JP4558182B2 - ５−カルボキシフタライドの製造法 - Google Patents

５−カルボキシフタライドの製造法 Download PDF

Info

Publication number
JP4558182B2
JP4558182B2 JP2000372224A JP2000372224A JP4558182B2 JP 4558182 B2 JP4558182 B2 JP 4558182B2 JP 2000372224 A JP2000372224 A JP 2000372224A JP 2000372224 A JP2000372224 A JP 2000372224A JP 4558182 B2 JP4558182 B2 JP 4558182B2
Authority
JP
Japan
Prior art keywords
carboxyphthalide
acid
mixture
temperature
process according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP2000372224A
Other languages
English (en)
Japanese (ja)
Other versions
JP2001206881A5 (https=
JP2001206881A (ja
Inventor
ダルアスタ レオネ
カサッザ ウムベルト
コッテサリ ジオバッニ
Original Assignee
インフォシント エスエー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26332721&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP4558182(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by インフォシント エスエー filed Critical インフォシント エスエー
Publication of JP2001206881A publication Critical patent/JP2001206881A/ja
Publication of JP2001206881A5 publication Critical patent/JP2001206881A5/ja
Application granted granted Critical
Publication of JP4558182B2 publication Critical patent/JP4558182B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/83—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Psychiatry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Seasonings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2000372224A 2000-01-18 2000-12-07 ５−カルボキシフタライドの製造法 Expired - Lifetime JP4558182B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT2000A000050 2000-01-18
IT2000MI000050A IT1317729B1 (it) 2000-01-18 2000-01-18 Procedimento per la preparazione della 5-carbossiftalide.
US09/690,301 US6458973B1 (en) 2000-01-18 2000-10-17 Process for the preparation of 5-carboxyphthalide

Publications (3)

Publication Number Publication Date
JP2001206881A JP2001206881A (ja) 2001-07-31
JP2001206881A5 JP2001206881A5 (https=) 2010-01-21
JP4558182B2 true JP4558182B2 (ja) 2010-10-06

Family

ID=26332721

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000372224A Expired - Lifetime JP4558182B2 (ja) 2000-01-18 2000-12-07 ５−カルボキシフタライドの製造法

Country Status (21)

Country Link
US (4) US6458973B1 (https=)
EP (2) EP1118614B2 (https=)
JP (1) JP4558182B2 (https=)
CN (1) CN1184220C (https=)
AT (1) ATE219489T1 (https=)
AU (1) AU779581B2 (https=)
BG (1) BG65763B1 (https=)
BR (1) BR0107853A (https=)
CA (1) CA2397497C (https=)
DE (1) DE60000226T3 (https=)
DK (1) DK1118614T4 (https=)
ES (1) ES2178626T5 (https=)
HK (1) HK1042290B (https=)
HU (1) HUP0204187A3 (https=)
IT (1) IT1317729B1 (https=)
MX (1) MXPA02007031A (https=)
PL (1) PL356563A1 (https=)
PT (1) PT1118614E (https=)
RO (1) RO121737B1 (https=)
WO (1) WO2001053284A1 (https=)
ZA (1) ZA200205475B (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR026063A1 (es) * 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
CN1427835A (zh) * 2000-03-13 2003-07-02 H·隆德贝克有限公司 5－取代的1－(4－氟苯基)－1,3－二氢异苯并呋喃的分步烷基化
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
US7687645B2 (en) * 2003-03-21 2010-03-30 H. Lundbeck A/S Intermediates for the preparation of citalopram and escitalopram
US20050154052A1 (en) * 2003-03-24 2005-07-14 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
CN100569765C (zh) 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
WO2006090409A1 (en) * 2005-02-28 2006-08-31 Kekule Pharma Ltd., An improved process for the preparation of 5 - carboxyphthalide

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3607884A (en) * 1969-03-11 1971-09-21 Mobil Oil Corp Preparation of 5-carboxyphthalide in liquid sodium trioxide
US3976751A (en) † 1974-10-21 1976-08-24 Allied Chemical Corporation Stabilization of liquid sulfur trioxide
DE2630927A1 (de) 1976-07-09 1978-01-19 Basf Ag Verfahren zur herstellung von phthalidcarbonsaeure-(5)
DE3605716A1 (de) 1986-02-22 1987-09-03 Henkel Kgaa Verwendung von unloeslichen schmutzsammlern zur regenerierung von wasch- und reinigungsloesungen
WO1998019513A2 (en) * 1997-07-08 1998-05-14 H. Lundbeck A/S Method for the preparation of citalopram
CA2291134C (en) * 1998-10-20 2006-05-23 H. Lundbeck A/S Method for the preparation of citalopram
AR026063A1 (es) * 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
AU1130901A (en) 1999-11-01 2001-05-14 H. Lundbeck A/S Method for the preparation of 5-carboxyphthalide
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram

Also Published As

Publication number Publication date
HUP0204187A3 (en) 2005-05-30
ES2178626T3 (es) 2003-01-01
ES2178626T5 (es) 2011-06-02
DE60000226T3 (de) 2012-02-16
US6703516B2 (en) 2004-03-09
MXPA02007031A (es) 2004-09-06
AU2679801A (en) 2001-07-31
BG106925A (bg) 2004-01-30
WO2001053284A1 (en) 2001-07-26
JP2001206881A (ja) 2001-07-31
DK1118614T3 (da) 2002-10-14
HK1042290A1 (en) 2002-08-09
AU779581B2 (en) 2005-01-27
ZA200205475B (en) 2003-12-31
DE60000226D1 (de) 2002-07-25
EP1118614A2 (en) 2001-07-25
CA2397497C (en) 2010-07-06
IT1317729B1 (it) 2003-07-15
EP1187822A1 (en) 2002-03-20
EP1118614B1 (en) 2002-06-19
ATE219489T1 (de) 2002-07-15
BR0107853A (pt) 2002-10-29
DK1118614T4 (da) 2011-06-27
DE60000226T2 (de) 2003-03-06
ITMI20000050A0 (it) 2000-01-18
US20080249319A1 (en) 2008-10-09
US20040171851A1 (en) 2004-09-02
US20030009038A1 (en) 2003-01-09
PT1118614E (pt) 2002-11-29
ITMI20000050A1 (it) 2001-07-18
CN1406236A (zh) 2003-03-26
EP1118614A3 (en) 2001-10-24
HUP0204187A2 (hu) 2003-03-28
HK1042290B (en) 2003-07-18
EP1118614B2 (en) 2011-03-09
US6458973B1 (en) 2002-10-01
CA2397497A1 (en) 2001-07-26
RO121737B1 (ro) 2008-03-28
BG65763B1 (bg) 2009-10-30
CN1184220C (zh) 2005-01-12
PL356563A1 (en) 2004-06-28

Similar Documents

Publication Publication Date Title
US20080249319A1 (en) Process for the preparation of 5-Carboxyphthalide
JP3911237B2 (ja) ２−ニトロ−４−メチルスルホニル安息香酸の精製
JPH10503530A (ja) ハロ置換芳香族酸の製造方法
JP5442603B2 (ja) フェノフィブラートの新規合成法
JPH0647568B2 (ja) ２，４‐ジクロロ‐５‐フルオロ安息香酸の製法
JP2502327B2 (ja) ジフエニルエ―テル化合物の製造方法
EP2173701A1 (fr) Procede de preparation du fenofibrate
CN114560862A (zh) 一种吡咯并[1,2-a]喹喔啉-4(5h)-酮及其衍生物的合成方法
JP3907787B2 (ja) 安息香酸誘導体の製造方法
KR100730623B1 (ko) 5-카복시프탈리드의 제조방법 및 시탈로프람의 생성을위한 그것의 사용
JPH10218847A (ja) タートラニル酸の製造法
JP2000239223A (ja) ３−ブロモ−５−フルオロ安息香酸誘導体の製造方法
KR100503267B1 (ko) 2-아세틸옥시-4-트리플루오로메틸 벤조산의 제조 방법
KR100898099B1 (ko) 잘토프로펜의 제조방법
JPH07196610A (ja) ５−クロロ−２−オキシンドールの製造法
SU1721051A1 (ru) Способ получени 2-галоидпроизводных фурана
JP2001261642A (ja) １−アルキルインドール−３−カルボン酸類の製造方法
JPS6011022B2 (ja) １−（３，５−ジメトキシ−４−ヒドロキシ）フエニル−２−（ｎ−メチル）アミノ−エタノ−ルの塩酸塩の製造法
JPH04288081A (ja) ベンゾピラノ〔２，３−ｂ〕ピリジン誘導体の合成法
FR2918662A1 (fr) Procede de preparation du fenofibrate
JPH05222028A (ja) ４−スルホ無水ナフタル酸の製造方法
HU203516B (en) Process for producing 1-naphtyl-acetic acid
JPH08165279A (ja) ５−ヒドロキシイソキノリンの製造方法
JPS63145253A (ja) ４−（２′ークロロエチル）安息香酸の製造方法

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20070920

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20091126

A871 Explanation of circumstances concerning accelerated examination

Free format text: JAPANESE INTERMEDIATE CODE: A871

Effective date: 20091126

A975 Report on accelerated examination

Free format text: JAPANESE INTERMEDIATE CODE: A971005

Effective date: 20091216

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20100119

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20100416

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20100707

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20100721

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20130730

Year of fee payment: 3

S111 Request for change of ownership or part of ownership

Free format text: JAPANESE INTERMEDIATE CODE: R313113

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20130730

Year of fee payment: 3

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20130730

Year of fee payment: 3

S801 Written request for registration of abandonment of right

Free format text: JAPANESE INTERMEDIATE CODE: R311801

ABAN Cancellation due to abandonment
FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20130730

Year of fee payment: 3

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350