BR0107853A - Processo para a preparação de 5-carboxiftalida e seu uso para a produção de citalopram - Google Patents

Processo para a preparação de 5-carboxiftalida e seu uso para a produção de citalopram

Info

Publication number
BR0107853A
BR0107853A BR0107853-4A BR0107853A BR0107853A BR 0107853 A BR0107853 A BR 0107853A BR 0107853 A BR0107853 A BR 0107853A BR 0107853 A BR0107853 A BR 0107853A
Authority
BR
Brazil
Prior art keywords
carboxyphthalide
preparation
citalopram
production
mixture
Prior art date
Application number
BR0107853-4A
Other languages
English (en)
Inventor
Leone Dall Asta
Umberto Casazza
Giovani Cotticelli
Original Assignee
Infosint S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26332721&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR0107853(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Infosint S A filed Critical Infosint S A
Publication of BR0107853A publication Critical patent/BR0107853A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/83—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Psychiatry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Seasonings (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

"PROCESSO PARA A PREPARAçãO DE 5-CARBOXIFTALIDA E SEU USO PARA A PRODUçãO DE CITALOPRAM". Onde o presente invento descreve um processo para a preparação de 5-carboxiftalida, que compreende adicionar ácido tereftálico a ácido sulfúrico fumegante contendo pelo menos 20% em peso de SO~ 3~, e então adicionar formaldeído à mistura, aquecer a mistura a uma temperatura de 120 - 145<198>C e isolar a 5-carboxiftalida da mistura de reação.
BR0107853-4A 2000-01-18 2001-01-17 Processo para a preparação de 5-carboxiftalida e seu uso para a produção de citalopram BR0107853A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT2000MI000050A IT1317729B1 (it) 2000-01-18 2000-01-18 Procedimento per la preparazione della 5-carbossiftalide.
US09/690,301 US6458973B1 (en) 2000-01-18 2000-10-17 Process for the preparation of 5-carboxyphthalide
PCT/EP2001/000617 WO2001053284A1 (en) 2000-01-18 2001-01-17 Process for the preparation of 5-carboxyphthalide and its use for the production of citalopram

Publications (1)

Publication Number Publication Date
BR0107853A true BR0107853A (pt) 2002-10-29

Family

ID=26332721

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0107853-4A BR0107853A (pt) 2000-01-18 2001-01-17 Processo para a preparação de 5-carboxiftalida e seu uso para a produção de citalopram

Country Status (21)

Country Link
US (4) US6458973B1 (pt)
EP (2) EP1118614B2 (pt)
JP (1) JP4558182B2 (pt)
CN (1) CN1184220C (pt)
AT (1) ATE219489T1 (pt)
AU (1) AU779581B2 (pt)
BG (1) BG65763B1 (pt)
BR (1) BR0107853A (pt)
CA (1) CA2397497C (pt)
DE (1) DE60000226T3 (pt)
DK (1) DK1118614T4 (pt)
ES (1) ES2178626T5 (pt)
HK (1) HK1042290B (pt)
HU (1) HUP0204187A3 (pt)
IT (1) IT1317729B1 (pt)
MX (1) MXPA02007031A (pt)
PL (1) PL356563A1 (pt)
PT (1) PT1118614E (pt)
RO (1) RO121737B1 (pt)
WO (1) WO2001053284A1 (pt)
ZA (1) ZA200205475B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR026063A1 (es) * 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
CA2402553A1 (en) * 2000-03-13 2001-09-20 H. Lundbeck A/S Stepwise alkylation of 5-substituted 1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
EP1611118A2 (en) 2003-03-21 2006-01-04 H. Lundbeck A/S Intermediates for the preparation of citalopram and escitalopram
US20050154052A1 (en) * 2003-03-24 2005-07-14 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
CN100569765C (zh) 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
WO2006090409A1 (en) * 2005-02-28 2006-08-31 Kekule Pharma Ltd., An improved process for the preparation of 5 - carboxyphthalide

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3607884A (en) * 1969-03-11 1971-09-21 Mobil Oil Corp Preparation of 5-carboxyphthalide in liquid sodium trioxide
US3976751A (en) † 1974-10-21 1976-08-24 Allied Chemical Corporation Stabilization of liquid sulfur trioxide
DE2630927A1 (de) 1976-07-09 1978-01-19 Basf Ag Verfahren zur herstellung von phthalidcarbonsaeure-(5)
DE3605716A1 (de) 1986-02-22 1987-09-03 Henkel Kgaa Verwendung von unloeslichen schmutzsammlern zur regenerierung von wasch- und reinigungsloesungen
DK1015416T3 (da) * 1997-07-08 2001-11-05 Lundbeck & Co As H Fremgangsmåde til fremstilling af citalopram
KR100411505B1 (ko) * 1998-10-20 2003-12-18 하. 룬트벡 아크티에 셀스카브 시탈로프람의 제조방법
AR026063A1 (es) † 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
WO2001032643A1 (en) 1999-11-01 2001-05-10 H. Lundbeck A/S Method for the preparation of 5-carboxyphthalide
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram

Also Published As

Publication number Publication date
HK1042290A1 (en) 2002-08-09
HUP0204187A3 (en) 2005-05-30
DK1118614T4 (da) 2011-06-27
BG65763B1 (bg) 2009-10-30
EP1118614A3 (en) 2001-10-24
JP2001206881A (ja) 2001-07-31
RO121737B1 (ro) 2008-03-28
US20040171851A1 (en) 2004-09-02
EP1118614B2 (en) 2011-03-09
DE60000226T2 (de) 2003-03-06
HUP0204187A2 (hu) 2003-03-28
PT1118614E (pt) 2002-11-29
EP1187822A1 (en) 2002-03-20
US20080249319A1 (en) 2008-10-09
CN1184220C (zh) 2005-01-12
PL356563A1 (en) 2004-06-28
BG106925A (bg) 2004-01-30
ITMI20000050A0 (it) 2000-01-18
DE60000226T3 (de) 2012-02-16
US6703516B2 (en) 2004-03-09
WO2001053284A1 (en) 2001-07-26
ZA200205475B (en) 2003-12-31
CA2397497C (en) 2010-07-06
MXPA02007031A (es) 2004-09-06
ES2178626T3 (es) 2003-01-01
DK1118614T3 (da) 2002-10-14
EP1118614A2 (en) 2001-07-25
ITMI20000050A1 (it) 2001-07-18
DE60000226D1 (de) 2002-07-25
US20030009038A1 (en) 2003-01-09
CA2397497A1 (en) 2001-07-26
EP1118614B1 (en) 2002-06-19
AU779581B2 (en) 2005-01-27
JP4558182B2 (ja) 2010-10-06
IT1317729B1 (it) 2003-07-15
ES2178626T5 (es) 2011-06-02
HK1042290B (zh) 2003-07-18
US6458973B1 (en) 2002-10-01
AU2679801A (en) 2001-07-31
CN1406236A (zh) 2003-03-26
ATE219489T1 (de) 2002-07-15

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

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