JP4519861B2 - 新規なアザ二環式誘導体、その製造方法、およびそれを含む医薬組成物 - Google Patents

新規なアザ二環式誘導体、その製造方法、およびそれを含む医薬組成物 Download PDF

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Publication number
JP4519861B2
JP4519861B2 JP2006553623A JP2006553623A JP4519861B2 JP 4519861 B2 JP4519861 B2 JP 4519861B2 JP 2006553623 A JP2006553623 A JP 2006553623A JP 2006553623 A JP2006553623 A JP 2006553623A JP 4519861 B2 JP4519861 B2 JP 4519861B2
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group
formula
compound
pharmaceutically acceptable
optionally substituted
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JP2007523135A (ja
JP2007523135A5 (https=
Inventor
カサラ，パトリック
ショレ，アン−マリー
デノ，アラン
ベール，リオネル
レスタージュ，ピエール
ロッカール，ブリアン
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Les Laboratoires Servier SAS
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Les Laboratoires Servier SAS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
JP2006553623A 2004-02-20 2005-02-18 新規なアザ二環式誘導体、その製造方法、およびそれを含む医薬組成物 Expired - Fee Related JP4519861B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0401690A FR2866647B1 (fr) 2004-02-20 2004-02-20 Nouveaux derives azabicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
PCT/FR2005/000382 WO2005089747A1 (fr) 2004-02-20 2005-02-18 Nouveaux derives azabicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (3)

Publication Number Publication Date
JP2007523135A JP2007523135A (ja) 2007-08-16
JP2007523135A5 JP2007523135A5 (https=) 2010-05-20
JP4519861B2 true JP4519861B2 (ja) 2010-08-04

Family

ID=34833930

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006553623A Expired - Fee Related JP4519861B2 (ja) 2004-02-20 2005-02-18 新規なアザ二環式誘導体、その製造方法、およびそれを含む医薬組成物

Country Status (29)

Country Link
US (1) US7576120B2 (https=)
EP (1) EP1720544B1 (https=)
JP (1) JP4519861B2 (https=)
KR (1) KR100885104B1 (https=)
CN (2) CN100577160C (https=)
AR (3) AR047685A1 (https=)
AT (1) ATE389398T1 (https=)
AU (1) AU2005224129B2 (https=)
BR (1) BRPI0507830A (https=)
CA (1) CA2555216C (https=)
CY (1) CY1108529T1 (https=)
DE (1) DE602005005456T2 (https=)
DK (1) DK1720544T3 (https=)
EA (1) EA010300B1 (https=)
ES (1) ES2303233T3 (https=)
FR (1) FR2866647B1 (https=)
GE (1) GEP20094578B (https=)
HR (1) HRP20080184T5 (https=)
MA (1) MA28342A1 (https=)
ME (1) ME01400B (https=)
MY (1) MY137282A (https=)
NO (1) NO337013B1 (https=)
NZ (1) NZ548898A (https=)
PL (1) PL1720544T3 (https=)
PT (1) PT1720544E (https=)
RS (1) RS50577B (https=)
SI (1) SI1720544T1 (https=)
WO (1) WO2005089747A1 (https=)
ZA (1) ZA200606558B (https=)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1717235A3 (en) * 2005-04-29 2007-02-28 Bioprojet Phenoxypropylpiperidines and -pyrrolidines and their use as histamine H3-receptor ligands
EP1717234A1 (en) * 2005-04-29 2006-11-02 Bioprojet Phenoxypropylpiperidines and -pyrrolidines and their use as histamine H3-receptor ligands
US20090023731A1 (en) * 2007-03-22 2009-01-22 Arete Therapeutics, Inc. Soluble epoxide hydrolase inhibitors
FR2932479A1 (fr) * 2008-06-13 2009-12-18 Servier Lab Nouveaux derives azabicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2937251B1 (fr) * 2008-10-16 2011-03-18 Servier Lab Utilisation du 4-{3-°hexahydrocyclopenta°c!pyrrol-2(1h)-yl! propoxy}benzamide pour l'obtention de medicaments destines au traitement des troubles du sommeil
FR2953513B1 (fr) 2009-12-09 2011-12-23 Servier Lab Nouveaux derives azabicyclo[3.2.0]hept-6-yl, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2953514B1 (fr) 2009-12-09 2011-12-23 Servier Lab Nouveaux derives azabicyclo[3.2.0]hept-3-yl, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2953515B1 (fr) 2009-12-09 2011-12-23 Servier Lab Nouveaux derives du type hexahydrocyclopenta[b]pyrrole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2953521B1 (fr) * 2009-12-09 2011-11-18 Servier Lab Nouveaux derives azabicyclo[3.1.0]hex-2-yl, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2974729B1 (fr) 2011-05-02 2013-04-19 Servier Lab Nouvelle association entre le 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1h)-yl]propoxy}benzamide et un inhibiteur de l'acetylcholinesterase et les compositions pharmaceutiques qui la contiennent
FR2976285B1 (fr) * 2011-06-08 2013-05-24 Servier Lab Procede de synthese et forme cristalline du chlorhydrate de 4-{3-[cis-hexahydrocypenta[c]pyrrol-2(1h)-yl]propoxy}benzamide ainsi que les compositions pharmaceutiques qui la contiennent
FR2976286B1 (fr) * 2011-06-08 2013-05-24 Servier Lab 4-{3-[trans-hexahydrocyclopenta[c]pyrrol-2(1h)-yl]propoxy}benzamide, son procede de preparation et les compositions pharmaceutiques qui le contiennent
EP2789608A4 (en) 2011-12-08 2015-07-01 Taisho Pharmaceutical Co Ltd PHENYLPYRROLDERIVAT
FR2983732B1 (fr) 2011-12-09 2013-11-22 Servier Lab Nouvelle association entre le 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1h)-yl]propoxy}pharmaceutiques qui la contiennent
TW201343636A (zh) * 2011-12-27 2013-11-01 大正製藥股份有限公司 苯基三唑衍生物
CN103183632A (zh) * 2011-12-29 2013-07-03 山东方明药业集团股份有限公司 一种3-氮杂双环辛烷盐酸盐的提纯方法
FR2999179A1 (fr) * 2012-12-07 2014-06-13 Servier Lab Procede de synthese d'un sel d'addition a un acide pharmaceutiquement acceptable du 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1h)-yl]propoxy}benzamide, ainsi que les formes cristallines associees
FR3003466B1 (fr) * 2013-03-22 2015-08-07 Servier Lab Utilisation du 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1h)-yl]propoxy}benzamide pour le traitement des douleurs neuropathiques
EP3594206A1 (en) * 2018-07-09 2020-01-15 Abivax Phenyl-n-quinoline derivatives for treating a rna virus infection
EP3594205A1 (en) 2018-07-09 2020-01-15 Abivax Phenyl-n-aryl derivatives for treating a rna virus infection
CN111377846B (zh) * 2018-12-27 2022-05-24 江苏恩华药业股份有限公司 一种哌嗪苯甲酰胺类衍生物及其应用
CN111377911B (zh) * 2018-12-27 2022-05-24 江苏恩华药业股份有限公司 一种吗啉苯甲酰胺类化合物及其应用

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US2962496A (en) * 1957-01-28 1960-11-29 Geschickter Fund Med Res Nu-substituted-3-azabicyclooctanes [3: 3: 0] and salts thereof
DE4341403A1 (de) * 1993-12-04 1995-06-08 Basf Ag N-substituierte 3-Azabicycloalkan-Derivate, ihre Herstellung und Verwendung
EP1299352B1 (en) * 2000-06-30 2005-12-28 Elan Pharmaceuticals, Inc. Compounds to treat alzheimer's disease
BR0108088A (pt) * 2000-07-13 2004-04-06 Abbott Lab Pirrolidinas 1,3-dissubstituìdas e 1,3,3-trissubstituìdas como ligandos receptores de histamina-3 e suas aplicações terapêuticas
FR2827288B1 (fr) * 2001-07-12 2003-10-31 Servier Lab Nouveaux derives d'octahydro-2h-pyrido[1,2-a]pyrazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
US20070197625A1 (en) 2007-08-23
JP2007523135A (ja) 2007-08-16
DE602005005456D1 (de) 2008-04-30
RS50577B (sr) 2010-05-07
CA2555216A1 (fr) 2005-09-29
SI1720544T1 (sl) 2008-06-30
CN100577160C (zh) 2010-01-06
ZA200606558B (en) 2008-01-08
MY137282A (en) 2009-01-30
FR2866647A1 (fr) 2005-08-26
AR047685A1 (es) 2006-02-01
KR20060114382A (ko) 2006-11-06
HK1123789A1 (en) 2009-06-26
AU2005224129A1 (en) 2005-09-29
EP1720544A1 (fr) 2006-11-15
EP1720544B1 (fr) 2008-03-19
EA010300B1 (ru) 2008-08-29
KR100885104B1 (ko) 2009-02-20
ATE389398T1 (de) 2008-04-15
CN1921848A (zh) 2007-02-28
CA2555216C (fr) 2011-10-11
CN101230033B (zh) 2011-03-09
PT1720544E (pt) 2008-05-08
ES2303233T3 (es) 2008-08-01
CY1108529T1 (el) 2014-04-09
HRP20080184T5 (en) 2008-10-31
EA200601512A1 (ru) 2007-02-27
DK1720544T3 (da) 2008-07-21
NO20064160L (no) 2006-09-14
ME01400B (en) 2013-12-20
MA28342A1 (fr) 2006-12-01
BRPI0507830A (pt) 2007-07-10
GEP20094578B (en) 2009-01-12
AU2005224129B2 (en) 2010-08-12
PL1720544T3 (pl) 2008-05-30
AR089451A2 (es) 2014-08-27
WO2005089747A1 (fr) 2005-09-29
HRP20080184T3 (hr) 2008-05-31
CN101230033A (zh) 2008-07-30
US7576120B2 (en) 2009-08-18
NO337013B1 (no) 2015-12-21
AR094601A2 (es) 2015-08-12
FR2866647B1 (fr) 2006-10-27
NZ548898A (en) 2010-06-25
DE602005005456T2 (de) 2009-04-09

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