ATE219489T1 - Verfahren zur herstellung von 5-carboxyphthalid - Google Patents
Verfahren zur herstellung von 5-carboxyphthalidInfo
- Publication number
- ATE219489T1 ATE219489T1 AT00203602T AT00203602T ATE219489T1 AT E219489 T1 ATE219489 T1 AT E219489T1 AT 00203602 T AT00203602 T AT 00203602T AT 00203602 T AT00203602 T AT 00203602T AT E219489 T1 ATE219489 T1 AT E219489T1
- Authority
- AT
- Austria
- Prior art keywords
- carboxyphthalide
- mixture
- producing
- isolating
- heating
- Prior art date
Links
- QTWUWCFGWYYRRL-UHFFFAOYSA-N 1-oxo-3h-2-benzofuran-5-carboxylic acid Chemical compound OC(=O)C1=CC=C2C(=O)OCC2=C1 QTWUWCFGWYYRRL-UHFFFAOYSA-N 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 abstract 3
- KKEYFWRCBNTPAC-UHFFFAOYSA-N Terephthalic acid Chemical compound OC(=O)C1=CC=C(C(O)=O)C=C1 KKEYFWRCBNTPAC-UHFFFAOYSA-N 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 238000010438 heat treatment Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- HIFJUMGIHIZEPX-UHFFFAOYSA-N sulfuric acid;sulfur trioxide Chemical compound O=S(=O)=O.OS(O)(=O)=O HIFJUMGIHIZEPX-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/83—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Life Sciences & Earth Sciences (AREA)
- Psychiatry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Seasonings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2000MI000050A IT1317729B1 (it) | 2000-01-18 | 2000-01-18 | Procedimento per la preparazione della 5-carbossiftalide. |
| US09/690,301 US6458973B1 (en) | 2000-01-18 | 2000-10-17 | Process for the preparation of 5-carboxyphthalide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE219489T1 true ATE219489T1 (de) | 2002-07-15 |
Family
ID=26332721
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00203602T ATE219489T1 (de) | 2000-01-18 | 2000-10-17 | Verfahren zur herstellung von 5-carboxyphthalid |
Country Status (21)
| Country | Link |
|---|---|
| US (4) | US6458973B1 (de) |
| EP (2) | EP1118614B2 (de) |
| JP (1) | JP4558182B2 (de) |
| CN (1) | CN1184220C (de) |
| AT (1) | ATE219489T1 (de) |
| AU (1) | AU779581B2 (de) |
| BG (1) | BG65763B1 (de) |
| BR (1) | BR0107853A (de) |
| CA (1) | CA2397497C (de) |
| DE (1) | DE60000226T3 (de) |
| DK (1) | DK1118614T4 (de) |
| ES (1) | ES2178626T5 (de) |
| HK (1) | HK1042290B (de) |
| HU (1) | HUP0204187A3 (de) |
| IT (1) | IT1317729B1 (de) |
| MX (1) | MXPA02007031A (de) |
| PL (1) | PL356563A1 (de) |
| PT (1) | PT1118614E (de) |
| RO (1) | RO121737B1 (de) |
| WO (1) | WO2001053284A1 (de) |
| ZA (1) | ZA200205475B (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR026063A1 (es) * | 1999-11-01 | 2002-12-26 | Lundbeck & Co As H | Metodo para la preparacion de 5-carboxiftalida. |
| IES20010157A2 (en) | 2000-03-03 | 2002-03-06 | Lundbeck & Co As H | Method for the preparation of citalopram |
| GB0005477D0 (en) | 2000-03-07 | 2000-04-26 | Resolution Chemicals Limited | Process for the preparation of citalopram |
| MXPA02008684A (es) * | 2000-03-13 | 2003-02-24 | Lundbeck & Co As H | Alquilacion gradual de 1-(4-fluorofenil)-1,3-dihidroisobenzofuranos 5-substituidos. |
| AR032455A1 (es) | 2000-05-12 | 2003-11-12 | Lundbeck & Co As H | Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva |
| CA2519629A1 (en) | 2003-03-21 | 2004-09-30 | H. Lundbeck A/S | Intermediates for the preparation of citalopram and escitalopram |
| WO2004085416A1 (en) * | 2003-03-24 | 2004-10-07 | Hetero Drugs Limited | Novel crystalline forms of (s)-citalopram oxalate |
| CN100569765C (zh) | 2003-12-19 | 2009-12-16 | 杭州民生药业集团有限公司 | 西酞普兰中间体晶体碱 |
| WO2006090409A1 (en) * | 2005-02-28 | 2006-08-31 | Kekule Pharma Ltd., | An improved process for the preparation of 5 - carboxyphthalide |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3607884A (en) * | 1969-03-11 | 1971-09-21 | Mobil Oil Corp | Preparation of 5-carboxyphthalide in liquid sodium trioxide |
| US3976751A (en) † | 1974-10-21 | 1976-08-24 | Allied Chemical Corporation | Stabilization of liquid sulfur trioxide |
| DE2630927A1 (de) | 1976-07-09 | 1978-01-19 | Basf Ag | Verfahren zur herstellung von phthalidcarbonsaeure-(5) |
| DE3605716A1 (de) | 1986-02-22 | 1987-09-03 | Henkel Kgaa | Verwendung von unloeslichen schmutzsammlern zur regenerierung von wasch- und reinigungsloesungen |
| KR100357975B1 (ko) * | 1997-07-08 | 2002-10-25 | 하. 룬트벡 아크티에 셀스카브 | 시탈로프램의 제조방법 |
| DK1123284T3 (da) * | 1998-10-20 | 2003-04-28 | Lundbeck & Co As H | Fremgangsmåde til fremstilling af citalopram |
| AU1130901A (en) | 1999-11-01 | 2001-05-14 | H. Lundbeck A/S | Method for the preparation of 5-carboxyphthalide |
| AR026063A1 (es) † | 1999-11-01 | 2002-12-26 | Lundbeck & Co As H | Metodo para la preparacion de 5-carboxiftalida. |
| GB0005477D0 (en) | 2000-03-07 | 2000-04-26 | Resolution Chemicals Limited | Process for the preparation of citalopram |
-
2000
- 2000-01-18 IT IT2000MI000050A patent/IT1317729B1/it active
- 2000-10-17 DK DK00203602.8T patent/DK1118614T4/da active
- 2000-10-17 AT AT00203602T patent/ATE219489T1/de not_active IP Right Cessation
- 2000-10-17 US US09/690,301 patent/US6458973B1/en not_active Expired - Fee Related
- 2000-10-17 PT PT00203602T patent/PT1118614E/pt unknown
- 2000-10-17 DE DE60000226T patent/DE60000226T3/de not_active Expired - Lifetime
- 2000-10-17 EP EP00203602A patent/EP1118614B2/de not_active Expired - Lifetime
- 2000-10-17 ES ES00203602T patent/ES2178626T5/es not_active Expired - Lifetime
- 2000-12-07 JP JP2000372224A patent/JP4558182B2/ja not_active Expired - Lifetime
-
2001
- 2001-01-17 EP EP01901181A patent/EP1187822A1/de not_active Withdrawn
- 2001-01-17 MX MXPA02007031A patent/MXPA02007031A/es active IP Right Grant
- 2001-01-17 BR BR0107853-4A patent/BR0107853A/pt not_active Application Discontinuation
- 2001-01-17 WO PCT/EP2001/000617 patent/WO2001053284A1/en not_active Ceased
- 2001-01-17 CA CA2397497A patent/CA2397497C/en not_active Expired - Fee Related
- 2001-01-17 AU AU26798/01A patent/AU779581B2/en not_active Revoked
- 2001-01-17 HU HU0204187A patent/HUP0204187A3/hu unknown
- 2001-01-17 RO ROA200200989A patent/RO121737B1/ro unknown
- 2001-01-17 PL PL01356563A patent/PL356563A1/xx not_active IP Right Cessation
- 2001-01-17 CN CNB018038484A patent/CN1184220C/zh not_active Expired - Lifetime
-
2002
- 2002-01-25 HK HK02100631.3A patent/HK1042290B/en not_active IP Right Cessation
- 2002-07-09 ZA ZA200205475A patent/ZA200205475B/xx unknown
- 2002-07-16 BG BG106925A patent/BG65763B1/bg unknown
- 2002-08-23 US US10/227,038 patent/US6703516B2/en not_active Expired - Fee Related
-
2004
- 2004-03-08 US US10/796,336 patent/US20040171851A1/en not_active Abandoned
-
2007
- 2007-10-22 US US11/975,842 patent/US20080249319A1/en not_active Abandoned
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEIH | Change in the person of patent owner | ||
| UEP | Publication of translation of european patent specification |
Ref document number: 1118614 Country of ref document: EP |
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| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |