BRPI0606197A2 - processo de produção de um composto - Google Patents

processo de produção de um composto

Info

Publication number
BRPI0606197A2
BRPI0606197A2 BRPI0606197-4A BRPI0606197A BRPI0606197A2 BR PI0606197 A2 BRPI0606197 A2 BR PI0606197A2 BR PI0606197 A BRPI0606197 A BR PI0606197A BR PI0606197 A2 BRPI0606197 A2 BR PI0606197A2
Authority
BR
Brazil
Prior art keywords
compound
production process
formula
temperature
production
Prior art date
Application number
BRPI0606197-4A
Other languages
English (en)
Inventor
Beat Weber
Stefan Rosenberger
Original Assignee
Galderma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galderma Sa filed Critical Galderma Sa
Publication of BRPI0606197A2 publication Critical patent/BRPI0606197A2/pt
Publication of BRPI0606197B1 publication Critical patent/BRPI0606197B1/pt
Publication of BRPI0606197B8 publication Critical patent/BRPI0606197B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

PROCESSO DE PRODUçãO DE UM COMPOSTO. A presente invenção refere-se a um processo aprimorado para a produção de base de Amorolfina, a qual é um composto de Fórmula (1) o dito processo compreendendo as etapas de: (i) colocar o composto de Formula (II) em contato com um catalisador de Friedel-Crafts a uma temperatura em uma faixa de 20 a 30°C; e (ii) adicionar um equivalente de 2-halogeno-2-metilbutano, caracterizado por a mistura reacional obtida na etapa (i) ser resfriada a uma temperatura entre -40°C e -6O°C antes da etapa (ii).
BRPI0606197A 2005-07-28 2006-07-27 processos para a produção de compostos BRPI0606197B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05291612.9 2005-07-28
EP05291612A EP1749825A1 (en) 2005-07-28 2005-07-28 Process of producing amorolfine
PCT/IB2006/003210 WO2007012983A2 (en) 2005-07-28 2006-07-27 Process of producing amorolfine

Publications (3)

Publication Number Publication Date
BRPI0606197A2 true BRPI0606197A2 (pt) 2009-06-02
BRPI0606197B1 BRPI0606197B1 (pt) 2021-03-30
BRPI0606197B8 BRPI0606197B8 (pt) 2021-05-25

Family

ID=35044548

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0606197A BRPI0606197B8 (pt) 2005-07-28 2006-07-27 processos para a produção de compostos

Country Status (15)

Country Link
US (1) US20090163711A1 (pt)
EP (2) EP1749825A1 (pt)
JP (1) JP2009502901A (pt)
AR (1) AR057087A1 (pt)
AT (1) ATE417839T1 (pt)
BR (1) BRPI0606197B8 (pt)
CA (1) CA2601149C (pt)
CY (1) CY1108884T1 (pt)
DE (1) DE602006004360D1 (pt)
DK (1) DK1917254T3 (pt)
ES (1) ES2319819T3 (pt)
PL (1) PL1917254T3 (pt)
PT (1) PT1917254E (pt)
SI (1) SI1917254T1 (pt)
WO (1) WO2007012983A2 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1935889A1 (en) * 2006-12-21 2008-06-25 Galderma S.A. Process of producing amorolfine
AU2009321601B2 (en) 2008-12-04 2012-11-01 F. Hoffmann-La Roche Ag Pyridazinone derivatives
ITFI20090032A1 (it) * 2009-02-20 2010-08-21 Synteco S P A Prodotti Di Sintesi Per L Ind Processo di produzione industriale dell'amorolfina cloridrato
WO2011003455A1 (de) * 2009-07-09 2011-01-13 Cilag Ag Verfahren zur herstellung von 4-(alkyl)-1-(2-methyl-3-(2,6-dimethylmorpholin)propyl) benzolverbindungen
WO2011066735A1 (en) * 2009-12-01 2011-06-09 Zhejiang Hisoar Pharmaceutical Co., Ltd An Amorolfine HCl Crystal and the Preparation thereof
CN108997246B (zh) * 2017-06-06 2021-08-31 江苏礼华生物技术有限公司 盐酸阿莫罗芬的制备方法
CN109232458A (zh) * 2018-06-15 2019-01-18 南通常佑药业科技有限公司 一种手性吗啉化合物的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2965247D1 (en) * 1978-08-08 1983-05-26 Hoffmann La Roche Synthesis of phenyl-propyl morpholine and piperidine derivatives
ZW15780A1 (en) 1979-08-17 1981-03-18 Hoffmann La Roche Heterocyclic compounds
FR2589858A1 (fr) * 1985-11-14 1987-05-15 Exxon Production Research Co Procede d'alkylation selective de composes aromatiques

Also Published As

Publication number Publication date
CA2601149A1 (en) 2007-02-01
JP2009502901A (ja) 2009-01-29
DK1917254T3 (da) 2009-03-16
BRPI0606197B1 (pt) 2021-03-30
ES2319819T3 (es) 2009-05-12
AR057087A1 (es) 2007-11-14
CA2601149C (en) 2011-01-04
DE602006004360D1 (de) 2009-01-29
EP1917254A2 (en) 2008-05-07
ATE417839T1 (de) 2009-01-15
SI1917254T1 (sl) 2009-04-30
US20090163711A1 (en) 2009-06-25
CY1108884T1 (el) 2014-07-02
PL1917254T3 (pl) 2009-06-30
BRPI0606197B8 (pt) 2021-05-25
EP1749825A1 (en) 2007-02-07
PT1917254E (pt) 2009-02-23
EP1917254B1 (en) 2008-12-17
WO2007012983A3 (en) 2007-05-03
WO2007012983A2 (en) 2007-02-01

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 30/03/2021, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 27/07/2006 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF