JP4467616B2 - Ａｕｒｏｒａキナーゼの阻害により有糸分裂の進行を阻止するための化合物および方法 - Google Patents

Ａｕｒｏｒａキナーゼの阻害により有糸分裂の進行を阻止するための化合物および方法 Download PDF

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JP4467616B2
JP4467616B2 JP2007513304A JP2007513304A JP4467616B2 JP 4467616 B2 JP4467616 B2 JP 4467616B2 JP 2007513304 A JP2007513304 A JP 2007513304A JP 2007513304 A JP2007513304 A JP 2007513304A JP 4467616 B2 JP4467616 B2 JP 4467616B2
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ring
aliphatic
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chloro
phenyl
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JP2007537268A5 (https=
JP2007537268A (ja
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クリストファー エフ． クレイボーン，
ロイド ジェイ． ペイン，
リチャード ジェイ． ボイス，
トッド ビー． セルズ，
ステファン ジー． ストラウド，
スチュアート トラバース，
トリシア ジェイ． ボス，
ガブリエル エス． ウェザーヘッド，
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Millennium Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C07D491/147—Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • General Chemical & Material Sciences (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Small-Scale Networks (AREA)
JP2007513304A 2004-05-14 2005-05-12 Ａｕｒｏｒａキナーゼの阻害により有糸分裂の進行を阻止するための化合物および方法 Expired - Lifetime JP4467616B2 (ja)

Applications Claiming Priority (3)

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US57165304P 2004-05-14 2004-05-14
US61722104P 2004-10-08 2004-10-08
PCT/US2005/016445 WO2005111039A2 (en) 2004-05-14 2005-05-12 Compounds and methods for inhibiting mitotic progression by inhibition of aurora kinase

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JP2008122788A Division JP5148358B2 (ja) 2004-05-14 2008-05-08 Ａｕｒｏｒａキナーゼの阻害により有糸分裂の進行を阻止するための化合物および方法

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JP2007537268A JP2007537268A (ja) 2007-12-20
JP2007537268A5 JP2007537268A5 (https=) 2008-06-26
JP4467616B2 true JP4467616B2 (ja) 2010-05-26

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JP2007513304A Expired - Lifetime JP4467616B2 (ja) 2004-05-14 2005-05-12 Ａｕｒｏｒａキナーゼの阻害により有糸分裂の進行を阻止するための化合物および方法
JP2008122788A Expired - Lifetime JP5148358B2 (ja) 2004-05-14 2008-05-08 Ａｕｒｏｒａキナーゼの阻害により有糸分裂の進行を阻止するための化合物および方法
JP2011203714A Withdrawn JP2012006972A (ja) 2004-05-14 2011-09-16 Ａｕｒｏｒａキナーゼの阻害により有糸分裂の進行を阻止するための化合物および方法
JP2014026015A Expired - Lifetime JP5827708B2 (ja) 2004-05-14 2014-02-14 Ａｕｒｏｒａキナーゼの阻害により有糸分裂の進行を阻止するための化合物および方法

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JP2011203714A Withdrawn JP2012006972A (ja) 2004-05-14 2011-09-16 Ａｕｒｏｒａキナーゼの阻害により有糸分裂の進行を阻止するための化合物および方法
JP2014026015A Expired - Lifetime JP5827708B2 (ja) 2004-05-14 2014-02-14 Ａｕｒｏｒａキナーゼの阻害により有糸分裂の進行を阻止するための化合物および方法

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US (9) US7572784B2 (https=)
EP (4) EP2261226B1 (https=)
JP (4) JP4467616B2 (https=)
KR (3) KR20120091275A (https=)
CN (1) CN104193750B (https=)
AR (1) AR049277A1 (https=)
AT (1) ATE381566T1 (https=)
AU (1) AU2005243175B2 (https=)
BR (1) BRPI0511139B8 (https=)
CA (1) CA2565411C (https=)
CY (2) CY1108092T1 (https=)
DE (1) DE602005003951T4 (https=)
DK (1) DK1771450T5 (https=)
EA (1) EA012112B1 (https=)
ES (3) ES2540987T3 (https=)
HR (2) HRP20080120T5 (https=)
IL (1) IL179063A (https=)
MX (1) MXPA06013042A (https=)
MY (1) MY139355A (https=)
NZ (1) NZ551370A (https=)
PL (1) PL1771450T3 (https=)
PT (2) PT1771450E (https=)
RS (2) RS52436B (https=)
TW (1) TWI338688B (https=)
WO (1) WO2005111039A2 (https=)

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JP2008285484A (ja) * 2004-05-14 2008-11-27 Millennium Pharmaceuticals Inc Ａｕｒｏｒａキナーゼの阻害により有糸分裂の進行を阻止するための化合物および方法
US10213436B2 (en) 2012-03-20 2019-02-26 Millennium Pharmaceuticals, Inc. Methods of treating cancer using aurora kinase inhibitors

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