BRPI0607781A2 - processo para produção de um composto de aminometil tiazol - Google Patents
processo para produção de um composto de aminometil tiazolInfo
- Publication number
- BRPI0607781A2 BRPI0607781A2 BRPI0607781-1A BRPI0607781A BRPI0607781A2 BR PI0607781 A2 BRPI0607781 A2 BR PI0607781A2 BR PI0607781 A BRPI0607781 A BR PI0607781A BR PI0607781 A2 BRPI0607781 A2 BR PI0607781A2
- Authority
- BR
- Brazil
- Prior art keywords
- formula
- compound represented
- defined above
- hexahydrotriazine
- hydroxylamine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/28—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
PROCESSO PARA PRODUçãO DE UM COMPOSTO DE AMINOMETIL TIAZOL. A presente invenção refere-se a um processo para a produção de um composto de tiazol da fórmula (3): em que xi é um átomo de hidrogênio ou um átomo de halogênio, que compreende a reação de um composto da fórmula (1): em que xi é tal como definido acima, e X2 representa um átomo de halogênio, com amónia e formaldeido para se obter um composto de hexaidrotriazina da fórmula (2): em que xi é tal como definido acima, e reação do composto de hexaidrotriazina resultante com hidroxilamina sob condições acídicas. De acordo com este processo, o composto de tiazol da fórmula (3) pode ser vantajosamente produzido industrialmente empregando-se amónia económica com supressão da formação de um subproduto da fórmula (4): em que X1 é tal como definido acima.representado pela fórmula (1). 5. Processo de acordo com a reivindicação 1, em que a quantidade de amónia a ser empregada é 2 a 10 mmols por moi do composto representado pela fórmula (1). 6. Processo de acordo com a reivindicação 1, em que, depois da reação do composto de hexaidrotriazina representado pela fórmula (2) com hidroxilamina, a mistura de reação é extraída com um solvente orgânico hidrofóbico sob condições básicas para separar uma camada orgânica contendo o composto de tiazol representado pela fórmula (3). 7. Processo para a produção de um composto de tiazol representado pela fórmula (3): em que X1 é tal como definido acima, que compreende reação de um composto de hexaidrotriazina representado pela fórmula (2): em que X1 é tal como definido acima, com hidroxilamina sob condições acídicas. 8. Processo de acordo com a reivindicação 7, em que, depois da reação do composto de hexaidrotriazina representado pela fórmula (2) com hidroxilamina, a mistura de reação é extraída com um solvente orgânico hidrofóbico sob condições básicas para separar uma camada orgânica contendo o composto de tiazol representado pela fórmula (3).
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005-110702 | 2005-04-07 | ||
| JP2005110702A JP4839660B2 (ja) | 2005-04-07 | 2005-04-07 | チアゾール化合物の製造法 |
| PCT/JP2006/307682 WO2006109811A1 (en) | 2005-04-07 | 2006-04-05 | Process for producing an aminomethyl thiazole compound |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BRPI0607781A2 true BRPI0607781A2 (pt) | 2009-06-13 |
| BRPI0607781B1 BRPI0607781B1 (pt) | 2014-01-21 |
Family
ID=36677162
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0607781-1A BRPI0607781B1 (pt) | 2005-04-07 | 2006-04-05 | Processo para produção de um composto de aminometil tiazol |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7977490B2 (pt) |
| EP (1) | EP1866297B1 (pt) |
| JP (1) | JP4839660B2 (pt) |
| KR (1) | KR101317066B1 (pt) |
| CN (1) | CN101189217B (pt) |
| AR (1) | AR053351A1 (pt) |
| AT (1) | ATE539067T1 (pt) |
| AU (1) | AU2006234523B2 (pt) |
| BR (1) | BRPI0607781B1 (pt) |
| DK (1) | DK1866297T3 (pt) |
| ES (1) | ES2376475T3 (pt) |
| IL (1) | IL186272A (pt) |
| RU (1) | RU2397161C2 (pt) |
| TW (1) | TW200635908A (pt) |
| WO (1) | WO2006109811A1 (pt) |
| ZA (1) | ZA200708532B (pt) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI344958B (en) * | 2004-06-17 | 2011-07-11 | Sumitomo Chemical Co | Process for preparing thiazole compound |
| CN101370765B (zh) * | 2005-12-15 | 2013-03-13 | 住友化学株式会社 | 选择性制备伯胺化合物的方法 |
| JP5130706B2 (ja) * | 2005-12-15 | 2013-01-30 | 住友化学株式会社 | 選択的一級アミン化合物の製造方法 |
| JP4848762B2 (ja) | 2005-12-26 | 2011-12-28 | 住友化学株式会社 | 一級アミン化合物の製造方法 |
| KR20100005089A (ko) * | 2007-04-24 | 2010-01-13 | 닛뽕소다 가부시키가이샤 | 치환 메틸아민 화합물의 제조방법 및 트리아진 유도체 |
| CN104370804A (zh) * | 2007-04-24 | 2015-02-25 | 日本曹达株式会社 | 取代甲胺化合物的制造方法 |
| CN103641776A (zh) * | 2007-04-24 | 2014-03-19 | 日本曹达株式会社 | N-亚甲基取代甲胺多聚物的制造方法和三嗪衍生物 |
| JP6217646B2 (ja) * | 2012-11-02 | 2017-10-25 | 住友化学株式会社 | 化合物の製造方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4125719A (en) * | 1977-08-01 | 1978-11-14 | Merck & Co., Inc. | 1,3,5-S-Hexahydrotrisubstituted triazines |
| SU798102A1 (ru) * | 1977-08-25 | 1981-01-23 | Предприятие П/Я В-2287 | Способ совместного получени , , -ТРибЕНзилгЕКСАгидРО-ТРиАзиНА-1,3,5 и -МЕТилбЕНзил-АМиНО- -бЕНзилиМиНОМЕТилЕНА |
| JPS5936688A (ja) * | 1982-08-24 | 1984-02-28 | Sumitomo Chem Co Ltd | １，２，４−オキサジアゾ−ル誘導体、その製造法およびそれを有効成分とする除草剤 |
| ES2061569T3 (es) * | 1987-08-01 | 1994-12-16 | Takeda Chemical Industries Ltd | Aminas insaturadas en alfa, su produccion y uso. |
| US5180833A (en) * | 1990-03-16 | 1993-01-19 | Takeda Chemical Industries, Ltd. | Process for the preparation of chlorothiazole derivatives |
| JPH0421674A (ja) * | 1990-05-15 | 1992-01-24 | Nippon Soda Co Ltd | ２―クロロ―５―（アミノメチル）チアゾールの製造方法 |
| JPH05208977A (ja) | 1991-05-27 | 1993-08-20 | Takeda Chem Ind Ltd | Ｎ−（２−クロロ−５−チアゾリルメチル）フタルイミドの製造方法、その中間体の製造方法及び新規な中間体 |
| JPH05286936A (ja) * | 1992-04-06 | 1993-11-02 | Takeda Chem Ind Ltd | ホルムアミド誘導体の製造法及び新規ホルムアミド誘導体 |
| JPH0714916A (ja) | 1993-06-22 | 1995-01-17 | Nec Corp | Ｍｏｓ電界効果トランジスタの分離構造およびその製造 方法 |
| IN182219B (pt) * | 1996-02-21 | 1999-02-06 | Kuraray Co | |
| TW541294B (en) * | 1998-10-12 | 2003-07-11 | Ihara Chemical Ind Co | Process for producing aminomethyl-heterocyclic derivative |
| JP4276720B2 (ja) * | 1998-11-05 | 2009-06-10 | 住友化学株式会社 | ５−アミノメチル−２−クロロチアゾールまたはその塩の製造方法 |
| JP4815660B2 (ja) | 2000-06-16 | 2011-11-16 | 三菱化学株式会社 | 非水電解液及び非水電解液二次電池 |
| DE10061083A1 (de) * | 2000-12-08 | 2002-06-13 | Bayer Ag | Bis-(2-chlor-thiazolyl-5-methyl)-amin und seine Salze sowie Verfahren zur Aufarbeitung von 5-Aminomethyl-2-chlor-thiazol und Bis-(2-chlor-thiazol-5-methyl)-amin enthaltenden Reaktionsgemischen |
| GB0312419D0 (en) * | 2003-05-30 | 2003-07-02 | Boots Healthcare Int Ltd | Use of a compound in the treatment of sleep disorders and the like, in providing refreshedness on waking and a method for the treatment of grogginess |
| TWI344958B (en) * | 2004-06-17 | 2011-07-11 | Sumitomo Chemical Co | Process for preparing thiazole compound |
-
2005
- 2005-04-07 JP JP2005110702A patent/JP4839660B2/ja not_active Expired - Fee Related
-
2006
- 2006-02-09 TW TW095104418A patent/TW200635908A/zh not_active IP Right Cessation
- 2006-04-05 DK DK06731629.9T patent/DK1866297T3/da active
- 2006-04-05 AT AT06731629T patent/ATE539067T1/de active
- 2006-04-05 EP EP06731629A patent/EP1866297B1/en not_active Not-in-force
- 2006-04-05 AU AU2006234523A patent/AU2006234523B2/en not_active Ceased
- 2006-04-05 ES ES06731629T patent/ES2376475T3/es active Active
- 2006-04-05 KR KR1020077022630A patent/KR101317066B1/ko not_active IP Right Cessation
- 2006-04-05 AR ARP060101350A patent/AR053351A1/es unknown
- 2006-04-05 WO PCT/JP2006/307682 patent/WO2006109811A1/en active Application Filing
- 2006-04-05 ZA ZA200708532A patent/ZA200708532B/xx unknown
- 2006-04-05 US US11/918,004 patent/US7977490B2/en not_active Expired - Fee Related
- 2006-04-05 CN CN2006800198410A patent/CN101189217B/zh active Active
- 2006-04-05 BR BRPI0607781-1A patent/BRPI0607781B1/pt not_active IP Right Cessation
- 2006-04-05 RU RU2007141199/04A patent/RU2397161C2/ru not_active IP Right Cessation
-
2007
- 2007-09-25 IL IL186272A patent/IL186272A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1866297B1 (en) | 2011-12-28 |
| TWI363055B (pt) | 2012-05-01 |
| US20110054185A1 (en) | 2011-03-03 |
| ES2376475T3 (es) | 2012-03-14 |
| ATE539067T1 (de) | 2012-01-15 |
| BRPI0607781B1 (pt) | 2014-01-21 |
| RU2007141199A (ru) | 2009-05-20 |
| KR20070116851A (ko) | 2007-12-11 |
| AR053351A1 (es) | 2007-05-02 |
| AU2006234523B2 (en) | 2011-09-01 |
| WO2006109811A1 (en) | 2006-10-19 |
| IL186272A0 (en) | 2008-01-20 |
| JP2006290758A (ja) | 2006-10-26 |
| EP1866297A1 (en) | 2007-12-19 |
| AU2006234523A1 (en) | 2006-10-19 |
| DK1866297T3 (da) | 2012-02-06 |
| CN101189217A (zh) | 2008-05-28 |
| TW200635908A (en) | 2006-10-16 |
| CN101189217B (zh) | 2011-01-26 |
| US7977490B2 (en) | 2011-07-12 |
| JP4839660B2 (ja) | 2011-12-21 |
| ZA200708532B (en) | 2009-03-25 |
| KR101317066B1 (ko) | 2013-10-11 |
| RU2397161C2 (ru) | 2010-08-20 |
| IL186272A (en) | 2012-08-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 05/04/2006, OBSERVADAS AS CONDICOES LEGAIS. |
|
| B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time | ||
| B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |