HUP0204187A2 - Eljárás 1-oxo-1,3-dihidro-izobenzofurán-5-karbonsav előállítására és a vegyület alkalmazása citaloprom szintézisére - Google Patents
Eljárás 1-oxo-1,3-dihidro-izobenzofurán-5-karbonsav előállítására és a vegyület alkalmazása citaloprom szintéziséreInfo
- Publication number
- HUP0204187A2 HUP0204187A2 HU0204187A HUP0204187A HUP0204187A2 HU P0204187 A2 HUP0204187 A2 HU P0204187A2 HU 0204187 A HU0204187 A HU 0204187A HU P0204187 A HUP0204187 A HU P0204187A HU P0204187 A2 HUP0204187 A2 HU P0204187A2
- Authority
- HU
- Hungary
- Prior art keywords
- dihydro
- oxo
- citalopram
- preparation
- production
- Prior art date
Links
- QTWUWCFGWYYRRL-UHFFFAOYSA-N 1-oxo-3h-2-benzofuran-5-carboxylic acid Chemical compound OC(=O)C1=CC=C2C(=O)OCC2=C1 QTWUWCFGWYYRRL-UHFFFAOYSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- WSEQXVZVJXJVFP-HXUWFJFHSA-N (R)-citalopram Chemical compound C1([C@@]2(C3=CC=C(C=C3CO2)C#N)CCCN(C)C)=CC=C(F)C=C1 WSEQXVZVJXJVFP-HXUWFJFHSA-N 0.000 title 1
- 229960001653 citalopram Drugs 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 abstract 3
- KKEYFWRCBNTPAC-UHFFFAOYSA-N Terephthalic acid Chemical compound OC(=O)C1=CC=C(C(O)=O)C=C1 KKEYFWRCBNTPAC-UHFFFAOYSA-N 0.000 abstract 2
- AKEJUJNQAAGONA-UHFFFAOYSA-N sulfur trioxide Chemical compound O=S(=O)=O AKEJUJNQAAGONA-UHFFFAOYSA-N 0.000 abstract 2
- 239000012467 final product Substances 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- HIFJUMGIHIZEPX-UHFFFAOYSA-N sulfuric acid;sulfur trioxide Chemical compound O=S(=O)=O.OS(O)(=O)=O HIFJUMGIHIZEPX-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/83—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Life Sciences & Earth Sciences (AREA)
- Psychiatry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Seasonings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Az (A) képletű 1-oxo-1,3-dihidro-izobenzofurán-5-karbonsav előállításieljárása során legalább 20 tömeg% kén-trioxidot tartalmazó füstölgőkénsavhoz (I) képletű tereftálsavat és formaldehidet adnak, az ígynyert reakciókeveréket 120-160 °C-on melegítik, majd a végterméketizolálják. Ó
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2000MI000050A IT1317729B1 (it) | 2000-01-18 | 2000-01-18 | Procedimento per la preparazione della 5-carbossiftalide. |
US09/690,301 US6458973B1 (en) | 2000-01-18 | 2000-10-17 | Process for the preparation of 5-carboxyphthalide |
PCT/EP2001/000617 WO2001053284A1 (en) | 2000-01-18 | 2001-01-17 | Process for the preparation of 5-carboxyphthalide and its use for the production of citalopram |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0204187A2 true HUP0204187A2 (hu) | 2003-03-28 |
HUP0204187A3 HUP0204187A3 (en) | 2005-05-30 |
Family
ID=26332721
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0204187A HUP0204187A3 (en) | 2000-01-18 | 2001-01-17 | Process for the preparation of 1-oxo-1,3-dihydro-5-isobenzofurancarboxylic acid and its use for the production of citalopram |
Country Status (21)
Country | Link |
---|---|
US (4) | US6458973B1 (hu) |
EP (2) | EP1118614B2 (hu) |
JP (1) | JP4558182B2 (hu) |
CN (1) | CN1184220C (hu) |
AT (1) | ATE219489T1 (hu) |
AU (1) | AU779581B2 (hu) |
BG (1) | BG65763B1 (hu) |
BR (1) | BR0107853A (hu) |
CA (1) | CA2397497C (hu) |
DE (1) | DE60000226T3 (hu) |
DK (1) | DK1118614T4 (hu) |
ES (1) | ES2178626T5 (hu) |
HK (1) | HK1042290B (hu) |
HU (1) | HUP0204187A3 (hu) |
IT (1) | IT1317729B1 (hu) |
MX (1) | MXPA02007031A (hu) |
PL (1) | PL356563A1 (hu) |
PT (1) | PT1118614E (hu) |
RO (1) | RO121737B1 (hu) |
WO (1) | WO2001053284A1 (hu) |
ZA (1) | ZA200205475B (hu) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR026063A1 (es) * | 1999-11-01 | 2002-12-26 | Lundbeck & Co As H | Metodo para la preparacion de 5-carboxiftalida. |
IES20010157A2 (en) | 2000-03-03 | 2002-03-06 | Lundbeck & Co As H | Method for the preparation of citalopram |
GB0005477D0 (en) | 2000-03-07 | 2000-04-26 | Resolution Chemicals Limited | Process for the preparation of citalopram |
CN1427835A (zh) * | 2000-03-13 | 2003-07-02 | H·隆德贝克有限公司 | 5-取代的1-(4-氟苯基)-1,3-二氢异苯并呋喃的分步烷基化 |
AR032455A1 (es) | 2000-05-12 | 2003-11-12 | Lundbeck & Co As H | Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva |
CN101362743A (zh) * | 2003-03-21 | 2009-02-11 | H.隆德贝克有限公司 | 用于制备西酞普兰和依他普仑的中间体 |
WO2004085416A1 (en) * | 2003-03-24 | 2004-10-07 | Hetero Drugs Limited | Novel crystalline forms of (s)-citalopram oxalate |
CN100569765C (zh) | 2003-12-19 | 2009-12-16 | 杭州民生药业集团有限公司 | 西酞普兰中间体晶体碱 |
WO2006090409A1 (en) * | 2005-02-28 | 2006-08-31 | Kekule Pharma Ltd., | An improved process for the preparation of 5 - carboxyphthalide |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3607884A (en) * | 1969-03-11 | 1971-09-21 | Mobil Oil Corp | Preparation of 5-carboxyphthalide in liquid sodium trioxide |
US3976751A (en) † | 1974-10-21 | 1976-08-24 | Allied Chemical Corporation | Stabilization of liquid sulfur trioxide |
DE2630927A1 (de) | 1976-07-09 | 1978-01-19 | Basf Ag | Verfahren zur herstellung von phthalidcarbonsaeure-(5) |
DE3605716A1 (de) | 1986-02-22 | 1987-09-03 | Henkel Kgaa | Verwendung von unloeslichen schmutzsammlern zur regenerierung von wasch- und reinigungsloesungen |
EA001728B1 (ru) * | 1997-07-08 | 2001-08-27 | Х.Лундбекк А/С | Способ получения циталопрама |
HU228576B1 (en) * | 1998-10-20 | 2013-04-29 | Lundbeck & Co As H | Method for the preparation of citalopram |
WO2001032643A1 (en) | 1999-11-01 | 2001-05-10 | H. Lundbeck A/S | Method for the preparation of 5-carboxyphthalide |
AR026063A1 (es) † | 1999-11-01 | 2002-12-26 | Lundbeck & Co As H | Metodo para la preparacion de 5-carboxiftalida. |
GB0005477D0 (en) | 2000-03-07 | 2000-04-26 | Resolution Chemicals Limited | Process for the preparation of citalopram |
-
2000
- 2000-01-18 IT IT2000MI000050A patent/IT1317729B1/it active
- 2000-10-17 EP EP00203602A patent/EP1118614B2/en not_active Expired - Lifetime
- 2000-10-17 ES ES00203602T patent/ES2178626T5/es not_active Expired - Lifetime
- 2000-10-17 AT AT00203602T patent/ATE219489T1/de not_active IP Right Cessation
- 2000-10-17 DE DE60000226T patent/DE60000226T3/de not_active Expired - Lifetime
- 2000-10-17 US US09/690,301 patent/US6458973B1/en not_active Expired - Fee Related
- 2000-10-17 PT PT00203602T patent/PT1118614E/pt unknown
- 2000-10-17 DK DK00203602.8T patent/DK1118614T4/da active
- 2000-12-07 JP JP2000372224A patent/JP4558182B2/ja not_active Expired - Lifetime
-
2001
- 2001-01-17 MX MXPA02007031A patent/MXPA02007031A/es active IP Right Grant
- 2001-01-17 HU HU0204187A patent/HUP0204187A3/hu unknown
- 2001-01-17 WO PCT/EP2001/000617 patent/WO2001053284A1/en active IP Right Grant
- 2001-01-17 AU AU26798/01A patent/AU779581B2/en not_active Revoked
- 2001-01-17 PL PL01356563A patent/PL356563A1/xx not_active IP Right Cessation
- 2001-01-17 CA CA2397497A patent/CA2397497C/en not_active Expired - Fee Related
- 2001-01-17 CN CNB018038484A patent/CN1184220C/zh not_active Expired - Lifetime
- 2001-01-17 RO ROA200200989A patent/RO121737B1/ro unknown
- 2001-01-17 BR BR0107853-4A patent/BR0107853A/pt not_active Application Discontinuation
- 2001-01-17 EP EP01901181A patent/EP1187822A1/en not_active Withdrawn
-
2002
- 2002-01-25 HK HK02100631.3A patent/HK1042290B/zh not_active IP Right Cessation
- 2002-07-09 ZA ZA200205475A patent/ZA200205475B/xx unknown
- 2002-07-16 BG BG106925A patent/BG65763B1/bg unknown
- 2002-08-23 US US10/227,038 patent/US6703516B2/en not_active Expired - Fee Related
-
2004
- 2004-03-08 US US10/796,336 patent/US20040171851A1/en not_active Abandoned
-
2007
- 2007-10-22 US US11/975,842 patent/US20080249319A1/en not_active Abandoned
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD9A | Lapse of provisional protection due to non-payment of fees |