The Board Of Trustees Of The Leland Stanford Junior University | Drug therapy for Celiac Sprue |
| AU2003234597A1 (en) * | 2002-05-14 | 2003-12-02 | The Board Of Trustees Of The Leland Stanford Junior University | Drug therapy for celiac sprue |
| WO2004045392A2 (en) | 2002-11-20 | 2004-06-03 | The Board Of Trustees Of The Leland Stanford Junior University | Diagnostic method for celiac sprue |
| GB0212885D0 (en) * | 2002-06-05 | 2002-07-17 | Isis Innovation | Therapeutic epitopes and uses thereof |
| US7579313B2 (en) | 2003-11-18 | 2009-08-25 | The Board Of Trustees Of The Leland Stanford Junior University | Transglutaminase inhibitors and methods of use thereof |
| US20070185021A1 (en) * | 2004-01-09 | 2007-08-09 | Scott Fraser W | Diabetogenic epitopes |
| US7563864B2 (en) | 2004-04-26 | 2009-07-21 | Celiac Sprue Research Foundation | Prolyl endopeptidase mediated destruction of T cell epitopes in whole gluten |
| US7534426B2 (en) | 2004-04-26 | 2009-05-19 | The Board Of Trustees Of The Leland Stanford Junior University | Glutenase enzyme assays |
| US7628985B2 (en) * | 2004-04-26 | 2009-12-08 | The Board Of Regents Of The Leland Stanford Junior University | Therapeutic enzyme formulations and uses thereof in celiac sprue and/or dermatitis herpetoformis |
| AU2011247868B2 (en) * | 2004-04-28 | 2014-05-22 | Btg International Limited | Epitopes related to coeliac disease |
| EP1755639B1 (en) * | 2004-04-28 | 2017-08-16 | BTG International Limited | Epitopes related to coeliac disease |
| US10105437B2 (en) | 2004-04-28 | 2018-10-23 | Btg International Limited | Epitopes related to coeliac disease |
| EP1612558A1 (en) * | 2004-06-30 | 2006-01-04 | Academisch Ziekenhuis Leiden | Method for detecting gluten |
| WO2007105024A1 (en) * | 2006-03-15 | 2007-09-20 | Isocell Pharma S.A. | Pharmaceutical compositions comprising sods and prolamine based peptide fragments |
| US7576040B2 (en) * | 2007-01-11 | 2009-08-18 | Halliburton Energy Services, Inc. | Cement compositions comprising humic acid grafted fluid loss control additives |
| AU2008229448B2 (en) | 2007-03-16 | 2013-01-24 | The Board Of Trustees Of The Leland Stanford Junior University | Combination enzyme therapy for digestion of dietary gluten |
| MX2010001734A (es) | 2007-08-13 | 2010-08-04 | Commw Scient Ind Res Org | Cebada con bajos niveles de hordeinas. |
| PT2367561E (pt) * | 2008-11-30 | 2015-10-23 | Immusant Inc | Composições e métodos para o tratamento da doença celíaca |
| US9517257B2 (en) | 2010-08-10 | 2016-12-13 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
| US9850296B2 (en) | 2010-08-10 | 2017-12-26 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
| AU2011289579B2 (en) | 2010-08-10 | 2016-11-17 | Ecole Polytechnique Federale De Lausanne | Erythrocyte-binding therapeutics |
| KR20190087665A (ko) * | 2011-01-20 | 2019-07-24 | 이뮤노사이언시스 랩. 인크. | 글루텐 과민성 검출 및 만성소화장애증과의 구별 방법 및 장치 |
| US20140037661A1 (en) * | 2011-02-08 | 2014-02-06 | Phadia Ab | Wheat Antigens and Peptides for Diagnosis of Wheat Induced Hypersensitivity |
| WO2012162697A1 (en) * | 2011-05-26 | 2012-11-29 | The Regents Of The University Of Colorado, A Body Corporate | Compounds that modulate autoimmunity and methods of using the same |
| US20160091491A1 (en) * | 2013-05-02 | 2016-03-31 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for diagnosis of celiac disease |
| US20160145636A1 (en) * | 2013-05-08 | 2016-05-26 | Jm Biologicals | Compositions and methods for the production of gluten free food products |
| WO2014191839A2 (en) * | 2013-05-14 | 2014-12-04 | Oslo Universitetssykehus Hf | Detection of gluten-specific t-cells |
| NZ631602A (en) | 2013-06-13 | 2019-09-27 | Grains Res & Dev Corp | Barley with very low levels of hordeins |
| WO2015038624A1 (en) | 2013-09-10 | 2015-03-19 | Immusant, Inc. | Dosage of a gluten peptide composition |
| US10946079B2 (en) | 2014-02-21 | 2021-03-16 | Ecole Polytechnique Federale De Lausanne | Glycotargeting therapeutics |
| US10046056B2 (en) | 2014-02-21 | 2018-08-14 | École Polytechnique Fédérale De Lausanne (Epfl) | Glycotargeting therapeutics |
| LT3107563T (lt) | 2014-02-21 | 2021-07-12 | Ecole Polytechnique Fédérale De Lausanne (Epfl) Epfl-Tto | Gliko-nukreipiantys terapiniai agenai |
| US10953101B2 (en) | 2014-02-21 | 2021-03-23 | École Polytechnique Fédérale De Lausanne (Epfl) | Glycotargeting therapeutics |
| WO2015164747A1 (en) * | 2014-04-24 | 2015-10-29 | Immusant, Inc. | Methods for diagnosing celiac disease using circulating cytokines/chemokines |
| US10370718B2 (en) | 2014-09-29 | 2019-08-06 | Immusant, Inc. | Use of HLA genetic status to assess or select treatment of celiac disease |
| EP3221344A2 (en) | 2014-11-21 | 2017-09-27 | Immusant Inc. | Peptides for use in treatment and diagnosis of type 1 diabetes |
| EP3247384B1 (en) | 2015-01-14 | 2023-10-04 | The Regents of the University of Colorado, a body corporate | In vitro method of diagnosis of type 1 diabetes with insulin mimotopes |
| DE102015204012A1 (de) | 2015-03-05 | 2016-09-08 | Clariant International Ltd. | SCR-Katalysator mit verbesserter Haftung |
| EP3432877B1 (en) | 2016-03-24 | 2023-01-11 | ImmunoMolecular Therapeutics, Inc. | D-alpha-methyldopa for treating autoimmune disease |
| CA3035484A1 (en) * | 2016-09-01 | 2018-03-08 | Cellectis | Methods for altering amino acid content in plants |
| US11253579B2 (en) | 2017-06-16 | 2022-02-22 | The University Of Chicago | Compositions and methods for inducing immune tolerance |
| US11052060B2 (en) | 2018-02-12 | 2021-07-06 | The Regents Of The University Of Colorado, A Body Corporate | Compounds and methods for treating autoimmunity |
| US11013707B2 (en) | 2018-03-23 | 2021-05-25 | The Regents Of The University Of Colorado, A Body Corporate | Administration of oral methyldopa |
| EA202092723A1 (ru) | 2018-05-09 | 2021-04-09 | Зе Юниверсити Оф Чикаго | Композиции и способы, касающиеся иммунной толерантности |
| CN110128549B (zh) * | 2019-05-27 | 2021-07-06 | 深圳市亚辉龙生物科技股份有限公司 | 脱酰胺基麦胶蛋白多肽重组抗原、重组抗原表达基因、重组表达载体及其制备方法和应用 |
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1999
- 1999-10-01 GB GBGB9923306.6A patent/GB9923306D0/en not_active Ceased
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2000
- 2000-10-02 EP EP05027922A patent/EP1672368B1/en not_active Expired - Lifetime
- 2000-10-02 EP EP00964460A patent/EP1218751B1/en not_active Expired - Lifetime
- 2000-10-02 AT AT05027922T patent/ATE449965T1/de active
- 2000-10-02 AT AT00964460T patent/ATE319091T1/de active
- 2000-10-02 PT PT00964460T patent/PT1218751E/pt unknown
- 2000-10-02 DE DE60043402T patent/DE60043402D1/de not_active Expired - Lifetime
- 2000-10-02 JP JP2001528704A patent/JP4932112B2/ja not_active Expired - Lifetime
- 2000-10-02 ES ES05027922T patent/ES2335895T3/es not_active Expired - Lifetime
- 2000-10-02 MX MXPA02003295A patent/MXPA02003295A/es active IP Right Grant
- 2000-10-02 US US10/089,700 patent/US7144569B1/en not_active Expired - Lifetime
- 2000-10-02 WO PCT/GB2000/003760 patent/WO2001025793A2/en not_active Ceased
- 2000-10-02 AU AU75394/00A patent/AU782262B2/en not_active Expired
- 2000-10-02 PT PT05027922T patent/PT1672368E/pt unknown
- 2000-10-02 DK DK05027922T patent/DK1672368T3/da active
- 2000-10-02 ES ES00964460T patent/ES2256042T3/es not_active Expired - Lifetime
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- 2000-10-02 DK DK00964460T patent/DK1218751T3/da active
- 2000-10-02 DE DE60026332T patent/DE60026332T2/de not_active Expired - Lifetime
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- 2006-11-03 US US11/556,218 patent/US7888460B2/en not_active Expired - Lifetime
- 2006-11-03 US US11/556,208 patent/US8329144B2/en not_active Expired - Fee Related
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2010
- 2010-02-24 CY CY20101100177T patent/CY1109837T1/el unknown
- 2010-06-15 JP JP2010135844A patent/JP5371890B2/ja not_active Expired - Lifetime
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2012
- 2012-11-08 US US13/672,183 patent/US20130318648A1/en not_active Abandoned
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